Cited by 308Medication Adherence and CompliancePharmaceutical Practices and Patient OutcomesPharmacy and Medical Practices

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Systematic review of the barriers affecting medication adherence in older adults

Yap, Angela Frances, Thirumoorthy, Thiru, Kwan, Yu Heng·2016·Geriatrics & Gerontology International

DOI 10.1111/ggi.12616

Open this paper in CoChat — free account

Abstract

Medication adherence is a crucial part in the management of chronic diseases. As older adults form a greater proportion of the population with chronic diseases and multiple morbidities, understanding medication adherence in older adults becomes important. In the present article, we aimed to systematically review the literature for the factors associated with medication adherence in the geriatric population. We carried out a literature search using electronic databases and related keywords. 17 391 articles were reviewed in total. 65 articles were found to be relevant to our objective. A total of 80 factors of five different categories were found to be associated with medication adherence in older adults. The factors, the types of studies and the number of studies that agreed or disagreed were presented. A flower model for medication adherence was also presented to allow clinicians to better understand the complex nature of medication adherence in this population. The 80 factors reviewed were categorized into five main categories; namely, patient factors, medication factors, physician factors, system-based factors and other factors as factors affecting poor medication adherence in older adults. Clinicians need to be mindful of the complex nature of factors affecting medication adherence in this population to optimize therapeutic outcomes. Clinicians have to be more skillful to discover and to optimize the medication adherence factors in geriatric patients. The flower model is p…

Integrity signals

Registry

Crossref · 10.1111/ggi.12616

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Personality and medication non‐adherence among older adults enrolled in a six‐year trial
Jerant, A., Chapman, B., Duberstein, P., Robbins, J., & Franks, P. (2011) · British Journal of Health Psychology · doi:10.1348/135910710x524219 · Cited by 86
Risk factors for medication nonadherence in older adults with cognitive impairment who live alone
Thiruchselvam, T., Naglie, G., Moineddin, R., Charles, J., Orlando, L., Jaglal, S., Snow, W., & Tierney, M. C. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3778 · Cited by 58

Show all 0 references

Research works printed but not linked: 70

10.1186/1741-7015-12-3 · DOI
10.1080/08870446.2013.863884 · DOI
10.1517/14740338.2014.947260 · DOI
10.1016/j.amjopharm.2011.11.005 · DOI · Paper page
10.1016/j.pmedr.2014.10.001 · DOI
10.1016/j.jsps.2015.01.013 · DOI
10.1016/j.amjopharm.2011.02.004 · DOI
10.1007/s40266-014-0153-9 · DOI
10.1093/geront/gns006 · DOI
10.1111/j.1532-5415.1999.tb02988.x · DOI
Yap AF, 2015, Medication adherence in the elderly, J Clin Gerontol Geriatr
10.1111/j.1447-0594.2012.00916.x · DOI
10.1016/S0002-9343(96)00172-6 · DOI
10.1331/JAPhA.2008.07040 · DOI
10.1046/j.1365-2648.1995.21050935.x · DOI
10.1007/s12160-010-9217-1 · DOI
10.2165/00129784-200808010-00006 · DOI
10.2165/00002512-200825100-00005 · DOI
10.1007/s11606-014-2956-0 · DOI
10.1016/j.cjca.2013.04.009 · DOI
10.1002/mds.21831 · DOI
Morgan SG, 2004, Persistence with hypertension treatment among community‐dwelling BC seniors, Can J Clin Pharmacol, 11, e267
10.2165/00002512-200825100-00008 · DOI
10.1111/jgs.12171 · DOI
10.1046/j.1532-5415.2002.50205.x · DOI
10.1111/pme.12035 · DOI
10.1111/j.1532-5415.2009.02639.x · DOI
10.1177/1043659609360707 · DOI
Lam PW, 2007, Drug non‐adherence and associated risk factors among Chinese geriatric patients in Hong Kong, Hong Kong Med J, 13, 284
10.1016/j.archger.2011.09.014 · DOI
10.1111/j.1442-2018.2011.00594.x · DOI
10.1007/s40266-012-0007-2 · DOI
10.1016/j.hrtlng.2014.05.001 · DOI
10.1093/ageing/aft083 · DOI
10.18553/jmcp.2014.20.1.58 · DOI
10.1177/0898264309332836 · DOI · Paper page
10.1007/BF00579707 · DOI
10.2165/11537320-000000000-00000 · DOI
10.1111/j.1524-4733.2009.00679.x · DOI
10.1111/j.1532-5415.2012.04239.x · DOI
10.1097/HPC.0b013e318230d423 · DOI
10.1097/00019442-200512000-00006 · DOI
10.1007/s00774-008-0007-9 · DOI
10.1080/03601277.2013.802186 · DOI
10.1016/j.pec.2010.05.006 · DOI
Iversen MD, 2011, Factors affecting adherence to osteoporosis medications: a focus group approach examining viewpoints of patients and providers, J Geriatr Phys Ther, 34, 72
10.1093/geronb/61.2.P102 · DOI · Paper page
10.1016/j.amjopharm.2008.11.001 · DOI
10.1111/ggi.12042 · DOI
10.1007/s11096-013-9863-z · DOI
10.1007/s11606-011-1886-3 · DOI
10.1080/10810730.2012.712611 · DOI
10.1002/nur.4770140108 · DOI
10.1016/j.sapharm.2012.12.002 · DOI
Kendrick R, 1982, Compliance with prescribed medication by elderly patients, Can Med Assoc J, 127, 961
10.1093/eurjhf/hfp059 · DOI
10.1002/pds.1766 · DOI
10.1111/j.1365-2702.2012.04144.x · DOI
10.1016/j.jpsychores.2010.07.014 · DOI
10.1007/s002280050358 · DOI
10.1097/01.JCN.0000287029.87746.58 · DOI
10.1071/HC13234 · DOI
10.1097/JGP.0b013e3181f1803d · DOI
10.1378/chest.09-3031 · DOI
10.1111/j.1547-5069.1991.tb00677.x · DOI
10.1016/j.amjopharm.2009.04.005 · DOI
10.2105/AJPH.83.5.711 · DOI
10.1136/emj.2008.058297 · DOI
10.1111/j.1369-7625.2005.00351.x · DOI
10.1016/j.socscimed.2014.11.010 · DOI

Sorted by citations

Items 201–234 of 234

Eye care adherence in pediatric and elderly: Understanding and addressing the challenges
Villani, E., Curci, A., Bonsignore, F., Diana, V., Doğru, M., Kolko, M., Nischal, K. K., Romano, M. R., Sacchi, M., Vrijens, B., et al. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101448
Patients’ Needs and Expectations for the Application of Prevention of Drug-related Problems Prevention Programs
Llopis, A., Ruiz-Ramos, J., Díaz, A. P., Campmany, M. P., Álvarez, A. B., Sampol-Mayol, C., & Juanes-Borrego, A. (2026) · Journal of Research in Pharmacy Practice · doi:10.4103/jrpp.jrpp_32_25
An application-based ontological knowledge base of medications to support health literacy and adherence for the consumer population: an aging population use case
Chen, C., Amith, M., Roberts, K., Mauldin, R. L., Komalasari, R., & Tao, C. (2026) · Journal of Biomedical Semantics · doi:10.1186/s13326-026-00347-8
Assessing the impact of automated devices for enhancing health and reducing medication errors in older adults with long-term health conditions (ADHERE): a study protocol for a randomised controlled trial in Bedfordshire, Luton and Milton Keynes, UK
Wainwright, J. E., Bennett, A., Randhawa, G., Pappas, Y., Singh, H., & Cook, E. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-104359
“These include memory-related factors such as forgetfulness or confusion, 20 as well as physical challenges like impaired vision, reduced dexterity or difficulty opening packaging.”
Hubungan Level Depresi terhadap Kepatuhan Minum Obat Pasien Diabetes Melitus Tipe 2 di Puskesmas Kota Makassar
Utami, M. C., Tangdilintin, F., Anggriani, A., & Bahar, M. (2025) · Jurnal Mandala Pharmacon Indonesia · doi:10.35311/jmpi.v11i2.789
Duloxetine and cognitive behavioral therapy with phone-based support for the treatment of chronic musculoskeletal pain: a randomized controlled trial
Ang, D. C., Kaplan, S. G., Keefe, F., Rice, W. Y., Anderson, A., Rini, C. K., Miles, C. M., Hartlieb, K. B., Willoughby, M. E., Revankar, N., et al. (2025) · Pain · doi:10.1097/j.pain.0000000000003861
Contexts and Mechanisms Related to the Efficacy of Digital Medication Adherence Interventions to Support Medication Adherence Among Adults With Chronic Diseases: Realist Review
Saha, S., Latham, Y., & Holland, C. (2026) · Interactive Journal of Medical Research · doi:10.2196/89803
“However, the findings of a systematic review by Yap et al [6] highlighted the conflicts in evidence regarding the factors associated with medication adherence and showed that barriers to medication adherence could vary among different contexts.”
Factors influencing adherence to glaucoma medication and treatment among patients in Hail, Saudi Arabia: A cross-sectional study
Algorinees, R., Al-Tamimi, A., & Alanzi, T. (2025) · The British Journal of Visual Impairment · doi:10.1177/02646196251358994
“…patient’s ability to self-administer medication, the occurrence of side effects, educational background, tendencies to forget medications, and challenges with prescription refills (Gatwood et al., 2022; Lacey et al., 2009; Newman-Casey, Robin, et al., 2015; Quaranta et al., 2023; Yap et al., 2016).”
Closing gaps in blood pressure control: a look at two major approaches
Nesbitt, S. D. (2025) · Exploration of Medicine · doi:10.37349/emed.2025.1001337
Frequency and Intensity of Depressive Symptoms and Frequency of Prescribed Opioid Use Among Older Adults in the United States
Zhu, X., Ge, S., Ma, W.-X., Wu, L.-C., Ma, H.-X., Hu, J., Lu, H.-D., & Lin, X. (2025) · Journal of Addictions Nursing · doi:10.1097/jan.0000000000000604
“For example, older adults with polypharmacy may have difficulty taking all of their medications at the right time and with the correct doses and have an increased risk of medication interactions (Yap et al., 2016).”
DMARD Adherence in Rheumatoid Arthritis Patients: A Cross-sectional Study from the Coastal Part of Kerala
Jalal, M. (2025) · Annals of Rheumatology and Autoimmunity · doi:10.4103/ara.ara_29_24
Primary Medication Adherence in Medicare Beneficiaries Prescribed Sacubitril-Valsartan or Renin-Angiotensin System Blockers for Heart Failure with Reduced Ejection Fraction.
Hwang, C. S., Desai, R., Kesselheim, A., Levin, R., & Rome, B. (2024) · American Heart Journal · doi:10.1016/j.ahj.2024.11.015
Funcionalidad familiar y adherencia al tratamiento antihipertensivo
Baccon, D. O., & Fleitas, J. E. P. (2024) · Revista de Medicina Familiar y Comunidad · doi:10.66476/mf.v1n1.4918
“Los adultos mayores pueden tener patrones de adherencia diferentes a los de poblaciones más jóve-nes, posiblemente influenciados por factores como la po-lifarmacia, el deterioro cognitivo leve o la presencia de cuidadores (13).”
Challenges and Strategies of Managing Mental Health Medication in Real-World Practices: Interview Study Among University Students
Li, J.-C., Steinberg, J., Mynatt, E. D., & Mishra, V. (2024) · JMIR Human Factors · doi:10.2196/67579
“Most prior works on medication management strategies focused on older adults [11,12] and individuals with disabilities [13], often categorizing younger populations as “healthier.””
Challenges in prescribing medication for the elderly population
Sumanasan, N. (2024) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2024.23.1.2113
“Clinicians should be more skillful in discovering and optimising the medication adherence factors in geriatric patients [37].”
Background
Ansvarshierarki i lægemiddelomsorgen på plejehjem
Frantzen, S. E., Dam, M. S., & Gjødsbøl, I. M. (2023) · Tidsskrift for forskning i sygdom og samfund · doi:10.7146/tfss.v21i39.136459
“Når befolkningen bliver ældre, vil flere leve med kroniske sygdomme, hvilket er tæt forbundet med et øget lægemiddelforbrug hos den enkelte ældre (Danmarks Statistik, 2021; Sundhedsstyrelsen, 2017, 2022; Yap et al., 2016).”
Background
Barriers and methods of assessing medication adherence in geriatric populations
G, S., Raju, S., R, S., & Vivekanandan, K. (2023) · World Journal of Biology Pharmacy and Health Sciences · doi:10.30574/wjbphs.2023.16.1.0412
“These include not having someone to look after you, having a heavy caretaker load, not seeing an instant improvement in health, having only one common disease, having COPD, having been hospitalized within the preceding six months, and having at least one prior episode of non-adherence [23].”
Background
Tailored interventions to improve adherence to medication in elderly patients with Parkinson’s disease: a study protocol for a randomized controlled trial (AdhCare)
Mendorf, S., Teschner, U., Lehmann, T., Prell, T., & Mühlhammer, H. M. (2023) · Trials · doi:10.1186/s13063-023-07663-9
“In the geriatric population, nonadherence contributes to adverse drug events, increased length of hospital stay and readmissions to hospitals, and lower quality of life [1, 2].”
Background
Development of a medication-adherence assessment tool to assess and support medication self-management by older adults
Sakane, K., Tsumoto, Y., Kobayashi, Y., Fukuma, M., Miyamoto, M., & Uchida, H. (2023) · Journal of International Nursing Research · doi:10.53044/jinr.2021-0003
Osteoporose-Therapie: Compliance und Adhärenz in COVID-19 Zeiten
Thomasius, F. (2021) · Osteologie/Osteology · doi:10.1055/a-1702-2304
“Auch auf diese wird im Folgenden eingegangen Patientenfaktoren Non Compliance Faktoren, die die Non Compliance/Medikamentenpersistenz-und adhärenz beeinflussen, sind reichlich untersucht und vielfältig sowie in verschiedene Kategorien unterteilbar [5]”
Background
The Main Factors Influencing Adherence to drug Therapy in Patients with Diabetes Mellitus
Vodolagin, M., & Polukhin, N. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i46a32880
“bad habits, and maintaining normal body weight, and these changes affect not only the patient himself but also his family [9].”
Background
Medication Management at Home and Medication Adherence in Older Patients with Polypharmacy: In-Depth Interviews with Home Visits
Vatcharavongvan, P., & Puttawanchai, V. (2021) · medRxiv · doi:10.1101/2021.09.15.21263068
“Older adults are at risk of poor medication adherence, and several factors determining medication adherence have been reported (13, 14).”
BackgroundResultInfluential
Can Personality Traits be Related to Medical Adherence in Patients with Myocardial Infarction?
Ma, B., Adomaitiene, & Gustienė, O. (2021) · Journal of Family Medicine · doi:10.26420/jfammed.2021.1258
“[8], thus its role as a risk factor for poor adherence after myocardial infarction is yet to be explored.”
Background
Patients' Perceptions of Compliance with Tuberculosis Medication in Lamongan
Octavia, D., & Utami, P. (2020) · JURNAL MIDPRO · doi:10.30736/md.v12i2.238
A Prospective Study of Usability and Workload of Electronic Medication Adherence Products by Older Adults, Caregivers, and Health Care Providers (Preprint)
Patel, T., Ivo, J., Faisal, S., McDougall, A., Carducci, J., Pritchard, S., & Chang, F. (2020) · doi:10.2196/preprints.18073
Adhärenz im Alter – Wie angehen?
Albus, C. (2019) · Drug Research · doi:10.1055/a-0982-5118
Und wenn ich der Patient wre
Stalder, H. (2019) · Schweizerische Ärztezeitung · doi:10.4414/saez.2019.17832
Kan een app de therapietrouw bij ouderen verbeteren?: Onderzoek naar eigenschappen van een app voor medicatieherinnering
Eecloo, F., Jans, E., Bulcke, G. V., Mieren, S. V. D., & Schoenmakers, B. (2017) · Huisarts Nu · doi:10.1007/s40954-017-0059-y
Adesão ao Tratamento Medicamentoso e Risco de Quedas em Idosos na Comunidade
Santos, M., Lourenço, T., Sousa, M., Andrade, K., Santos, M., Moreira, D., Novita, R., & Teixeira, N. (2022) · JIM · doi:10.29073/jim.v3i2.503
Medication Self-management Strategies and Adherence in Community-dwelling Older Adults
Koyama, A., Koyama, T., Ito, M., Shimura, A., Fukushima, W., Yamazaki, T., & Uchida, Y. (2022) · Journal of Japan Academy of Nursing Science · doi:10.5630/jans.42.176
Simulação de polimedicação e percepções sobre farmacoterapia em estudantes de universidade no Ceará: estudo-piloto
Bezerra, Y. M., Pereira, I. D. S., Sarubbi, R. D., Viana, A. B., & Quidute, A. R. (2021) · Revista Brasileira de Educação Médica · doi:10.1590/1981-5271v45.3-20210026
Non Compliance and Non Adherence to Antiretroviral Therapy (Art) at Kitwe Teaching Hospital
Moondoma, R., & Siziya, S. (2021) · doi:10.37421/2155-6113.2021.12.861
“As older adults form a greater proportion of the population with chronic diseases and multiple morbidities, understanding medication adherence in older adults becomes really important [2] .”
Dementia and Chronic Disease: Management of Comorbid Medical Conditions
Catic, A. (2020) · doi:10.1007/978-3-030-46398-4
Impact of Incident Cancer on Coronary Artery Disease-Related Concomitant Medication Adherence, Short-Term Health and Economic Outcomes Among Elderly Medicare Beneficiaries with Coronary Artery Diseas
Chopra, I. (2017) · doi:10.33915/etd.5362
“While many patient, provider, and health-system factors affect medication adherence in the elderly [139-142], development of an additional chronic condition may also impact adherence.”
Background

Authors: Yap, A. F., Thirumoorthy, T., & Kwan, Y. H.
Affiliations: Duke-NUS Medical School (SG)
Corresponding author: Kwan, Yu Heng
ORCID: Kwan, Yu Heng
Venue: Geriatrics & Gerontology International
Publisher: Wiley
Published: 2015-10-20
Volume: 16
Issue: 10
Pages: 1093-1101
ISSN: 1444-1586 (ISSN-L)
1447-0594
DOI: 10.1111/ggi.12616
OpenAlex: W2116716283
Cited by: 308
References: 0
Citations by year: 2026: 20 · 2025: 25 · 2024: 35 · 2023: 40 · 2022: 63 · 2021: 41 · 2020: 24 · 2019: 22 · 2018: 23 · 2017: 11 · 2016: 3
FWCI: 2.05
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Geriatrics and gerontology international/Geriatrics & gerontology international (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
Keywords: medication adherence, older adults, barriers to adherence, chronic disease management, patient factors, physician characteristics, elderly patients
MeSH terms: Aged, Aged, 80 and over, Chronic Disease, Cognition Disorders, Dementia, Humans, Socioeconomic Factors, Geriatric Assessment, Incidence, Drug Monitoring, Risk Assessment, Needs Assessment, Medication Adherence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Systematic review of the barriers affecting medication adherence in older adults

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks