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Cited by 287Cancer Risks and FactorsGlobal Cancer Incidence and ScreeningBRCA gene mutations in cancer

A large-scale, hospital-based case-control study of risk factors of breast cancer according to menopausal status

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Hirose, Kaoru, Tajima, Kazuo, Hamajima, Nobuyuki, Inoue, Manami, Takezaki, Toshiro, Kuroishi, Tetsuo, Yoshida, Minoru, Tokudome, Shinkan·1995·Japanese Journal of Cancer Research
DOI 10.1111/j.1349-7006.1995.tb03032.xPMC PMC5920764
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Abstract

We conducted a large‐scale, hospital‐based case‐control study to evaluate differences and similarities in the risk factors of female breast cancer according to menopausal status. This study is based on a questionnaire survey on life style routinely obtained from outpatients who first visited the Aichi Cancer Center Hospital between January 1, 1988 and December 31, 1992. Among 36,944 outpatients, 1,186 women with breast cancer detected by histological examination were taken as the case group (607 premenopausal women and 445 postmenopausal women) and 23,163 women confirmed to be free of cancer were selected as the control group. New findings and reconfirmed factors of breast cancer were as follows. 1) The risk of at least one breast cancer history among subjects’ first‐degree relatives was relatively high among pre‐ as well as post‐menopausal women. 2) A protective effect of physical activity against breast cancer was observed among both pre‐ and post‐menopausal women. 3) Dietary control decreased the risk of premenopausal breast cancer. 4) Current smoking and drinking elevated the risk of breast cancer in premenopausal women. 5) Decreasing trends of breast cancer risk were associated with intake of bean curd, green‐yellow vegetables, potato or sweet potato, chicken and ham or sausage in premenopausal women, while in postmenopausal women a risk reduction was associated with a more frequent intake of boiled, broiled and/or raw fish (sashimi). Further study will be needed to clarify the age group‐ and/or birth cohort‐specific risk factors for breast cancer among the young generation in Japan.

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  • Of 44 case-control studies, 32 showed higher consumption of soy foods and/or soy isoflavones was associated with lower risk for primary breast cancer, breast cancer mortality, or improved markers of prognosis among the overall study population.

    “Overall, of the 44 case control studies, 32 showed that higher consumption of soy foods and/ or soy isoflavones was associated with lower risk for primary breast cancer [42-46,49-51,53,54,56-58,61-64,66,71-73,75,77-79,81,83], breast cancer mortality [55], or improved markers of prognosis (ER+ status vs receptor negative status) [74,82] among the overall study population.”

    From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [53]

    The opening study summary (page not supplied) reports that more frequent bean-curd intake was associated with decreasing breast-cancer risk in premenopausal women. It does not report that association for the overall study population; the cited paper also does not establish the citing authors’ aggregate count of 32 of 44 studies. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Hirose, K., Tajima, K., Hamajima, N., Inoue, M., Takezaki, T., Kuroishi, T., Yoshida, M., & Tokudome, S.
Affiliations
  • Aichi Cancer Center (JP)
  • Aichi Cancer Center Research Institute (JP)
  • Nagoya City University (JP)
ORCID
Venue
Japanese Journal of Cancer Research
Publisher
Wiley
Published
1995-02
Volume
86
Issue
2
Pages
146-154
ISSN
0910-5050 (ISSN-L)
DOI
10.1111/j.1349-7006.1995.tb03032.x
PMC
PMC5920764
OpenAlex
W1985216158
Cited by
287
References
0
Citations by year
2025: 1 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 9 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 2
FWCI
3.89
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3857 d)
Locations
  • Japanese Journal of Cancer Research (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Keywords
breast cancer, risk factors, menopausal status, premenopausal women, postmenopausal women, family history of breast cancer, physical activity, dietary factors, smoking, alcohol consumption, fish consumption, tofu, vegetable consumption, Japanese women
MeSH terms
Adult, Aged, Breast Neoplasms, Female, Humans, Japan, Life Style, Menopause, Middle Aged, Risk Factors, Multivariate Analysis, Logistic Models, Case-Control Studies

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