Selection for reluctance to avoid humans during the domestication of mice
Open accessAbstract
Many animal species have been domesticated over the course of human history and became tame as a result of domestication. Tameness is a behavioral characteristic with 2 potential components: (1) reluctance to avoid humans and (2) motivation to approach humans. However, the specific behavioral characteristics selected during domestication processes remain to be clarified for many species. To quantify these 2 different components of tameness separately, we established 3 behavioral tests: the ‘active tame’, ‘passive tame’ and ‘stay‐on‐hand’ tests. We subjected genetically diverse mouse strains to these tests, including 10 wild strains (BFM/2Ms, PGN2/Ms, HMI/Ms, BLG2/Ms, NJL/Ms, KJR/Ms, SWN/Ms, CHD/Ms, MSM/Ms and CAST/Ei), a fancy strain (JF1/Ms) and 6 standard laboratory strains (C3H/HeNJcl, CBA/J, BALB/cAnNCrlCrlj, DBA/2JJcl, 129+Ter/SvJcl and C57BL/6JJcl). To analyze the effects of domestication, these 17 strains were divided into 2 groups: domesticated strains (fancy and laboratory strains) and wild strains. Significant differences between strains were observed in all traits, and the calculated estimates of broad‐sense heritability were 0.15–0.72. These results illustrate that tameness in mice is significantly influenced by genetic background. In addition, they clearly show the differences in the features of tameness in domesticated and wild strains. Most of the domesticated strains showed significantly greater reluctance to avoid humans than wild strains, whereas there was no significant difference in the level of motivation to approach humans between these 2 groups. These results might help to clarify the genetic basis of tameness in mice.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Laboratory strains of mice were more prone to head toward a human hand and stay on it when handled compared to wild animals, but the level of tameness differed between strains.
“Less is known about the effect of domestication on the behavior of laboratory mice, but Goto et al have shown that laboratory strains of mice were more prone to head toward a human hand and stay on it when handled in comparison to wild animals, but the level of tameness differed between the strains.43”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
From wild animals to domestic pets, an evolutionary view of domestication
Driscoll, C. A., Macdonald, D. W., & O'Brien, S. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901586106 · Cited by 639 · see citing works
Early canid domestication: the farm-fox experiment.
Trut, L. (1999) · American Scientist · doi:10.1511/1999.2.160 · Cited by 626 · see citing works
Flow of mitochondrial DNA across a species boundary.
Ferris, S. D., Sage, R. D., Huang, C.-M., Nielsen, J. T., Ritte, U., & Wilson, A. C. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.8.2290 · Cited by 469 · see citing works
High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population
Svenson, K. L., Gatti, D. M., Valdar, W. S. J., Welsh, C. E., Cheng, R., Chesler, E. J., Palmer, A. A., McMillan, L., & Churchill, G. A. (2012) · Genetics · doi:10.1534/genetics.111.132597 · Cited by 466 · see citing works
Genetic influence on daily wheel running activity level.
Lightfoot, J., Turner, M. J., Daves, M., Vordermark, A., & Kleeberger, S. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00125.2004 · Cited by 259 · see citing works
Genetic and Environmental Effects on Complex Traits in Mice
Valdar, W. S. J., Solberg, L. C., Gauguier, D., Cookson, W., Rawlins, J. N. P., Mott, R., & Jonathan Flint, C. (2006) · Genetics · doi:10.1534/genetics.106.060004 · Cited by 206 · see citing works
Inter- and intrastrain variation in mouse critical running speed
Billat, V. L., Mouisel, É., Roblot, N., & Melki, J. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00991.2004 · Cited by 176 · see citing works
Albert, F. W., Shchepina, O., Winter, C., Römpler, H., Teupser, D., Palme, R., Ceglarek, U., Kratzsch, J., Sohr, R., Trut, L. N., et al. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.11.010 · Cited by 157 · see citing works
Behavioral profile of wild mice in the elevated plus-maze test for anxiety
Holmes, A., Parmigiani, S., Ferrari, P. F., Palanza, P., & Rodgers, R. J. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00373-5 · Cited by 148 · see citing works
Sugimoto, H., Okabe, S., Kato, M., Koshida, N., Shiroishi, T., Mogi, K., Kikusui, T., & Koide, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022093 · Cited by 148 · see citing works
Self-citationGenetic architecture of tameness in a rat model of animal domestication
Albert, F. W., Carlborg, O., Plyusnina, I., Besnier, F., Hedwig, D., Lautenschläger, S., Lorenz, D., McIntosh, J., Neumann, C., Richter, H., et al. (2009) · Genetics · doi:10.1534/genetics.109.102186 · Cited by 136 · see citing works
Gregorová, S., & Forejt, J. (2000) · Folia Biologica · doi:10.14712/fb2000046010031 · Cited by 126 · see citing works
A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele
Koide, T., Moriwaki, K., Uchida, K., et al. (1998) · Mammalian Genome · doi:10.1007/s003359900672 · Cited by 119 · see citing works
Self-citationDemarest, K., Koyner, J. L., McCaughran, J. A., Cipp, L., & HITZEMANN, R. J. (2001) · Behavior Genetics · doi:10.1023/a:1010261909853 · Cited by 104 · see citing works
Koide, T., Moriwaki, K., Ikeda, K., Niki, H., & Shiroishi, T. (2000) · Mammalian Genome · doi:10.1007/s003350010129 · Cited by 101 · see citing works
Self-citationLittle, C. C., & Tyzzer, E. E. (1916) · PubMed · Cited by 99 · see citing works
Wahłsten, D., Metten, P., & Crabbe, J. C. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00012.x · Cited by 89 · see citing works
Strain screen and haplotype association mapping of wheel running in inbred mouse strains
Lightfoot, J. T., Leamy, L. J., Pomp, D., Turner, M. J., Fodor, A. A., Knab, A. M., Bowen, R. S., Ferguson, D. P., Moore-Harrison, T. L., & Hamilton, A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00525.2010 · Cited by 86 · see citing works
Multivariate Analysis of Temporal Descriptions of Open-field Behavior in Wild-derived Mouse Strains
Takahashi, A., Kato, K., Makino, J., Shiroishi, T., & Koide, T. (2006) · Behavior Genetics · doi:10.1007/s10519-005-9038-3 · Cited by 60 · see citing works
Self-citationUnique Inbred Strain MSM/Ms Established from the Japanese Wild Mouse
Moriwaki, K., Miyashita, N., Mita, A., et al. (2009) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.58.123 · Cited by 53 · see citing works
Self-citationHayssen, V. (1997) · Journal of comparative psychology · doi:10.1037/0735-7036.111.4.419 · Cited by 41 · see citing works
Mhyre, T. R., Chesler, E. J., Thiruchelvam, M. J., Lungu, C., Cory‐Slechta, D. A., Fry, J. D., & Richfield, E. K. (2004) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2004.00102.x · Cited by 40 · see citing works
Cottle, C. A., & Price, E. O. (1987) · Journal of comparative psychology · doi:10.1037/0735-7036.101.4.390 · Cited by 36 · see citing works
Fernandes, C., Liu, L., Paya-Cano, J. L., Gregorov�, S. A., Forejt, J., & Schalkwyk, L. C. (2004) · Behavior Genetics · doi:10.1007/s10519-004-5589-y · Cited by 29 · see citing works
Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains
Furuse, T., Blizard, D. A., Moriwaki, K., et al. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00636-0 · Cited by 29 · see citing works
Self-citationAlbert, F. W., Hodges, E., Jensen, J. D., Besnier, F., Xuan, Z., Rooks, M., Bhattacharjee, A., Brizuela, L., Good, J. M., Green, R. E., et al. (2011) · Heredity · doi:10.1038/hdy.2011.4 · Cited by 28 · see citing works
A New Twist on Behavioral Genetics by Incorporating Wild-Derived Mouse Strains
Koide, T., Ikeda, K., Ogasawara, M., et al. (2011) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.60.347 · Cited by 22 · see citing works
Self-citationGenomic Mixing to Elucidate the Genetic System of Complex Traits
Koide, T., Goto, T., & Takano‐Shimizu, T. (2012) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.61.503 · Cited by 13 · see citing works
Self-citationThe tumors of the Japanese waltzing Mouse and of its Hybrids.
Tyzzer, E. E. (1915) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Belyaev DK Destabilizing selection as a factor in domestication J Hered 1978 70 301 308 528781
- Bonhomme F Brown SDM Guénet J-L Lyon MF Rastan S The laboratory mouse and its wild relatives Genetic Variants and Strains of the Laboratory Mouse 1996 Oxford Oxford University Press 1577 1596
- Festing MFW Inbred Strains in Biomedical Research 1979 New York Oxford University Press
- Moriwaki K Shiroishi T Yonekawa H Genetics in Wild Mice 1994 Tokyo/Basel Japan Scientific Societies Press/Karger
- Silver LM Mouse Genetics 1995 New York Oxford University Press
Cited by
Sorted by citations
Ecological validity of social interaction tests in rats and mice
Kondrakiewicz, K., Kostecki, M., Szadzińska, W., & Knapska, E. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12525 · Cited by 136 · see citing works
Genomic signatures of domestication on neurogenetic genes in Drosophila melanogaster
Stanley, C. E., & Kulathinal, R. J. (2016) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0580-1 · Cited by 29 · see citing works
A missense mutation in <i>RRM1</i> contributes to animal tameness
Dou, M., Li, M., Zheng, Z., Chen, Q., Wu, Y., Wang, J., Shan, H., Wang, F., Dai, X., Li, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf4068 · Cited by 10 · see citing works
- Authors
- Goto, T., Tanave, A., Moriwaki, K., Shiroishi, T., & Koide, T.
- Affiliations
- National Institute of Genetics (JP)
- RIKEN BioResource Research Center (JP)
- Corresponding author
- Koide, T.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2013-10-07
- Volume
- 12
- Issue
- 8
- Pages
- 760-770
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC4282115
- OpenAlex
- W1792344868
- Cited by
- 35
- References
- 29
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Genes Brain & Behavior (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Research Organization of Information and Systems
- Japan Society for the Promotion of Science (23650243, 22300146, 24658240)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Keywords
- tameness, domestication, approach motivation, mouse strains, broad-sense heritability, genetic background, behavioral genetics
- MeSH terms
- Animals, Animals, Domestic, Avoidance Learning, Behavior, Animal, Handling, Psychological, Humans, Mice, Inbred Strains, Selection, Genetic, Evolution, Molecular, Quantitative Trait, Heritable, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
