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Cited by 131Evolution and Genetic DynamicsMathematical and Theoretical Epidemiology and Ecology ModelsRNA and protein synthesis mechanisms

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Virus Evolution: Insights from an Experimental Approach

Elena, Santiago F., Sanjuán, Rafael·2007·Annual Review of Ecology, Evolution, and Systematics
DOI 10.1146/annurev.ecolsys.38.091206.095637
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Abstract

Viruses represent a serious problem faced by human and veterinary medicine and agronomy. New viruses are constantly emerging while old ones evolve and challenge the latest advances in antiviral pharmaceutics, thus generating tremendous social alarm, sanitary problems, and economical losses. However, they constitute very powerful tools for experimental evolution. These two faces of virology are tightly related because future antiviral treatments shall be rationally designed by considering evolutionary principles. Evidence indicates that the evolution of viruses is determined mainly by key features such as their small genomes, enormous population sizes, and short generation times, and at least for RNA viruses, large selection coefficients, antagonistic epistasis, and high mutation rates. We summarize recent advances in the field of experimental virus evolution. Increasing our understanding of the roles of selection, mutation, chance, and historical contingency on the ecology and epidemiology of viral infections could determine our ability to combat them.

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  • In silico coevolution models, in vitro evolution and genomic analyses have shown that parasites actively promote diversity and evolvability.

    “In silico coevolution models [333,334], in vitro evolution [335,336] and genomic analyses [337,338] have shown that parasites actively promote diversity and evolvability, as illustrated by the phylogenetic trees in figure 9a,b.”

    From Fundamental constraints to the logic of living systems (2024) · cites this paper as [335]

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Metadata

Authors
Elena, S. F., & Sanjuán, R.
Affiliations
Consejo Superior de Investigaciones Científicas (ES)
ORCID
Venue
Annual Review of Ecology, Evolution, and Systematics
Publisher
Annual Reviews
Published
2007-12-01
Volume
38
Issue
1
Pages
27-52
ISSN
  • 1543-592X (ISSN-L)
  • 1545-2069
DOI
10.1146/annurev.ecolsys.38.091206.095637
OpenAlex
W2149029025
Cited by
131
References
11
Citations by year
2026: 3 · 2025: 2 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 12 · 2014: 4 · 2013: 10 · 2012: 6
FWCI
0.83
Type
journal article
Language
en
Open access
closed
Locations
Annual Review of Ecology Evolution and Systematics (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Physical Sciences › Mathematics › Applied Mathematics › Mathematical and Theoretical Epidemiology and Ecology Models
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
experimental evolution, viral evolution, RNA viruses, selection coefficients, mutation rate, historical contingency, antiviral drug design, viral population dynamics, emerging viruses

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