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Cited by 193PI3K/AKT/mTOR signaling in cancerT-cell and B-cell ImmunologySignaling Pathways in Disease

mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

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Huang, Hongling, Long, Lingyun, Zhou, Peipei, Chapman, Nicole M., Chi, Hongbo·2020·Immunological Reviews
DOI 10.1111/imr.12845PMC PMC8101438
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Abstract

The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates signals from the environment to coordinate downstream signaling events and various cellular processes. T cells rely on mTOR activity for their development and to establish their homeostasis and functional fitness. Here, we review recent progress in our understanding of the upstream signaling and downstream targets of mTOR. We also provide an updated overview of the roles of mTOR in T‐cell development, homeostasis, activation, and effector‐cell fate decisions, as well as its important impacts on the suppressive activity of regulatory T cells. Moreover, we summarize the emerging roles of mTOR in T‐cell exhaustion and transdifferentiation. A better understanding of the contribution of mTOR to T‐cell fate decisions will ultimately aid in the therapeutic targeting of mTOR in human disease.

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  • PI3K-AKT-mTOR signalling is essential for T cell activation and differentiation by upregulating metabolic programs and supporting their bioenergetic needs.

    “It is well established that PI3K–AKT–mTOR signalling is essential for T cell activation and differentiation by upregulating metabolic programs and supporting their bioenergetic needs46,47.”

    From Proteotoxic stress response drives T cell exhaustion and immune evasion (2025) · cites this paper as [47]

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Authors
Huang, H., Long, L., Zhou, P., Chapman, N. M., & Chi, H.
Affiliations
St. Jude Children's Research Hospital (US)
Corresponding author
Chi, Hongbo
ORCID
Venue
Immunological Reviews
Publisher
Wiley
Published
2020-03-25
Volume
295
Issue
1
Pages
15-38
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
DOI
10.1111/imr.12845
PMC
PMC8101438
OpenAlex
W3012963517
Cited by
193
References
36
Citations by year
2026: 26 · 2025: 22 · 2024: 33 · 2023: 46 · 2022: 36 · 2021: 28 · 2020: 2
FWCI
2.68
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
Foundation for the National Institutes of Health (AI1055887, AI131703, AI140761, AI150241, AI150514, CA221290)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
mTOR signaling, mTORC1, mTORC2, T cell development, T cell homeostasis, T cell activation, regulatory T cells, T cell exhaustion, downstream targets, mTOR inhibitors
MeSH terms
Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Animals, Cell Differentiation, Cytoskeleton, Energy Metabolism, Humans, Immunologic Memory, Lymphocyte Activation, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocyte Subsets, Cytokines, Cell Transdifferentiation, TOR Serine-Threonine Kinases

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