Medication Adherence in Healthy Elders: Small Cognitive Changes Make a Big Difference
Open accessAbstract
Objective: This was a cross-sectional study of the ability of independently living healthy elders to follow a medication regimen. Participants were divided into a group with High Cognitive Function (HCF) or Low Cognitive Function (LCF) based on their scores on the ADAS-Cog. Method: Thirty-eight participants aged 65 or older and living independently in the community followed a twice-daily vitamin C regimen for 5 weeks. Adherence was measured using an electronic 7-day pillbox. Results: The LCF group had significantly poorer total adherence than the HCF group (LCF: 63.9 ± 11.2%, HCF: 86.8 ± 4.3%, t 36 = 2.57, p = .007), and there was a 4.1 relative risk of non-adherence in the LCF group as compared to the HCF group. Discussion: This study has important implications for the conduct of clinical drug trials, as it provides strong evidence that even very mild cognitive impairment in healthy elderly has a detrimental impact on medication adherence.
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Mild cognitive impairment in older adults is associated with poor medication adherence in most studies.
“Also, mild cognitive impairment (MCI) in older adults has been found to be associated with poor medication adherence in most studies.11–13”
From Effectiveness of eHealth interventions targeted to improve medication adherence among older adults with mild cognitive impairment: a protocol for a systematic review and meta-analysis (2022) · cites this paper as [11]
The Discussion reports that poorer cognitive function distinguished older adults with poorer medication adherence. However, only three participants could qualify for mild cognitive impairment, and the results were unchanged when they were excluded. The paper also does not establish that an MCI–adherence association was found in most studies; its statement about “most studies” concerns the measures they used. (LLM, conf=0.88)
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
Journal of Clinical Psychiatry
(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974 · see citing works
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Kirk, J. M. W., MacDonald, A., Lavender, P., Dean, J. M., & Rubin, G. (2017) · Biomedicine Hub · doi:10.1159/000480347 · Cited by 3,901 · see citing works
Kushner (2021) · doi:10.12788/jfp · Cited by 3,799 · see citing works
Ho, P. M., Rumsfeld, J. S., Masoudi, F. A., McClure, D. L., Plomondon, M. E., Steiner, J. F., & Magid, D. J. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.17.1836 · Cited by 1,135 · see citing works
Fillenbaum, G. G., & Smyer, M. A. (1981) · Journal of Gerontology · doi:10.1093/geronj/36.4.428 · Cited by 1,127 · see citing works
How often is medication taken as prescribed? A novel assessment technique
Cramer, J. A. (1989) · JAMA · doi:10.1001/jama.261.22.3273 · Cited by 1,032 · see citing works
Rasmussen, J. N., Chong, A., & Alter, D. A. (2007) · JAMA · doi:10.1001/jama.297.2.177 · Cited by 975 · see citing works
The Role of Medication Noncompliance and Adverse Drug Reactions in Hospitalizations of the Elderly
Col, N. F. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.1990.00390160093019 · Cited by 765 · see citing works
Alzheimer Disease and Associated Disorders
Post, S. G., & Whitehouse, P. J. (1992) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199205000-00001 · Cited by 461 · see citing works
Impact of Dosage Frequency on Patient Compliance
Paes, A. H. P., Bakker, A., & Soe-Agnie, C. J. (1997) · Diabetes Care · doi:10.2337/diacare.20.10.1512 · Cited by 411 · see citing works
Executive Function, Working Memory, and Medication Adherence Among Older Adults
Insel, K., Morrow, D., Brewer, B., & Figueredo, A. (2006) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/61.2.p102 · Cited by 343 · see citing works
Medication Compliance in the Elderly
Stewart, R. B., & Caranasos, G. J. (1989) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30616-2 · Cited by 297 · see citing works
Compliance with drug therapy for postmenopausal osteoporosis
Weycker, D. A., Macarios, D., Edelsberg, J., & Oster, G. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0179-x · Cited by 197 · see citing works
Medication Use Characteristics in the Elderly: The Iowa 65 + Rural Health Study
Helling, D. K., Lemke, J. H., Semla, T. P., Wallace, R. B., Lipson, D. P., & Cornoni‐Huntley, J. C. (1987) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1987.tb01312.x · Cited by 179 · see citing works
Demographic characteristics and normative observations for derived-trail making test indices.
Drane, D. L., Yuspeh, R. L., Huthwaite, J. S., & Klingler, L. K. (2002) · PubMed · Cited by 175 · see citing works
An Electronic Pillbox for Continuous Monitoring of Medication Adherence
Hayes, T. L., Hunt, J. M., Adami, A., & Kaye, J. A. (2006) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2006.260367 · Cited by 157 · see citing works
Self-citationHo, P. M., Magid, D. J., Masoudi, F. A., McClure, D. L., & Rumsfeld, J. S. (2006) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-6-48 · Cited by 157 · see citing works
Medication Usage in an Elderly Population
Ostrom, J. R., Hammarlund, E. R., Christensen, D. B., Plein, J. B., & Kethley, A. J. (1985) · Medical Care · doi:10.1097/00005650-198502000-00006 · Cited by 141 · see citing works
Differential validity of psychometric tests in dementia of the Alzheimer type
Ihl, R., Frölich, L., Dierks, T., Martin, E.-M., & Maurer, K. (1992) · Psychiatry Research · doi:10.1016/0165-1781(92)90044-4 · Cited by 135 · see citing works
Edelberg, H. K., Shallenberger, E., & Wei, J. Y. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb02574.x · Cited by 125 · see citing works
Adherence to Antihypertensive Medications Across the Life Span
Morrell, R. W., Park, D. C., Kidder, D. P., & Martin, M. (1997) · The Gerontologist · doi:10.1093/geront/37.5.609 · Cited by 109 · see citing works
Clinical assessment and management of adherence to medical regimens.
Dunbar‐Jacob, J. M., Burke, L. E., & Puczynski, S. (1995) · American Psychological Association eBooks · doi:10.1037/10511-009 · Cited by 103 · see citing works
Home assessment of adherence to long-term medication in the elderly.
Rj, B., & Dudrak, R. (1992) · PubMed · Cited by 96 · see citing works
Graham, D. P., Cully, J. A., Snow, A. L., et al. (2005) · PubMed · Cited by 90 · see citing works
Medication compliance in the elderly.
Salzman, C. (1995) · PubMed · Cited by 89 · see citing works
Compliance with prescribed medication by elderly patients.
Kendrick, R., & Bayne, J. R. (1982) · PubMed · Cited by 82 · see citing works
An Analysis of Systems of Classifying Mild Cognitive Impairment in Older People
Collie, A., & Maruff, P. T. (2002) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2002.00972.x · Cited by 64 · see citing works
Drug-Related Emergency Department Visits in an Elderly Veteran Population
Yee, J. L., Hasson, N. K., & Schreiber, D. H. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e541 · Cited by 63 · see citing works
Mild memory impairment in healthy older adults is distinct from normal aging
Cargin, J. W., Maruff, P. T., Collie, A., & Masters, C. L. (2006) · Brain and Cognition · doi:10.1016/j.bandc.2005.10.004 · Cited by 60 · see citing works
Assessment of Capacity to Comply with Medication Regimens in Older Patients
Fitten, L. J., Coleman, L. T., Siembieda, D. W., Yu, M., & Ganzell, S. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb05808.x · Cited by 60 · see citing works
Optimal medication use in elders. Key to successful aging.
Monane, M., Monane, S., & Semla, T. P. (1997) · PubMed · Cited by 54 · see citing works
Wong, J. L. (1994) · Journal of Clinical Psychology · doi:10.1002/1097-4679(199407)50:4 · Cited by 27 · see citing works
Mental Status and Self-Medication Ability in the Hospitalized Elderly
Patrick, L., & Howell, K. (1998) · Canadian Journal on Aging / La Revue canadienne du vieillissement · doi:10.1017/s0714980800012691 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Gorkin L Goldstein MG Follick MJ Lefrbvre RC Shumaker SA Schron EB Ockene JK 1990 Strategies for enhancing adherence in clinical trials Handbook of Health Behavior Change 361 375 New York Springer
- Insel K Morrow D Brewer B Figueredo A 2006 Executive function, working memory, and medication adherence among older adults J Gerontol B Psychol Sci Soc Sci 61 2 102 107 16497953
- Welsh K Breitner J Magruder-Habib K 1993 Detection of dementia in the elderly using telephone screening of cognitive status Neuroscience Letters (Neuropsychiatry, Neuropsychology and Behavioral Neurology) 103 110
Cited by
Sorted by citations
Piau, A., Wild, K., Mattek, N., & Kaye, J. (2019) · Journal of Medical Internet Research · doi:10.2196/12785 · Cited by 252 · see citing works
Self-citationMedication Adherence in Older Adults With Cognitive Impairment: A Systematic Evidence-Based Review
Campbell, N. L., Boustani, M. A., Skopelja, E. N., Gao, S., Unverzagt, F. W., & Murray, M. D. (2012) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2012.04.004 · Cited by 206 · see citing works
Neurocognitive changes after lung transplantation
Smith, P. J., Rivelli, S., Waters, A., Reynolds, J., Hoyle, A., Flowers, M., Davis, R. D., Palmer, S. M., Mathew, J., Durheim, M., et al. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201406-232oc · Cited by 60 · see citing works
Alsaeed, D., Jamieson, E., Gul, M. O., & Smith, F. J. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.050 · Cited by 45 · see citing works
Gustafsson, M., Sjölander, M., Pfister, B., Schneede, J., & Lövheim, H. (2018) · Pharmacy · doi:10.3390/pharmacy6010007 · Cited by 25 · see citing works
Shin, J., Jang, J., & Afaya, A. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-060590 · Cited by 2 · see citing works
- Authors
- Hayes, T. L., Larimer, N., Adami, A., & Kaye, J. A.
- Affiliations
- Oregon Health & Science University (US)
- Universidade de Caxias do Sul, Brazil
- Corresponding author
- Hayes, Tamara L.
- ORCID
- Kaye, Jeffrey A.
- Venue
- Journal of Aging and Health
- Publisher
- SAGE Publications
- Published
- 2009-04-01
- Volume
- 21
- Issue
- 4
- Pages
- 567-580
- ISSN
- 0898-2643 (ISSN-L)
- 1552-6887
- PMC
- PMC2910516
- OpenAlex
- W2161182511
- Semantic Scholar
- 8941204d2a7d0407cc104ae66cf28713e72500ae
- Cited by
- 192
- References
- 41
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 16 · 2019: 11 · 2018: 26 · 2017: 12 · 2016: 13 · 2015: 23 · 2014: 12 · 2013: 9 · 2012: 8
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Aging and Health (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG024059, P30AG008017, P30AG024978, P30AG0801718)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- medication adherence, older adults, cognitive impairment, mild cognitive impairment, vitamin C supplementation, ADAS-Cog, healthy older adults, clinical drug trials, independent living
- MeSH terms
- Assessment of Medication Adherence, Activities of Daily Living, Aged, Aged, 80 and over, Ascorbic Acid, Cognition, Cognition Disorders, Cross-Sectional Studies, Female, Health Status, Humans, Male, Oregon, Psychiatric Status Rating Scales, Self Administration, Self Care, Geriatric Assessment, Drug Monitoring, Medication Adherence
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