The role of PARP1 in neurodegenerative diseases and aging

Ageing as a risk factor for neurodegenerative disease

Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0244-7 · Cited by 3,310 · see citing works

Poly(ADP-ribose): novel functions for an old molecule

Schreiber, V., Dantzer, F., Amé, J., & de MURCIA, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1963 · Cited by 1,917 · see citing works

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242 · see citing works

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.004 · Cited by 837 · see citing works

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

Krishnakumar, R., & Kraus, W. L. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.017 · Cited by 836 · see citing works

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

Gupte, R., Liu, Z., & Kraus, W. L. (2017) · Genes & Development · doi:10.1101/gad.291518.116 · Cited by 681 · see citing works

Regulation of SIRT1 in cellular functions: Role of polyphenols

Chung, S., Yao, H., Caito, S. W., Hwang, J., Arunachalam, G., & Rahman, I. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.003 · Cited by 651 · see citing works

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

van de Haar, H. J., Burgmans, S., Jansen, J. F. A., van Osch, M. J. P., van Buchem, M. A., Muller, M., Hofman, P. A. M., Verhey, F. R. J., & Backes, W. H. (2016) · Radiology · doi:10.1148/radiol.2016152244 · Cited by 601 · see citing works

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588 · see citing works

Poly(ADP-ribose) polymerase inhibition: past, present and future

Curtin, N. J., & Szabó, C. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0076-6 · Cited by 576 · see citing works

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.004 · Cited by 575 · see citing works

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

Kam, T.-I., Mao, X., Park, H., Chou, S.-C., Karuppagounder, S. S., Umanah, G. E., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., et al. (2018) · Science · doi:10.1126/science.aat8407 · Cited by 476 · see citing works

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

Robinson, N., Ganesan, R., Hegedűs, C., Kovács, K. É., Kufer, T. A., & Virág, L. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101239 · Cited by 370 · see citing works

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

Bai, P., & Cantó, C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.016 · Cited by 312 · see citing works

Acetylation of Poly(ADP-ribose) Polymerase-1 by p300/CREB-binding Protein Regulates Coactivation of NF-κB-dependent Transcription

Hassa, P. O., Haenni, S. S., Buerki, C., Meier, N. I., Lane, W. S., Owen, H., Gersbach, M., Imhof, R., & Hottiger, M. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507553200 · Cited by 306 · see citing works

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1

He, Y., She, H., Zhang, T., Xu, H., Cheng, L., Yepes, M., Zhao, Y., & Mao, Z. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201701049 · Cited by 291 · see citing works

Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

Morra, J. H., Tu, Z., Apostolova, L. G., Green, A. E., Avedissian, C., Madsen, S. K., Parikshak, N., Toga, A. W., Jack, C. R., Schuff, N. W., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.043 · Cited by 241 · see citing works

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

Martire, S., Mosca, L., & D’Erme, M. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.04.001 · Cited by 228 · see citing works

Poly(ADP‐ribose) polymerase‐1 activity promotes NF‐κB‐driven transcription and microglial activation: implication for neurodegenerative disorders

Chiarugi, A., & Moskowitz, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01684.x · Cited by 216 · see citing works

NAD and the aging process: role in life, death and everything in between

Chini, C. C. S., Tarragó, M. G., & Chini, E. N. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.003 · Cited by 208 · see citing works

Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE

Farez, M., Quintana, F., Gandhi, R., Izquierdo, G., Lucas, M., & Weiner, H. (2009) · Nature Immunology · doi:10.1038/ni.1775 · Cited by 207 · see citing works

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

Wang, H., Guo, W., Mitra, J., Hegde, P. M., Vandoorne, T., Eckelmann, B. J., Mitra, S., Tomkinson, A. E., Van Den Bosch, L., & Hegde, M. L. (2018) · Nature Communications · doi:10.1038/s41467-018-06111-6 · Cited by 205 · see citing works

Inhibition of Crm1–p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

Kanai, M., Hanashiro, K., Kim, S., Hanai, S., Boulares, A. H., Miwa, M., & Fukasawa, K. (2007) · Nature Cell Biology · doi:10.1038/ncb1638 · Cited by 203 · see citing works

Vascular senescence in cardiovascular and metabolic diseases

Katsuumi, G., Shimizu, I., Yoshida, Y., & Minamino, T. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00018 · Cited by 196 · see citing works

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage

Rulten, S. L., Rotheray, A., Green, R. L., Grundy, G. J., Moore, D. A. Q., Gómez-Herreros, F., Hafezparast, M., & Caldecott, K. W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt835 · Cited by 190 · see citing works

Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism

Anandhan, A., Jacome, M. S., Lei, S., Hernández-Franco, P., Pappa, A., Panayiotidis, M. I., Powers, R., & Franco, R. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.009 · Cited by 161 · see citing works

Mitochondrial Dynamics: Biogenesis, Fission, Fusion, and Mitophagy in the Regulation of Stem Cell Behaviors

Fu, W., Liu, Y., & Yin, H. (2019) · Stem Cells International · doi:10.1155/2019/9757201 · Cited by 159 · see citing works

Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis

Liu, T., Yang, Q., Zhang, X., Qin, R., Shan, W., Zhang, H., & Chen, X. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118116 · Cited by 158 · see citing works

Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

Meng, Q., Guo, T., Li, G., Sun, S., He, S., Cheng, B., Shi, B., & Shan, A. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0248-y · Cited by 152 · see citing works

The expanding field of poly(ADP‐ribosyl)ation reactions

Hakmé, A., Wong, H., Dantzer, F., & Schreiber, V. (2008) · EMBO Reports · doi:10.1038/embor.2008.191 · Cited by 148 · see citing works

3D maps localize caudate nucleus atrophy in 400 Alzheimer’s disease, mild cognitive impairment, and healthy elderly subjects

Madsen, S. K., Ho, A. J., Hua, X., Saharan, P., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.002 · Cited by 144 · see citing works

Oxidative Stress in Aging-Matters of the Heart and Mind

Venkataraman, K., Khurana, S., & Tai, T. C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917897 · Cited by 143 · see citing works

Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease

Sasaki, T., Liu, K., Agari, T., Yasuhara, T., Morimoto, J., Okazaki, M., Takeuchi, H., Toyoshima, A., Sasada, S., Shinko, A., et al. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.11.003 · Cited by 140 · see citing works

Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

Muiras, M.-L., Müller, M. C., Schächter, F., & Bürkle, A. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050226 · Cited by 140 · see citing works

Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling

Zhang, N., Zhang, Y., Qian, H. R., Wu, S., Cao, L., & Sun, Y. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0523-2 · Cited by 127 · see citing works

PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury

Stoica, B. A., Loane, D. J., Zhao, Z., Kabadi, S. V., Hanscom, M., Byrnes, K. R., & Faden, A. I. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.3194 · Cited by 122 · see citing works

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation

Mangerich, A., & Bürkle, A. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/321653 · Cited by 121 · see citing works

Genome instability in Alzheimer disease

Hou, Y., Song, H., Croteau, D. L., Akbari, M., & Bohr, V. A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.04.005 · Cited by 120 · see citing works

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and Beyond

Ke, Y., Wang, C., Zhang, J., Zhong, X., Wang, R., Zeng, X., & Ba, X. (2019) · Cells · doi:10.3390/cells8091047 · Cited by 120 · see citing works

Social hallmarks of aging: Suggestions for geroscience research

Crimmins, E. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101136 · Cited by 120 · see citing works

Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?

Yuan, Y., & Padanilam, B. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2202-5 · Cited by 119 · see citing works

Contributions of DNA Damage to Alzheimer’s Disease

Lin, X., Kapoor, A., Gu, Y., Chow, M. J., Peng, J., Zhao, K., & Tang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051666 · Cited by 117 · see citing works

PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation

Yang, Z., Li, L., Chen, L., Yuan, W., Dong, L., Zhang, Y., Wu, H., & Wang, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400359 · Cited by 114 · see citing works

Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin‐Deficient mdx Mice

Sebori, R., Kuno, A., Hosoda, R., Hayashi, T., & Horio, Y. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9179270 · Cited by 113 · see citing works

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

Kauppinen, T. M., Suh, S., Higashi, Y., Berman, A. E., Escartin, C., Won, S., Wang, C., Cho, S.-H., Gan, L., & Swanson, R. A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-152 · Cited by 112 · see citing works

The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1

Fischbach, A., Krüger, A., Hampp, S., Assmann, G. M., Rank, L., Hufnagel, M., Stöckl, M. T., Fischer, J. M. F., Veith, S., Rossatti, P., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1205 · Cited by 111 · see citing works

The expanding field of poly(ADP‐ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

Hakmé, A., Wong, H., Dantzer, F., & Schreiber, V. (2008) · EMBO Reports · doi:10.1038/embor.2008.213 · Cited by 109 · see citing works

Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

Horváth, I., Weise, C., Andersson, E. K., Chorell, E., Sellstedt, M., Bengtsson, C., Olofsson, A., Hultgren, S. J., Chapman, M. R., Wolf‐Watz, M., et al. (2012) · Journal of the American Chemical Society · doi:10.1021/ja209829m · Cited by 106 · see citing works

Sex differences in Alzheimer’s disease: Understanding the molecular impact

Toro, C. A., Zhang, L., Cao, J., & Cai, D. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.031 · Cited by 97 · see citing works

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

Szczęsny, B., Brunyánszki, A., Oláh, G., MITRA, S. P., & Szabó, C. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1089 · Cited by 96 · see citing works

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease

Kim, T. W., Cho, H. M., Choi, S. Y., Suguira, Y., Hayasaka, T., Setou, M., Koh, H. C., Hwang, E. M., Park, J., Kang, S. J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.447 · Cited by 95 · see citing works

OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos

Wang, R., Li, C., Qiao, P., Xue, Y., Zheng, X., Chen, H., Zeng, X., Liu, W., Boldogh, I. R., & Ba, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0680-0 · Cited by 94 · see citing works

The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier

Magaki, S., Tang, Z., Tung, S., Williams, C. K., Lo, D., Yong, W. H., Khanlou, N., & Vinters, H. V. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.06.004 · Cited by 93 · see citing works

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1

Beneke, S., Cohausz, O., Malanga, M., Boukamp, P., Althaus, F., & Bürkle, A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn615 · Cited by 88 · see citing works

The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolismPreprint

Szántó, M., & Bai, P. (2020) · Genes & Development · doi:10.1101/gad.334284.119 · Cited by 88 · see citing works

Characterization of nucleic acids by tandem mass spectrometry ‐ The second decade (2004–2013): From DNA to RNA and modified sequences

Schürch, S. (2014) · Mass Spectrometry Reviews · doi:10.1002/mas.21442 · Cited by 83 · see citing works

Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases

Beurel, E. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00018 · Cited by 82 · see citing works

Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment

Nho, K. T., Corneveaux, J. J., Kim, S., Lin, H., Risacher, S. L., Shen, L., Swaminathan, S., Ramanan, V. K., Liu, Y., Foroud, T., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.24 · Cited by 81 · see citing works

Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons

Narne, P., Pandey, V., Simhadri, P. K., & Phanithi, P. B. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.11.007 · Cited by 80 · see citing works

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1‐BMAL1 Pathway in 6‐OHDA‐Induced Models of Parkinson’s Disease

Wang, Y., Lv, D.-J., Liu, W., Li, S., Chen, J., Shen, Y., Fen, W., Hu, L., & Liu, C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4854732 · Cited by 79 · see citing works

Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer

Zhou, Z. G., Sun, B., Huang, S., Yu, D., & Zhang, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02794-2 · Cited by 77 · see citing works

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

Qian, M., Liu, Z., Peng, L., Tang, X., Meng, F., Ao, Y., Zhou, M., Wang, M., Cao, X., Qin, B., et al. (2018) · eLife · doi:10.7554/elife.34836 · Cited by 76 · see citing works

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

van de Haar, H. J., Burgmans, S., Jansen, J. F. A., van Osch, M. J. P., van Buchem, M. A., Muller, M., Hofman, P. A. M., Verhey, F. R. J., & Backes, W. H. (2017) · Radiology · doi:10.1148/radiol.2017164043 · Cited by 76 · see citing works

Poly (ADP‐ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α‐synuclein degradation via transcription factor EB‐dependent autophagy in mutant α‐synucleinA53T model of Parkinson's disease

Mao, K., Chen, J., Yu, H., Li, H., Ren, Y., Wu, X. G., Wen, Y., Zou, F., & Li, W. (2020) · Aging Cell · doi:10.1111/acel.13163 · Cited by 76 · see citing works

Transcriptomics in Alzheimer’s Disease: Aspects and Challenges

Bagyinszky, E., Giau, V. V., & An, S. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103517 · Cited by 75 · see citing works

Sumoylation of poly(ADP‐ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function

Messner, S., Schuermann, D., Altmeyer, M., Kassner, I., Schmidt, D., Schär, P., Müller, S. P., & Rottiger, M. O. (2009) · The FASEB Journal · doi:10.1096/fj.09-137695 · Cited by 73 · see citing works

Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work

Brunyánszki, A., Szczęsny, B., Virág, L., & Szabó, C. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.024 · Cited by 73 · see citing works

Naked mole rat cells display more efficient excision repair than mouse cells

Evdokimov, A. N., Kutuzov, M. M., Petruseva, I. O., Lukjanchikova, N., Kashina, E. V., Kolova, E., Zemerova, T., Romanenko, S. A., Perelman, P. L., Prokopov, D., et al. (2018) · Aging · doi:10.18632/aging.101482 · Cited by 73 · see citing works

Poly(ADP-ribose) Polymerase-1 Inhibition in Brain Endothelium Protects the Blood—Brain Barrier under Physiologic and Neuroinflammatory Conditions

Rom, S., Zuluaga‐Ramirez, V., Dykstra, H., Reichenbach, N. L., Ramirez, S. H., & Persidsky, Y. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.167 · Cited by 71 · see citing works

NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1

Vuong, B., Hogan-Cann, A. D., Alano, C. C., Stevenson, M., Chan, W., Anderson, C. M., Swanson, R. A., & Kauppinen, T. M. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0448-8 · Cited by 71 · see citing works

Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes

Ding, S.-L., & Shen, C. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s1957 · Cited by 69 · see citing works

Cardiac specific deletion of N -methyl- d -aspartate receptor 1 ameliorates mtMMP-9 mediated autophagy/mitophagy in hyperhomocysteinemia

Tyagi, N., Vacek, J. C., Givvimani, S., Sen, U., & Tyagi, S. C. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799891003614808 · Cited by 66 · see citing works

Oxidative DNA Damage Repair and parp 1 and parp 2 Expression in Epstein-Barr Virus-Immortalized B Lymphocyte Cells from Young Subjects, Old Subjects, and Centenarians

Chevanne, M., Calia, C., Zampieri, M., Cecchinelli, B., Caldini, R., Monti, D., Bucci, L., Franceschi, C., & Caiafa, P. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0514 · Cited by 64 · see citing works

Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length

Kesäniemi, J., Lavrinienko, A., Tukalenko, E., Boratyński, Z., Kivisaari, K., Mappes, T., Milinevsky, G. P., Møller, A. P., Mousseau, T. A., & Watts, P. C. (2019) · Scientific Reports · doi:10.1038/s41598-018-37164-8 · Cited by 63 · see citing works

Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma

Zhou, B., Yan, J., Guo, L., Zhang, B., Liu, S., Yu, M., Chen, Z., Zhang, K., Zhang, W., Li, X., et al. (2020) · Theranostics · doi:10.7150/thno.44417 · Cited by 63 · see citing works

Centrality of Early Synaptopathy in Parkinson’s Disease

Imbriani, P., Schirinzi, T., Meringolo, M., Mercuri, N. B., & Pisani, A. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00103 · Cited by 60 · see citing works

Nicotinamide Augments the Anti-Inflammatory Properties of Resveratrol through PARP1 Activation

Yanez, M., Jhanji, M., Murphy, K. P., Gower, R. M., Sajish, M., & Jabbarzadeh, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-46678-8 · Cited by 58 · see citing works

USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis

Takahashi, M., Kitaura, H., Kakita, A., Kakihana, T., Katsuragi, Y., Nameta, M., Zhang, L., Iwakura, Y., Nawa, H., Higuchi, M., et al. (2018) · iScience · doi:10.1016/j.isci.2018.11.006 · Cited by 54 · see citing works

PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

Zha, S., Li, Z., Cao, Q., Wang, F., & Liu, F. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0961-7 · Cited by 50 · see citing works

Metabolic alterations in plasma from patients with familial and idiopathic Parkinson’s disease

Yakhine-Diop, S. M. S., Morales-García, J. A., Niso-Santano, M., González-Polo, R. A., Uribe-Carretero, E., Martinez-Chacon, G., Durand, S., Maiuri, M. C., Aiastui, A., Zulaica, M., et al. (2020) · Aging · doi:10.18632/aging.103992 · Cited by 50 · see citing works

Telomere length and mortality in the Ludwigshafen Risk and Cardiovascular Health study

Pusceddu, I., Kleber, M. E., Delgado, G., Herrmann, W., März, W., & Herrmann, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198373 · Cited by 48 · see citing works

Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis

Espinoza‐Derout, J., Shao, X. M., Bankole, E., Hasan, K. M., Mtume, N., Liu, Y., Sinha‐Hikim, A. P., & Friedman, T. C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00320 · Cited by 47 · see citing works

c-Abl–Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes

Bohio, A. A., Aman, S., Wang, R., Wang, X., Sah, R. K., Guo, X., Zeng, X., Ke, Y., Boldogh, I. R., & Ba, X. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801616 · Cited by 46 · see citing works

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function

Galindo-Campos, M. A., Bedora-Faure, M., Farrés, J., Lescale, C., Moreno-Lama, L., Martínez, C. M., Martín‐Caballero, J., Ampurdanés, C., Aparício, P., Dantzer, F., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0326-5 · Cited by 45 · see citing works

Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

Wencel, P. L., Lukiw, W. J., Strosznajder, J. B., & Strosznajder, R. P. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0646-8 · Cited by 43 · see citing works

Zinc Inhibits Astrocyte Glutamate Uptake by Activation of Poly(ADP-ribose) Polymerase-1

Suh, S. W., Aoyama, K., Alano, C. C., Anderson, C. M., Hamby, A. M., & Swanson, R. A. (2007) · Molecular Medicine · doi:10.2119/2007-00043.suh · Cited by 42 · see citing works

NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling

Shen, A., Kim, H.-J., Oh, G., Lee, S.-B., Lee, S. H., Pandit, A., Khadka, D., Choe, S., Kwak, S. C., Yang, S. H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03418-0 · Cited by 42 · see citing works

HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation

Lin, S., Wang, Y., Zhang, X., Kong, Q., Li, C., Li, Y., Ding, Z., & Liu, L. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2586706 · Cited by 41 · see citing works

FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration

Yu, C., Kim, B., & Kim, E. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.99 · Cited by 41 · see citing works

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription

Bütepage, M., Preisinger, C., von Kriegsheim, A., Scheufen, A., Lausberg, E., Li, J., Kappes, F., Feederle, R., Ernst, S., Eckei, L., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25137-w · Cited by 40 · see citing works

MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair

Ruiz, P. D., Hamilton, G. A., Park, J. W., & Gamble, M. J. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00230-19 · Cited by 40 · see citing works

Intermediate flortaucipir uptake is associated with Aβ-PET and CSF tau in asymptomatic adults

McSweeney, M., Binette, A. P., Meyer, P., Gonneaud, J., Bedetti, C., Ozlen, H., Labonté, A., Rosa‐Neto, P., Breitner, J. C. S., Poirier, J., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000008905 · Cited by 37 · see citing works

Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases

Bickford, P. C., Flowers, A., & Grimmig, B. A. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.027 · Cited by 36 · see citing works

The interplay between microRNAs and histone deacetylases in neurological diseases

Bourassa, M. W., & Ratan, R. R. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.03.012 · Cited by 33 · see citing works

The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells

Booth, L. A., Roberts, J. L., Samuel, P., Avogadri-Connors, F., Cutler, R. E., Lalani, A. S., Poklepovic, A. S., & Dent, P. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1436024 · Cited by 33 · see citing works

Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity

Ponce, D., Salech, F., Martin, C., Silva, M., Xiong, C., Roe, C. M., Henríquez, M., Quest, F., & Behrens, M. I. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666141001113135 · Cited by 32 · see citing works

PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients

Salech, F., Ponce, D. P., SanMartín, C. D., Rogers, N. K., Chacón, C., Henríquez, M., & Behrens, M. I. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00310 · Cited by 30 · see citing works

Regulated Cell Death Signaling Pathways and Marine Natural Products That Target Them

Guzmán, E. A. (2019) · Marine Drugs · doi:10.3390/md17020076 · Cited by 28 · see citing works

VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2

Yun, S. P., Kim, H., Ham, S., Kwon, S., Lee, G. H., Shin, J., Lee, S. H., Ko, H. S., & Lee, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.157 · Cited by 26 · see citing works

The poly(ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-κB activation

Faraoni, I., Aloisio, F. M., Gabrieli, A. D., Consalvo, M. I., Lavorgna, S., Voso, M. T., Lo‐Coco, F., & Graziani, G. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.03.008 · Cited by 26 · see citing works

DNA-dependent SUMO modification of PARP-1

Zilio, N., Williamson, C. T., Eustermann, S., Punatar, R. S., West, S. C., Neuhaus, D., & Ulrich, H. D. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.07.001 · Cited by 23 · see citing works

Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment

Regier, M., Liang, J., Choi, A. H., Verma, K. C., Libien, J. M., & Hernandez, A. I. (2019) · Neural Plasticity · doi:10.1155/2019/4383258 · Cited by 22 · see citing works

Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson’s Disease Penetrance

Zanon, A., Pramstaller, P. P., Hicks, A. A., & Pichler, I. (2018) · Parkinson s Disease · doi:10.1155/2018/8684906 · Cited by 21 · see citing works

In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer’s disease

Hu, X., Dong, W., Cui, Z.-W., Gao, C., Yu, Z., Yuan, Q., & Min, Z.-L. (2018) · Journal of Molecular Modeling · doi:10.1007/s00894-018-3696-6 · Cited by 20 · see citing works

Effects of Boswellia serrata resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson's disease.

Doaee, P., Rajaei, Z., Roghani, M., Alaei, H., & Kamalinejad, M. (2019) · PubMed Central · doi:10.22038/ajp.2019.12403 · Cited by 19 · see citing works

Autophagy regulation is an effective strategy to improve the prognosis of chemically induced acute liver injury based on experimental studies

Hu, C., Zhao, L., Shen, M., Wu, Z., & Li, L. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15565 · Cited by 19 · see citing works

Molecular Crosstalk Between Circadian Rhythmicity and the Development of Neurodegenerative Disorders

Sharma, A., Lee, S., Kim, H., Yoon, H., Ha, S., & Kang, S. U. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00844 · Cited by 19 · see citing works

Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models

Kim, H., Ham, S., Lee, J. Y., Jo, A., Lee, G. H., Lee, Y., Cho, M., Shin, H., Kim, D., Pletniková, O., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21828 · Cited by 18 · see citing works

PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ

Harvey, A., Mielke, N., Grimstead, J. W., Jones, R. E., Nguyen, T., Mueller, M. R., Baird, D. M., & Hendrickson, E. A. (2018) · Oncotarget · doi:10.18632/oncotarget.26201 · Cited by 17 · see citing works

Cytotoxicity and Differentiating Effect of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Myelodysplastic Syndromes

Faraoni, I., Consalvo, M. I., Aloisio, F. M., Fabiani, E., Giansanti, M., Cristino, F. D., Falconi, G., Tentori, L., Veroli, A. D., Curzi, P., et al. (2019) · Cancers · doi:10.3390/cancers11091373 · Cited by 16 · see citing works

Dysregulation of PARP1 is involved in development of Barrett’s esophagus

Zhang, C., Ma, T., Luo, T., Li, A., Gao, X., Wang, Z., & Li, F. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i9.982 · Cited by 15 · see citing works

High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition

Ye, T., Lu, Y., Yan, X., Hu, X., & Wang, X.-L. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i36.5434 · Cited by 13 · see citing works

Differential Localisation of PARP-1 N-Terminal Fragment in PARP-1+/+ and PARP-1−/− Murine Cells

Rajiah, I. R., & Skepper, J. N. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0077 · Cited by 5 · see citing works

Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

Hrubša, M., Siatka, T., Najmanová, I., Vopršalová, M., Krčmová, L. K., Matoušová, K., Javorská, L., Macáková, K., Mercolini, L., Remião, F., et al. (2022) · Nutrients · doi:10.3390/nu14030484 · Cited by 277 · see citing works

Inflammation and DNA damage: cause, effect or both

Pezone, A., Olivieri, F., Napoli, M. V., Procopio, A., Avvedimento, E. V., & Gabrielli, A. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00905-1 · Cited by 212 · see citing works

Causes and consequences of DNA single-strand breaks

Caldecott, K. W. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.11.001 · Cited by 132 · see citing works

Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease

Welch, G., & Tsai, L. (2022) · The EMBO Reports · doi:10.15252/embr.202154217 · Cited by 129 · see citing works

Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson’s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment

Que, R., Zheng, J., Chang, Z., Zhang, W., Li, H., Xie, Z., Huang, Z., Wang, H., Xu, J., Jin, D., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.794770 · Cited by 111 · see citing works

PARP1: Liaison of Chromatin Remodeling and Transcription

Zong, W., Gong, Y., Sun, W., Li, T., & Wang, Z. (2022) · Cancers · doi:10.3390/cancers14174162 · Cited by 91 · see citing works

The threat of programmed DNA damage to neuronal genome integrity and plasticity

Caldecott, K. W., Ward, M. E., & Nussenzweig, A. (2022) · Nature Genetics · doi:10.1038/s41588-021-01001-y · Cited by 80 · see citing works

NAD+ regulates nucleotide metabolism and genomic DNA replication

Munk, S. H. N., Merchut‐Maya, J. M., Adelantado-Rubio, A., Hall, A., Pappas, G. D., Milletti, G., Lee, M., Johnsen, L. G., Guldberg, P., Bártek, J., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01280-z · Cited by 71 · see citing works

Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities

Xu, X., Sun, B., & Zhao, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106314 · Cited by 70 · see citing works

Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases

Kovács, Z., Brunner, B., & Ari, C. (2021) · Nutrients · doi:10.3390/nu13072197 · Cited by 67 · see citing works

DNA repair as a shared hallmark in cancer and ageing

Clarke, T. L., & Mostoslavsky, R. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13285 · Cited by 68 · see citing works

Parthanatos: Mechanisms, modulation, and therapeutic prospects in neurodegenerative disease and stroke

Liu, Y., Guttman, L. C., Dawson, V. L., & Dawson, T. M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116174 · Cited by 64 · see citing works

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023) · Nutrients · doi:10.3390/nu15020445 · Cited by 60 · see citing works

Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose)

Reber, J. M., & Mangerich, A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab618 · Cited by 57 · see citing works

A Double-Edged Sword: The Two Faces of PARylation

Kang, M., Park, S., Park, S., Lee, H. G., & Park, J. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179826 · Cited by 46 · see citing works

Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography

Mayor, E. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1161814 · Cited by 46 · see citing works

Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer’s Disease

Maggiore, A., Casale, A. M., Toscanelli, W., Cappucci, U., Rotili, D., Grieco, M., Gagné, J.-P., Poirier, G. G., d’Erme, M., & Piacentini, L. (2022) · Cells · doi:10.3390/cells11081284 · Cited by 40 · see citing works

Probiotics as functional foods: How probiotics can alleviate the symptoms of neurological disabilities

Aghamohammad, S., Hafezi, A., & Rohani, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114816 · Cited by 40 · see citing works

Pleiotropic role of PARP1: an overview

Kumar, V., Kumar, A., Mir, K. U. I., Yadav, V., & Chauhan, S. S. (2021) · 3 Biotech · doi:10.1007/s13205-021-03038-6 · Cited by 34 · see citing works

PARP1 at the crossroad of cellular senescence and nucleolar processes

Kołacz-Milewska, K., & Robaszkiewicz, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102206 · Cited by 34 · see citing works

Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor

Johannes, J. W., Balazs, A., Barratt, D. G., Biśta, M., Chuba, M. D., Cosulich, S. C., Critchlow, S. E., Degorce, S. L., Fruscia, P. D., Edmondson, S. D., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01725 · Cited by 33 · see citing works

A blood‐based multi‐pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups

Jiang, Y., Uhm, H., Ip, F. C., Ouyang, L., Lo, R. M. N., Cheng, E. Y. L., Cao, X., Tan, C. M. C., Law, B. C. H., Ortiz‐Romero, P., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13676 · Cited by 36 · see citing works

Dihuang-Yinzi Alleviates Cognition Deficits via Targeting Energy-Related Metabolism in an Alzheimer Mouse Model as Demonstrated by Integration of Metabolomics and Network Pharmacology

Han, G., Zhen, W., Dai, Y., Yu, H., Li, D., & Ma, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.873929 · Cited by 30 · see citing works

The Beneficial Role of Sirtuin 1 in Preventive or Therapeutic Options of Neurodegenerative Diseases

Liu, H., Xu, S., Wang, C., Deng, Y. L., Xu, B., Yang, T., Sun, J., & Liu, W. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.09.021 · Cited by 30 · see citing works

Mitochondria in aging and age-associated diseases.

Pahal, S., Mainali, N., Balasubramaniam, M., Reis, R. S., & Ayyadevara, S. (2025) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2025.102022 · Cited by 25 · see citing works

DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson’s Disease

Yazar, V., Dawson, V. L., Dawson, T. M., & Kang, S.-U. (2023) · Journal of Parkinson s Disease · doi:10.3233/jpd-223517 · Cited by 28 · see citing works

Endothelial dysfunction in the aging kidney

Borri, M., Jacobs, M. E., Carmeliet, P., Rabelink, T. J., & Dumas, S. J. (2025) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00287.2024 · Cited by 30 · see citing works

New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders

Liu, J., Duan, W., Deng, Y., Zhang, Q., Li, R., Long, J., Waqas, A., Gu, C., Qiu, Y., Cai, H., et al. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2203058 · Cited by 26 · see citing works

Alteration in the chromatin landscape during the DNA damage response: Continuous rotation of the gear driving cellular senescence and aging

Qian, J., Zhou, X., Tanaka, K., & Takahashi, A. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103572 · Cited by 25 · see citing works

Existing Evidence for the Repurposing of PARP-1 Inhibitors in Rare Demyelinating Diseases

Mekhaeil, M., Dev, K. K., & Conroy, M. J. (2022) · Cancers · doi:10.3390/cancers14030687 · Cited by 25 · see citing works

Ambient particulate matter exposure causes visual dysfunction and retinal neuronal degeneration

Li, L., Song, M., Zhou, J., Sun, X., & Lei, Y. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114231 · Cited by 25 · see citing works

PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration

Zhang, H., Xie, Z., Peng, Y., Xie, A., Fu, C., Zheng, D., Cai, Z., Zhong, J., Ming, Q., Li, M., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114630 · Cited by 24 · see citing works

Poly ( ADP ‐ribose) polymerase 1‐mediated defective mitophagy contributes to painful diabetic neuropathy in the db/db model

Yuan, P., Song, F., Zhu, P., Fan, K., Liao, Q., Huang, L., & Liu, Z. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15606 · Cited by 24 · see citing works

Inter-Organelle Crosstalk in Oxidative Distress: A Unified TRPM2-NOX2 Mediated Vicious Cycle Involving Ca2+, Zn2+, and ROS Amplification

Shitaw, E. E., AlAhmad, M., & Sivaprasadarao, A. (2025) · Antioxidants · doi:10.3390/antiox14070776 · Cited by 26 · see citing works

Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting

Wang, Y., Pleasure, D., Deng, W., & Guo, F. (2021) · Advanced Science · doi:10.1002/advs.202102853 · Cited by 22 · see citing works

DNA damage and regulation of protein homeostasis

Paull, T. T. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103155 · Cited by 21 · see citing works

Protein modification in neurodegenerative diseases

Ramazi, S., Dadzadi, M., Darvazi, M., Seddigh, N., & Allahverdi, A. (2024) · MedComm · doi:10.1002/mco2.674 · Cited by 24 · see citing works

Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders

Giri, A., Mehan, S., Khan, Z., Gupta, G. D., Narula, A. S., & Kalfin, R. E. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02939-y · Cited by 20 · see citing works

Genetic and pharmacological PARP inhibition reduces axonal degeneration in C. elegans models of ALS

Tossing, G., Livernoche, R., Maios, C., Bretonneau, C., Labarre, A., & Parker, J. A. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac116 · Cited by 20 · see citing works

Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

Mousavi, H., Rimaz, M., & Zeynizadeh, B. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00055 · Cited by 20 · see citing works

Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity

Espinar, L., García‐Cao, M., Schmidt, A., Kourtis, S., Zapater, A. G., Aranda-Vallejo, C., Ghose, R., Garcia-Lopez, L., Sheraj, I., Lorente, N. P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53877-z · Cited by 19 · see citing works

Single nuclei transcriptomics in diabetic mice reveals altered brain hippocampal endothelial cell function, permeability, and behavior

Nuthikattu, S., Milenković, D., Norman, J., & Villablanca, A. C. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166970 · Cited by 19 · see citing works

Involvement of regulated cell deaths in aging and age-related pathologies

Torre, L. D., Beato, A., Capone, V., Carannante, D., Verrilli, G., Favale, G., Gaudio, N. D., Megchelenbrink, W., Benedetti, R., Altucci, L., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102251 · Cited by 19 · see citing works

Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43

Dent, P., Booth, L. A., Roberts, J. L., Poklepovic, A. S., Cridebring, D., & Reiman, E. M. (2021) · Aging · doi:10.18632/aging.203297 · Cited by 18 · see citing works

Interaction between polyphenols and amyloids: from the view of prevention of protein misfolding disorders related diseases

Ruan, C., Kong, J., He, X., Hu, B., & Zeng, X. (2022) · Food Materials Research · doi:10.48130/fmr-2022-0002 · Cited by 17 · see citing works

Small molecule tractable PARP inhibitors: Scaffold construction approaches, mechanistic insights and structure activity relationship

Thakur, A., Rana, M., Ritika, Mathew, J., Nepali, S., Pan, C.-H., Liou, J. P., & Nepali, K. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106893 · Cited by 17 · see citing works

Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells

de Lucia, C., Murphy, T., Maruszak, A., Wright, P., Powell, T. R., Hartopp, N., de Jong, S., O'Sullivan, M. J., Breen, G. D., Price, J., et al. (2021) · Aging and Disease · doi:10.14336/ad.2021.0409 · Cited by 16 · see citing works

Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms

Mohammadkhanizadeh, A., Sheibani, M., Taherkhani, S., Nourabadi, D., Mohamadi-Zarch, S.-M., Nikbakht, F., & Azizi, Y. (2025) · Brain Disorders · doi:10.1016/j.dscb.2025.100189 · Cited by 16 · see citing works

Uncovering Cell Cycle Dysregulations and Associated Mechanisms in Cancer and Neurodegenerative Disorders: A Glimpse of Hope for Repurposed Drugs

Advani, D., & Kumar, P. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04130-7 · Cited by 16 · see citing works

Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity

Marty, F. H., Bettamin, L., Thouard, A., Bourgade, K., Allart, S., Larrieu, G., Malnou, C. E., Gonzalez‐Dunia, D., & Suberbielle, E. (2021) · iScience · doi:10.1016/j.isci.2021.103621 · Cited by 16 · see citing works

Mitochondrial dysfunction drives cellular senescence: Molecular mechanisms of inter-organelle communication

Xie, Z., Zhang, X., Li, Y., & Zhu, R. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112913 · Cited by 16 · see citing works

Resveratrol Preconditioning Downregulates PARP1 Protein to Alleviate PARP1-Mediated Cell Death Following Cerebral Ischemia

Jackson, C. W., Xu, J., Escobar, I., Saul, I., Fagerli, E. A., Dave, K. R., & Pérez‐Pinzón, M. A. (2023) · Translational Stroke Research · doi:10.1007/s12975-022-01119-z · Cited by 15 · see citing works

STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes

Murata, H., Yasui, Y., Oiso, K., Ochi, T., Tomonobu, N., Yamamoto, K., Kinoshita, R., & Sakaguchi, M. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110717 · Cited by 14 · see citing works

Effects of Amyloid-β-Mimicking Peptide Hydrogel Matrix on Neuronal Progenitor Cell Phenotype for the in vitro Modeling of Alzheimer's Disease

Mathes, T. G., Monirizad, M., Ermis, M., de Barros, N. R., Rodriguez, M., Kraatz, H., Jucaud, V., Khademhosseini, A., & Falcone, N. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.05.020 · Cited by 15 · see citing works

Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand

Zhou, X., Chen, J., Patel, J. S., Ran, W., Li, Y., Van, R. S., Ibrahim, M. M. H., Zhao, C., Gao, Y., Rong, J., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.020 · Cited by 14 · see citing works

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

Ding, Y., Botchway, B. O. A., Zhang, Y., & Liu, X. (2023) · Food & Function · doi:10.1039/d2fo03484k · Cited by 13 · see citing works

NAD + depletion is central to placental dysfunction in an inflammatory subclass of preeclampsia

Jahan, F., Vasam, G., Cariaco, Y., Nik-Akhtar, A., Green, A. E., Menzies, K. J., & Bainbridge, S. A. (2024) · Life Science Alliance · doi:10.26508/lsa.202302505 · Cited by 12 · see citing works

Protective effect of saffron carotenoids against amyloid b eta‐induced neurotoxicity in differentiated PC12 cells via the unfolded protein response and autophagy

Sanjari‐Pour, M., Faridi, N., Wang, P., & Bathaie, S. Z. (2023) · Phytotherapy Research · doi:10.1002/ptr.7773 · Cited by 11 · see citing works

A Review of PARP-1 Inhibitors: Assessing Emerging Prospects and Tailoring Therapeutic Strategies

Ramesh, S., Almeida, S. D., Hammigi, S., Radhakrishna, G. K., Sireesha, G., Theivendren, P., Vellingiri, S., Kunjiappan, S., Ammunje, D. N., & Pavadai, P. (2023) · Drug Research · doi:10.1055/a-2181-0813 · Cited by 12 · see citing works

DNA damage induced PARP ‐1 overactivation confers paclitaxel‐induced neuropathic pain by regulating mitochondrial oxidative metabolism

Ge, M., Hu, J., Zhou, Y., Tian, Y., Liu, Z., Yang, H., Zhou, Y., Qiu, Q., & Ye, D. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70012 · Cited by 11 · see citing works

Deciphering the mechanisms underlying the neuroprotective potential of kaempferol: a comprehensive investigation

Chaubey, S., & Singh, L. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03515-8 · Cited by 12 · see citing works

Exploring Non‐Coding RNA Regulation of the Blood–Brain Barrier in Neurodegenerative Diseases: A Systematic Review

Maazouzi, M., Rasheed, M., Mbarek, L., Wang, X., Liang, J., Ma, H., Chen, Z., & Deng, Y. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70031 · Cited by 11 · see citing works

Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing

Makeeva, V. S., Dyrkheeva, N. S., Lavrik, O. I., Zakian, S. M., & Malakhova, A. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316798 · Cited by 11 · see citing works

The brain—from neurodevelopment to neurodegeneration

Abramov, A. Y. (2022) · FEBS Journal · doi:10.1111/febs.16436 · Cited by 11 · see citing works

NOX2-TRPM2 coupling promotes Zn2+ inhibition of complex III to exacerbate ROS production in a cellular model of Parkinson’s disease

AlAhmad, M., Isbea, H., Shitaw, E., Li, F., & Sivaprasadarao, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-66630-9 · Cited by 11 · see citing works

Application trends of hydrogen-generating nanomaterials for the treatment of ROS-related diseases

Li, X., Wang, X., Chen, G., & Tian, B. (2024) · Biomaterials Science · doi:10.1039/d4bm01450b · Cited by 10 · see citing works

Direct hybridization and bioinformatics analysis of circulating microRNAs in patients with Alzheimer’s disease under intravenous trehalose treatment

Radbakhsh, S., Abrego-Guandique, D. M., Bacchetti, T., Aghaee‐Bakhtiari, S. H., Mahmoudi, A. A., Manteghi, A. A., Bazyari, M. J., Cione, E., Ferretti, G., & Sahebkar, A. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149607 · Cited by 10 · see citing works

Poly (ADP-Ribose) Polymerase 1 Regulates Cajal–Retzius Cell Development and Neural Precursor Cell Adhesion

Nelson, M. M., Hoff, J. D., Zeese, M. L., & Corfas, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.693595 · Cited by 10 · see citing works

Lactylation-driven nuclear RIG-I promoted by lactate transporter inhibitor suppresses DNA damage repair through inhibiting PARP1 activity

Li, Y., Wang, C., Zhou, S., Shi, Y., Zhu, D., & Zheng, X. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116854 · Cited by 11 · see citing works

Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases

Tong, J., Chen, B., Tan, P. W., Kurpiewski, S., & Cai, Z. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1062432 · Cited by 9 · see citing works

Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration

Hastings, L., Sokratian, A., Apicco, D. J., Stanhope, C. M., Smith, L., Hirst, W. D., West, A. B., & Kelly, K. (2022) · Brain Communications · doi:10.1093/braincomms/fcac042 · Cited by 8 · see citing works

Autophagy–NAD+ axis: emerging insights into neuronal homeostasis and neurodegenerative diseases

Koçak, G., Dimas, M. M., Silva, L., Silva-Amaral, D., Sun, C., Cruddas, S., Barrett, T. G., Martins‐de‐Souza, D., Cunha‐Neto, E., Brocardo, P. S., et al. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1695486 · Cited by 8 · see citing works

Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic frontiers

Ercin, N., Beşli, N., Beker, M., & Kılıç, Ü. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02260-y · Cited by 8 · see citing works

Synthetically accessible de novo design using reaction vectors: Application to PARP1 inhibitors**

Ghiandoni, G. M., Flanagan, S. R., Bodkin, M. J., Nizi, M. G., Galera‐Prat, A., Brai, A., Chen, B., Wallace, J. E. A., Hristozov, D., Webster, J., et al. (2024) · Molecular Informatics · doi:10.1002/minf.202300183 · Cited by 8 · see citing works

Broken strands, broken minds: Exploring the nexus of DNA damage and neurodegeneration

Stavgiannoudaki, I., Goulielmaki, E., & Garinis, G. A. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103699 · Cited by 8 · see citing works

Prudent tactics to sail the boat of PARP inhibitors as therapeutics for diverse malignancies

Rana, M., Thakur, A., Kaur, C., Pan, C., Lee, S., Liou, J., & Nepali, K. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2241818 · Cited by 7 · see citing works

Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons

Varghese, N., Szabo, L., Cader, M. Z., Lejri, I., Grimm, A., & Eckert, A. (2025) · Communications Biology · doi:10.1038/s42003-025-08152-2 · Cited by 12 · see citing works

NAD+ glycohydrolases-CD38 as a therapeutic target in aging: physiological roles, molecular mechanisms, and future opportunities in anti-aging research

Sun, J.-Y., Wang, Z., Xu, W., & Zhao, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117050 · Cited by 7 · see citing works

From bench to bedside: Synthetic strategies and clinical application of PARP inhibitors

Man, X., Zhang, Y., He, J., Wang, P., & Qu, W. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108761 · Cited by 7 · see citing works

Repurposing oncology drugs for Alzheimer’s: multi-omic convergence targeting cell-cycle, proteostasis, immunometabolism, and senescence

Gopukumar, S. T., Dwivedi, D., Gowri, K., Karpakavalli, M., Nair, C., Singh, D., & Das, U. (2025) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2025.100237 · Cited by 8 · see citing works

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor

Dyrkheeva, N. S., Malakhova, A. A., Zakharenko, A. L., Okorokova, L. S., Shtokalo, D. N., Pavlova, S. V., Medvedev, S. P., Zakian, S. M., Nushtaeva, A. A., Tupikin, A. E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065148 · Cited by 7 · see citing works

Nicotinamide mononucleotide combined with PJ-34 protects microglial cells from lipopolysaccharide-induced mitochondrial impairment through NMNAT3-PARP1 axis

Jia, L., Cheng, X.-Y., Ma, R., Zou, B., Zhang, Y., Wu, M.-M., Yao, Y., & Li, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06280-1 · Cited by 6 · see citing works

Cremastra appendiculata Polysaccharides Alleviate Neurodegenerative Diseases in Caenorhabditis elegans: Targeting Amyloid-β Toxicity, Tau Toxicity and Oxidative Stress

Xu, H. K., Wang, Q., Zhou, Y., Chen, H., Tao, J., Huang, J., Miao, Y., Zhao, J., & Wang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083900 · Cited by 6 · see citing works

The role of Poly-ADP ribose polymerase (PARP) enzymes in chemotherapy-induced cognitive impairments – parallels with other neurodegenerative disorders

Ordaz, D. A., Gupta, K., & Bota, D. A. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1615843 · Cited by 6 · see citing works

Precision Enzyme: Targeted Drug Discovery in Neurodegenerative Disorders

Paul, S., Tiwari, P. K., & Dubey, S. (2025) · Protein and Peptide Letters · doi:10.2174/0109298665391103250825102319 · Cited by 7 · see citing works

Mitochondrial DNA Instability and Neuroinflammation: Connecting the Dots Between Base Excision Repair and Neurodegenerative Disease

Pittman, M. N., Nelsen, M. B., Thompson, M. K., & Prakash, A. (2026) · Genes · doi:10.3390/genes17010082 · Cited by 6 · see citing works

Biochemical, Structural Analysis, and Docking Studies of Spiropyrazoline Derivatives

Adamus-Grabicka, A. A., Daśko, M., Hikisz, P., Kusz, J., Małecka, M., & Budzisz, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116061 · Cited by 6 · see citing works

Telomere length is causally connected to brain MRI image derived phenotypes: A mendelian randomization study

Salih, A. M., Galazzo, I. B., Petersen, S. E., Lekadir, K., Radeva, P. I., Menegaz, G., & Altmann, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277344 · Cited by 6 · see citing works

Early detection of Alzheimer’s disease using small RNAs. Results from the EPAD cohort

Sikosek, T., Heuvelman, M., Mika, J., Kahraman, M., Jehn, J., Frank, M., Daniel-Moreno, A., Ceiler, J., Skottke, J., Sánchez-Delgado, M., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100257 · Cited by 5 · see citing works

Connexins and blood-brain barrier: Beyond the gap

Chagnot, A., & Montagne, A. (2023) · Neuron · doi:10.1016/j.neuron.2023.10.032 · Cited by 5 · see citing works

A Method for Bridging Population-Specific Genotypes to Detect Gene Modules Associated with Alzheimer’s Disease

Dai, Y.-L., Jia, P., Zhao, Z.-M., & Gottlieb, A. (2022) · Cells · doi:10.3390/cells11142219 · Cited by 7 · see citing works

SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis

Breunig, K., Lei, X., Montalbano, M., Guardia, G. D. A., Ostadrahimi, S., Alers, V. A., Kosti, A., Chiou, J., Klein, N., Vinarov, C., et al. (2025) · eLife · doi:10.7554/elife.98152.3 · Cited by 5 · see citing works

The many connections of UFMylation with Alzheimer’s disease: a comprehensive review

Yan, T., Clarkson, B. D. S., Lou, Z., Springer, W., & Fiesel, F. C. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00855-8 · Cited by 4 · see citing works

Low-intensity transcranial ultrasound neuromodulation promotes neuronal regeneration: A new hope for noninvasive treatment of neurodegenerative diseases

Xia, S., He, C., Li, Y., Li, H., Wang, B., Xu, L., & Zhao, X. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00113 · Cited by 5 · see citing works

The Central Role of Neuronal Cell Death in Alzheimer’s Disease Pathobiology

Kwak, S., Kim, J. K., Lee, Y., Baek, H. S., Kwon, Y. J., Park, M.-N., Hong, J., Lee, S.-B., Kim, H. W., & Kim, S. H. (2026) · Biomedicines · doi:10.3390/biomedicines14050953 · Cited by 5 · see citing works

Current Advances in PARP1‐Targeted Theranostics

Tong, J., Chen, B., Volpi, T., Li, Y., Ellison, P. A., & Cai, Z. (2025) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.4135 · Cited by 4 · see citing works

Blood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways

Chang, Y., Zhang, X., Zhang, S., & Qu, G. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03639-w · Cited by 4 · see citing works

Advances in the expression and purification of human PARP1: A user-friendly protocol

Conceição, C. J. F., Salgueiro, B. A., Ribeiro, P. A., Raposo, M., & Moe, E. (2023) · Protein Expression and Purification · doi:10.1016/j.pep.2023.106336 · Cited by 4 · see citing works

Anemonin ameliorates human diploid fibroblasts 2BS and IMR90 cell senescence by PARP1-NAD+-SIRT1 signaling pathway

Zhao, L., Hu, K., Liu, W.-T., Qi, H., Li, G., Chen, J., & Han, L. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105255 · Cited by 4 · see citing works

Poly-(ADP-ribose) polymerase 1-modulated production of CXCL1 in the dorsal root ganglion and spinal dorsal horn exacerbated inflammatory pain in rats

Bai, L., Gao, Y., Li, L., Liang, Z., Qiao, Y., Wang, X., Yv, L., Yang, J., & Xu, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113370 · Cited by 4 · see citing works

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

Martire, S., Mosca, L., & D’Erme, M. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.04.001 · Cited by 228 · see citing works

Roles and therapeutic potential of PARP-1 in neurodegenerative diseases

Liu, C., Lai, F., Zhang, T., Mao, K., Wan, H., & He, Y. T. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117373 · Cited by 6 · see citing works

Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: past, present, and future

Hu, M.-L., Pan, Y.-R., Yong, Y.-Y., Liu, Y., Yu, L., Qin, D.-L., Qiao, G., Law, B. Y.-K., Wu, J.-M., Zhou, X.-G., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102078 · Cited by 44 · see citing works

Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons

Narne, P., Pandey, V., Simhadri, P. K., & Phanithi, P. B. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.11.007 · Cited by 80 · see citing works

Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases

Thapa, K., Khan, H., Sharma, U., Grewal, A. K., & Singh, T. G. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118975 · Cited by 92 · see citing works