Cited by 311Inflammasome and immune disordersImmune Response and InflammationAdipokines, Inflammation, and Metabolic Diseases

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Metabolic regulation of NLRP 3

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Hughes, Mark M., O'Neill, Luke A.J.·2018·Immunological Reviews

DOI 10.1111/imr.12608

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Abstract

Summary: A shift in our understanding of macrophage biology has come about as a result of recent discoveries in the area of metabolic reprogramming of macrophages. The NLRP 3 inflammasome drives the activation of caspase‐1, leading to the production of IL ‐1β, IL ‐18, and a type of cell death termed pyroptosis. The NLRP 3 inflammasome has been shown to sense metabolites such as palmitate, uric acid, and cholesterol crystals and is inhibited by ketone bodies produced during metabolic flux. The NLRP 3 inflammasome has also been shown to be regulated by mitochondrial reactive oxygen species and components of glycolysis, such as Hexokinase. Here, we review these findings and discuss their importance for inflammation and furthermore discuss potential therapeutic benefits of targeting NLRP 3.

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3 retracted

RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
Moon, J.-S., Hisata, S., Park, M. A., DeNicola, G. M., Ryter, S. W., Nakahira, K., & Choi, A. M. K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.046 · Cited by 379
Retracted
RETRACTED ARTICLE: NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages
Moon, J.-S., Nakahira, K., Chung, K.-P., DeNicola, G. M., Koo, M. J., Pabón, M. A., Rooney, K. T., Yoon, J.-H., Ryter, S. W., Stout-Delgado, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4153 · Cited by 291
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UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
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Authors: Hughes, M. M., & O'Neill, L. A. J.
Affiliations: Trinity College Dublin (IE)
Corresponding author: Hughes, Mark M.
ORCID: Hughes, Mark M.
O'Neill, Luke A.J.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2017-12-16
Volume: 281
Issue: 1
Pages: 88-98
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/imr.12608
OpenAlex: W2778840601
Cited by: 311
References: 86
Citations by year: 2026: 12 · 2025: 24 · 2024: 50 · 2023: 48 · 2022: 49 · 2021: 49 · 2020: 47 · 2019: 18 · 2018: 13 · 2017: 1
FWCI: 2.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Science Foundation Ireland
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: NLRP3 inflammasome, macrophage metabolic reprogramming, caspase-1 activation, IL-1β, IL-18, pyroptosis, palmitate, uric acid, cholesterol crystals, ketone bodies, mitochondrial reactive oxygen species, hexokinase, glycolysis, inflammation, inflammasome inhibition
MeSH terms: Pyroptosis, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Cholesterol, Hexokinase, Humans, Ketone Bodies, Macrophages, Uric Acid, Reactive Oxygen Species, Palmitic Acid, Caspase 1, Inflammasomes, Cellular Reprogramming

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