The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Heterologous immunity between viruses
Open accessAbstract
Summary: Immune memory responses to previously encountered pathogens can sometimes alter the immune response to and the course of infection of an unrelated pathogen by a process known as heterologous immunity. This response can lead to enhanced or diminished protective immunity and altered immunopathology. Here, we discuss the nature of T‐cell cross‐reactivity and describe matrices of epitopes from different viruses eliciting cross‐reactive CD8+ T‐cell responses. We examine the parameters of heterologous immunity mediated by these cross‐reactive T cells during viral infections in mice and humans. We show that heterologous immunity can disrupt T‐cell memory pools, alter the complexity of the T‐cell repertoire, change patterns of T‐cell immunodominance, lead to the selection of viral epitope‐escape variants, alter the pathogenesis of viral infections, and, by virtue of the private specificity of T‐cell repertoires within individuals, contribute to dramatic variations in viral disease. We propose that heterologous immunity is an important factor in resistance to and variations of human viral infections and that issues of heterologous immunity should be considered in the design of vaccines.
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Cites
A Direct Estimate of the Human αβ T Cell Receptor Diversity
Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., & Kourilsky, P. (1999) · Science · doi:10.1126/science.286.5441.958 · Cited by 931
Turnover of naive- and memory-phenotype T cells.
Tough, D. F., & Sprent, J. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1127 · Cited by 869
Herpesvirus latency confers symbiotic protection from bacterial infection
Barton, E. S., White, D. W., Cathelyn, J. S., Brett-McClellan, K. A., Engle, M., Diamond, M. S., Miller, V. L., & Virgin, H. W. (2007) · Nature · doi:10.1038/nature05762 · Cited by 763
Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, A. B., Williams, M. A., Jones, T. R., Shirasugi, N., Durham, M. M., Kaech, S. M., Wherry, E. J., Onami, T., Lanier, J. G., Kokko, K. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317477 · Cited by 616
Aaby, P., Samb, B., Simondon, F., Seck, A. M. C., Knudsen, K., & Whittle, H. (1995) · BMJ · doi:10.1136/bmj.311.7003.481 · Cited by 344
Liu, F., & Whitton, J. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.5936 · Cited by 149
Cited by
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
Nelde, A., Bilich, T., Heitmann, J. S., Maringer, Y., Salih, H. R., Roerden, M., Lübke, M., Bauer, J., Rieth, J., Wacker, M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00808-x · Cited by 582
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans
Bacher, P., Hohnstein, T., Beerbaum, E., Röcker, M., Blango, M. G., Kaufmann, S., Röhmel, J., Eschenhagen, P., Grehn, C., Seidel, K., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.041 · Cited by 473
Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults
Su, L. F., Kidd, B. A., Han, A., Kotzin, J. J., & Davis, M. M. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.021 · Cited by 429
“Cross-reactive TCRs have been implicated in the pathogenesis of a number of autoimmune diseases (Benoist and Mathis, 2001) and have been proposed to explain why sequential infections in mice result in differences in immune pathology and the hierarchy of immunodominance (Welsh et al., 2010).”
BackgroundBacher, P., Rosati, E., Esser, D., Martini, G. R., Saggau, C., Schiminsky, E., Dargvainiene, J., Schröder, I., Wieters, I., Khodamoradi, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.11.016 · Cited by 314
Cytomegalovirus infection enhances the immune response to influenza
Furman, D., Jojic, V., Sharma, S., Shen-Orr, S. S., L. Angel, C. J., Onengut-Gumuscu, S., Kidd, B. A., Maecker, H. T., Concannon, P., Dekker, C. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa2293 · Cited by 332
Metadata
- Authors
- Welsh, R. M., Che, J. W., Brehm, M. A., & Selin, L. K.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2010-04-28
- Volume
- 235
- Issue
- 1
- Pages
- 244-266
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2137879329
- Cited by
- 292
- References
- 6
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Welsh, R. M., Che, J. W., Brehm, M. A., & Selin, L. K. (2010). Heterologous immunity between viruses. Immunological Reviews. https://doi.org/10.1111/j.0105-2896.2010.00897.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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