The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ultraviolet radiation and skin cancer: molecular mechanisms
Abstract
Abstract: Every living organism on the surface of the earth is exposed to the ultraviolet (UV) fraction of the sunlight. This electromagnetic energy has both life‐giving and life‐endangering effects. UV radiation can damage DNA and thus mutagenize several genes involved in the development of the skin cancer. The presence of typical signature of UV‐induced mutations on these genes indicates that the ultraviolet‐B part of sunlight is responsible for the evolution of cutaneous carcinogenesis. During this process, variable alterations of the oncogenic, tumor‐suppressive, and cell‐cycle control signaling pathways occur. These pathways include (a) mutated PTCH (in the mitogenic Sonic Hedgehog pathway) and mutated p53 tumor‐suppressor gene in basal cell carcinomas, (b) an activated mitogenic ras pathway and mutated p53 in squamous cell carcinomas, and (c) an activated ras pathway, inactive p16, and p53 tumor suppressors in melanomas. This review presents background information about the skin optics, UV radiation, and molecular events involved in photocarcinogenesis.
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Cites
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Sunburn and p53 in the onset of skin cancer
Ziegler, A., Jonason, A. S., Leffellt, D. J., Simon, J. A., Sharma, H. W., Kimmelman, J., Remington, L., Jacks, T., & Brash, D. E. (1994) · Nature · doi:10.1038/372773a0 · Cited by 1,497
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
Cited by
Oxidation events and skin aging
Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980
The effect of environmental humidity and temperature on skin barrier function and dermatitis
Engebretsen, K. A., Johansen, J. D., Kezic, S., Linneberg, A., & Thyssen, J. P. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13301 · Cited by 349
Understanding the Molecular Genetics of Basal Cell Carcinoma
Pellegrini, C., Maturo, M., Di Nardo, L., Ciciarelli, V., Gutiérrez García-Rodrigo, C., & Fargnoli, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112485 · Cited by 242
Damage to Skin Extracellular Matrix Induced by UV Exposure
Watson, R. E. B., Gibbs, N. K., Griffiths, C. E. M., & Sherratt, M. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5653 · Cited by 179
Ultraviolet Radiation and Melanoma
Kanavy, H. E., & Gerstenblith, M. R. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.08.003 · Cited by 170
Metadata
- Authors
- Hussein, M. R.
- Venue
- Journal of Cutaneous Pathology
- Publisher
- Wiley
- Published
- 2005-02-08
- Volume
- 32
- Issue
- 3
- Pages
- 191-205
- ISSN
- 0303-6987 (ISSN-L)
- 1600-0560
- OpenAlex
- W2003006686
- Cited by
- 352
- References
- 3
- FWCI
- 25.64
- Type
- journal article
- Language
- en
- Open access
- closed
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