A missense mutation in RRM1 contributes to animal tameness
Open accessAbstract
The increased tameness to reduce avoidance of human in wild animals has been long proposed as the key step of animal domestication. The tameness is a complex behavior trait and largely determined by genetic factors. However, the underlying genetic mutations remain vague and how they influence the animal behaviors is yet to be explored. Behavior tests of a wild-domestic hybrid goat population indicate the locus under strongest artificial selection during domestication may exert a huge effect on the flight distance. Within this locus, only one missense mutation RRM1 I241V which was present in the early domestic goat ~6500 years ago. Genome editing of RRM1 I241V in mice showed increased tameness and sociability and reduced anxiety. These behavioral changes induced by RRM1 I241V were modulated by the alternation of activity of glutamatergic synapse and some other synapse-related pathways. This study established a link between RRM1 I241V and tameness, demonstrating that the complex behavioral change can be achieved by mutations under strong selection during animal domestication.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The genetics of domestication are relatively well understood for livestock.
“However, domestication is a long and difficult process, but the genetics of domestication are relatively well understood for livestock143–148.”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [148]
The Discussion reports a domestication-related genetic locus in goats, supporting some knowledge of livestock domestication genetics. But the Abstract says the mutations underlying tameness remain vague; the paper does not establish that domestication genetics are relatively well understood across livestock. No page numbers are available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets
Kumar, S., Stecher, G., & Tamura, K. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw054 · Cited by 43,923 · see citing works
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895 · see citing works
The variant call format and VCFtools
Danecek, P., Auton, A., Abecasis, G. R., Albers, C. A., Banks, E., DePristo, M. A., Handsaker, R. E., Lunter, G. A., Marth, G., Sherry, S. T., et al. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr330 · Cited by 16,008 · see citing works
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
Kim, D., Paggi, J. M., Park, C., Bennett, C., & Salzberg, S. L. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0201-4 · Cited by 15,022 · see citing works
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
Wang, K., Li, M., & Hakonarson, H. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq603 · Cited by 14,380 · see citing works
Self-citationStringTie enables improved reconstruction of a transcriptome from RNA-seq reads
Pertea, M., Pertea, G. M., Antonescu, C. M., Chang, T.-C., Mendell, J. T., & Salzberg, S. L. (2015) · Nature Biotechnology · doi:10.1038/nbt.3122 · Cited by 14,118 · see citing works
SWISS-MODEL: homology modelling of protein structures and complexes
Waterhouse, A. M., Bertoni, M., Bienert, S., Studer, G., Tauriello, G., Gumienny, R., Heer, F. T., de Beer, T., Rempfer, C., Bordoli, L., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky427 · Cited by 13,005 · see citing works
Aligning sequence reads, clone sequences and assembly contigs with BWA-MEMPreprint
Li, H. (2013) · arXiv (Cornell University) · doi:10.48550/arxiv.1303.3997 · Cited by 9,540 · see citing works
KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases
Xie, C., Mao, X., Huang, J., Ding, Y., Wu, J., Dong, S., Kong, L., Gao, G., Li, C., & Wei, L. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr483 · Cited by 5,078 · see citing works
Self-citationBrowning, S. R., & Browning, B. L. (2007) · The American Journal of Human Genetics · doi:10.1086/521987 · Cited by 3,138 · see citing works
ANGSD: Analysis of Next Generation Sequencing Data
Korneliussen, T. S., Albrechtsen, A., & Nielsen, R. (2014) · BMC Bioinformatics · doi:10.1186/s12859-014-0356-4 · Cited by 2,982 · see citing works
AdapterRemoval v2: rapid adapter trimming, identification, and read merging
Schubert, M., Lindgreen, S., & Orlando, L. (2016) · BMC Research Notes · doi:10.1186/s13104-016-1900-2 · Cited by 2,091 · see citing works
mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters
Jónsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F., & Orlando, L. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt193 · Cited by 1,669 · see citing works
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
selscan: An Efficient Multithreaded Program to Perform EHH-Based Scans for Positive Selection
Szpiech, Z. A., & Hernandez, R. D. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu211 · Cited by 780 · see citing works
The Evolution of Animal Domestication
Larson, G., & Fuller, D. Q. (2014) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-110512-135813 · Cited by 640 · see citing works
Structure of ribonucleotide reductase protein R1
Uhlin, U., & Eklund, H. (1994) · Nature · doi:10.1038/370533a0 · Cited by 578 · see citing works
Primer3_masker: integrating masking of template sequence with primer design software
Kõressaar, T., Lepamets, M., Kaplinski, L., et al. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty036 · Cited by 555 · see citing works
SweeD: Likelihood-Based Detection of Selective Sweeps in Thousands of Genomes
Pavlidis, P., Živković, D., Stamatakis, A., & Alachiotis, N. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst112 · Cited by 452 · see citing works
Pathways to Animal Domestication
Zeder, M. A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139019514.013 · Cited by 341 · see citing works
Convergent genomic signatures of domestication in sheep and goats
Alberto, F. J., Boyer, F., Orozco-terWengel, P., Streeter, I., Servin, B., de Villemereuil, P., Benjelloun, B., Librado, P., Biscarini, F., Colli, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03206-y · Cited by 339 · see citing works
A population genetics view of animal domestication
Larson, G., & Bürger, J. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.01.003 · Cited by 297 · see citing works
Animal domestication in the era of ancient genomics
Frantz, L., Bradley, D. G., Larson, G., & Orlando, L. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0225-0 · Cited by 290 · see citing works
Blumstein, D. T., Anthony, L. L., Harcourt, R. G., & Ross, G. (2002) · Biological Conservation · doi:10.1016/s0006-3207(02)00180-5 · Cited by 240 · see citing works
Aggression, Social Stress, and the Immune System in Humans and Animal Models
Takahashi, A., Flanigan, M. E., McEwen, B. S., & Russo, S. J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00056 · Cited by 234 · see citing works
Brain motor and fear circuits regulate leukocytes during acute stress
Poller, W. C., Downey, J., Mooslechner, A. A., Khan, N., Li, L., Chan, C. T., McAlpine, C. S., Xu, C., Kahles, F., He, S., et al. (2022) · Nature · doi:10.1038/s41586-022-04890-z · Cited by 234 · see citing works
Determinants of uncertainty in wildlife responses to human disturbance
Tablado, Z., & Jenni, L. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12224 · Cited by 232 · see citing works
Using the tube test to measure social hierarchy in mice
Fan, Z., Zhu, H. L., Zhou, T., Wang, S., Wu, Y., & Hu, H. (2019) · Nature Protocols · doi:10.1038/s41596-018-0116-4 · Cited by 227 · see citing works
Self-citationAncient goat genomes reveal mosaic domestication in the Fertile Crescent
Daly, K. G., Delser, P. M., Mullin, V. E., Scheu, A., Mattiangeli, V., Teasdale, M. D., Hare, A. J., Bürger, J., Verdugo, M. P., Collins, M. J., et al. (2018) · Science · doi:10.1126/science.aas9411 · Cited by 223 · see citing works
Paternally expressed genes predominate in the placenta
Wang, X., Miller, D. C., Harman, R. M., Antczak, D. F., & Clark, A. G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308998110 · Cited by 191 · see citing works
Self-citationThe origin of domestication genes in goats
Zheng, Z., Wang, X., Li, M., Li, Y., Yang, Z., Wang, X., Pan, X., Gong, M., Zhang, Y., Guo, Y., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz5216 · Cited by 184 · see citing works
Self-citationHartmann, J., Karl, R. M., Alexander, R. P. D., Adelsberger, H., Brill, M. S., Rühlmann, C., Ansel, A., Sakimura, K., Baba, Y., Kurosaki, T., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.027 · Cited by 177 · see citing works
A central master driver of psychosocial stress responses in the rat
Kataoka, N., Shima, Y., Nakajima, K., & Nakamura, K. (2020) · Science · doi:10.1126/science.aaz4639 · Cited by 164 · see citing works
Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours
Kukekova, A. V., Johnson, J. L., Xiang, X., Feng, S., Liu, S., Rando, H. M., Kharlamova, A. V., Herbeck, Y., Serdyukova, N. A., Xiong, Z., et al. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0611-6 · Cited by 145 · see citing works
Self-citationMitochondrial DNA: Impacting Central and Peripheral Nervous Systems
Carelli, V., & Chan, D. C. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.022 · Cited by 127 · see citing works
Dong, Y., Zhang, X., Xie, M., Arefnezhad, B., Wang, Z., Wang, W., Feng, S., Huang, G., Guan, R., Shen, W., et al. (2015) · BMC Genomics · doi:10.1186/s12864-015-1606-1 · Cited by 116 · see citing works
Herded and hunted goat genomes from the dawn of domestication in the Zagros Mountains
Daly, K. G., Mattiangeli, V., Hare, A. J., Davoudi, H., Fathi, H., Doost, S. B., Amiri, S., Khazaeli, R., Decruyenaere, D., Nokandeh, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100901118 · Cited by 106 · see citing works
Wang, X., Pipes, L., Trut, L. N., Herbeck, Y., Vladimirova, A. V., Gulevich, R. G., Kharlamova, A. V., Johnson, J. L., Acland, G. M., Kukekova, A. V., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800889115 · Cited by 100 · see citing works
Self-citationEarly-emerging and highly heritable sensitivity to human communication in dogs
Bray, E. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K., Kennedy, B. S., Famula, T. R., & MacLean, E. L. (2021) · Current Biology · doi:10.1016/j.cub.2021.04.055 · Cited by 93 · see citing works
Responsiveness of dairy cows to human approach and novel stimuli
Gibbons, J. M., Lawrence, A. B., & Haskell, M. J. (2008) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2008.08.009 · Cited by 75 · see citing works
Engelhardt, S. C., & Weladji, R. B. (2011) · Canadian Journal of Zoology · doi:10.1139/z11-054 · Cited by 73 · see citing works
Jardat, P., & Lansade, L. (2021) · Animal Cognition · doi:10.1007/s10071-021-01557-6 · Cited by 72 · see citing works
Demontis, D., Walters, R. K., Rajagopal, V. M., Waldman, I. D., Grove, J., Als, T. D., Dalsgaard, S., Ribasés, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20443-2 · Cited by 50 · see citing works
Majewski, Ł., Maciąg, F., Boguszewski, P. M., Wasilewska, I., Wiera, G., Wójtowicz, T., Mozrzymas, J. W., & Kuźnicki, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.11.025 · Cited by 43 · see citing works
Li, Y., Wang, G.-D., Wang, M.-S., Irwin, D. M., Wu, D.-D., & Zhang, Y.-P. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu245 · Cited by 38 · see citing works
Self-citationNanaei, H. A., 西北农林科技大学动物科技学院, 陕. 杨. 7., Cai, Y., Alshawi, A., Wen, J., Hussain, T., Fu, W., Xu, N., Essa, A., Lenstra, J. A., et al. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.242 · Cited by 36 · see citing works
Self-citationSelection for reluctance to avoid humans during the domestication of mice
Goto, T., Tanave, A., Moriwaki, K., Shiroishi, T., & Koide, T. (2013) · Genes, Brain and Behavior · doi:10.1111/gbb.12088 · Cited by 35 · see citing works
Fu, W., Wang, R., Yu, J., Hu, D., Cai, Y., Shao, J., & Jiang, Y. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.03.003 · Cited by 25 · see citing works
Self-citationA protocol of human animal interaction to habituate young sheep and goats for behavioural studies
González-Pech, P. G., Marin-Tun, C. G., Valladares-González, D. A., et al. (2018) · Behavioural Processes · doi:10.1016/j.beproc.2018.04.007 · Cited by 20 · see citing works
Shintaku, J., Pernice, W. M., Eyaid, W., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci145660 · Cited by 17 · see citing works
Craig, J. C., Bennett, G. D., Miranda, R. C., Mackler, S. A., & Finnell, R. H. (2000) · Teratology · doi:10.1002/(sici)1096-9926(200004)61:4 · Cited by 15 · see citing works
Parvez, A., Ravikumar, Y., Bisht, R., et al. (2022) · ACS Synthetic Biology · doi:10.1021/acssynbio.1c00555 · Cited by 12 · see citing works
Specks, J., Lecona, E., Lopez-Contreras, A. J., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00475-15 · Cited by 10 · see citing works
Allele-specific expression analyses reveal immune divergences between ibex and goat species
Yang, Z., 西北农林科技大学动物科技学院, 陕. 杨. 7., Li, J., Zheng, Z., Zhao, C., Wang, Y., Li, M., Nanaei, H. A., Dai, X., Li, Y.-J., et al. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.003 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Paton, T., Wintle, R. F., Engstrom, M. D., Gunn, A., & Scherer, S. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-67270-9 · Cited by 4 · see citing works
“However, domestication is a long and difficult process, but the genetics of domestication are relatively well understood for livestock 143–148 .”
Background
- Authors
- Dou, M., Li, M., Zheng, Z., Chen, Q., Wu, Y., Wang, J., Shan, H., Wang, F., Dai, X., Li, Y., Yang, Z., Tan, G., Luo, F., Chen, L., Shi, Y. S., Wu, J. W., Luo, X.-J., Asadollahpour Nanaei, H., Niyazbekova, Z., Zhang, G., Wang, W., Zhao, S., Zheng, W., Wang, X., & Jiang, Y.
- Affiliations
- Northwest A&F University (CN)
- University of Konstanz (DE)
- Huazhong Agricultural University (CN)
- Xinjiang Agricultural University (CN)
- Northwestern Polytechnical University (CN)
- Model Animal Research Center (CN)
- Chinese Academy of Sciences (CN)
- Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi, 712100, China.
- Zhejiang University (CN)
- Xinjiang Academy of Animal Science (CN)
- Corresponding author
- Dou, Mingle
- Li, Ming
- Zheng, Zhuqing
- Zhao, Shanting
- Zheng, Wenxin
- Wang, Xihong
- Jiang, Yu
- ORCID
- Dou, Mingle
- Li, Ming
- Zheng, Zhuqing
- Chen, Qiuming
- Wang, Jinxin
- Shan, Huiquan
- Wang, Fei
- Dai, Xuelei
- Li, Yunjia
- Yang, Zhirui
- Tan, Guanghui
- Luo, Funong
- Chen, Lei
- Shi, Yun Stone
- Wu, Jiang Wei
- Luo, Xiong-Jian
- Asadollahpour Nanaei, Hojjat
- Niyazbekova, Zhannur
- Zhang, Guojie
- Wang, Wen
- Zhao, Shanting
- Zheng, Wenxin
- Wang, Xihong
- Jiang, Yu
- Venue
- Science Advances
- Published
- 2023-06-23
- Volume
- 9
- Issue
- 25
- Pages
- eadf4068-eadf4068
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC10289655
- OpenAlex
- W4381804400
- Cited by
- 10
- References
- 57
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (2022YFF1000100, U21A20247)
- Chinese Academy of Sciences
- Natural Science Foundation of Shaanxi Province
- Northwest A and F University
- Institute of Zoology, Chinese Academy of Sciences
- Kunming Institute of Zoology, Chinese Academy of Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- RRM1, missense mutations, animal domestication, flight distance, sociability, anxiety, glutamatergic synapses, selective breeding, behavioral genetics
- MeSH terms
- Domestication, Animals, Animals, Domestic, Behavior, Animal, Goats, Ribonucleoside Diphosphate Reductase, Selection, Genetic, Mutation, Missense, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
