The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Interleukin-10 Downregulates Anti-Microbial Peptide Expression in Atopic Dermatitis
Open accessAbstract
Recurrent skin infections in extrinsic atopic dermatitis (EAD) may be because of the suppression of anti-microbial peptide (AMP) expression by interleukin (IL)-4 and IL-13. Twenty to thirty percent of AD, however, are classified as intrinsic atopic dermatitis (IAD). They exhibit normal serum IgE levels, no allergen-specific sensitization, and lower levels of IL-4 and IL-13 than EAD. Both forms of AD have increased propensity to skin infection, suggesting a novel mechanism for infection in IAD. In this study, we observed significantly decreased human beta-defensin (HBD)-2 gene expression in the skin of both IAD (p = 0.010) and EAD (p = 0.004), as compared with psoriasis patients. Conversely, IAD (p = 0.019) and EAD (p = 0.002) skin lesions exhibited elevated IL-10 gene expression when compared with psoriasis. Using primary keratinocytes, we found that the deficiency in AMP expression is an acquired rather than a constitutive defect. Interestingly, neutralizing antibodies to IL-10 augmented the production of tumor necrosis factor-alpha and interferon-gamma by peripheral blood mononuclear cell from AD patients. Additionally, treatment of AD skin explants with anti-IL-10 augmented the expression of both HBD-2 and LL-37. Thus, increased levels of IL-10 may contribute to the AMP deficiency in both IAD and EAD by reducing cytokines that induce AMP.
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“AMP expression is highly dependent on the cytokine milieu present in the skin and proinflammatory cytokines, such as IL-1, IL-6, IL-8, and tumor necrosis factor α (TNFα), are typically strong inducers of AMPs, whereas IL-4, IL-13, and IL-10 have been shown to dampen AMP responses.33–35”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [35]
Citations
Cites
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IL-10 inhibits cytokine production by activated macrophages
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Self-citationEndogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citationNew insights into atopic dermatitis
Leung, D. Y. M., Boguniewicz, M., Howell, M. D., Nomura, I., & Hamid, Q. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21060 · Cited by 1,435
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A peptide antibiotic from human skin
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Innate antimicrobial peptide protects the skin from invasive bacterial infection
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Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Self-citationLL-37, the only human member of the cathelicidin family of antimicrobial peptides
Dürr, U. H. N., Sudheendra, U. S., & Ramamoorthy, A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.03.030 · Cited by 1,049
Allakhverdi, Z., Comeau, M. R., Jessup, H. K., Yoon, B. P., Brewer, A. W., Chartier, S., Paquette, N., Ziegler, S. F., Sarfati, M., & Delespesse, G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062211 · Cited by 787
Th2 Cytokines and Atopic Dermatitis
Brandt, E. B. (2011) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000110 · Cited by 658
The Roles of Antimicrobial Peptides in Innate Host Defense
Diamond, G., Beckloff, N., Weinberg, A., & Kisich, K. O. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682325 · Cited by 679
Metadata
- Authors
- Howell, M. D., Novak, N., Bieber, T., Pastore, S., Girolomoni, G., Boguniewicz, M., Streib, J., Wong, C., Gallo, R. L., & Leung, D. Y. M.
- Affiliations
- National Jewish Health (US)
- University of Bonn (DE)
- Istituto Dermopatico dell'Immacolata (IT)
- University of California San Diego (US)
- Corresponding author
- Leung, Donald Y.M.
- ORCID
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 125
- Issue
- 4
- Pages
- 738-745
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2092527023
- Cited by
- 193
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 10 · 2016: 3 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 9
- FWCI
- 22.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (454/1-1, 454/2-1)
- National Institutes of Health (T32 AI 07365)
- Ministero della Salute (AI052453, HL37260, HL36577, R21 AR051634-01, AR45676, AR41256)
- Cancer Center, University of Colorado
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- IL-10, atopic dermatitis, antimicrobial peptides, human beta-defensin 2, LL-37, skin infections, intrinsic atopic dermatitis, extrinsic atopic dermatitis, keratinocytes, IL-4, IL-13, TNF-α, interferon-gamma, psoriasis
- MeSH terms
- Adult, Cells, Cultured, Dermatitis, Atopic, Gene Expression Regulation, Humans, Immunohistochemistry, Middle Aged, Psoriasis, Down-Regulation, Interleukin-10, Interleukin-13, beta-Defensins, Antimicrobial Cationic Peptides, Cathelicidins
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