The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Mitochondrial biogenesis and clearance: a balancing act
Abstract
Mitochondria are semi‐autonomous organelles of prokaryotic origin that are postulated to have been acquired by eukaryotic cells through an early endosymbiotic event. Except for their main role in energy production, they are also implicated in fundamental cellular processes, including ion homeostasis, lipid metabolism, and initiation of apoptotic cell death. Perturbed mitochondrial function has been correlated with severe human pathologies such as type‐2 diabetes, cardiovascular, and neurodegenerative diseases. Thus, proper mitochondrial physiology is a prerequisite for health and survival. Cells have developed sophisticated and elaborate mechanisms to adapt to stress conditions and alterations in metabolic demands, by regulating mitochondrial number and function. Hence, the generation of new and the removal of damaged or unwanted mitochondria are highly regulated processes that need to be accurately coordinated for the maintenance of mitochondrial and cellular homeostasis. Here, we survey recent research findings that advance our understanding and highlight the importance of the underlying molecular mechanisms.
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Mitophagy in human health, ageing and disease
Picca, A., Faitg, J., Auwerx, J., Ferrucci, L., & D’Amico, D. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00930-8 · Cited by 635
Impact of the natural compound urolithin a on health, disease, and aging
D’Amico, D., Andreux, P. A., Valdés, P., Singh, A., Rinsch, C., & Auwerx, J. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.04.009 · Cited by 419
Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence
Song, M., Franco, A., Fleischer, J. A., Zhang, L., & Dorn, G. W. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.023 · Cited by 309
Oxidative stress and mitochondrial impairment: Key drivers in neurodegenerative disorders
Wen, P., Sun, Z., Gou, F., Wang, J., Fan, Q., Zhao, D., & Yang, L. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102667 · Cited by 253
Hypoxia and Selective Autophagy in Cancer Development and Therapy
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Metadata
- Authors
- Ploumi, C., Daskalaki, I., & Tavernarakis, N.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2016-08-11
- Volume
- 284
- Issue
- 2
- Pages
- 183-195
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2482486185
- Cited by
- 463
- References
- 16
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- closed
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