Cited by 533melanin and skin pigmentationHair Growth and DisordersMelanoma and MAPK Pathways

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Hair Follicle Pigmentation

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Slominski, Andrzej, Wortsman, Jacobo, Plonka, Przemyslaw M., Schallreuter, Karin U., Paus, Ralf, Tobin, Desmond J.·2005·Journal of Investigative Dermatology

DOI 10.1111/j.0022-202x.2004.23528.xPMC PMC1201498

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Abstract

Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, keratinocytes, and dermal papilla fibroblasts. Follicular melanogenesis (FM) involves sequentially the melanogenic activity of follicular melanocytes, the transfer of melanin granules into cortical and medulla keratinocytes, and the formation of pigmented hair shafts. This activity is in turn regulated by an array of enzymes, structural and regulatory proteins, transporters, and receptors and their ligands, acting on the developmental stages, cellular, and hair follicle levels. FM is stringently coupled to the anagen stage of the hair cycle, being switched-off in catagen to remain absent through telogen. At the organ level FM is precisely coupled to the life cycle of melanocytes with changes in their compartmental distribution and accelerated melanoblast/melanocyte differentiation with enhanced secretory activity. The melanocyte compartments in the upper hair follicle also provides a reservoir for the repigmentation of epidermis and, for the cyclic formation of new anagen hair bulbs. Melanin synthesis and pigment transfer to bulb keratinocytes are dependent on the availability of melanin precursors, and regulation by signal transduction pathways intrinsic to skin and hair follicle, which are both receptor dependent and independent, act through auto-, para- or intracrine mechanisms and can be modified by hormonal signals. The important regulators are MC1 receptor its and adrenocorticotropic hormone, melanocyte stimulating hormone, agouti protein ligands (in rodents), c-Kit, and the endothelin receptors with their ligands. Melanin itself has a wide range of bioactivities that extend far beyond its determination of hair color.

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Melanin pigmentation in mammalian skin and its hormonal regulation
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Sim, J. H., Jang, S., Park, T., Chi, W., & Kim, S. (2020) · Cosmetics · doi:10.3390/cosmetics7040094
“TRP-1, TRP-2, and TYR proteins migrate to the melanosomes to produce eumelanin and pheomelanin [6].”
Background
From hair colour to diagnosis
Broshtilova, V. (2021) · GSC Advanced Research and Reviews · doi:10.30574/gscarr.2021.7.2.0107
“Raised serum levels of methionine in “oast-house” disease presents with lightening of hair and recurrent facial oedema [19].”
Grundlagen der Hautpigmentierung: Biochemie und Regulation der Melaninsynthese
Brennen, M., & Berking, C. (2010) · Der Hautarzt
Lamivudine associated hair repigmentation and a comprehensive review on reversal canities
Ghassemi, M., Behrangi, E., Roohaninasab, M., Sadeghzadeh‐Bazargan, A., Nobari, N. N., Hasannejad, H., & Goodarzi, A. (2021) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs211561975
“melanocortin 1 receptor (MC1R), adrenocorticotropic hormone, melanocyte-stimulating hormone, agouti protein ligands (in rodents), c-Kit, and the endothelin receptors with their ligands [9] .”
Background
Thermopsis turcica Kit Tan, Vural&Küçüködük’ ün α-amilaz, α-glukozidaz, tirozinaz, asetilkolin esteraz enzim inhibisyon özellikleri ve uçucu yağ bileşimi
Aksoy, L., SUYUNDIKOV, M., & Düz, M. (2021) · ANADOLU JOURNAL OF AGRICULTURAL SCIENCES · doi:10.7161/omuanajas.886585
PERANCANGAN PROGRAM APLIKASI UNTUK OPTIMASI PRODUKSI DENGAN PEMPROGRAMAN LINEAR INTEGER DISERTAI DUKUNGAN UJI HIPOTESIS (STUDI KASUS : PT. CATERINDO GARMENT INDUSTRI)
Meliana, M. (2006)
ROLE OF PSYCHOLOGICAL FACTORS IN AKALA PALITYA: A REVIEW
Manisha, M., Kaushik, A., & Gaur, M. (2022) · International Journal of Research in Ayurveda and Pharmacy · doi:10.7897/2277-4343.1206178
Melanoma: is hair the root of the problem?
(2011) · SciVee · doi:10.4016/29174.01
Synthesis and Melanogenesis Effect of 7,8-Dimethoxy-4-Methylcoumarin via MAPK Signaling-Mediated Microphthalmia-Associated Transcription Factor Upregulation
Kang, M.-S., Jang, S., Park, T., Kim, M.-S., Park, J., Chi, W., & Kim, S. (2022) · Natural Product Communications · doi:10.1177/1934578x221076647
“Tyrosinase is a direct inhibitor of the synthesis of eumelanin and pheomelanin, whereas TRP1 and TRP2 are deeply involved in the synthesis of eumelanin.(8) In mice, it was reported that TRP1 oxidize 5,6-dihydroxyindole-2-carboxylic acid to produce indole-5,6-quinone-2-carboxylic acid,(9) although the activity of this…”
Background
Fungal Pigments
Fouillaud, M., Dufossé, L., & Caro, Y. (2018) · MDPI eBooks · doi:10.3390/books978-3-03842-788-9
Skin Anatomy
Fodor, L., & Dumitraşcu, D. I. (2019) · Springer eBooks · doi:10.1007/978-3-030-22829-3_1
The Biology of Pigmentation
Dobry, A. S., & Fisher, D. E. (2019) · Springer eBooks · doi:10.1007/978-1-4614-7147-9_24
Skin Anatomy
Fodor, L., Ullmann, Y., & Elman, M. (2010) · Springer eBooks · doi:10.1007/978-1-84996-456-2_1
Melanoma: is hair the root of the problem?
(2011) · SciVee · doi:10.4016/27761.01
Supravenous Repigmentation of Hair Shafts in a Patient with Regrowing Alopecia Totalis: A Case Report and Hypothesis
Rotrosen, E. T., Lam, J., & Goldberg, L. J. (2022) · Skin Appendage Disorders · doi:10.1159/000524247
Characterization of Human Head Hairs via Proteomics
Donfack, J., Lawas, M., Abonamah, J. V., & Eckenrode, B. A. (2022) · Wiley eBooks · doi:10.1002/9781119591726.ch8
Melanocytes Exhibit Distinct Cell States Governed by A Gene Regulatory Network Under Stochastic InfluencePreprint
Aggarwal, A., Nasreen, A., Sahoo, S., Faruq, M., Pandey, R., Jolly, M. K., Singh, A., Gokhale, R. S., & Natarajan, V. T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.10.540111
A Comprehensive Review on the Use of Walnut Husk Extract as a Natural Hair Dye
Sarode, S. S., Goswami, A. K., & Kulkarni, S. J. (2023) · Advances in civil and industrial engineering book series · doi:10.4018/979-8-3693-0044-2.ch018

Authors: Slominski, A., Wortsman, J., Plonka, P. M., Schallreuter, K. U., Paus, R., & Tobin, D. J.
Affiliations: University of Tennessee Health Science Center (US)
SIU Medicine (US)
Jagiellonian University (PL)
University of Bradford (GB)
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author: Slominski, Andrzej
ORCID: Slominski, Andrzej
Plonka, Przemyslaw M.
Paus, Ralf
Tobin, Desmond J.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2005-01
Volume: 124
Issue: 1
Pages: 13-21
ISSN: 0022-202X (ISSN-L)
DOI: 10.1111/j.0022-202x.2004.23528.x
PMC: PMC1201498
OpenAlex: W2072657606
Cited by: 532
References: 68
Citations by year: 2026: 17 · 2025: 31 · 2024: 24 · 2023: 25 · 2022: 27 · 2021: 27 · 2020: 20 · 2019: 35 · 2018: 38 · 2017: 24 · 2016: 27 · 2015: 25 · 2014: 25 · 2013: 29 · 2012: 19
FWCI: 1.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3987 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (1R01-AR047079, R01AR047079)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords: hair follicle pigmentation, melanocytes, keratinocytes, dermal papilla, anagen, hair cycle, melanocyte differentiation, MC1 receptor, ACTH, melanocyte-stimulating hormone, agouti protein, CD117, endothelin receptors, melanin precursors, signal transduction, hair color
MeSH terms: Animals, Hair Color, Humans, Melanocytes, Hair Follicle

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