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Metabolic regulation of NLRP 3
Open accessAbstract
Summary: A shift in our understanding of macrophage biology has come about as a result of recent discoveries in the area of metabolic reprogramming of macrophages. The NLRP 3 inflammasome drives the activation of caspase‐1, leading to the production of IL ‐1β, IL ‐18, and a type of cell death termed pyroptosis. The NLRP 3 inflammasome has been shown to sense metabolites such as palmitate, uric acid, and cholesterol crystals and is inhibited by ketone bodies produced during metabolic flux. The NLRP 3 inflammasome has also been shown to be regulated by mitochondrial reactive oxygen species and components of glycolysis, such as Hexokinase. Here, we review these findings and discuss their importance for inflammation and furthermore discuss potential therapeutic benefits of targeting NLRP 3.
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“A number of molecules in lipid metabolism pathways have been identified to regulate NLRP3 inflammasome activation [41].”
From HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV (2025) · cites this paper as [41]
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3 retracted
RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
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Self-citationCaspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
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Metadata
- Authors
- Hughes, M. M., & O'Neill, L. A. J.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Hughes, Mark M.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2017-12-16
- Volume
- 281
- Issue
- 1
- Pages
- 88-98
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2778840601
- Cited by
- 311
- References
- 86
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 50 · 2023: 48 · 2022: 49 · 2021: 49 · 2020: 47 · 2019: 18 · 2018: 13 · 2017: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- NLRP3 inflammasome, macrophage metabolic reprogramming, caspase-1 activation, IL-1β, IL-18, pyroptosis, palmitate, uric acid, cholesterol crystals, ketone bodies, mitochondrial reactive oxygen species, hexokinase, glycolysis, inflammation, inflammasome inhibition
- MeSH terms
- Pyroptosis, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Cholesterol, Hexokinase, Humans, Ketone Bodies, Macrophages, Uric Acid, Reactive Oxygen Species, Palmitic Acid, Caspase 1, Inflammasomes, Cellular Reprogramming
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