Trial registration and selective outcome reporting in Endodontic Research: Evidence over a 5‐year period
Open accessAbstract
Aim To assess the prevalence of registration of clinical trials in endodontic research and to identify outcome reporting discrepancies between trial registration entries and respective final publications. Associations with publication characteristics, such as journal, year of publication, origin, number of centres and authors, funding and statistical significance of the findings, were also sought. Methodology All reports of endodontic randomized controlled trials (RCTs) published in 4 endodontic specialty and 4 general dental journals from 1 January 2016 to 31 December 2020 were identified. Trial registration frequency patterns were assessed for the included RCTs, whilst for the ones registered, outcome reporting discrepancies were recorded. Article characteristics such as year of publication, geographic region, number of centres, authors participating in the publication, funding, type of registration and others were identified. Descriptive statistics and univariable/multivariable logistic regression were performed to examine the effect of study characteristics on identified registration practices. Results One hundred and fifty-five RCTs were included, with the majority published in specialty journals (121/155; 78.1%). A total of 42.6% of the identified RCTs was registered (66/155), mostly retrospectively (38/66; 57.6%). There was strong evidence that each additional year for more recent publication accounted for 1.42 times higher odds of being registered (adjusted Odds Ratio…
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Studies in specific dental areas such as endodontics, orthodontics, and implantology found high rates of SOR.
“studies in specific dental areas such as endodontics, orthodontics, and implantology found high rates of SOR (Koufatzidou et al. 2019; Sendyk et al. 2019; Tzanetakis and Koletsi 2021)”
From Nonpublication and Selective Outcome Reporting of Oral Health Trials (2023) · cites this paper as Tzanetakis and Koletsi 2021
This rate is consistent with SOR rates in endodontics (36.4%), implantology (55%), and orthodontics (47%).
“This rate is consistent with SOR rates in endodontics (36.4%) (Tzanetakis and Koletsi 2021), implantology (55%) (Sendyk et al. 2019), and orthodontics (47%) (Koufatzidou et al. 2019).”
From Nonpublication and Selective Outcome Reporting of Oral Health Trials (2023) · cites this paper as Tzanetakis and Koletsi 2021
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- Authors
- Tzanetakis, G. N., & Koletsi, D.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- University of Zurich (CH)
- Corresponding author
- Tzanetakis, Giorgos N.
- Venue
- International Endodontic Journal
- Publisher
- Wiley
- Published
- 2021-07-09
- Volume
- 54
- Issue
- 10
- Pages
- 1794-1803
- ISSN
- 0143-2885 (ISSN-L)
- 1365-2591
- OpenAlex
- W3160714445
- Cited by
- 15
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 5
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- Locations
- International Endodontic Journal (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Social Sciences › Decision Sciences › Information Systems and Management › Academic Publishing and Open Access
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmaceutical industry and healthcare
- Keywords
- clinical trial registration, selective outcome reporting, endodontic research, randomized controlled trials, registration practice, research transparency, publication year, retrospective registration, primary and secondary outcomes
- MeSH terms
- Endodontics, Registries, Randomized Controlled Trials as Topic
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