Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus‐bone marrow feedback loop

Goldschneider, Irving

doi:10.1111/j.0105-2896.2006.00354.x

Cited by 51T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus‐bone marrow feedback loop

Goldschneider, Irving·2006·Immunological Reviews

DOI 10.1111/j.0105-2896.2006.00354.x

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Abstract

Summary: It has recently been observed, as in the fetal thymus, that the importation of hematogenous thymocyte progenitors by the adult thymus is a gated phenomenon, whereby saturating numbers of progenitors periodically enter the thymus and occupy a finite number of intrathymic niches. In addition, the mobilization of thymocyte progenitors from the bone marrow appears to be a cyclical process that coincides temporally with the periods of thymic receptivity (open gate). It is proposed that these events are coordinated by a thymus‐bone marrow feedback loop in which a wave of developing triple negative (CD3–CD4–CD8–) thymocytes interacts with stromal cells in the stratified regions of the thymus cortex to sequentially induce the release of diffusible cytokines that regulate the production, mobilization, and recruitment of thymocyte progenitors. The likely components of this feedback loop are described here, as are the properties of the intrathymic vascular gates and niches for thymocyte progenitors. The cyclical production and release of thymocyte progenitors from the bone marrow is placed in the context of a general phenomenon of oscillatory feedback regulation involving all lymphohemopoietic cell lineages. Lastly, the question of whether the gated (as opposed to the continuous) entry of thymocyte progenitors is essential for normal thymocytopoiesis in adult life is discussed.

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The PU.1-high stages of thymocyte development are relatively obscure in the context of the whole thymus, yet their accurate regulation is crucial for establishment of immune system homeostasis and avoidance of leukemia.
“The PU.1-high stages of thymocyte development are relatively obscure in the context of the whole thymus, yet their accurate regulation is crucial for establishment of immune system homeostasis and avoidance of leukemia (125, 126).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [125]

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Mechanisms of thymus organogenesis and morphogenesis
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Changes in primary lymphoid organs with aging
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Reduced Thymic Output Is a Major Mechanism of Immune Reconstitution Failure in HIV-Infected Patients After Long-term Antiretroviral Therapy
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Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25
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Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion
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Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
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Chapter 3 Thymic Microenvironments for T-Cell Repertoire Formation
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Immune Regulation of Osteoclast Function in Postmenopausal Osteoporosis: A Critical Interdisciplinary Perspective
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Transcriptional Regulation of Thymus Organogenesis and Thymic Epithelial Cell Differentiation
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Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture
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T Cell Development by the Numbers
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Thymus aging and immune reconstitution, progresses and challenges
Li, Y. R., & Zúñiga‐Pflücker, J. C. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101837 · Cited by 57 · see citing works
Multiple extrathymic precursors contribute to T-cell development with different kinetics
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CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation
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Endogenous thymic regeneration: restoring T cell production following injury
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Lymphoid and Myeloid Recovery in Rhesus Macaques Following Total Body X-Irradiation
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Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors
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Immune Cell Reconstitution After Exposure to Potentially Lethal Doses of Radiation in the Nonhuman Primate
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Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution
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Authors: Goldschneider, I.
Affiliations: UConn Health (US)
Corresponding author: Goldschneider, Irving
Venue: Immunological Reviews
Publisher: Wiley
Published: 2006-01-31
Volume: 209
Issue: 1
Pages: 58-75
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.0105-2896.2006.00354.x
OpenAlex: W2137888459
Cited by: 51
References: 152
Citations by year: 2026: 1 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 5
FWCI: 0.38
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai033741-23)
National Institute of Allergy and Infectious Diseases (AI-33741, R01AI060735, AI060735)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: thymic stromal cells, adult thymus
MeSH terms: Animals, Bone Marrow Cells, Cell Communication, Cell Differentiation, Cell Movement, Hematopoietic Stem Cells, T-Lymphocytes, Thymus Gland, Cytokines, Stromal Cells, Models, Immunological, Feedback, Physiological, Lymphopoiesis, Cell Proliferation, Mice

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Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus‐bone marrow feedback loop

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