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Cited by 430melanin and skin pigmentationMelanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

MITF-the first 25 years

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Goding, Colin R., Arnheiter, Heinz·2019·Genes & Development
DOI 10.1101/gad.324657.119PMC PMC6672050
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Abstract

All transcription factors are equal, but some are more equal than others. In the 25 yr since the gene encoding the microphthalmia-associated transcription factor (MITF) was first isolated, MITF has emerged as a key coordinator of many aspects of melanocyte and melanoma biology. Like all transcription factors, MITF binds to specific DNA sequences and up-regulates or down-regulates its target genes. What marks MITF as being remarkable among its peers is the sheer range of biological processes that it appears to coordinate. These include cell survival, differentiation, proliferation, invasion, senescence, metabolism, and DNA damage repair. In this article we present our current understanding of MITF's role and regulation in development and disease, as well as those of the MITF-related factors TFEB and TFE3, and highlight key areas where our knowledge of MITF regulation and function is limited.

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  • The closest human homolog of Rtg3p is an isoform of the microphthalmia-associated transcription factor (MITF).

    “The closest human homolog of Rtg3p is an isoform of the microphthalmia-associated transcription factor (MITF) (Goding and Arnheiter 2019).”

    From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Goding and Arnheiter 2019

    The MITF genetics section says MITF has multiple isoforms and describes homologs in primitive metazoans, but it does not identify Rtg3p or compare it with human MITF. Searches for “Rtg3p” and for a yeast retrograde transcription-factor homolog found no passage establishing the claimed closest-homolog relationship. No page numbers were provided in our copy. (LLM, conf=0.73)

    Experimental — accuracy not yet measured

  • The human homolog of Rtg3p is the microphthalmia-associated transcription factor (MITF).

    “The human homolog of Rtg3p is the microphthalmia-associated transcription factor (MITF) (Goding and Arnheiter 2019), which is not involved in mitonuclear signaling that in Metazoa evolved independently and uses different mechanisms (Butow and Avadhani 2004; Jazwinski 2014; English et al. 2020).”

    From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Goding and Arnheiter 2019

    The MITF genetics section (page unavailable) describes human MITF and traces Mitf homologs to primitive metazoans, but does not identify Rtg3p as one of them. Searches for Rtg3p and yeast retrograde-response homology found no passage establishing the claimed relationship. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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200 of 219 shown

Cited by

Sorted by citations

Authors
Goding, C. R., & Arnheiter, H.
Affiliations
  • University of Oxford (GB)
  • National Institutes of Health (US)
ORCID
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2019-05-23
Volume
33
Issue
15-16
Pages
983-1007
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.324657.119
PMC
PMC6672050
OpenAlex
W2945954586
Cited by
430
References
11
Citations by year
2026: 38 · 2025: 63 · 2024: 66 · 2023: 67 · 2022: 58 · 2021: 79 · 2020: 45 · 2019: 14
Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Genes & Development (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Ludwig Institute for Cancer Research
  • National Institutes of Health (PO1 CA128814-06A1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
  • Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
Keywords
MITF, microphthalmia-associated transcription factor, melanocytes, melanoma, transcription factors, TFEB, TFE3, transcriptional regulation, melanocyte differentiation, cell proliferation, DNA repair, senescence, melanocyte development
MeSH terms
Animals, Humans, Melanocytes, Melanoma, Protein Binding, Gene Expression Regulation, Neoplastic, Genome, Protein Isoforms, Microphthalmia-Associated Transcription Factor, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

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