The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Immune activation and HIV persistence: implications for curative approaches to HIV infection
Open accessAbstract
Summary: Despite complete or near‐complete suppression of human immunodeficiency virus (HIV) replication with combination antiretroviral therapy, both HIV and chronic inflammation/immune dysfunction persist indefinitely. Untangling the association between the virus and the host immune environment during therapy might lead to novel interventions aimed at either curing the infection or preventing the development of inflammation‐associated end‐organ disease. Chronic inflammation and immune dysfunction might lead to HIV persistence by causing virus production, generating new target cells, enabling infecting of activated and resting target cells, altering the migration patterns of susceptible target cells, increasing the proliferation of infected cells, and preventing normal HIV‐specific clearance mechanisms from function. Chronic HIV production or replication might contribute to persistent inflammation and immune dysfunction. The rapidly evolving data on these issues strongly suggest that a vicious cycle might exist in which HIV persistence causes inflammation that in turn contributes to HIV persistence.
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Cites
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“Using markers such as CD45RA (a tyrosine phosphatase), CCR7 (a lymph node homing receptor), and CD27 (a member of the TNF superfamily critical for the long-term maintenance of immunological memory) (112, 113), it has been possible to demonstrate that HIV primarily persists in three memory Tcell subsets endowed with di…”
BackgroundMethodA distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Self-citation
Cited by
Systemic Effects of Inflammation on Health during Chronic HIV Infection
Deeks, S. G., Tracy, R., & Douek, D. C. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.001 · Cited by 868
Self-citationHIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination
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The Molecular Basis for Human Immunodeficiency Virus Latency
Mbonye, U., & Karn, J. (2017) · Annual Review of Virology · doi:10.1146/annurev-virology-101416-041646 · Cited by 182
Activating PKC-ε induces HIV expression with improved tolerability
Irrinki, A. M., Kaur, J., Randhawa, B., McFadden, R., Snyder, C., Truong, H., Soohoo, D., Hu, E., Yu, H., Murray, B. P., et al. (2025) · PLOS Pathogens · doi:10.1371/journal.ppat.1012874 · Cited by 5
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Metadata
- Authors
- Klatt, N. R., Chomont, N., Douek, D. C., & Deeks, S. G.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2013-06-16
- Volume
- 254
- Issue
- 1
- Pages
- 326-342
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2070036973
- Cited by
- 435
- References
- 17
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Klatt, N. R., Chomont, N., Douek, D. C., & Deeks, S. G. (2013). Immune activation and HIV persistence: implications for curative approaches to HIV infection. Immunological Reviews. https://doi.org/10.1111/imr.12065
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
