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Bioactivity and physicochemical characterization of Centella asiatica and Marigold extract serums: Antioxidant, anti‐inflammatory, anti‐tyrosinase and skin barrier function insights
Open accessAbstract
Centella asiatica extract (CAE) and Marigold extract (ME) have been renowned for centuries in traditional medicine, particularly in Asia, for their wound-healing, anti-inflammatory and skin-regenerative properties. This study presents the formulation and comprehensive evaluation of serums enhanced with these extracts, aiming to harness their bioactive properties for skin health. Serums were selected over creams due to their lightweight, water-based nature, which ensures faster absorption and enhanced skin penetration of active ingredients. The serums, developed in varying concentrations (0.2%, 0.5% and 1.0%), were assessed for physicochemical properties, stability, bioactivity and skin barrier enhancement. Stability tests confirmed the serums' robustness, maintaining consistent pH (5.0-6.5), viscosity and organoleptic properties over 60 days. The MTT assay revealed that both extracts were non-cytotoxic, maintaining cell viability above 100%, with formulations containing CAE, demonstrating a concentration-dependent proliferative effect, reaching nearly 120%. Antibacterial evaluation using the agar well diffusion assay showed that both extracts exhibited considerable activity, with CAE achieving greater inhibition zones, particularly against S. aureus. Antioxidant, anti-inflammatory and anti-tyrosinase activities confirmed the strong bioactive potential of both extracts in combating oxidative stress, reducing inflammation, and regulating pigmentation. Skin barrier and permeability studies demonstrated the serums' ability to improve barrier integrity and facilitate active compound delivery. These findings demonstrate the potential of Centella asiatica and Marigold extracts for multifunctional skincare formulations, combining regeneration, hydration, antioxidant and antibacterial benefits.
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Centella asiatica-derived triterpenoids support epidermal barrier function and improve skin hydration through regulation of lipid organization and inflammatory mediators.
“In addition, Centella asiatica-derived triterpenoids have been reported to support epidermal barrier function and improve skin hydration through regulation of lipid organization and inflammatory mediators [25,26].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [26]
The Permeability of active components section reports reduced transepidermal water loss with Centella asiatica extract serum and suggests improved hydration and skin-barrier function (page unavailable). The paper does not establish that triterpenoids specifically produce those effects through regulation of lipid organization or inflammatory mediators. (LLM, conf=0.87)
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Metadata
- Authors
- Bikiaris, R. E., Paczkowska‐Walendowska, M., Koumentakou, I., Niti, A., Cielecka‐Piontek, J., & Kyzas, G. Z.
- Affiliations
- Democritus University of Thrace (GR)
- Poznan University of Medical Sciences (PL)
- BIOHELLENIKA S.A. Thessaloniki Greece
- Corresponding author
- Koumentakou, Ioanna
- Kyzas, George Z.
- ORCID
- Venue
- International Journal of Cosmetic Science
- Publisher
- Wiley
- Published
- 2025-07-10
- Volume
- 47
- Issue
- 6
- Pages
- 1070-1084
- ISSN
- 0142-5463 (ISSN-L)
- 1468-2494
- OpenAlex
- W4412155505
- Cited by
- 7
- References
- 45
- Citations by year
- 2026: 6 · 2025: 1
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- International Journal of Cosmetic Science (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Centella asiatica extract, marigold extract, antioxidant activity, anti-inflammatory activity, tyrosinase inhibition, skin barrier function, antibacterial activity, Staphylococcus aureus, cytotoxicity, formulation stability, skin pigmentation, wound healing, skin regeneration
- MeSH terms
- Anti-Inflammatory Agents, Antioxidants, Humans, Plant Extracts, Skin, Triterpenes, Monophenol Monooxygenase, Centella
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