Antigenic Analysis of Polioviruses Isolated from a Child with Agammaglobulinemia and Paralytic Poliomyelitis after Sabin Vaccine Administration
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A 3‐year‐old boy with agammaglobulinemia developed paralytic poliomyelitis on day 553 after being fed poliovaccine. Non‐vaccine‐like type 2 polioviruses were isolated from 22 stools obtained within 684 days after the onset of illness. Antigenic variations were observed among these viruses. The non‐vaccine‐like virus isolated 1 week after the onset of paralysis differed in virulence from the Sabin type 2 vaccine strain in the neurovirulence test in monkeys, and did not have the same antigenic character as the wild virulent strains. Another virus isolated on day 348 before the onset of illness was also classified as non‐vaccine‐like. However, the Sabin type 2 strain was shown to be homologous with this strain by the McBride test. Some Sabin‐like particles were found in this stock virus. We may conclude that the non‐vaccine‐like virus isolates were derived from Sabin vaccine by antigenic variation that occurred during long‐term multiplication in the intestinal tract.
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All VDPV isolates characterized so far have antigenic properties distinct from the original Sabin strains.
“Moreover, all VDPV isolates characterized so far have antigenic properties distinct from the original Sabin strains (12, 71, 84, 117, 177, 180, 226).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [71]
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Cites
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- Authors
- Hara, M., Saito, Y., Komatsu, T., Kodama, H., Abo, W., Chiba, S., & Nakao, T.
- Affiliations
- Sapporo Medical University (JP)
- ORCID
- Saito, Yoshiko
- Venue
- Microbiology and Immunology
- Publisher
- Wiley
- Published
- 1981-09
- Volume
- 25
- Issue
- 9
- Pages
- 905-913
- ISSN
- 0385-5600 (ISSN-L)
- 1348-0421
- OpenAlex
- W2134453112
- Cited by
- 56
- References
- 17
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2017: 2 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Microbiology and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Keywords
- poliovirus, agammaglobulinemia, paralytic poliomyelitis, oral polio vaccine, vaccine-derived poliovirus, antigenic variation, poliovirus type 2, neurovirulence
- MeSH terms
- Agammaglobulinemia, Animals, Haplorhini, Antigens, Viral, Child, Preschool, Humans, Male, Mutation, Poliomyelitis, Poliovirus Vaccine, Oral, Poliovirus
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