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Cannabis use predicts future psychotic symptoms, and vice versa
Abstract
AIMS: To assess if cannabis use is a risk factor for future psychotic symptoms, and vice versa, in adolescents and young adults from the general population. DESIGN: Cohort study. SETTING/PARTICIPANTS: 'Zuid Holland' study, a 14-year follow-up study of 1580 initially 4-16-year-olds who were drawn randomly from the Dutch general population. Because cannabis use is generally condoned in the Netherlands, false-negative reports of cannabis use may occur less frequently than in countries with stricter drug policies, which supports the value of the present study. MEASUREMENTS: Life-time cannabis use and psychotic symptoms, assessed with the Composite International Diagnostic Interview (CIDI). FINDINGS: Cannabis use, in individuals who did not have psychotic symptoms before they began using cannabis, predicted future psychotic symptoms (hazard ratio = 2.81; 95% confidence interval = 1.79-4.43). However, psychotic symptoms in those who had never used cannabis before the onset of psychotic symptoms also predicted future cannabis use (hazard ratio = 1.70; 95% confidence interval = 1.13-2.57). CONCLUSIONS: The results imply either a common vulnerability with varying order of onset or a bi-directional causal relationship between cannabis use and psychosis. More research on patterns and timings of these relationships is needed to narrow down the possibilities.
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“Evidence from most case-control and cross-sectional studies support an association between cannabis use and schizophrenia (4-6) and psychotic symptoms (7)(8)(9).”
From Association Between Cannabis and Psychosis: Epidemiologic Evidence (2016) · cites this paper as [7]
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Metadata
- Authors
- Ferdinand, R. F., Sondeijker, F., Van Der Ende, J., Selten, J., Huizink, A., & Verhulst, F. C.
- Affiliations
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Ferdinand, Robert F.
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2005-04-22
- Volume
- 100
- Issue
- 5
- Pages
- 612-618
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- OpenAlex
- W1993562858
- Cited by
- 212
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 12
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cannabis use, psychotic symptoms, psychosis risk, adolescents, young adults, bidirectional causality, onset time, lifetime cannabis use
- MeSH terms
- Adolescent, Marijuana Abuse, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Male, Netherlands, Psychoses, Substance-Induced, Psychotic Disorders, Risk Factors, Cohort Studies
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