The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Co‐evolution of Mycobacterium tuberculosis and Homo sapiens
Open accessAbstract
Summary: The causative agent of human tuberculosis ( TB ), M ycobacterium tuberculosis , is an obligate pathogen that evolved to exclusively persist in human populations. For M . tuberculosis to transmit from person to person, it has to cause pulmonary disease. Therefore, M . tuberculosis virulence has likely been a significant determinant of the association between M . tuberculosis and humans. Indeed, the evolutionary success of some M . tuberculosis genotypes seems at least partially attributable to their increased virulence. The latter possibly evolved as a consequence of human demographic expansions. If co‐evolution occurred, humans would have counteracted to minimize the deleterious effects of M . tuberculosis virulence. The fact that human resistance to infection has a strong genetic basis is a likely consequence of such a counter‐response. The genetic architecture underlying human resistance to M . tuberculosis remains largely elusive. However, interactions between human genetic polymorphisms and M . tuberculosis genotypes have been reported. Such interactions are consistent with local adaptation and allow for a better understanding of protective immunity in TB . Future ‘genome‐to‐genome’ studies, in which locally associated human and M . tuberculosis genotypes are interrogated in conjunction, will help identify new protective antigens for the development of better TB vaccines.
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Cites
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Ecology and evolution of Mycobacterium tuberculosis
Gagneux, S. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2018.8 · Cited by 599
Self-citationStucki, D., Brites, D., Jeljeli, L., Coscolla, M., Liu, Q., Trauner, A., Fenner, L., Rutaihwa, L., Borrell, S., Luo, T., et al. (2016) · Nature Genetics · doi:10.1038/ng.3704 · Cited by 423
Self-citationWang, J., Ge, P., Lei, Z., Lu, Z., Qiang, L., Chai, Q., Zhang, Y., Zhao, D., Li, B., Su, J., et al. (2021) · The EMBO Reports · doi:10.15252/embr.202052175 · Cited by 47
Metadata
- Authors
- Brites, D., & Gagneux, S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2015-02-20
- Volume
- 264
- Issue
- 1
- Pages
- 6-24
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1967585857
- Cited by
- 298
- References
- 139
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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