The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Innate and adaptive immunity in female genital tract: cellular responses and interactions
Abstract
Summary: The mucosal immune system in the female reproductive tract (FRT) has evolved to meet the unique requirements of dealing with sexually transmitted bacterial and viral pathogens, allogeneic spermatozoa, and the immunologically distinct fetus. Analysis of the FRT indicates that the key cells of the innate and adaptive immune systems are present and functionally responsive to antigens. Acting through Toll‐like receptors in the Fallopian tubes, uterus, cervix, and in the vagina, epithelial cells, macrophages, natural killer cells, and neutrophils confer protection through the production of chemokines and cytokines, which recruit and activate immune cells, as well as bactericidal and virucidal agents, which confer protection at times when adaptive immunity is downregulated by sex hormones to meet the constraints of procreation. The overall goal of this paper is to define the innate immune system in the FRT and, where possible, to define the regulatory influences that occur during the menstrual cycle that contribute to protection from and susceptibility to potential pathogens. By understanding the nature of this protection and the ways in which innate and adaptive immunity interact, these studies provide the opportunity to contribute to the foundation of information essential for ensuring reproductive health.
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Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
Berger, E. A., Murphy, P. M., & Farber, J. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.657 · Cited by 2,180
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Natural killer cells and pregnancy
Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235
Neutrophil granules and secretory vesicles in inflammation
Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162
Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor
Ashcroft, G. S., Mills, S. J., Lei, K., Gibbons, L., Jeong, M.-J., Taniguchi, M., Burow, M., Horan, M. A., Wahl, S. M., & Nakayama, T. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16288 · Cited by 335
Steroid receptor expression in uterine natural killer cells
Henderson, T. A., Saunders, P. T. K., Moffett-King, A., Groome, N. P., & Critchley, H. O. D. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021174 · Cited by 283
The endocrinology of menstruation – a role for the immune system
Critchley, H. O. D., Kelly, R. W., Brenner, R. M., & Baird, D. T. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01432.x · Cited by 203
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Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926
Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors
Gonçalves, B., Ferreira, C., Alves, C. T., Henriques, M., Azeredo, J., & Silva, S. (2016) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2015.1091805 · Cited by 669
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Haase, A. T. (2010) · Nature · doi:10.1038/nature08757 · Cited by 593
The role of sex hormones in immune protection of the female reproductive tract
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Metadata
- Authors
- Wira, C. R., Fahey, J. V., Sentman, C. L., Pioli, P. A., & Shen, L.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2005-07-28
- Volume
- 206
- Issue
- 1
- Pages
- 306-335
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2048254575
- Cited by
- 520
- References
- 11
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wira, C. R., Fahey, J. V., Sentman, C. L., Pioli, P. A., & Shen, L. (2005). Innate and adaptive immunity in female genital tract: cellular responses and interactions. Immunological Reviews. https://doi.org/10.1111/j.0105-2896.2005.00287.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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