Methods, transparency and reporting of clinical trials in orthodontics and periodontics
Open accessAbstract
Objective: The aim of this study was to explore the methods, reporting and transparency of clinical trials in orthodontics and compare them to the field of periodontics, as a standard within dentistry. Design/setting: Cross-sectional bibliographic study Methods: A total of 300 trials published in 2017–2018 and evenly distributed in orthodontics and periodontics were selected, assessed and analysed statistically to explore key aspects of the conduct and reporting of orthodontic clinical trials compared to trials in periodontics. Results: Several aspects are often neglected in orthodontic and periodontic trials and could be improved upon, including use of statistical expertise (22.3% of assessed trials), blinding of outcome assessors (62.3%), prospective trial registration (12.0%), adequate sample size calculation (35.7%), adherence to CONSORT (14.3%) and open data sharing (4.3%). The prevalence of statistically significant findings among orthodontic and periodontic trials was 62.3%, which was significantly associated with several methodological traits like statistician involvement (odds ratio [OR] = 0.5; 95% confidence interval [CI] = 0.3–0.9), blind outcome assessor (OR = 0.5; 95% CI = 0.2–1.0), lack of prospective trial registration (OR = 2.8; 95% CI = 1.3–5.9) and non-adherence to CONSORT (OR = 4.5; 95% CI = 1.3–15.8). Conclusions: Although trials in orthodontics seem to be significantly worse compared to periodontics in aspects like trial registration, adherence to CONSORT and declaration of competing interests or financial support, their methods do seem to have improved considerably in recent years.
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The findings align with previous biomedical and dental research, which reported the presence of more articles with statement of conflict of interest and funding than data and code sharing and protocol registration.
“Our findings align with previous biomedical and dental research, which reported the presence of more articles with statement of conflict of interest and funding than data and code sharing and protocol registration [27–30].”
From Assessing transparency practices in dental randomized controlled trials (2024) · cites this paper as [30]
Data and code sharing has been the least reported aspect in many studies.
“and data and code sharing has been the least reported aspect in many studies [25–30, 41].”
From Assessing transparency practices in dental randomized controlled trials (2024) · cites this paper as [30]
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EVIDENCE-BASED PERIODONTOLOGY: ETHICAL CONSIDERATIONS IN RESEARCH AND PUBLICATION
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- Authors
- Papageorgiou, S. N., Antonoglou, G. N., Martin, C., & Eliades, T.
- Affiliations
- University of Zurich (CH)
- Universidad Complutense de Madrid (ES)
- BIOCRAN (Craniofacial Biology: Orthodontics and Dentofacial Orthopedics) Research Group, Department of Orthodontics, Faculty of Dentistry, University Complutense, Madrid, Spain
- Corresponding author
- Papageorgiou, Spyridon N
- Venue
- Journal of Orthodontics
- Publisher
- SAGE Publications
- Published
- 2019-05-08
- Volume
- 46
- Issue
- 2
- Pages
- 101-109
- ISSN
- 1465-3125 (ISSN-L)
- 1465-3133
- OpenAlex
- W2944758021
- Cited by
- 40
- References
- 35
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 4
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Locations
- Journal of Orthodontics (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- trial reporting quality, orthodontics, periodontics, clinical trial registration, sample size determination, statistical expertise, conflict of interest disclosure, open data sharing, methodological quality
- MeSH terms
- Clinical Trials as Topic, Cross-Sectional Studies, Orthodontics, Periodontics, Prospective Studies, Odds Ratio
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