The familial aggregation of cannabis use disorders
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Aims The aim of this paper is to examine the familial aggregation of cannabis use disorders and other psychiatric conditions among first‐degree relatives and spouses of probands with a cannabis use disorder. Design Controlled family study methods. Setting Out‐patient psychiatric clinics and the local community (same geographic area). Participants Two hundred and sixty‐two probands with a life‐time history of cannabis use disorder, alcohol dependence, anxiety disorders or no history of any disorder, and their first‐degree relatives and spouses. Measurements Cannabis use disorders and other DSM‐III‐R disorders in the relatives and spouses using the Schedule for Affective Disorders and Schizophrenia. Findings Results reveal an elevated risk of life‐time history of cannabis use disorders among siblings [odds ratio (OR: 3.6), adult offspring (OR): 6.9], and spouses (OR: 4.4) of probands with cannabis use disorders. There is a latent familial factor underlying cannabis use disorders that was shared partially with alcohol abuse/dependence. Comorbid mood and anxiety disorders aggregated independently from cannabis use disorders in families. Equal elevation in the magnitude of the association among the first‐degree adult relatives and spouses of probands with a cannabis use disorder suggests the probable contribution of both environmental and genetic factors. Conclusions These findings support a family‐based approach to drug abuse intervention and the importance of future research concerning environmental mediators of familial transmission of drug abuse.
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Familial studies have shown that several genetic modifications (mutations or polymorphisms) in key genes could give rise to a sufficient mood imbalance background.
“Therefore it seems that both questions eventually got answers in the way that it has been shown by familial studies [202, 203] that several genetic modifications (mutations or polymorphisms) in key genes could give rise to a sufficient mood imbalance background.”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [203]
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“In this way, interesting questions could arise: in what way the genetic component would formulate a sufficient background for affective disorders pathological development and, on the other way around, how complex would the environmental interaction be in order to provide sufficient risk for pathologies to occur via ox…”
Background
- Authors
- Merikangas, K. R., Li, J. J., Stipelman, B., Yu, K., Fucito, L., Swendsen, J., & Zhang, H.
- Affiliations
- National Institutes of Health (US)
- Yale University (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Merikangas, Kathleen R.
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2009-03-17
- Volume
- 104
- Issue
- 4
- Pages
- 622-629
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- PMC
- PMC2794246
- OpenAlex
- W2087765593
- Cited by
- 33
- References
- 71
- Citations by year
- 2026: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k05mh000049-15)
- National Institute on Alcohol Abuse and Alcoholism (R01AA007080, AA12044, R01AA012044, AA-07080)
- National Institute of Mental Health (MH 36197, R01MH036197, MH0049, Z01MH002849)
- National Institute on Drug Abuse (DA016750, DA09055, K02DA017713, DA12468, R01DA012468, R01DA009055, DA017713, R01DA016750)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- cannabis use disorder, familial aggregation, first-degree relatives, spouses, alcoholism, anxiety disorders, mood disorders, genetic factors, environmental factors
- MeSH terms
- Adult, Alcoholism, Anxiety Disorders, Marijuana Abuse, Family, Female, Humans, Male, Phenotype, Risk Factors, Spouses, Genetic Predisposition to Disease, Diagnostic and Statistical Manual of Mental Disorders
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