The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human acellular dermal wound matrix: evidence and experience
Abstract
A chronic wound fails to complete an orderly and timely reparative process and places patients at increased risk for wound complications that negatively impact quality of life and require greater health care expenditure. The role of extracellular matrix ( ECM ) is critical in normal and chronic wound repair. Not only is ECM the largest component of the dermal skin layer, but also ECM proteins provide structure and cell signalling that are necessary for successful tissue repair. Chronic wounds are characterised by their inflammatory and proteolytic environment, which degrades the ECM . Human acellular dermal matrices, which provide an ECM scaffold, therefore, are being used to treat chronic wounds. The ideal human acellular dermal wound matrix (HADWM) would support regenerative healing, providing a structure that could be repopulated by the body's cells. Experienced wound care investigators and clinicians discussed the function of ECM , the evidence related to a specific HADWM (Graftjacket ® regenerative tissue matrix, Wright Medical Technology, Inc., licensed by KCI USA , Inc., San Antonio, TX ), and their clinical experience with this scaffold. This article distills these discussions into an evidence‐based and practical overview for treating chronic lower extremity wounds with this HADWM.
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“Extracellular matrix (ECM) is critical in wound healing, as it could provide structural support and signals to modulate cellular responses [12].”
From Efficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis (2017) · cites this paper as [12]
In the citing paper
“It serves as a scaffold and may provide signals that can promote proliferation, cell attachment, migration etc [11,12].”
From Efficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis (2017) · cites this paper as [12]
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Citations
Cites
The Extracellular Matrix: Not Just Pretty Fibrils
Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527
Interactions of cytokines, growth factors, and proteases in acute and chronic wounds
Mast, B. A., & Schultz, G. S. (1996) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1996.40404.x · Cited by 598 · cited 2×
“In chronic wounds, the ECM is often dysfunctional, not only due to the inflammatory and proteolytic environment of chronic wounds, which breaks down ECM but also due to the relative deficiency in protease inhibitors, which normally regulate proteases (6,7).”
Background
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Cited by
Guo, X., Mu, D., & Gao, F. (2017) · International Journal of Surgery · doi:10.1016/j.ijsu.2017.02.008 · Cited by 80
Barsch, F., Mamilos, A., Schmitt, V. H., Babel, M., Winter, L., Wagner, W., Winther, H., Ottomann, C., Niedermair, T., Schreml, S., et al. (2022) · Cells · doi:10.3390/cells11182834 · Cited by 6
Metadata
- Authors
- Kirsner, R. S., Bohn, G., Driver, V. R., Mills, J. L., Nanney, L. B., Williams, M. L., & Wu, S. C.
- Affiliations
- Department of Dermatology and Cutaneous Surgery University of Miami, Miller School of Medicine Miami FL USA
- Trinity Center for Wound Care and Hyperbaric Medicine Bettendorf IA USA
- Department of Surgery VA New England Health Care Division Providence RI USA
- Department of Vascular & Endovascular Surgery, Health Sciences Center University of Arizona Tucson AZ USA
- Department of Plastic Surgery Vanderbilt School of Medicine Nashville TN USA
- Division of Podiatry Aventura Hospital and Medical Center Aventura FL USA
- Dr. William M. Scholl College of Podiatric Medicine Rosalind Franklin University of Medicine Chicago IL USA
- Venue
- International Wound Journal
- Publisher
- Wiley
- Published
- 2013-11-28
- Volume
- 12
- Issue
- 6
- Pages
- 646-654
- ISSN
- 1742-4801
- 1742-481X
- Cited by
- 86
- References
- 2
- Language
- en
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- Kirsner, R. S., Bohn, G., Driver, V. R., Mills, J. L., Nanney, L. B., Williams, M. L., & Wu, S. C. (2015). Human acellular dermal wound matrix: evidence and experience. International Wound Journal. https://doi.org/10.1111/iwj.12185
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
