The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Apoptotic cell recognition receptors and scavenger receptors
Open accessAbstract
Summary: Phosphatidylserine recognition receptors are a highly diverse set of receptors grouped by their ability to recognize the ‘eat‐me’ signal phosphatidylserine on apoptotic cells. Most of the phosphatidylserine recognition receptors dampen inflammation by inducing the production of anti‐inflammatory mediators during the phagocytosis of apoptotic corpses. However, many phosphatidylserine receptors are also capable of recognizing other ligands, with some receptors being categorized as scavenger receptors. It is now appreciated that these receptors can elicit different downstream events for particular ligands. Therefore, how phosphatidylserine recognition receptors mediate specific signals during recognition of apoptotic cells versus other ligands, and how this might help regulate the inflammatory state of a tissue is an important question that is not fully understood. Here, we revisit the work on signaling downstream of the phosphatidylserine recognition receptor BAI 1, and evaluate how these and other signaling modules mediate signaling downstream from other receptors, including Stabilin‐2, Mer TK, and αvβ5. We also propose the concept that phosphatidylserine recognition receptors could be viewed as a subset of scavenger receptors that are capable of eliciting anti‐inflammatory responses to apoptotic cells.
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Cited by
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341
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Phagocytosis: Our Current Understanding of a Universal Biological Process
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Clearance of apoptotic neutrophils and resolution of inflammation
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Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses
Elliott, M. R., Koster, K. M., & Murphy, P. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601520 · Cited by 440
Metadata
- Authors
- Penberthy, K. K., & Ravichandran, K. S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2015-12-19
- Volume
- 269
- Issue
- 1
- Pages
- 44-59
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2215274411
- Cited by
- 201
- References
- 19
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
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