The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Plasticity in programming of effector and memory CD8+ T‐cell formation
Open accessAbstract
Summary: CD8+ T cells (also called cytotoxic T lymphocytes) play a major role in protective immunity against many infectious pathogens and can eradicate malignant cells. The path from naive precursor to effector and memory CD8+ T‐cell development begins with interactions between matured antigen‐bearing dendritic cells (DCs) and antigen‐specific naive T‐cell clonal precursors. By integrating differences in antigenic, costimulatory, and inflammatory signals, a developmental program is established that governs many key parameters associated with the ensuing response, including the extent and magnitude of clonal expansion, the functional capacities of the effector cells, and the size of the memory pool that survives after the contraction phase. In this review, we discuss the multitude of signals that drive effector and memory CD8+ T‐cell differentiation and how the differences in the nature of these signals contribute to the diversity of CD8+ T‐cell responses.
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Cites
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Self-citation
Cited by
Harugade, A., Sherje, A. P., & Pethe, A. (2023) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2023.105634 · Cited by 474
Kang, X., Liu, C., Ding, Y., Ni, Y., Ji, F., Lau, H. C. H., Jiang, L., Sung, J. J., Wong, S. H., & Yu, J. (2023) · Gut · doi:10.1136/gutjnl-2023-330291 · Cited by 394
FOXO transcription factors throughout T cell biology
Hedrick, S. M., Michelini, R. H., Doedens, A. L., Goldrath, A. W., & Stone, E. L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3278 · Cited by 347
Cheng, Y., Wong, M. T., van der Maaten, L., & Newell, E. W. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501928 · Cited by 67
Metadata
- Authors
- Arens, R., & Schoenberger, S. P.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2010-04-28
- Volume
- 235
- Issue
- 1
- Pages
- 190-205
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2165652595
- Cited by
- 207
- References
- 21
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
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