Personality and medication non‐adherence among older adults enrolled in a six‐year trial
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Objectives. Personality factors parsimoniously capture the variation in dispositional characteristics that affect behaviours, but their value in predicting medication non‐adherence is unclear. We investigated the relationship between five‐factor model personality factors (Conscientiousness, Neuroticism, Agreeableness, Extraversion, and Openness) and medication non‐adherence among older participants during a six‐year randomized placebo‐controlled trial (RCT). Design. Observational cohort data from 771 subjects aged ≥72 years enrolled in the Ginkgo Evaluation of Memory study, a RCT of Ginkgo biloba for prevention of dementia. Methods. Random effects logistic regression analyses examined effects of NEO Five‐Factor Inventory scores on medication non‐adherence, determined via pill counts every 6 months (median follow‐up 6.1 years) and defined as taking <80% of prescribed pills. Analyses adjusted for covariates linked with non‐adherence in prior studies. Results. Each 5 year increment in participant age was associated with a 6.7% greater probability of non‐adherence (95% confidence interval, CI [2.4, 11.0]). Neuroticism was the only personality factor associated with non‐adherence: a 1 SD increase was associated with a 3.8% increase in the probability of non‐adherence (95% CI [0.4, 7.2]). Lower cognitive function was also associated with non‐adherence: a 1 SD decrease in mental status exam score was associated with a 3.0% increase in the probability of non‐adherence (95% CI [0.2, 5.9]). Conclusions. Neuroticism was associated with medication non‐adherence over 6 years of follow‐up in a large sample of older RCT participants. Personality measurement in clinical and research settings might help to identify and guide interventions for older adults at risk for medication non‐adherence.
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Adherence to medication and study drop-out appear to be related to personality characteristics.
“Adherence to medication and study drop-out alike appears to be related to personality characteristics [265–267].”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [267]
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- Authors
- Jerant, A., Chapman, B., Duberstein, P., Robbins, J., & Franks, P.
- Affiliations
- University of California Davis Medical Center (US)
- University of Rochester Medicine (US)
- University of California, Davis (US)
- Corresponding author
- Jerant, Anthony
- Venue
- British Journal of Health Psychology
- Publisher
- Wiley
- Published
- 2011-01-12
- Volume
- 16
- Issue
- 1
- Pages
- 151-169
- ISSN
- 1359-107X (ISSN-L)
- 2044-8287
- PMC
- PMC3126620
- OpenAlex
- W1927249329
- Cited by
- 86
- References
- 53
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 12
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- British Journal of Health Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG005133)
- National Institute of Mental Health (K24MH072712, T32MH073452)
- National Institute of Allergy and Infectious Diseases (U01AI000162)
- National Center for Complementary and Integrative Health (U01AT000162)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- medication non-adherence, personality, Big Five personality traits, neuroticism, conscientiousness, agreeableness, extraversion, openness to experience, older adults, cognitive function, Ginkgo biloba, dementia prevention, pill count
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Dementia, Female, Follow-Up Studies, Humans, Male, Phytotherapy, Memory, Neurotic Disorders, Personality, Personality Inventory, United States, Cohort Studies, Geriatric Assessment, Drug Monitoring, Ginkgo biloba, Medication Adherence
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