Genetic architecture of tameness in a rat model of animal domestication
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A common feature of domestic animals is tameness—i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.
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Linkage mapping of rat lines selected for high and low aggression found only weak linkage between domestication traits.
“Similarly, linkage mapping of rat lines selected for high and low aggression, initially by Belyaev himself, (Albert et al. 2009) found only weak linkage between domestication traits.”
From The neural crest cell hypothesis: no unified explanation for domestication (2021) · cites this paper as Albert et al. 2009
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- Authors
- Albert, F. W., Carlborg, O., Plyusnina, I., Besnier, F., Hedwig, D., Lautenschläger, S., Lorenz, D., McIntosh, J., Neumann, C., Richter, H., Zeising, C., Kozhemyakina, R., Shchepina, O., Kratzsch, J., Trut, L., Teupser, D., Thiery, J., Schöneberg, T., Andersson, L., & Pääbo, S.
- Affiliations
- Max Planck Institute for Evolutionary Anthropology (DE)
- Department of Animal Breeding and Genetics , Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden
- Institute of Cytology and Genetics (RU)
- Department of Evolutionary Genetics , Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
- Institute of Laboratory Medicine , Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany
- University Hospital Leipzig (DE)
- Institute of Biochemistry, Molecular Biochemistry, Medical Faculty , University of Leipzig, 04103 Leipzig, Germany
- Uppsala University (SE)
- Corresponding author
- Albert, Frank W
- ORCID
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06-01
- Volume
- 182
- Issue
- 2
- Pages
- 541-554
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- PMC
- PMC2691762
- OpenAlex
- W2170665517
- Cited by
- 136
- References
- 60
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 14 · 2019: 9 · 2018: 21 · 2017: 10 · 2016: 12 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 8
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Stiftelsen för Strategisk Forskning
- Svenska Forskningsrådet Formas
- Max-Planck-Gesellschaft
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- tameness, animal domestication, aggression, quantitative trait loci, epistasis, genetic architecture, adrenal weight, Rattus norvegicus, serum components, organ weight
- MeSH terms
- Aggression, Animals, Animals, Domestic, Behavior, Animal, Female, Genetic Markers, Hair, Humans, Hybridization, Genetic, Male, Phenotype, Pigmentation, Species Specificity, Genomics, Models, Animal, Quantitative Trait Loci, Rats
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