Cited by 1,301Immunotherapy and Immune ResponsesImmune Response and InflammationT-cell and B-cell Immunology

The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.

Human dendritic cell subsets: an update

Open access

Collin, Matthew, Bigley, Venetia·2018·Immunology

Open this paper in CoChat — free account Open PDF

Abstract

Dendritic cells (DC) are a class of bone-marrow-derived cells arising from lympho-myeloid haematopoiesis that form an essential interface between the innate sensing of pathogens and the activation of adaptive immunity. This task requires a wide range of mechanisms and responses, which are divided between three major DC subsets: plasmacytoid DC (pDC), myeloid/conventional DC1 (cDC1) and myeloid/conventional DC2 (cDC2). Each DC subset develops under the control of a specific repertoire of transcription factors involving differential levels of IRF8 and IRF4 in collaboration with PU.1, ID2, E2-2, ZEB2, KLF4, IKZF1 and BATF3. DC haematopoiesis is conserved between mammalian species and is distinct from monocyte development. Although monocytes can differentiate into DC, especially during inflammation, most quiescent tissues contain significant resident populations of DC lineage cells. An extended range of surface markers facilitates the identification of specific DC subsets although it remains difficult to dissociate cDC2 from monocyte-derived DC in some settings. Recent studies based on an increasing level of resolution of phenotype and gene expression have identified pre-DC in human blood and heterogeneity among cDC2. These advances facilitate the integration of mouse and human immunology, support efforts to unravel human DC function in vivo and continue to present new translational opportunities to medicine.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/imm.12888

Cites

203 of 203 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129
Simultaneous epitope and transcriptome measurement in single cells
Stoeckius, M., Hafemeister, C., Stephenson, W., Houck-Loomis, B., Chattopadhyay, P. K., Swerdlow, H., Satija, R., & Smibert, P. (2017) · Nature Methods · doi:10.1038/nmeth.4380 · Cited by 3,098
Nomenclature of monocytes and dendritic cells in blood
Ziegler‐Heitbrock, L., Ancuța, P., Crowe, S. M., Dalod, M., Grau, V., Hart, D. N. J., Leenen, P. J. M., Liu, Y.-J., MacPherson, G. G., Randolph, G. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-258558 · Cited by 2,436
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
Villani, A.-C., Satija, R., Reynolds, G., Sarkizova, S., Shekhar, K., Fletcher, J., Griesbeck, M., Butler, A., Zheng, S., Lazo, S., et al. (2017) · Science · doi:10.1126/science.aah4573 · Cited by 2,413
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293
IRF-7 is the master regulator of type-I interferon-dependent immune responses
Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N., et al. (2005) · Nature · doi:10.1038/nature03464 · Cited by 2,229
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y.-T., Grishin, N. V., et al. (2015) · Science · doi:10.1126/science.aaa2630 · Cited by 1,927
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,923
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., & Colonna, M. (1999) · Nature Medicine · doi:10.1038/11360 · Cited by 1,734
BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood
Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D., & Schmitz, J. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.11.6037 · Cited by 1,433

Flagged first, then by citations

Show all 203 references

Sorted by citations

Items 401–500 of 998

Using Tumor-Infiltrating Immune Cells and a ceRNA Network Model to Construct a Prognostic Analysis Model of Thyroid Carcinoma
Zhang, F., Yu, X., Lin, Z., Wang, X., Gao, T., Teng, D., & Teng, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.658165 · Cited by 24
“Dendritic cells (DCs), also known as professional antigenpresenting cells (APC), can promote immunity or tolerance by sampling and presenting antigens to T cells and by providing immunomodulatory signals through cell-cell contact and cytokines (58, 59).”
Background
Single-Cell Analysis Reveals the Heterogeneity of Monocyte-Derived and Peripheral Type-2 Conventional Dendritic Cells
Gao, Y., Li, H., Li, Z., Xie, L., Liu, X., Huang, Z., Chen, B., Lin, X., Wang, X., Zheng, Y., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100094 · Cited by 24
Immunology of Osteoporosis: Relevance of Inflammatory Targets for the Development of Novel Interventions
Ahmad, S. S., Ahmed, F., Ali, R., Ghoneim, M. M., Alshehri, S., Najmi, A. K., Ahmad, S., Ahmad, M. Z., Ahmad, J., & Khan, M. A. (2022) · Immunotherapy · doi:10.2217/imt-2021-0282 · Cited by 25
CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells
Pietraforte, I., Butera, A., Gaddini, L., Mennella, A., Palazzo, R., Campanile, D., Stefanantoni, K., Riccieri, V., Lande, R., & Frasca, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010653 · Cited by 24
Single-cell transcriptomics reveals striking heterogeneity and functional organization of dendritic and monocytic cells in the bovine mesenteric lymph node
Barut, G. T., Kreuzer, M., Bruggmann, R., Summerfield, A., & Talker, S. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1099357 · Cited by 24
“33 Distinction of three DC subsets (cDC1, cDC2, pDC) is well established and based on differences in 34 ontogeny, expression of key genes, phenotype, and function (12-14).”
Background
Mucosal neuroimmune mechanisms in gastro-oesophageal reflux disease (GORD) pathogenesis
Leech, T., & Peiris, M. (2024) · Journal of Gastroenterology · doi:10.1007/s00535-023-02065-9 · Cited by 24
“Similar categorisations exist for DCs in blood as well as at other barrier sites such as the gastric mucosa and skin [103].”
Background
Indeterminate DC histiocytosis is distinct from LCH and often associated with other hematopoietic neoplasms
Özkaya, N., Melloul, S., Venkataraman, G., Karai, L. J., Fraitag, S., Razanamahery, J., Pittaluga, S., Battistella, M., Pack, S., Pelletier, F. L., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013545 · Cited by 24
“10,33 CD1c is also known to be positive in cDC2 lineage but is not completely restricted to cDC2 and may be expressed in monocyte-derived DCs. 10 This combination of ﬁ ndings may suggest immunophenotypic similarities between IDCH and the cDC2 lineage.”
Influential
BMP7 aberrantly induced in the psoriatic epidermis instructs inflammation-associated Langerhans cells
Borek, I., Köffel, R., Feichtinger, J., Spies, M., Glitzner, E., Hochgerner, M., Sconocchia, T., Krump, C., Tam‐Amersdorfer, C., Passegger, C. A., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.12.011 · Cited by 23
IGF1R Axis Inhibition Restores Dendritic Cell Antitumor Response in Ovarian Cancer
Somri-Gannam, L., Meisel-Sharon, S., Hantisteanu, S., Groisman, G. M., Limonad, O., Hallak, M., & Bruchim, I. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100790 · Cited by 23
“Conventional DCs can be divided into two main subsets: DC1 (CD141+) and DC2 (CD1c+, CD11c+, and CD11b+) [49].”
Background
A novel β-glucan–oligonucleotide complex selectively delivers siRNA to APCs via Dectin-1
Uno, A., Arima, K., Shimazaki, M., Ushida, M., Amano, K., Namikawa, R., & Sakurai, K. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.09.011 · Cited by 23
SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma
Zhang, X., Wu, Z., & Ma, K. (2022) · BMC Cancer · doi:10.1186/s12885-022-09289-7 · Cited by 23
The Dendritic Cell Dilemma in the Skin: Between Tolerance and Immunity
Scheib, N., Tiemann, J., Becker, C., Probst, H. C., Raker, V., & Steinbrink, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929000 · Cited by 24
Nanovaccines: Merits, and diverse roles in boosting antitumor immune responses
Yin, Q., Wang, Y., Xiang, Y., & Xu, F. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2119020 · Cited by 23
Bioinformatic Analysis of the CXCR2 Ligands in Cancer Processes
Korbecki, J., Bosiacki, M., Chlubek, D., & Baranowska‐Bosiacka, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713287 · Cited by 23
“It should be noted that monocyte-derived DCs are a distinct subset of DCs that differ from conventional and plasmacytoid DCs [65].”
BackgroundResultInfluential
Comprehensive analysis utilizing flow cytometry and immunohistochemistry reveals inflammatory changes in local endometrial and systemic dendritic cell populations in endometriosis
Hey‐Cunningham, A. J., Wong, C., Hsu, J., Fromm, P. D., Clark, G. J., Kupresanin, F., Miller, E. J., Markham, R., & McGuire, H. M. (2020) · Human Reproduction · doi:10.1093/humrep/deaa318 · Cited by 23
Dendritic Cell Subsets in Melanoma: Pathophysiology, Clinical Prognosis and Therapeutic Exploitation
Cuevas, E. S., Saas, P., & Aspord, C. (2023) · Cancers · doi:10.3390/cancers15082206 · Cited by 24
“Dendritic cells are antigen-presenting cells specialized in antigen uptake and presentation or crosspresentation through their major histocompatibility complexes (MHC) type I and II [3].”
BackgroundInfluential
Controlling Antigen Fate in Therapeutic Cancer Vaccines by Targeting Dendritic Cell Receptors
Wijfjes, Z., van Dalen, F. J., Gall, C. M. L., & Verdoes, M. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00330 · Cited by 23
Development and function of chicken XCR1+ conventional dendritic cells
Wu, Z., Shih, B. B.-J., Macdonald, J., Meunier, D., Hogan, K., Chintoan‐Uta, C., Gilhooley, H. J., Hu, T., Beltrán, M., Henderson, N. C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1273661 · Cited by 22
Microbiota substances modulate dendritic cells activity: A critical view
Shvets, Y. V., Khranovska, N., Senchylo, N., Ostapchenko, D., Tymoshenko, I., Onysenko, S., Kobyliak, N. M., & Falalyeyeva, T. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27125 · Cited by 26
“Furthermore, the initial recognition of bacterial substances by DCs influences both DC maturation and the polarization of the immune response [44].”
Background
Tumor-Infiltrating Immune Cells in Colorectal Cancer
Ferkel, S. A. M., Holman, E. A., Sojwal, R. S., Rubin, S. J. S., & Rogalla, S. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101091 · Cited by 26
MPC-mediated lactate production drives histone lactylation in dendritic cells to affect tumor progression and immunotherapy
Zhang, B., Xu, A., Wang, H., Yan, W., Zhang, Q., & Wang, S. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05881-9 · Cited by 27
“Pre‐DCs are defined as DC‐restricted precursors that do not yet express the full phenotype of mature DCs [ 41 ].”
Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential
Jin, F., Xie, L., Zhang, H., Fan, X., Tian, J., Liu, W., Xiao, Y., & Fan, X. (2025) · MedComm · doi:10.1002/mco2.70455 · Cited by 29
Characterization of the Myeloid Cell Populations’ Resident in the Porcine Palatine Tonsil
Soldevila, F., Edwards, J. C., Graham, S. P., Stevens, L. M., Crudgington, B., Crooke, H., Werling, D., & Steinbach, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01800 · Cited by 22
Multi-Immune Agonist Nanoparticle Therapy Stimulates Type I Interferons to Activate Antigen-Presenting Cells and Induce Antigen-Specific Antitumor Immunity
Levy, E. S., Chang, R., Zamecnik, C. R., Dhariwala, M. O., Fong, L. H., & Desai, T. A. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00984 · Cited by 23
A novel therapeutic modality using CRISPR-engineered dendritic cells to treat allergies
Kim, B., Lee, Y. E., Yeon, J. W., Go, G.-Y., Byun, J., Lee, K., Lee, H. K., Hur, J. K., Jang, M., & Kim, T. H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120798 · Cited by 22
Organized Chaos: Deciphering Immune Cell Heterogeneity’s Role in Inflammation in the Heart
Corker, A., Neff, L. S., Broughton, P. X., Bradshaw, A. D., & DeLeon‐Pennell, K. Y. (2021) · Biomolecules · doi:10.3390/biom12010011 · Cited by 22
“According to their hematopoietic origin, dendritic cells are classified into two main populations: plasmacytoid (pDCs) or conventional/myeloid dendritic cells (mDCs) [51].”
Background
Neuroprotective Potential of Dendritic Cells and Sirtuins in Multiple Sclerosis
Piacente, F., Bottero, M., Benzi, A., Vigo, T., Uccelli, A., Bruzzone, S., & Ferrara, G. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084352 · Cited by 21
Single-cell sequencing reveals the cell map and transcriptional network of sporadic vestibular schwannoma
Chu, Y.-D., Chen, L., Deng, H.-X., Li, Y.-G., & Shen, Z.-S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.984529 · Cited by 20
“According to the classical cell marker genes, the clusters highly expressing CLEC9A, TXNIP, and AREG were defined as dendritic cells (Figures 3A,B; Collin and Bigley, 2018).”
Background
SLC11A1 associated with tumor microenvironment is a potential biomarker of prognosis and immunotherapy efficacy for colorectal cancer
Ma, Y., Zhan, L., Yang, J., & Zhang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.984555 · Cited by 21
“the function of linking and activating adaptive immunity (Collin and Bigley, 2018).”
Background
Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target
Li, H.-Y., Huang, L., Huang, X.-R., Wu, D., Chen, X.-C., Tang, J.-X., An, N., Liu, H.-F., & Yang, C. (2023) · Journal of Immunological Research · doi:10.1155/2023/7625817 · Cited by 24
“transmit antigen information to activate T cells [87, 88].”
Background
The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations
Ricciardelli, A., Robledo, A., Fish, J. E., Kan, P. T. M., Harris, T. H., & Wythe, J. D. (2023) · Biomedicines · doi:10.3390/biomedicines11112876 · Cited by 24
cDC2 plasticity and acquisition of a DC3‐like phenotype mediated by IL‐6 and PGE2 in a patient‐derived colorectal cancer organoids model
Subtil, B., van der Hoorn, I. A. E., Cuenca‐Escalona, J., Becker, A. M. D., Alvarez‐Begue, M., Iyer, K. K., Janssen, J. B. E., van Oorschot, T. G. M., Poel, D., Gorris, M. A. J., et al. (2024) · European Journal of Immunology · doi:10.1002/eji.202350891 · Cited by 23
MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1
Lopes, A. P., van Roon, J. A. G., Blokland, S. L. M., Wang, M., Chouri, E., Hartgring, S. A. Y., van der Wurff‐Jacobs, K. M. G., Kruize, A. A., Burgering, B. M. T., Rossato, M., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01335 · Cited by 22
Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells
Perros, A. J., Esguerra‐Lallen, A., Rooks, K. M., Chong, F., Engkilde‐Pedersen, S., Faddy, H. M., Hewlett, E. K., Naidoo, R., Tung, J., Fraser, J. F., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15154 · Cited by 22
Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation
Beijnen, E. M. S., & van Haren, S. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.607977 · Cited by 22
Ex vivo dendritic cell generation—A critical comparison of current approaches
Han, P., Hanlon, D. J., Sobolev, O., Chaudhury, R., & Edelson, R. L. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.10.003 · Cited by 22
The Evolving Role of Dendritic Cells in Atherosclerosis
Britsch, S., Langer, H. F., Duerschmied, D., & Becher, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042450 · Cited by 21
pH-dependent Osteoimmunomodulation: Molecular mechanisms and therapeutic targeting in bone disorders
Wu, C., Sun, Z., He, C., & Sun, R. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107838 · Cited by 24
Immune cell landscape and immunotherapy of medulloblastoma
Zhang, J., & Wang, T. (2021) · Pediatric Investigation · doi:10.1002/ped4.12261 · Cited by 21
“DCs are myeloid-derived, potent antigen-presenting cells (APCs) that are divided into three major subsets: plasmacytoid DC (pDC), myeloid/conventional DC1 (cDC1), and myeloid/conventional DC2 (cDC2).(45,46) They play a critical role in the adaptive immune response by governing T cell immunity and tolerance with a spec…”
Background
Antigen Presenting Cells Contribute to Persistent Immune Activation Despite Antiretroviral Therapy Initiation During Hyperacute HIV-1 Infection
Naidoo, K. K., Ndumnego, O. C., Ismail, N., Dong, K. L., & Ndung’u, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.738743 · Cited by 21
Breaking Bad: Autophagy Tweaks the Interplay Between Glioma and the Tumor Immune Microenvironment
Fan, Y., Wang, Y.-B., Zhang, J., Dong, X.-C., Gao, P., Liu, K., Ma, C.-Y., & Zhao, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.746621 · Cited by 23
Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection
Albayrak, N., Cano, C. O., Karimi, S., Dogahe, D., Praet, A. V., Godefroid, A., del Mármol, V., Grimaldi, D., Bondue, B., Vooren, J. V., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.769839 · Cited by 22
Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people
Vitallé, J., Pérez‐Gómez, A., Ostos, F. J., Gasca‐Capote, C., Jiménez‐León, M. R., Bachiller, S., Rivas‐Jeremías, I., Silva-Sánchez, M. D. M., Ruiz-Mateos, A. M., Martín-Sánchez, M. Á., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.161045 · Cited by 20
“This is in accordance with the important function of CD141+ 438 mDCs in antigen presentation to T cells (60, 61).”
Result
Neddylation Regulation of Immune Responses
Mao, H., Lin, X., & Sun, Y. (2023) · Research · doi:10.34133/research.0283 · Cited by 21
“Mature DCs present foreign antigens to naive T cells, inducing an efficient T cell response required for controlling the infection [74,75].”
Background
Can Dendritic Cell Vaccination Prevent Leukemia Relapse?
O’Brien, L., Guillerey, C., & Radford, K. J. (2019) · Cancers · doi:10.3390/cancers11060875 · Cited by 21
In vitro generation of human monocyte-derived dendritic cells methodological aspects in a comprehensive review
Cechim, G., & Chies, J. A. B. (2019) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201920190310 · Cited by 21
Dendritic Cells Currently under the Spotlight; Classification and Subset Based upon New Markers
Soltani, S., Mahmoudi, M., & Farhadi, E. (2020) · Immunological Investigations · doi:10.1080/08820139.2020.1783289 · Cited by 23
“Regulatory DCs (DCregs) keep their ability in antigen presentation to the antigen-specific T lymphocytes; however, the expression of costimulatory molecules (e.g., CD80, CD86, CD40) and proinflammatory cytokines (IL-12) is downregulated.”
BackgroundInfluential
Mucosal Immunity against SARS-CoV-2 in the Respiratory Tract
Noh, H. E., & Rha, M. (2024) · Pathogens · doi:10.3390/pathogens13020113 · Cited by 21
“…cDC1s in the vascular wall and mucosa stimulate Th1 responses, while CD1c-expressing cDC2s in the lamina propria produce inflammatory chemokines, facilitating immune cell aggregation, and may contribute to immune tolerance [40]. pDCs are present throughout the lung tissue including the airway.”
Background
Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma
Paczkowska, J., Tang, M., Wright, K., Song, L., Luu, K., Shanmugam, V., Welsh, E. L., Weirather, J. L., Besson, N. R., Olszewski, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54512-7 · Cited by 21
“…stimulation (Cluster 14), Type-2 conventional dendritic cells (cDCs) (Cluster 10, CD33 + , CLEC10A + , CD1c + and MHC class II [ HLA-DMA , HLA-DPA1 and HLA-DRA ] high ) and plasmacytoid dendritic cells (pDCs) (Cluster 18, CLEC4C + , CD123 + , NRP1 + and CD11c [ITGAX] − ) were also detected 76 (Fig.”
CD47 as a potent target in cancer immunotherapy: A review
Ahvati, H., Roudi, R., Sobhani, N., & Safari, F. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189294 · Cited by 20
Differential expression of immune markers in the patients with obstructive sleep apnea/hypopnea syndrome
Xie, H., Yin, J., Bai, Y., Peng, H., Zhou, X., & Bai, J. (2018) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-018-5219-6 · Cited by 20
Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A Dragon-Like Weapon in a Non-fantasy Game of Thrones
Angrini, M., Varthaman, A., & Cremer, I. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-44518-8_9 · Cited by 20
Mosquito-bite infection of humanized mice with chikungunya virus produces systemic disease with long-term effects
Hibl, B. M., Garnes, N. D., Kneubehl, A. R., Vogt, M. B., Clinton, J. L. S., & Rico-Hesse, R. R. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009427 · Cited by 21
Extensive Phenotype of Human Inflammatory Monocyte-Derived Dendritic Cells
Coutant, F., Pin, J., & Miossec, P. (2021) · Cells · doi:10.3390/cells10071663 · Cited by 21
“These DC subsets exhibit distinct Toll-like receptor (TLR) profiles that transduce inflammatory signals and then modulate their functions [4].”
Background
Single-Cell RNA Sequencing Reveals the Heterogeneity of Infiltrating Immune Cell Profiles in the Hepatic Cystic Echinococcosis Microenvironment
Yasen, A., Sun, W., Aini, A., Aji, T., Shao, Y., Wang, H., Li, K., Li, W., Zhang, C., Ahan, A., et al. (2021) · Infection and Immunity · doi:10.1128/iai.00297-21 · Cited by 20
Viewing keloids within the immune microenvironment.
Shan, M., & Wang, Y. (2022) · PubMed Central · Cited by 21
Diversification of circulating and tumor‐infiltrating plasmacytoid DCs towards the P3 (CD80+ PDL1−)‐pDC subset negatively correlated with clinical outcomes in melanoma patients
Cuevas, E. S., Bendriss‐Vermare, N., Mouret, S., de Fraipont, F., Charles, J., Valladeau‐Guilemond, J., Chaperot, L., & Aspord, C. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1382 · Cited by 20
“29–31 Later on, multiparametric phenotypic characterisation and unbiased single-cell RNA sequencing of human blood and tonsils samples identified a contamination of the pDC gate (CD45+Lin HLADR+BDCA2+) by a closely related DC precursor population (AS DCs) expressing CD2, CD5 and Axl,32–34 which are counterparts of the…”
Influential
Distinct responses of newly identified monocyte subsets to advanced gastrointestinal cancer and COVID-19
Rigamonti, A., Castagna, A., Viatore, M., Colombo, F., Terzoli, S., Peano, C., Marchesi, F., & Locati, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.967737 · Cited by 18
“Based on the expression of IL3RA/ CD123, CLEC4C and NRP1, 2 clusters (c8, c16) were recognized as pDCs (36) (Figures 1C and S1E).”
Background
Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma
Decraene, B., Vanmechelen, M., Clément, P. M., Daisne, J., Bempt, I. V., Sciot, R., Garg, A. D., Agostinis, P., Smet, F. D., & Vleeschouwer, S. D. (2023) · Cancer Medicine · doi:10.1002/cam4.5681 · Cited by 18
Dendritic Cells as a Therapeutic Strategy in Acute Myeloid Leukemia: Vaccines
Palomares, F., Pina, A., Dakhaoui, H., Leiva‐Castro, C., Múnera‐Rodríguez, A. M., Cejudo‐Guillén, M., Granados, B., Álba, G., Santa‐María, C., Sobrino, F., et al. (2024) · Vaccines · doi:10.3390/vaccines12020165 · Cited by 20
“They express CD14 and CD1a/CD1c surface markers, playing a key role in the inflammation process [43,44], and are often named “inflammatory mo-DC” [45].”
Background
Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level
Kessler, S., Burke, B. E., Andrieux, G., Schinköthe, J., Hamberger, L., Kacza, J., Zhan, S., Reasoner, C., Dutt, T. S., Osman, M. K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48934-6 · Cited by 22
The tumor microenvironment and dendritic cells: Developers of pioneering strategies in colorectal cancer immunotherapy?
Ghorbaninezhad, F., Nour, M. A., Farzam, O. R., Saeedi, H., Vanan, A. G., Bakhshivand, M., Jafarlou, M., Hatami‐Sadr, A., & Baradaran, B. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189281 · Cited by 26
Ebola virus glycoprotein stimulates IL-18–dependent natural killer cell responses
Wagstaffe, H. R., Clutterbuck, E., Bockstal, V., Stoop, J. N., Lühn, K., Douoguih, M., Shukarev, G., Snape, M. D., Pollard, A. J., Riley, E. M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci132438 · Cited by 20
“org Volume 130 Number 7 July 2020 IL-12(p40)+ cells in CD14–CD11c+ myeloid DCs (mDCs) (30), total CD14– cells, and CD14+ monocytes compared with medium alone.”
Background
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice
van Uden, D., Koudstaal, T., van Hulst, J. A. C., Bergen, I. M., Gootjes, C., Morrell, N. W., Loo, G., von der Thüsen, J. H., van den Bosch, T. P. P., Ghigna, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041756 · Cited by 20
“Several DC subsets exist under steady state conditions, including (i) plasmacytoid DC (pDC) which are known for their interferon production, (ii) type 1 conventional DCs (cDC1s) that excel in cross-presentation of antigens, and (iii) type 2 cDCs (cDC2s) which are known for CD4+ T cell induction [12].”
BackgroundMethodInfluential
A Novel Inflammatory Dendritic Cell That Is Abundant and Contiguous to T Cells in the Kidneys of Patients With Lupus Nephritis
Parikh, S. V., Malvar, A., Shapiro, J. P., Turman, J. M., Song, H., Alberton, V. G., Lococo, B., Mejia-Vilet, J. M., Madhavan, S. M., Zhang, J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.621039 · Cited by 20
Dendritic cell vaccine as a potential strategy to end the COVID-19 pandemic. Why should it be Ex Vivo?
Jonny, J., Putranto, T. A., Sitepu, E. C., & Irfon, R. (2022) · Expert Review of Vaccines · doi:10.1080/14760584.2022.2080658 · Cited by 25
“pDC, cDC1, and cDC2 are present constantly in the body [39].”
Background
Complexity of synovial fluid-derived monocyte-macrophage-lineage cells in knee osteoarthritis
Mikulková, Z., Gallo, J., Manukyan, G. P., Trajerová, M., Savara, J., Shrestha, B., Dýšková, T., Nesnadna, R., Slobodová, Z., Štefančík, M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115011 · Cited by 19
Dendritic cell immunotherapy advances for solid tumors: Vaccination and modulation
Clayton, G., Toffoli, E. C., de Gruijl, T. D., & van Kooyk, Y. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102412 · Cited by 21
“12,15,16 Human DC subset ontogeny has mostly been investigated through in vitro differentiation models; while there is evidence in steady state that cDC subsets can originate from pre-DC lineages, the pDCs and DC3 differentiation pathways are less clear, with limited validation techniques available.”
Gene regulation by non-Coding RNAs in infertility: a mechanistic review
Borji, A., Aram, C., Ziyadloo, F., Zadeh, M. R., Rouzbahani, K. A., Kazemi, M., Barancheshmeh, M., Alishvandi, A., & Daraei, A. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01862-5 · Cited by 22
Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria
Loughland, J. R., Woodberry, T., Boyle, M. J., Tipping, P. E., Piera, K. A., Amante, F. H., Kenangalem, E., Price, R. N., Engwerda, C. R., Anstey, N. M., et al. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy555 · Cited by 19
“Historically, the classification of CD16+ DCs has been ambiguous, and some degree of controversy remains around whether these cells classify as DC or nonclassic monocytes (recently reviewed in [15]).”
Background
The innate immune response in Zika virus infection
de Sousa, J. R., Azevedo, R. D. S. D. S., Quaresma, J. A. S., & Vasconcelos, P. F. D. C. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2166 · Cited by 19
“DCs belong to a heterogeneous group of antigen‐presenting cells (APCs), presently described as sentinels, that orchestrate the initiation of both the innate and adaptive immune responses.(19,20) In the skin, an organ with a complex tissue immune system, DCs play a central role in the infectious process triggered by ZI…”
Background
Peripheral Blood Mononuclear Cell Populations Correlate with Outcome in Patients with Metastatic Breast Cancer
Larsson, A.-M., Nordström, O., Johansson, A., Rydén, L., Leandersson, K., & Bergenfelz, C. (2022) · Cells · doi:10.3390/cells11101639 · Cited by 19
“MDC1 are potent cross-presenters of antigens to activate Th1 and CD8+ T lymphocytes and may associate with an improved anti-tumor immune response [41].”
Background
Peripheral Blood T Cells of Patients with IPAH Have a Reduced Cytokine-Producing Capacity
van Uden, D., Koudstaal, T., van Hulst, J. A. C., Vink, M., van Nimwegen, M., van den Toorn, L. M., Chandoesing, P. P., van den Bosch, A. E., Kool, M., Hendriks, R. W., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126508 · Cited by 19
“The presence and activation status of DCs or monocytes in peripheral blood may not necessarily resemble their equivalents in the lung [37].”
Background
Unique CLR expression patterns on circulating and tumor-infiltrating DC subsets correlated with clinical outcome in melanoma patients
Cuevas, E. S., Valladeau‐Guilemond, J., Mouret, S., Roubinet, B., de Fraipont, F., Landemarre, L., Charles, J., Bendriss‐Vermare, N., Chaperot, L., & Aspord, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1040600 · Cited by 22
STATs signaling pathways in dendritic cells: As potential therapeutic targets?
Sohrabi, S., Masoumi, J., Naseri, B., Ghorbaninezhad, F., Alipour, S., Kazemi, T., Heris, J. A., Maleki, L. A., Basirjafar, P., Zandvakili, R., et al. (2023) · International Reviews of Immunology · doi:10.1080/08830185.2023.2274576 · Cited by 21
“DCs are a kind of antigen-presenting cell (APC) that coordinates the bridging of innate and adaptive immunity and are crucial for generating and regulating Ag-specific immune responses [16].”
BackgroundInfluential
Modulation of antigen delivery and lymph node activation in nonhuman primates by saponin adjuvant saponin/monophosphoryl lipid A nanoparticle
Yousefpour, P., Zhang, Y. J., Maiorino, L., Melo, M. B., Ramirez, M. A. A., Kumarapperuma, S. C., Xiao, P., Silva, M., Li, N., Michaels, K. K., et al. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae529 · Cited by 19
Messing with the Sentinels—The Interaction of Staphylococcus aureus with Dendritic Cells
Darisipudi, M. N., Nordengrün, M., Bröker, B. M., & Péton, V. (2018) · Microorganisms · doi:10.3390/microorganisms6030087 · Cited by 20
“Compared to cDC1, cDC2 in mouse and human are less capable of presenting antigens via MHC class II [46].”
Background
In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy
Calmeiro, J., Mendes, L., Duarte, I. F., Leitão, C., Tavares, A. R., Ferreira, D. A., Gomes, C. M. F., Serra, J., Falcão, A. C., Cruz, M. T., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.593363 · Cited by 19
Conventional type 1 dendritic cells (cDC1) as cancer therapeutics: challenges and opportunities
Johnson, P. C., Rosendahl, N., & Radford, K. J. (2021) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2022.1994943 · Cited by 18
Impaired activation of plasmacytoid dendritic cells via toll-like receptor 7/9 and STING is mediated by melanoma-derived immunosuppressive cytokines and metabolic drift
Monti, M., Ferrari, G., Grosso, V., Missale, F., Bugatti, M., Cancila, V., Zini, S., Segala, A., Via, L. L., Consoli, F., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1227648 · Cited by 21
“…cells involved in anti-tumor immune response, Plasmacytoid Dendritic cells (pDCs) play a crucial role bridging the innate and adaptive immunity (8). pDCs are the major type I interferon (I-IFN) producing cells upon nucleic acids sensing through Toll-like receptor (TLR) 7-and 9-dependent…”
Background
Dendritic cells immunotargeted therapy for atherosclerosis
Li, Z., Yang, Y., Zong, J., Zhang, B., Li, X., Qi, H., Yu, T., & Li, Y. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.12.029 · Cited by 18
“Instead, they express an array of markers including CD303 (CLEC4C; BDCA-2), CD304 (neuro-pilin; BDCA-4), CD85k (ILT3), CD85g (ILT7), and other recently identiﬁed antigens like Fc ε R1, BTLA, DR6 (TNFRSF21/CD358), and CD300A 75,82 .”
Immunology in Osseointegration After Implantation
Liu, Y., Gao, M., Yan, Y., Wang, X., Dong, Z., Cheng, L., & Xu, Y. (2025) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35566 · Cited by 20
Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering
Witzel, I., Nasser, R. A., Garcia‐Sabaté, A., Sapudom, J., Ma, C., Chen, W., & Teo, J. C. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801126 · Cited by 17
Plasmacytoid dendritic cells and asthma: a review of current knowledge
Xi, Y., & Upham, J. W. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1803741 · Cited by 19
Severe Acute Respiratory Syndrome Coronavirus 2: The Role of the Main Components of the Innate Immune System
Anaeigoudari, A., Mollaei, H. R., Arababadi, M. K., & Nosratabadi, R. (2021) · Inflammation · doi:10.1007/s10753-021-01519-7 · Cited by 19
“DCs express a wide range of PRRs such as TLR2 and TLR4 to recognize SARS/MERS-CoV proteins and TLR3, 7 and TLR8 to detect viral RNA [108].”
Background
Modulation of the immune response by heterogeneous monocytes and dendritic cells in lung cancer
Kwiecień, I., Rutkowska, E., Raniszewska, A., Rzepecki, P., & Domagala-Kulawik, J. J. (2021) · World Journal of Clinical Oncology · doi:10.5306/wjco.v12.i11.966 · Cited by 20
Comprehensive Analyses of Immune Subtypes of Stomach Adenocarcinoma for mRNA Vaccination
You, W., Ouyang, J., Cai, Z., Chen, Y., & Wu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827506 · Cited by 18
“To explore the potential mechanisms, we analyzed the relationships between these four targets and transcription factors that regulate dendritic cell function, including BATF3, IRF4, IRF8, ZEB2, ID2, KLF4, E2-2, and IKZF1 (39, 40).”
BackgroundInfluential
Development of a standardized and validated flow cytometry approach for monitoring of innate myeloid immune cells in human blood
van der Pan, K., de Bruin-Versteeg, S., Damasceno, D., Hernández-Delgado, A., van der Sluijs‐Gelling, A. J., van den Bossche, W. B. L., de Laat, I. F., Díez, P., Naber, B. A. E., Diks, A. M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.935879 · Cited by 19
Distinct mechanisms of dysfunctional antigen‐presenting DC s and monocytes by single‐cell sequencing in multiple myeloma
Jiang, J., Xiang, J., Chen, M., Wan, Y., Zhong, L., Han, X., Chen, X., Wang, J., Xiao, F., Liu, J., et al. (2023) · Cancer Science · doi:10.1111/cas.15800 · Cited by 18
Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy
Sirkis, D. W., Solsberg, C. W., Johnson, T. P., Bonham, L. W., Sturm, V. E., Lee, S. E., Rankin, K. P., Rosen, H. J., Boxer, A. L., Seeley, W. W., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01205-3 · Cited by 19
“Our differential expression analyses identified cDCs (cluster 14) as the cell type with the highest number of DEGs with absolute LFC > 0.2.”
BackgroundInfluential
Dendritic cell vaccine of gliomas: challenges from bench to bed
Zheng, Y., Ma, X., Feng, S., Zhu, H., Chen, X., Yu, X., Shu, K., & Zhang, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1259562 · Cited by 19
Recent Advances in the Biology and CD123-Directed Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm
Pemmaraju, N., Deconinck, É., Mehta, P., Walker, I., Herling, M., Garnache‐Ottou, F., Gabarin, N., Campbell, C. J. V., Duell, J., Moshe, Y., et al. (2023) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2023.12.010 · Cited by 18
RETRACTED: Dendritic cell-derived exosomes (Dex): Underlying the role of exosomes derived from diverse DC subtypes in cancer pathogenesis
Tuluwengjiang, G., Rasulova, I., Ahmed, S., Kiasari, B. A., Sârbu, I., Ciongradi, C. I., Omar, T. M., Hussain, F., Jawad, M. J., Castillo-Acobo, R. Y., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155097 · Cited by 18
Retracted
Unleashing Tumour-Dendritic Cells to Fight Cancer by Tackling Their Three A’s: Abundance, Activation and Antigen-Delivery
Murgaski, A., Bardet, P. M. R., Arnouk, S. M., Clappaert, E. J., & Laoui, D. (2019) · Cancers · doi:10.3390/cancers11050670 · Cited by 19
“In humans, these pDCs can be identified as CD123+CD33− [15,16].”
Background
Cyclic AMP in dendritic cells: A novel potential target for disease‐modifying agents in asthma and other allergic disorders
Chinn, A. M., & Insel, P. A. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15095 · Cited by 18
“…dendritic cells [cDC1 and cDC2]) possess distinct functions and can be defined by cellular markers and expression of transcription factors (Collin & Bigley, 2018; Mildner & Jung, 2014). cDC2s preferentially prime naïve T cells to differentiate into Th2 and Th17 cells and have been shown…”
Background
The Immune-Modulatory Properties of iPSC-Derived Antigen-Presenting Cells
Ackermann, M., Dragon, A. C., & Lachmann, N. (2020) · Transfusion Medicine and Hemotherapy · doi:10.1159/000512721 · Cited by 18
Designing the next‐generation therapeutic vaccines to cure chronic hepatitis B: focus on antigen presentation, vaccine properties and effect measures
Jansen, D. T. S. L., Dou, Y., de Wilde, J. W., Woltman, A. M., & Buschow, S. I. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1232 · Cited by 18
“Dendritic cells recognise and take up pathogens or diseased, malignant or dying cells using a repertoire of pattern recognition receptors.(11) Ingested material is processed by their intracellular machinery dedicated to antigen presentation on both HLA II (HLA-DR/DP/DQ) and HLA I (HLA-A/B/C) to prime (i.”
Background
On Deep Landscape Exploration of COVID-19 Patients Cells and Severity Markers
Vázquez-Jiménez, A., de León, U. A.-P., Matadamas-Guzman, M. L., Muciño-Olmos, E. A., Martínez-López, Y. E., Escobedo-Tapia, T., & Reséndis-Antonio, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705646 · Cited by 18
Isolator-based point-of-care manufacturing: a practical solution for GMP-compliant cell and extracellular vesicles therapy production
Chiu, Y.-S., Wang, K.-L., & Wu, K.-L. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1644318 · Cited by 17
“DCs are identi ﬁ ed by high expression of CD11c and HLA-DR, with co-stimulatory molecules such as CD80 and CD86 used to con ﬁ rm identity and maturation status (Szabolcs et al., 1996; Liu et al., 2009; Collin and Bigley, 2018).”
Pan-Cancer Analyses Refine the Single-Cell Portrait of Tumor-Infiltrating Dendritic Cells
Ma, T., Chu, X., Wang, J., Li, X., Zhang, Y., Tong, D., Xu, W., Dang, G., Qi, L., Miao, Y., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3595 · Cited by 20
“Developmental models related to AS DC could be summarized into two types: from progenitor to cDC2 (73) or as a transiting state between pDC and cDC2 (19).”

Authors: Collin, M., & Bigley, V.
Affiliations: Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
Corresponding author: Collin, Matthew
ORCID: Collin, Matthew
Bigley, Venetia
Venue: Immunology
Publisher: Wiley
Published: 2018-02-27
Volume: 154
Issue: 1
Pages: 3-20
ISSN: 0019-2805 (ISSN-L)
1365-2567
DOI: 10.1111/imm.12888
PMC: PMC5904714
OpenAlex: W2781617771
Cited by: 1,301
References: 203
Citations by year: 2026: 69 · 2025: 169 · 2024: 167 · 2023: 191 · 2022: 237 · 2021: 198 · 2020: 155 · 2019: 87 · 2018: 27
FWCI: 11.83
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity) (cc-by)
Funders: Cancer Research UK (C30484/A21025)
Wellcome Trust (101155/Z/13/Z)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: dendritic cells, dendritic cell subsets, plasmacytoid dendritic cells, myeloid dendritic cells, DC1, DC2, transcription factors, IRF8, IRF4, PU.1, monocyte-derived dendritic cells, cell surface markers, innate immunity, adaptive immunity
MeSH terms: Kruppel-Like Factor 4, Cell Communication, Cell Differentiation, Dendritic Cells, Humans, Immunity, Phenotype, Signal Transduction, Biomarkers, Immunophenotyping

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human dendritic cell subsets: an update

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks