Cited by 1,301Immunotherapy and Immune ResponsesImmune Response and InflammationT-cell and B-cell Immunology

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Human dendritic cell subsets: an update

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Collin, Matthew, Bigley, Venetia·2018·Immunology

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Abstract

Dendritic cells (DC) are a class of bone-marrow-derived cells arising from lympho-myeloid haematopoiesis that form an essential interface between the innate sensing of pathogens and the activation of adaptive immunity. This task requires a wide range of mechanisms and responses, which are divided between three major DC subsets: plasmacytoid DC (pDC), myeloid/conventional DC1 (cDC1) and myeloid/conventional DC2 (cDC2). Each DC subset develops under the control of a specific repertoire of transcription factors involving differential levels of IRF8 and IRF4 in collaboration with PU.1, ID2, E2-2, ZEB2, KLF4, IKZF1 and BATF3. DC haematopoiesis is conserved between mammalian species and is distinct from monocyte development. Although monocytes can differentiate into DC, especially during inflammation, most quiescent tissues contain significant resident populations of DC lineage cells. An extended range of surface markers facilitates the identification of specific DC subsets although it remains difficult to dissociate cDC2 from monocyte-derived DC in some settings. Recent studies based on an increasing level of resolution of phenotype and gene expression have identified pre-DC in human blood and heterogeneity among cDC2. These advances facilitate the integration of mouse and human immunology, support efforts to unravel human DC function in vivo and continue to present new translational opportunities to medicine.

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Figure 1 Ontological overview and functional specialization of human dendritic cells (DC). (a) DC are often depicted as a single ‘all purpose’ cell in diagrams of T‐cell differentiation but each subset is specialized to make specific responses to pathogen or danger signals. Depending on the context, many different responses may be observed and selected principal functions of human plasmacytoid DC (pDC), conventional DC1 (cDC1) and cDC2 are depicted. (b) Ontological basis of DC, monocyte and macrophage classification. Haematopoietic stem cells (HSC) give rise to DC and monocyte‐derived cells by distinct routes marked by differences in the relative expression of interferon regulatory factor 8 (IRF8) and IRF4 as shown in schematic bivariate plots beneath. Monocytes are IRF4/8 low but can be induced to differentiate into monocyte‐derived DC (mo‐DC). Monocyte‐derived macrophages are also ontologically distinct from many populations of long‐lived resident macrophages derived from early myeloid progenitors (EMP).CC BY · PubMed Central

Figure 2 Classical and revised models of human haematopoiesis. (a) In classical models of haematopoiesis, cell potential partitions by successive bifurcations descending from the apex where common lymphoid and common myeloid progenitors (CLP; CMP) arise from the haematopietic stem cell (HSC). Each progenitor population has homogeneous differentiation potential such that every cell has an equal probability of two mutually exclusive fates. Hence, dendritic cells (DC) were proposed to arise in the sequence: CMPs, granulocyte–macrophage DC progenitor (GMDP), macrophage DC progenitor (MDP), common DC progenitor (CDP) with a final pre‐DC stage leading to conventional DC1 (cDC1) and cDC2. Each population is given a uniform colour to indicate homogeneous potential. (b) Experimental data support several revisions to the classical model. First lineage is primed in early progenitors so that most populations contain only cells with a single potential. Second, lymphoid and myeloid potential run together originating as the lymphoid primed multi‐potent progenitor (LMPP) that separates from megakaryocyte and erythroid potential (MkE) at the apex. Hence the gates defined by CD38 (blue borders) and CD45RA (red borders) contain phenotypically related cells but with restricted potentials, indicated by bands of colour each corresponding to a discrete lineage.CC BY · PubMed Central

Figure 3 Segregation of human dendritic cell (DC) potential in late precursor compartments. The CD34+ CD38+ CD45RA+ human granulocyte–macrophage DC progenitor (GMDP) contains only a minority of progenitor cells with bi‐ or tri‐potential indicated in yellow and red, respectively in the diagrams of cell potential of several hundred individual progenitors differentiated in vitro (schematic redrawn from data of Lee et al.32). A small minority of progenitors in the GMDP qualify as MDP [except without plasmacytoid DC (pDC) potential] or common DC progenitor (CDP; all three DC potentials). The CD123+ fraction of GMDP has been described as a CDP; although it does not contain monocyte potential, trilineage common DC progenitors are not found in this gate. In the blood, a CD34+ CD123− precursor fraction is found to contain conventional DC1 (cDC1) and cDC2 potential9 together with a CD34– CD123+ AXL+ SIGLEC6+ pre‐DC with mainly cDC2 potential.9, 10 Traces of cDC1 potential are also found in CD123+ cells. It is not known how the CD34+ CD123− blood precursor relates to GMDP, if it is a physiological route of cDC differentiation, or whether this occurs via AXL+ precursors. Broken lines indicate unconfirmed relationships.CC BY · PubMed Central

Figure 4 Features of the principal human dendritic cell (DC) subsets. Diagrams of the main surface markers, pathogen sensors and responses of (a) plasmacytoid DC (pDC); (b) conventional DC1 (cDC1) and (c) cDC2. Data are principally drawn from observations on freshly isolated blood DC and do not capture the full range of responses possible following inflammatory activation.CC BY · PubMed Central

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Villani, A.-C., Satija, R., Reynolds, G., Sarkizova, S., Shekhar, K., Fletcher, J., Griesbeck, M., Butler, A., Zheng, S., Lazo, S., et al. (2017) · Science · doi:10.1126/science.aah4573 · Cited by 2,413
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Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N., et al. (2005) · Nature · doi:10.1038/nature03464 · Cited by 2,229
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Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y.-T., Grishin, N. V., et al. (2015) · Science · doi:10.1126/science.aaa2630 · Cited by 1,927
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Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,923
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Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., & Colonna, M. (1999) · Nature Medicine · doi:10.1038/11360 · Cited by 1,734
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Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D., & Schmitz, J. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.11.6037 · Cited by 1,433

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Result
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Background
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Wang, M., Zhao, X., Hou, S., Wu, Z., & Yin, H. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s549102 · Cited by 2
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Nanobiotechnology for dendritic cell-based cancer immunotherapy
Li, R. H., Yi, W., Qian, X., Hu, S., Shen, H., Yan, D., & Li, Y. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2026.100485 · Cited by 2
Clinical applications and challenges of CD40/CD40L signaling regulation in autoimmune diseases
Man, Y., Chen, X., Liu, Y., Zhang, B., Hu, J., & Hou, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1830312 · Cited by 2
“Enrichment and phenotypic analyses of dendritic cell subsets isolated from human peripheral blood, tonsillar tissue, and dermis have de ﬁ ned distinct populations in these compartments, and several of these, including epidermal Langerhans cells, have been shown to express functional CD40 (91 – 94).”
Dendritic cells as predictive markers of responsiveness to hydroxychloroquine treatment in primary cicatricial alopecia patients
Kłosowicz, A., Pastuszczak, M., Dyduch, G., Englert, K., Łukasik, A., & Wojas‐Pelc, A. (2020) · Dermatologic Therapy · doi:10.1111/dth.14509 · Cited by 2
“DCs are divided into five major subsets: plasmacytoid DCs (pDCS), myeloid/conventional DC1 (cDC1), myeloid/conventional DC2 (cDC2), Langerhans cells (LCs) and monocyte-derived dendritic cells (mo-DCs).(12) Innate recognition of pathogens and the activation of adaptive immunity mediated by DCs require a wide range of m…”
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(2021) · Frontiers research topics · doi:10.3389/978-2-88966-718-5 · Cited by 3
Generation of high cross-presentation ability human dendritic cells by combination of interleukin 4, interferon β and GM-CSF
Pi, Y., Li, Y.-F., Liang, R., Jian, X., Leng, J., & Zhang, L. (2022) · Central European Journal of Immunology · doi:10.5114/ceji.2022.117767 · Cited by 2
“As a heterogeneous population, human DCs include resting-state DCs, inflammatory DCs, and Langerhans cells [3].”
Background
Adenovirus-Inspired Virus-like-Particles Displaying Melanoma Tumor Antigen Specifically Target Human DC Subsets and Trigger Antigen-Specific Immune Responses
Besson, S., Laurin, D., Chauvière, C., Thépaut, M., Kleman, J.-P., Pezet, M., Manches, O., Fieschi, F., Aspord, C., & Fender, P. (2022) · Biomedicines · doi:10.3390/biomedicines10112881 · Cited by 2
“Plasmacytoid DC are specialized to sense and respond to viruses, whereas conventional DC are more specialized in cross presentation via MHC class I to activate CD8+ T cells [21].”
Background
Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection
Wu, X., & Xu, F. (2023) · Clinical and Translational Discovery · doi:10.1002/ctd2.173 · Cited by 2
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Staal, A. H. J., Cortenbach, K. R. G., Gorris, M. A. J., van der Woude, L. L., Srinivas, M., Heijmen, R. H., Geuzebroek, G. S. C., Grewal, N., Hebeda, K. M., de Vries, I. J. M., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1127685 · Cited by 2
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Scalisi, G., Ricciuti, D., & Manni, G. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3366-3_5 · Cited by 2
Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity
Zhang, H., Liu, C., Zhai, X., Zhang, Q., Zhou, Y., Huang, H., Ding, M., Shi, Q., Liu, Y., Wang, H., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110907 · Cited by 2
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“These cells are essential for initiating humoral and cellular immune responses, as well as for protecting against infectious diseases [52–54].”
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“CD11c + monocytes can differentiate into dendritic cells with potent antigen-presenting capabilities, [35] potentially enhancing immune recognition of premalignant plasma cells.”
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Wang, Y., Liu, X., Bond, A. C., Oh, S., Ochiai, S., Larson, A. R., Qualls, A., Sun, I., Chopin, M., Gardner, J. M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2508184122 · Cited by 2
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Schloss, J. M., Ali, R., Babad, J., Guerrero‐Ros, I., Pongsachai, J., He, L.-Z., Keler, T., & DiLorenzo, T. P. (2019) · ImmunoHorizons · doi:10.4049/immunohorizons.1900014 · Cited by 2
“Although humans possess DCs with similar phenotypes to the murine subsets, they are not exactly parallel (16).”
Background
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Molchanov, O., Maistrenko, D. N., Гранов, Д. А., Lisitsin, I. Y., & Romanov, A. A. (2023) · Urology reports (St - Petersburg) · doi:10.17816/uroved112576 · Cited by 2
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“pDCs are distributed in the lung’s parenchyma, airways, and alveolar septa, and they are the primary source of type I IFN involved in the viral response [24,25].”
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Lamendour, L., Gilotin, M., Deluce, N. K.-N., Lakhrif, Z., Meley, D., Anne Poupon, B., Laboute, T., di Tommaso, A., Pin, J., Mulleman, D., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1369117 · Cited by 2
“Hence, pDCs were identi ﬁ ed by CD123 + /CD303 + , cDC1 cells by CD11c + /CD141 + , and cDC2 cells by CD11c + /CD1c + labeling in the HLA-DR gate (30, 31).”
Background
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Das, B., Sethy, C., Bhal, S., Acharya, S. S., Kundu, C. N., & Das, B. (2024) · Springer eBooks · doi:10.1007/978-981-97-7022-9_6 · Cited by 2
Antigen Presentation to Lymphocytes
Muharemagic, D., Scott, W., & Mishto, M. (2019) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0001227.pub3 · Cited by 2
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Cerovic, V., & Milling, S. W. F. (2021) · Immunology · doi:10.1111/imm.13422 · Cited by 2
“In particular, a subset of DCs referred to as DC1 [5] have been shown to have a propensity for efficient cross- presentation, which appear to be evolutionarily conserved across multiple species [6].”
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Background
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“FAM129C , suggested as a transcriptional marker of plasmacytoid dendritic cells (pDCs) 29 was the most dysregulated (log 2 FC 3.08) in PP skin with PASI 10. pDCs have been recognized in the development of psoriasis 30 and our results lends further weight to their roles increased disease activity.”
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“cDC2s have been reported to present antigens through MHC class II and activate the expansion of CD4 T cells [9, 10].”
Background
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Background
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Authors: Collin, M., & Bigley, V.
Affiliations: Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
Corresponding author: Collin, Matthew
ORCID: Collin, Matthew
Bigley, Venetia
Venue: Immunology
Publisher: Wiley
Published: 2018-02-27
Volume: 154
Issue: 1
Pages: 3-20
ISSN: 0019-2805 (ISSN-L)
1365-2567
DOI: 10.1111/imm.12888
PMC: PMC5904714
OpenAlex: W2781617771
Cited by: 1,301
References: 203
Citations by year: 2026: 69 · 2025: 169 · 2024: 167 · 2023: 191 · 2022: 237 · 2021: 198 · 2020: 155 · 2019: 87 · 2018: 27
FWCI: 11.83
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity) (cc-by)
Funders: Cancer Research UK (C30484/A21025)
Wellcome Trust (101155/Z/13/Z)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: dendritic cells, dendritic cell subsets, plasmacytoid dendritic cells, myeloid dendritic cells, DC1, DC2, transcription factors, IRF8, IRF4, PU.1, monocyte-derived dendritic cells, cell surface markers, innate immunity, adaptive immunity
MeSH terms: Kruppel-Like Factor 4, Cell Communication, Cell Differentiation, Dendritic Cells, Humans, Immunity, Phenotype, Signal Transduction, Biomarkers, Immunophenotyping

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