Part II: Predictors of Depression after Stroke and Impact of Depression on Stroke Outcome: An Updated Systematic Review of Observational Studies
Abstract
Background We previously published a systematic review in 2005 on factors associated with the development of depression in people with stroke. Aim To update and expand that review to include published data on the impact of depression on stroke outcome. Methods We included all published observational studies (to May 31, 2013) with prospective consecutive recruitment of people with a clinical diagnosis of stroke where an attempt was made to assess the variables associated with, or predictive of, the development of depression. Results We included data from 23 studies including 18,374 people. Depression after stroke was associated with prestroke depression, more severe neurological deficit and physical disability in the acute phase, and later after stroke. No consistent relationship between depression and demographic parameters or stroke features was identified. The review of the impact of depression on stroke outcome included data from 14 cohorts, including 4498 people, and found that depression was negatively associated with functional outcome in stroke survivors. Conclusions Early identification of patients at high risk of depression after stroke, those with a history of depression and physical disability after stroke, would enable the early implementation of effective management and prevention strategies for depression. The reciprocal relationship between depression and physical disability highlights the need for interventions that reduce disability after stroke, which may in…
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Cognitive impairment can limit appropriate, flexible goal setting and behaviour, and mood disturbance can impact motivation which may reduce engagement in rehabilitation.
“For example, cognitive impairment can limit appropriate, flexible goal setting and behaviour, and mood disturbance can impact motivation which may reduce engagement in rehabilitation (Beadle et al., 2018;Kutlubaev & Hackett, 2014;Whyte et al., 2011).”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Kutlubaev & Hackett, 2014
Cognitive impairment can limit appropriate, flexible goal setting and behaviour.
“cognitive impairment can limit appropriate, flexible goal setting and behaviour”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Kutlubaev & Hackett, 2014
Mood disturbance can impact motivation which may reduce engagement in rehabilitation.
“mood disturbance can impact motivation which may reduce engagement in rehabilitation”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Kutlubaev & Hackett, 2014
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works
A self-rating depression scale
ZUNG, W. W. K. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01720310065008 · Cited by 9,813 · see citing works
Frequency of Depression After Stroke: A Systematic Review of Observational Studies
Hackett, M. L., Yapa, C., Parag, V., & Anderson, C. S. (2005) · Stroke · doi:10.1161/01.str.0000165928.19135.35 · Cited by 1,464 · see citing works
Self-citationEffect of mood symptoms on recovery one year after stroke
Donnellan, C., Hickey, A., Hevey, D., & O'Neill, D. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2482 · Cited by 132 · see citing works
Saxena, S. K., Ng, T. P., Yong, D., Fong, N. P., & Koh, G. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00922.x · Cited by 48 · see citing works
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Neuropsychiatric sequelae of stroke
Ferro, J. M., Caeiro, L., & Figueira, M. L. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.46 · Cited by 237 · see citing works
Anxiety After Stroke: The Importance of Subtyping
Chun, H.-Y. Y., Whiteley, W. N., Dennis, M. S., Mead, G. E., & Carson, A. J. (2018) · Stroke · doi:10.1161/strokeaha.117.020078 · Cited by 172 · see citing works
Kang, H.-J., Bae, K.-Y., Kim, S.-W., Kim, J.-T., Park, M.-S., Cho, K.-H., & Kim, J.-M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.001 · Cited by 86 · see citing works
General Self-Efficacy as a Driving Factor of Post-Stroke Depression: A Longitudinal Study
Volz, M., Voelkle, M. C., & Werheid, K. (2019) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2017.1418392 · Cited by 65 · see citing works
Backhouse, E. V., McHutchison, C. A., Cvoro, V., Shenkin, S. D., & Wardlaw, J. M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0200525 · Cited by 58 · see citing works
Sathananthan, N., Dimech-Betancourt, B., Morris, E., Vicendese, D., Knox, L., Gillanders, D., Das Nair, R., & Wong, D. (2022) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2021.1971094 · Cited by 31 · see citing works
“For example, cognitive impairment can limit appropriate, flexible goal setting and behaviour, and mood disturbance can impact motivation which may reduce engagement in rehabilitation (Beadle et al., 2018; Kutlubaev & Hackett, 2014; Whyte et al., 2011).”
BackgroundSathananthan, N., Morris, E., Gillanders, D., das Nair, R., Knox, L., & Wong, D. (2025) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2024.2359992 · Cited by 14 · see citing works
“…commonly experience lasting changes in cognitive and emotional functioning which negatively impact daily activities, participation in meaningful life roles, and overall wellbeing and quality of life (Draper et al., 2007; Kutlubaev & Hackett, 2014; Stolwyk et al., 2021; Wood & Rutterford, 2006).”
Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors
Etherton, M. R., Shah, S., Haolin, X., Xian, Y., Maisch, L., Hannah, D., Lindholm, B., Lytle, B., Thomas, L., Smith, E. E., et al. (2021) · Stroke and Vascular Neurology · doi:10.1136/svn-2020-000691 · Cited by 10 · see citing works
Zirk, M., & Storm, V. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00918 · Cited by 11 · see citing works
Yasuno, F., Ando, D., Yamamoto, A., Koshino, K., & Yokota, C. (2019) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2019.01.015 · Cited by 6 · see citing works
- Authors
- Kutlubaev, M. A., & Hackett, M. L.
- Affiliations
- Republican Clinical Hospital named after G.G. Kuvatova (RU)
- The University of Sydney (AU)
- Corresponding author
- Hackett, Maree L.
- Venue
- International Journal of Stroke
- Publisher
- SAGE Publications
- Published
- 2014-08-26
- Volume
- 9
- Issue
- 8
- Pages
- 1026-1036
- ISSN
- 1747-4930 (ISSN-L)
- 1747-4949
- OpenAlex
- W1976232783
- Cited by
- 407
- References
- 7
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 39 · 2023: 44 · 2022: 46 · 2021: 48 · 2020: 32 · 2019: 38 · 2018: 37 · 2017: 34 · 2016: 23 · 2015: 13
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Stroke (publishedVersion)
- PubMed (publishedVersion)
- CLOK (University of Central Lancashire) (acceptedVersion)
- Funders
- National Health and Medical Research Council (NHMRC) (632925)
- National Heart Foundation Future Leader Fellowship (100034)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- post-stroke depression, stroke, risk factors for depression, physical disability, neurological deficit, functional outcome, stroke survivors
- MeSH terms
- Depression, Humans, Predictive Value of Tests, Stroke, Observational Studies as Topic
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