Insulin action and signalling in fat and muscle from dexamethasone-treated rats

Burén, J.; Lai, Y.C.; Lundgren, M.; Eriksson, J.W.; Jensen, J.

doi:10.1016/j.abb.2008.02.034

Cited by 125Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Insulin action and signalling in fat and muscle from dexamethasone-treated rats

Burén, J., Lai, Y.C., Lundgren, M., Eriksson, J.W., Jensen, J.·2008·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2008.02.034

Open this paper in CoChat — free account

Abstract

Glucocorticoids initiate whole body insulin resistance and the aim of the present study was to investigate effects of dexamethasone on protein expression and insulin signalling in muscle and fat tissue. Rats were injected with dexamethasone (1mg/kg/day, i.p.) or placebo for 11 days before insulin sensitivity was evaluated in vitro in soleus and epitrochlearis muscles and in isolated epididymal adipocytes. Dexamethasone treatment reduced insulin-stimulated glucose uptake and glycogen synthesis by 30-70% in epitrochlearis and soleus, and insulin-stimulated glucose uptake by approximately 40% in adipocytes. 8-bromo-cAMP-stimulated lipolysis was approximately 2-fold higher in adipocytes from dexamethasone-treated rats and insulin was less effective to inhibit cAMP-stimulated lipolysis. A main finding was that dexamethasone decreased expression of PKB and insulin-stimulated Ser(473) and Thr(308) phosphorylation in both muscles and adipocytes. Expression of GSK-3 was not influenced by dexamethasone treatment in muscles or adipocytes and insulin-stimulated GSK-3beta Ser(9) phosphorylation was reduced in muscles only. A novel finding was that glycogen synthase (GS) Ser(7) phosphorylation was higher in both muscles from dexamethasone-treated rats. GS expression decreased (by 50%) in adipocytes only. Basal and insulin-stimulated GS Ser(641) and GS Ser(645,649,653,657) phosphorylation was elevated in epitrochlearis and soleus muscles and GS fractional activity was reduced correspondingly. In conclusion, dexamethasone treatment (1) decreases PKB expression and insulin-stimulated phosphorylation in both muscles and adipocytes, and (2) increases GS phosphorylation (reduces GS fractional activity) in muscles and decreases GS expression in adipocytes. We suggest PKB and GS as major targets for dexamethasone-induced insulin resistance.

Integrity signals

Registry

Crossref · 10.1016/j.abb.2008.02.034

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Glucocorticoid-induced hyperinsulinaemia is regarded as an adaptation of pancreatic β-cell function to glucocorticoid-induced insulin resistance in liver, muscle, and adipose tissues.
“Glucocorticoid-induced hyperinsulinaemia is regarded as an adaptation of pancreatic â-cell function to the GC-induced insulin resistance in liver, muscle and adipose tissues, either through hyperglycaemia, by other signalling mechanisms, or most likely a combination of these mechanisms.27,28”
From Twenty‐four‐hour profiles of plasma glucose, insulin, C‐peptide and free fatty acid in subjects with varying degrees of glucose tolerance following short‐term, medium‐dose prednisone (20 mg/day) treatment: evidence for differing effects on insulin secretion and action (2012) · cites this paper as [27]

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267 · see citing works
Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by<sup>13</sup>C Nuclear Magnetic Resonance Spectroscopy
Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248 · see citing works
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal · doi:10.1042/bj3330471 · Cited by 953 · see citing works
Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats
Kraegen, E. W., Clark, P. W., Jenkins, A. B., Daley, E. A., Chisholm, D. J., & Storlien, L. H. (1991) · Diabetes · doi:10.2337/diab.40.11.1397 · Cited by 601 · see citing works
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600633 · Cited by 594 · see citing works
Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding
Oakes, N. D., Cooney, G. J., Camilleri, S., Chisholm, D. J., & Kraegen, E. W. (1997) · Diabetes · doi:10.2337/diab.46.11.1768 · Cited by 414 · see citing works
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
Saad, M. J., Folli, F., Kahn, J. A., & Kahn, C. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116803 · Cited by 349 · see citing works
Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle
DIMITRIADIS, G., LEIGHTON, B., PARRY-BILLINGS, M., SASSON, S., YOUNG, M., KRAUSE, U., BEVAN, S., PIVA, T., WEGENER, G., & NEWSHOLME, E. A. (1997) · Biochemical Journal · doi:10.1042/bj3210707 · Cited by 266 · see citing works
In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus.
Kashiwagi, A., Verso, M. A., Andrews, J., Vasquez, B., Reaven, G., & Foley, J. E. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111080 · Cited by 250 · see citing works
Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signalling and the effects of a selective glycogen synthase kinase-3 inhibitor
Ruzzin, J., Wagman, A. S., & Jensen, J. (2005) · Diabetologia · doi:10.1007/s00125-005-1886-0 · Cited by 243 · see citing works
Self-citation
The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading
Jørgensen, S. B., Nielsen, J. N., Birk, J. B., Olsen, G. S., Viollet, B., Andreelli, F., Schjerling, P., Vaulont, S., Hardie, D. G., Hansen, B. F., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3074 · Cited by 241 · see citing works
High-Fat Feeding Impairs Insulin-Stimulated GLUT4 Recruitment via an Early Insulin-Signaling Defect
Zierath, J. R., Houseknecht, K. L., Gnudi, L., & Kahn, B. B. (1997) · Diabetes · doi:10.2337/diab.46.2.215 · Cited by 238 · see citing works
A Role for 14-3-3 in Insulin-stimulated GLUT4 Translocation through Its Interaction with the RabGAP AS160
Ramm, G., Larance, M., Guilhaus, M., & James, D. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603274200 · Cited by 200 · see citing works
Comparison of two methods for determining human adipose cell size
Smith, U., Sjöström, L., & Björntorp, P. A. (1972) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39356-1 · Cited by 188 · see citing works
Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
Burén, J., Liu, H., Jensen, J., & Eriksson, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460419 · Cited by 160 · see citing works
Self-citation
Glucocorticoid-Induced Insulin Resistance: Dexamethasone Inhibits the Activation of Glucose Transport in Rat Skeletal Muscle by Both Insulin- and Non-Insulin-Related Stimuli
Weinstein, S. P., Paquin, T., Pritsker, A., & Haber, R. S. (1995) · Diabetes · doi:10.2337/diab.44.4.441 · Cited by 145 · see citing works
Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats
Chalkley, S. M., Hettiarachchi, M., Chisholm, D. J., & Kraegen, E. W. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00173.2001 · Cited by 140 · see citing works
Mechanisms regulating phosphoinositide 3‐kinase signalling in insulin‐sensitive tissues
Shepherd, P. R. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01382.x · Cited by 130 · see citing works
Radiometric assays for glycerol, glucose, and glycogen
Bradley, D. C., & Kaslow, H. R. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90081-x · Cited by 119 · see citing works
Insulin Regulation of Skeletal Muscle PDK4 mRNA Expression Is Impaired in Acute Insulin-Resistant States
Kim, Y. I., Lee, F. N., Choi, W. S., Lee, S., & Youn, J. H. (2006) · Diabetes · doi:10.2337/db05-1606 · Cited by 119 · see citing works
Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling
Jensen, J., Jebens, E., Brennesvik, E. O., Ruzzin, J., Soos, M. A., Engebretsen, E. M. L., O'Rahilly, S., & Whitehead, J. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2005 · Cited by 114 · see citing works
Self-citation
Hormonal Regulation of Adipocyte Enzymes
Khoo, J. C., Steinberg, D. H., Thompson, B., & Mayer, S. E. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43808-8 · Cited by 113 · see citing works
Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat
Chalkley, S. M., Hettiarachchi, M., Chisholm, D. J., & Kraegen, E. W. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90287-6 · Cited by 109 · see citing works
Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro
Thompson, A. L., Lim-Fraser, M. Y.-C., Kraegen, E. W., & Cooney, G. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e577 · Cited by 107 · see citing works
Dissection of the Protein Phosphorylation Cascades Involved in Insulin and Growth Factor Action
Cohen, P. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210555 · Cited by 106 · see citing works
Phosphorylation of Sites 3a and 3b (Ser640 and Ser644) in the Control of Rabbit Muscle Glycogen Synthase
Skurat, A. V., & Roach, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12491 · Cited by 96 · see citing works
Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles
Coderre, L., Monfar, M., Chen, K. S., Heydrick, S. J., Kurowski, T. G., Ruderman, N. B., & Pilch, P. F. (1992) · Endocrinology · doi:10.1210/endo.131.4.1396328 · Cited by 79 · see citing works
Role of Glucose Transporters in Glucocorticoid-Induced Insulin Resistance: GLUT4 Isoform in Rat Skeletal Muscle is Not Decreased by Dexamethasone
Haber, R. S., & Weinstein, S. P. (1992) · Diabetes · doi:10.2337/diab.41.6.728 · Cited by 77 · see citing works
Electrogenic sodium-bicarbonate cotransport in human ciliary muscle cells
Stahl, F., Lepple-Wienhues, A., Kuppinger, M., Tamm, E. R., & Wiederholt, M. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.2.c427 · Cited by 76 · see citing works
13C and 31P NMR Studies on the Effects of Increased Plasma Free Fatty Acids on Intramuscular Glucose Metabolism in the Awake Rat
Jucker, B. M., Rennings, A. J. M., Cline, G. W., & Shulman, G. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10464 · Cited by 76 · see citing works
Metabolic Impairment Precedes Insulin Resistance in Skeletal Muscle During High-Fat Feeding in Rats
Kim, J. K., Wi, J. K., & Youn, J. H. (1996) · Diabetes · doi:10.2337/diab.45.5.651 · Cited by 75 · see citing works
Mitogen-Activated Protein Kinase (MAPK) Phosphatase-1 and -4 Attenuate p38 MAPK during Dexamethasone-Induced Insulin Resistance in 3T3-L1 Adipocytes
Bazuine, M., Carlotti, F., Tafrechi, R. J., Hoeben, R. C., & Maassen, J. A. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0213 · Cited by 62 · see citing works
Mechanisms of disease: regulation of glucocorticoid and receptor levels – impact on the metabolic syndrome
Witchel, S. F., & DeFranco, D. B. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0323 · Cited by 58 · see citing works
Regulation of glycogen synthesis in rat skeletal muscle after glycogen-depleting contractile activity: effects of adrenaline on glycogen synthesis and activation of glycogen synthase and glycogen phosphorylase
Franch, J., Aslesen, R., & Jensen, J. (1999) · Biochemical Journal · doi:10.1042/bj3440231 · Cited by 54 · see citing works
Self-citation
Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle
WHITEHEAD, J. P., SOOS, M. A., ASLESEN, R., O'RAHILLY, S., & JENSEN, J. (2000) · Biochemical Journal · doi:10.1042/bj3490775 · Cited by 48 · see citing works
Self-citation
Glycogen content and contraction regulate glycogen synthase phosphorylation and affinity for UDP-glucose in rat skeletal muscles
Lai, Y., Stuenæs, J. T., Kuo, C., & Jensen, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00113.2007 · Cited by 48 · see citing works
Self-citation
Effects of prednisolone and dexamethasone in vivo and in vitro: Studies of insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes
Pirro, R. D., Green, A., Kao, M., & Olefsky, J. M. (1981) · Diabetologia · doi:10.1007/bf00251283 · Cited by 46 · see citing works
Possible role for the glucose-fatty acid cycle in dexamethasone-induced insulin antagonism in rats
Venkatesan, N., Davidson, M. B., & Hutchinson, A. (1987) · Metabolism · doi:10.1016/0026-0495(87)90098-9 · Cited by 44 · see citing works
Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation
Yu, Z., Jansson, P., Posner, B. I., Smith, U., & Eriksson, J. W. (1997) · Diabetologia · doi:10.1007/s001250050807 · Cited by 40 · see citing works
Self-citation
The mechanism of the potentiating effect of glucocorticoids on catecholamine-induced lipolysis
Lamberts, S. W. J., TIMMERMANS, H. A. T., Kramer-Blankestijn, M., & Birkenhäger, J. C. (1975) · Metabolism · doi:10.1016/0026-0495(75)90035-9 · Cited by 40 · see citing works
Improved insulin-stimulated glucose uptake and glycogen synthase activation in rat skeletal muscles after adrenaline infusion: role of glycogen content and pkb phosphorylation
Jensen, J., Ruzzin, J., Jebens, E., Brennesvik, E. O., & Knardahl, S. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01437.x · Cited by 39 · see citing works
Self-citation
Transgenic overexpression of protein targeting to glycogen markedly increases adipocytic glycogen storage in mice
Jurczak, M. J., Danos, A. M., Rehrmann, V. R., Allison, M. B., Greenberg, C. C., & Brady, M. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00559.2006 · Cited by 38 · see citing works
Is insulin resistance caused by defects in insulin's target cells or by a stressed mind?
Burén, J., & Eriksson, J. W. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.567 · Cited by 36 · see citing works
Self-citation
Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats
Ruzzin, J., & Jensen, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00587.2004 · Cited by 33 · see citing works
Self-citation
Effects of dexamethasone treatment on insulin-stimulated rates of glycolysis and glycogen synthesis in isolated incubated skeletal muscles of the rat
Leighton, B., Challiss, R. A. J., Lozeman, F. J., & Newsholme, E. A. (1987) · Biochemical Journal · doi:10.1042/bj2460551 · Cited by 31 · see citing works
Regulation of glycogen concentration and glycogen synthase activity in skeletal muscle of insulin-resistant rats
Coderre, L., Vallega, G., Pilch, P. F., & Chipkin, S. R. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.04.012 · Cited by 20 · see citing works
Specific Desensitization of Glycogen Synthase Activation by Insulin in 3T3-L1 Adipocytes
Jensen, T. C., Crosson, S. M., Kartha, P. M., & Brady, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004902200 · Cited by 20 · see citing works
Spatial Reorganization of Glycogen Synthase upon Activation in 3T3-L1 Adipocytes
Ou, H., Yan, L., Osmanovic, S., Greenberg, C. C., & Brady, M. (2004) · Endocrinology · doi:10.1210/en.2004-1022 · Cited by 16 · see citing works
Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity
Jensen, J., Grønning-Wang, L. M., Jebens, E., Whitehead, J. P., Zorec, R., & Shepherd, P. R. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0471-z · Cited by 14 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

The effects of glucocorticoids on adipose tissue lipid metabolism
Peckett, A. J., Wright, D. C., & Riddell, M. C. (2011) · Metabolism · doi:10.1016/j.metabol.2011.06.012 · Cited by 548 · see citing works
Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
Beaupere, C., Liboz, A., Fève, B., Blondeau, B., & Guillemain, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020623 · Cited by 271 · see citing works
Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy
Hartmann, K., Koenen, M., Schauer, S., Wittig-Blaich, S., Ahmad, M., Baschant, U., & Tuckermann, J. P. (2016) · Physiological Reviews · doi:10.1152/physrev.00011.2015 · Cited by 249 · see citing works
Metabolic functions of glucocorticoid receptor in skeletal muscle
Kuo, T., Harris, C. A., & Wang, J.-C. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.003 · Cited by 240 · see citing works
Glucocorticoid-Induced Hyperglycemia
Kwon, S., Hermayer, K. L., & Hermayer, K. L. (2013) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31828a6a01 · Cited by 181 · see citing works
Glucocorticoid-Induced Fatty Liver Disease
Rahimi, L., Rajpal, A., & Ismail‐Beigi, F. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s247379 · Cited by 148 · see citing works
Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management
Scaroni, C., Zilio, M., Foti, M., & Boscaro, M. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1105 · Cited by 140 · see citing works
Metabolic control through glucocorticoid hormones: An update
Rose, A. J., & Herzig, S. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.007 · Cited by 134 · see citing works
New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it
Ferris, H. A., & Kahn, C. R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci66180 · Cited by 132 · see citing works
Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats
Wu, T., Yang, L., Jiang, J., Ni, Y., Zhu, J., Zheng, X., Wang, Q., Lu, X., & Fu, Z. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.11.049 · Cited by 126 · see citing works
A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure
Watson, M. L., Baehr, L. M., Reichardt, H. M., Tuckermann, J. P., Bodine, S. C., & Furlow, J. D. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2011 · Cited by 120 · see citing works
Role of glucocorticoids and the glucocorticoid receptor in metabolism: Insights from genetic manipulations
Rose, A. J., Vegiopoulos, A., & Herzig, S. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.010 · Cited by 112 · see citing works
Minireview: New Molecular Mediators of Glucocorticoid Receptor Activity in Metabolic Tissues
Patel, R., Williams‐Dautovich, J., & Cummins, C. L. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1062 · Cited by 108 · see citing works
Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes
Pereira, M. J., Carvalho, E., Eriksson, J. W., Crans, D. C., & Aureliano, M. (2009) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2009.09.015 · Cited by 92 · see citing works
Self-citation
Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance
Jensen, J., & Lai, Y.-C. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450902778171 · Cited by 90 · see citing works
Self-citation
Impact of Glucocorticoid Excess on Glucose Tolerance: Clinical and Preclinical Evidence
Pasieka, A. M., & Rafacho, A. (2016) · Metabolites · doi:10.3390/metabo6030024 · Cited by 91 · see citing works
Glucocorticoid Receptor and Adipocyte Biology
Lee, R. A., Harris, C. A., & Wang, J.-C. (2018) · Nuclear Receptor Research · doi:10.32527/2018/101373 · Cited by 92 · see citing works
Glucocorticoid-induced apoptosis and cellular mechanisms of myopathy
Dirks‐Naylor, A. J., & Griffiths, C. L. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.05.014 · Cited by 85 · see citing works
Glucocorticoids in Vivo Induce Both Insulin Hypersecretion and Enhanced Glucose Sensitivity of Stimulus-Secretion Coupling in Isolated Rat Islets
Rafacho, A., Marroquí, L., Taboga, S. R., Abrantes, J. L. F., Silveira, L. R., Boschero, A. C., Carneiro, E. M., Bosqueiro, J. R., Nadal, A., & Quesada, I. (2010) · Endocrinology · doi:10.1210/en.2009-0704 · Cited by 80 · see citing works
Potential Adverse Effects of Dexamethasone Therapy on COVID-19 Patients: Review and Recommendations
Chen, F., Hao, L., Zhu, S., Yang, X., Shi, W., Zheng, K., Wang, T., & Chen, H. (2021) · Infectious Diseases and Therapy · doi:10.1007/s40121-021-00500-z · Cited by 80 · see citing works
Exercise training prevents hyperinsulinemia, muscular glycogen loss and muscle atrophy induced by dexamethasone treatment
Barel, M., Perez, O. A. B., Giozzet, V. A. G., Rafacho, A., Bosqueiro, J. R., & Amaral, S. L. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1272-6 · Cited by 81 · see citing works
Lactoferrin increases 172ThrAMPK phosphorylation and insulin-induced p473SerAKT while impairing adipocyte differentiation
Moreno‐Navarrete, J. M., Ortega, F. J., Ricart, W., & Fernández‐Real, J. M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.143 · Cited by 68 · see citing works
Distinct mechanisms involving diacylglycerol, ceramides, and inflammation underlie insulin resistance in oxidative and glycolytic muscles from high fat-fed rats
Jani, S., Eira, D. D., Hadday, I., Bikopoulos, G. J., Mohasses, A., Pinho, R. A., & Ceddia, R. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-98819-7 · Cited by 62 · see citing works
Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats
Bai, X., Sukumaran, S., Nie, J., Jusko, W. J., DuBois, D. C., & Almon, R. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017386 · Cited by 59 · see citing works
Twenty‐four‐hour profiles of plasma glucose, insulin, C‐peptide and free fatty acid in subjects with varying degrees of glucose tolerance following short‐term, medium‐dose prednisone (20 mg/day) treatment: evidence for differing effects on insulin secretion and action
Yuen, K. C. J., McDaniel, P. A., & Riddle, M. C. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04242.x · Cited by 58 · see citing works
Chronic glucocorticoid treatment enhances lipogenic activity in visceral adipocytes of male Wistar rats
Chimin, P., de Farias, T. D. S. M., Torres‐Leal, F. L., Lopes, A. B., Campaña, A. B., Andreotti, S., & Lima, F. B. (2014) · Acta Physiologica · doi:10.1111/apha.12226 · Cited by 56 · see citing works
Low‐dose dexamethasone prevents endotoxaemia‐induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle
Crossland, H., Constantin‐Teodosiu, D., Greenhaff, P. L., & Gardiner, S. M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.183699 · Cited by 55 · see citing works
Glucose and lipid metabolism abnormalities in C ushing's syndrome
Salehidoost, R., & Korbonits, M. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13143 · Cited by 56 · see citing works
The Metabolic Implications of Glucocorticoids in a High-Fat Diet Setting and the Counter-Effects of Exercise
Dunford, E. C., & Riddell, M. C. (2016) · Metabolites · doi:10.3390/metabo6040044 · Cited by 55 · see citing works
The ‘Jekyll and Hyde’ of Gluconeogenesis: Early Life Adversity, Later Life Stress, and Metabolic Disturbances
Seal, S. V., & Turner, J. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073344 · Cited by 54 · see citing works
The adaptive compensations in endocrine pancreas from glucocorticoid‐treated rats are reversible after the interruption of treatment
Rafacho, A., Quallio, S., Ribeiro, D. L., Taboga, S. R., de Paula, F. M. M., Boschero, A. C., & Bosqueiro, J. R. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02146.x · Cited by 51 · see citing works
Glucocorticoids and Cardiovascular Risk Factors
Strohmayer, E., & Krakoff, L. R. (2011) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2011.01.011 · Cited by 45 · see citing works
Alterations of the Gut Microbiota Associated With Promoting Efficacy of Prednisone by Bromofuranone in MRL/lpr Mice
He, Z.-X., Kong, X.-Y., Shao, T., Zhang, Y., & Wen, C.-P. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00978 · Cited by 42 · see citing works
The dysregulation of the hypothalamic–pituitary–adrenal axis in diet-induced prediabetic male Sprague Dawley rats
Mosili, P., Mkhize, B. C., Ngubane, P. S., Sibiya, N. H., & Khathi, A. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00532-1 · Cited by 45 · see citing works
Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats
Buhl, E. S., Jensen, T. K., Jessen, N., Elfving, B., Buhl, C. S., Kristiansen, S. B., Pold, R., Solskov, L., Schmitz, O., Wegener, G., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00606.2009 · Cited by 43 · see citing works
Corticosterone suppresses insulin- and NO-stimulated muscle glucose uptake in broiler chickens (Gallus gallus domesticus)
Zhao, J. P., Lin, H., Jiao, H., & Song, Z. (2008) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.10.106 · Cited by 43 · see citing works
Glucose metabolism in Cushing's syndrome
Sharma, A. R., & Vella, A. V. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000537 · Cited by 37 · see citing works
Altered gene and protein expression of glucose transporter1 underlies dexamethasone inhibition of insulin-stimulated glucose uptake in chicken muscles1
Zhao, J. P., Bao, J., Wang, X., Jiao, H., Song, Z., & Lin, H. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5100 · Cited by 37 · see citing works
Adipose tissue in cortisol excess: What Cushing’s syndrome can teach us?
Bavaresco, A., Mazzeo, P., Lazzara, M., & Barbot, M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116137 · Cited by 40 · see citing works
The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D
Speelman, T., Dale, L., Louw, A., & Verhoog, N. J. D. (2022) · Cells · doi:10.3390/cells11142163 · Cited by 35 · see citing works
Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis
Kuo, T., Chen, T.-C., Lee, R. A., Nguyen, N. H. T., Broughton, A. E., Zhang, D., & Wang, J.-C. (2017) · Diabetes · doi:10.2337/db16-0831 · Cited by 32 · see citing works
Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats
Karagiannides, I., Golovatscka, V., Bakirtzi, K., Sideri, A., Salas, M. C., Stavrakis, D. G., Polytarchou, C., Iliopoulos, D., Pothoulakis, C., & Bradesi, S. (2014) · Physiological Reports · doi:10.14814/phy2.284 · Cited by 31 · see citing works
Aspartame: Should Individuals with Type II Diabetes be Taking it?
Choudhary, A. K. (2017) · Current Diabetes Reviews · doi:10.2174/1573399813666170601093336 · Cited by 31 · see citing works
Non-invasive muscle contraction assay to study rodent models of sarcopenia
Chiu, C., Weber, H. H., Adamski, S. A., Rauch, A., Gentile, M. A., Alves, S. E., Kath, G. S., Flores, O. A., & Wilkinson, H. A. (2011) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-12-246 · Cited by 30 · see citing works
Glucose homoeostasis in rats exposed to acute intermittent hypoxia
Rafacho, A., Gonçalves-Neto, L. M., Ferreira, F. B. D., Protzek, A. O. P., Boschero, A. C., Nunes, E. A., & Zoccal, D. B. (2013) · Acta Physiologica · doi:10.1111/apha.12118 · Cited by 30 · see citing works
Reversal of dexamethasone induced insulin resistance in 3T3L1 adipocytes by 3β-taraxerol of Mangifera indica
Sangeetha, K. N., Shilpa, K., kumari, P. J., & Lakshmi, B. S. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.10.011 · Cited by 28 · see citing works
JNK and IKKβ phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats
Motta, K., Barbosa, A. M., Bobinski, F., Boschero, A. C., & Rafacho, A. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.09.024 · Cited by 27 · see citing works
Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats
Williams, D. B., Wan, Z., Frier, B. C., Bell, R. C., Field, C. J., & Wright, D. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00304.2011 · Cited by 27 · see citing works
The Synergetic Effect of Egyptian Portulaca oleracea L. (Purslane) and Cichorium intybus L. (Chicory) Extracts against Glucocorticoid-Induced Testicular Toxicity in Rats through Attenuation of Oxidative Reactions and Autophagy
Saleh, S. R., Manaa, A., Sheta, E., Ghareeb, D. A., & Abdel-Monem, N. M. (2022) · Antioxidants · doi:10.3390/antiox11071272 · Cited by 25 · see citing works
Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism
Banke, E., Rödström, K. E. J., Ekelund, M., Dalla‐Riva, J., Lagerstedt, J. O., Nilsson, S., Degerman, E., Lindkvist‐Petersson, K., & Nilson, B. (2014) · Metabolism · doi:10.1016/j.metabol.2014.03.004 · Cited by 26 · see citing works
Timing of glucocorticoid administration determines severity of lipid metabolism and behavioral effects in rats
Wu, T., Jiang, J., Yang, L., Li, H., Zhang, W., Chen, Y., Zhao, B., Kong, B., Lü, P., Zhao, Z., et al. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1238831 · Cited by 25 · see citing works
Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease
Llewellyn, K. J., Nalbandian, A., Jung, K., Nguyen, C., Avanesian, A., Mozaffar, T., Piomelli, D., & Kimonis, V. E. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt523 · Cited by 24 · see citing works
Cushing Syndrome, Hypercortisolism, and Glucose Homeostasis: A Review
DeFronzo, R. A., & Auchus, R. J. (2025) · Diabetes · doi:10.2337/db25-0120 · Cited by 30 · see citing works
The influence of goutweed (Aegopodium podagraria L.) tincture and metformin on the carbohydrate and lipid metabolism in dexamethasone-treated rats
Товчига, О. В. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1221-y · Cited by 23 · see citing works
Fish oil supplementation attenuates changes in plasma lipids caused by dexamethasone treatment in rats
Barbosa, A. M., Francisco, P. D. C., Motta, K., Chagas, T. R., dos Santos, C., Rafacho, A., & Nunes, E. A. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0487 · Cited by 23 · see citing works
Brown adipose tissue remodelling induced by corticosterone in male Wistar rats
Mousovich‐Neto, F., Matos, M. S., Costa, A. C. R., Reis, R. A. D. M., Atella, G. C., Miranda‐Alves, L., de Carvalho, D. P., Ketzer, L. A., & da Costa, V. M. C. (2019) · Experimental Physiology · doi:10.1113/ep087332 · Cited by 22 · see citing works
4‐Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes
Xu, T., Chen, R., Wang, P., Zhang, R., Ke, S., & Miao, C. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05328.x · Cited by 20 · see citing works
Glucocorticoid-induced CREB activation and myostatin expression in C2C12 myotubes involves phosphodiesterase-3/4 signaling
Xie, Y., Perry, B. D., Espinoza, D., Zhang, P., & Price, S. R. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.056 · Cited by 20 · see citing works
Clinical pathological characteristics of breast cancer patients with secondary diabetes after systemic therapy: a retrospective multicenter study
Li, J., Wen, W., Liu, Z., Chen, C., Cheng, J., Yiping, G., Changhua, W., De-hua, Y., & Shengrong, S. (2015) · Tumor Biology · doi:10.1007/s13277-015-3380-8 · Cited by 19 · see citing works
Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons
Harno, E., Sefton, C., Wray, J. R., Allen, T.-J., Davies, A., Coll, A. P., & White, A. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-93378-3 · Cited by 18 · see citing works
Effects of a single glucocorticoid injection on propylene glycol-treated cows with clinical ketosis
van der Drift, S. G. A., Houweling, M., Bouman, M., Koets, A. P., Tielens, A. G. M., Nielen, M., & Jorritsma, R. (2015) · The Veterinary Journal · doi:10.1016/j.tvjl.2015.01.016 · Cited by 18 · see citing works
Effects of Dexamethasone-21-Isonicotinate on Peripheral Insulin Action in Dairy Cows 5 days after Surgical Correction of Abomasal Displacement
Kusenda, M., Kaske, M., Piechotta, M., Locher, L., Starke, A., Huber, K., & Rehage, J. (2012) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12010 · Cited by 17 · see citing works
Verification of glycemic profiles using continuous glucose monitoring: cases with steroid use, liver cirrhosis, enteral nutrition, or late dumping syndrome
Kishimoto, M., & Noda, M. (2015) · The Journal of Medical Investigation · doi:10.2152/jmi.62.1 · Cited by 17 · see citing works
Glucose homeostasis in rats treated with 4-vinylcyclohexene diepoxide is not worsened by dexamethasone treatment
Battiston, F. G., dos Santos, C., Barbosa, A. M., Sehnem, S., Leonel, E. C. R., Taboga, S. R., Anselmo-Franci, J. A., Lima, F. B., & Rafacho, A. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.06.001 · Cited by 17 · see citing works
Curcumin limits weight gain, adipose tissue growth, and glucose intolerance following the cessation of exercise and caloric restriction in rats
Teich, T., Pivovarov, J. A., Porras, D. P., Dunford, E. C., & Riddell, M. C. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01115.2016 · Cited by 16 · see citing works
Natural mineral-rich water ingestion improves hepatic and fat glucocorticoid-signaling and increases sirtuin 1 in an animal model of metabolic syndrome
Pereira, C., Severo, M., Neves, D., Ascensão, A. A. M. R., Magalhães, J., Guimarães, J. T., Monteiro, R., & Martins, M. J. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0032 · Cited by 16 · see citing works
Insights into the molecular mechanism of glucose metabolism regulation under stress in chicken skeletal muscle tissues
Liu, W., & Zhao, J. (2014) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2014.01.005 · Cited by 18 · see citing works
Microcystin‐LR disrupts insulin signaling by hyperphosphorylating insulin receptor substrate 1 and glycogen synthase
Liu, J., Xu, C., Zhang, S., Li, H., Chen, K., Huang, P., Guo, Z., & Xu, L. (2017) · Environmental Toxicology · doi:10.1002/tox.22456 · Cited by 16 · see citing works
Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue
Gathercole, L., Morgan, S., Bujalska, I. J., Stewart, P. M., & Tomlinson, J. (2011) · Nutrition and Diabetes · doi:10.1038/nutd.2010.3 · Cited by 15 · see citing works
Animal Models of Cushing's Syndrome
Nishiyama, M., Iwasaki, Y., & Makino, S. (2022) · Endocrinology · doi:10.1210/endocr/bqac173 · Cited by 15 · see citing works
Regulation of Glucocorticoid Receptor Signaling and the Diabetogenic Effects of Glucocorticoid Excess
Ortsäter, H., Sjöholm, Å., & Rafacho, A. (2012) · InTech eBooks · doi:10.5772/51759 · Cited by 14 · see citing works
Disruption of glucose tolerance caused by glucocorticoid excess in rats is partially prevented, but not attenuated, by arjunolic acid.
Gonçalves-Neto, L. M., Ferreira, F. B. D., de Souza, L. F., dos Santos, C., Boschero, A. C., Facundo, V. A., Santos, A. R. S., Nunes, E. A., & Rafacho, A. (2014) · PubMed · Cited by 14 · see citing works
Single-Gene Congenic Strain Reveals the Effect of Zbtb16 on Dexamethasone-Induced Insulin Resistance
Krupková, M., Liška, F., Kazdová, L., Šedová, L., Kábelová, A., Krenová, D., Křen, V., & Šeda, O. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00185 · Cited by 13 · see citing works
Medical treatment of Cushing’s disease with concurrent diabetes mellitus
Mehlich, A., Bolanowski, M., Mehlich, D., & Witek, P. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1174119 · Cited by 13 · see citing works
Effects of high doses of glucocorticoids on insulin-mediated vasodilation in the mesenteric artery of rats
Araújo, J. E. D. S., Miguel‐dos‐Santos, R., Macedo, F. N., Cunha, P. S., Fontes, M. T., Murata, G. M., Lauton‐Santos, S., Santana‐Filho, V. J., Silva, A. M. D. O. E., Antoniolli, Â. R., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230514 · Cited by 12 · see citing works
Dexamethasone-Induced Insulin Resistance Attenuation by Oral Sulfur–Oxidovanadium(IV) Complex Treatment in Mice
Batista, E. K. D. L., de Lima, L. M. A., Gomes, D. A., Crans, D. C., Silva, W. E., Belian, M. F., & Lira, E. C. (2024) · Pharmaceuticals · doi:10.3390/ph17060760 · Cited by 12 · see citing works
A systems biology analysis connects insulin receptor signaling with glucose transporter translocation in rat adipocytes
Bergqvist, N., Nyman, E., Cedersund, G., & Stenkula, K. G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.787515 · Cited by 12 · see citing works
Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats
Fang, J., DuBois, D. C., He, Y., Almon, R. R., & Jusko, W. J. (2011) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-011-9194-4 · Cited by 13 · see citing works
Inhaled Corticosteroids Use Is Not Associated With an Increased Risk of Pregnancy-Induced Hypertension and Gestational Diabetes Mellitus
Lee, C., Kim, J., Jang, E. J., Lee, J. H., Kim, Y. J., Choi, S., Kim, D. K., Yim, J., & Yoon, H. I. (2016) · Medicine · doi:10.1097/md.0000000000003627 · Cited by 12 · see citing works
Alpha lipoic acid protects against dexamethasone-induced metabolic abnormalities via APPL1 and PGC-1 α up regulation
Mohammed, M. A., Mahmoud, M. O., Awaad, A. S., Gamal, G. M., & Abdelfatah, D. (2019) · Steroids · doi:10.1016/j.steroids.2019.01.004 · Cited by 11 · see citing works
Meta-Modeling of Methylprednisolone Effects on Glucose Regulation in Rats
Fang, J., Sukumaran, S., DuBois, D. C., Almon, R. R., & Jusko, W. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081679 · Cited by 11 · see citing works
Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats
Inácio, M. D., Rafacho, A., Camaforte, N. A. D. P., Teixeira, P., Vareda, P. M. P., Violato, N. M., & Bosqueiro, J. R. (2018) · International Journal of Endocrinology · doi:10.1155/2018/3257812 · Cited by 10 · see citing works
Chemical denervation using botulinum toxin increases Akt expression and reduces submaximal insulin-stimulated glucose transport in mouse muscle
Li, Z., Näslund-Koch, L., Henríquez‐Olguín, C., Knudsen, J. R., Li, J., Madsen, A. B., Ato, S., Wienecke, J., Ogasawara, R., Nielsen, J. B., et al. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.10.014 · Cited by 10 · see citing works
Effects of combination of thiazolidinediones with melatonin in dexamethasone-induced insulin resistance in mice
Ahire, Y., Gandhi, S., Ghaisas, M. M., Dandawate, P. R., & Mule, M. (2011) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.100232 · Cited by 9 · see citing works
Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes
Fleuren, W. W. M., Linssen, M. M. L., Toonen, E. J. M., van der Zon, G. C. M., Guigas, B., de Vlieg, J., Dokter, W. H. A., Ouwens, D. M., & Alkema, W. B. L. (2013) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.774022 · Cited by 9 · see citing works
Effect of insulin and contraction on glycogen synthase phosphorylation and kinetic properties in epitrochlearis muscles from lean and obese Zucker rats
Lin, F. C., Bolling, A., Stuenæs, J. T., Cumming, K. T., Ingvaldsen, A., Lai, Y., Ivy, J. L., & Jensen, J. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00430.2011 · Cited by 9 · see citing works
Self-citation
Long‐term dexamethasone treatment alters the histomorphology of acinar cells in rat parotid and submandibular glands
Bighetti, B., de Assis, G. F., Vieira, D. C., Violato, N. M., Cestari, T. M., Taga, R., Bosqueiro, J. R., & Rafacho, A. (2014) · International Journal of Experimental Pathology · doi:10.1111/iep.12092 · Cited by 9 · see citing works
Lithium treatment mitigates the diabetogenic effects of chronic cortico-therapy
Delangre, E., Pommier, G., Tolu, S., Uzan, B., Bailbé, D., & Movassat, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114895 · Cited by 9 · see citing works
The difference between steroid diabetes mellitus and type 2 diabetes mellitus: a whole-body 18F-FDG PET/CT study
Zhao, Q., Zhou, J., Pan, Y., Ju, H., Zhū, L., Liu, Y., & Zhang, Y. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01566-w · Cited by 8 · see citing works
Insulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid
Paula, F. M. D., Boschero, A. C., Carneiro, E. M., Bosqueiro, J. R., & Rafacho, A. (2011) · Biological Research · doi:10.4067/s0716-97602011000300006 · Cited by 7 · see citing works
Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging
Song, M. K., Kim, Y. J., Kim, S. H., Yeo, S. G., & Kim, Y. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111552 · Cited by 7 · see citing works
Decreased Gene Expressions of Insulin Signal Molecules in Canine Hyperadrenocorticism
Nozawa, S., Oda, H., AKIYAMA, R., Kaori, U. E. D. A., Saeki, K., Shono, S., Maruyama, N., MURATA, A., Tazaki, H., Mori, A., et al. (2014) · Journal of Veterinary Medical Science · doi:10.1292/jvms.14-0033 · Cited by 7 · see citing works
The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment
Flis, D. J., Bialobrodzka, E. G., Rodziewicz-Flis, E. A., Jost, Z., Borkowska, A., Ziółkowski, W., & Kaczor, J. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020748 · Cited by 6 · see citing works
Mécanismes d’action directs mis en jeu dans les myopathies toxiques
Khelfi, A., Azzouz, M., Abtroun, R., Reggabi, M., & Alamir, B. (2017) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2017.04.002 · Cited by 6 · see citing works
The effects of short‐term treatment of microcystin‐LR on the insulin pathway in both the HL7702 cell line and livers of mice
Huang, P., Chen, K., Ma, T., Cao, N., Weng, D., Xu, C., & Xu, L. (2020) · Environmental Toxicology · doi:10.1002/tox.22907 · Cited by 6 · see citing works
Protective Role of Gallic Acid Against Corticosterone-Induced Hepatic Toxicity: Modulation of Oxidative Stress and Inflammatory Pathways in Wistar Rats
Tiwari, P., Kumar, P., Srikrishna, S., Siddiqi, N. J., & Sharma, B. (2025) · Toxics · doi:10.3390/toxics13100897 · Cited by 5 · see citing works
Association between glucocorticoid use and all-cause mortality in critically ill patients with heart failure: A cohort study based on the MIMIC-III database
Zhu, J.-L., Liang, H., Yuan, S., Xu, X.-M., Wei, J., & Yin, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1118551 · Cited by 5 · see citing works
Metabolic effects of prazosin on skeletal muscle insulin resistance in glucocorticoid-treated male rats
Dunford, E. C., Mandel, E. R., Mohajeri, S., Haas, T. L., & Riddell, M. C. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00146.2016 · Cited by 5 · see citing works
Steroid growth promoter modified glucose profile and liver morphology in broiler by altering the localization and expression pattern of hepatic glucocorticoid receptors
Sultana, N., Islam, R., Das, R. R., Haque, Z., Rafiq, K., & Khan, M. A. H. N. A. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.08.024 · Cited by 5 · see citing works
Black pepper (Piper nigrum L.) essential oil counteracts dexamethasone-induced hepatic injury via modulating PGC-1α/ PPAR-α pathway in rats
Mahmoud, M. F., Mahdi, I., Ali, N., Dib, H., El-Shazly, A. M., Mostafa, I., Abdelfattah, M. A. O., Hasan, R. A., & Sobeh, M. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.105690 · Cited by 5 · see citing works

Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signalling and the effects of a selective glycogen synthase kinase-3 inhibitor
Ruzzin, J., Wagman, A. S., & Jensen, J. (2005) · Diabetologia · doi:10.1007/s00125-005-1886-0 · Cited by 243 · see citing works
Self-citation
Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
Burén, J., Liu, H., Jensen, J., & Eriksson, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460419 · Cited by 160 · see citing works
Self-citation
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
Saad, M. J., Folli, F., Kahn, J. A., & Kahn, C. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116803 · Cited by 349 · see citing works
JNK and IKKβ phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats
Motta, K., Barbosa, A. M., Bobinski, F., Boschero, A. C., & Rafacho, A. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.09.024 · Cited by 27 · see citing works
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.
Sakoda, H., Ogihara, T., Anai, M., Funaki, M., Inukai, K., Katagiri, H., Fukushima, Y., Onishi, Y., Ono, H., Fujishiro, M., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.10.1700 · Cited by 241 · see citing works

Authors: Burén, J., Lai, Y. C., Lundgren, M., Eriksson, J. W., & Jensen, J.
Affiliations: University Hospital of Umeå (SE)
National Institute of Occupational Health (NO)
Corresponding author: Jensen, J.
ORCID: Burén, J.
Lai, Y.C.
Jensen, J.
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2008-06
Volume: 474
Issue: 1
Pages: 91-101
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2008.02.034
OpenAlex: W2050972898
Cited by: 125
References: 50
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 9 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 7 · 2012: 8
FWCI: 3.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Torsten Söderbergs Stiftelse
Vetenskapsrådet (12663, 14287)
Novo Nordisk Fonden
Medicinska fakulteten, Umeå Universitet
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: dexamethasone, glucocorticoids, insulin resistance, insulin signaling, Akt, glycogen synthase, glycogen synthase kinase-3, muscle glucose uptake, adipocyte lipolysis, glycogen synthesis, soleus muscle, epitrochlearis muscle, epididymal adipocytes
MeSH terms: Adipose Tissue, Animals, Dexamethasone, Glucose, Insulin, Lipolysis, Male, Phosphorylation, Blotting, Western, Signal Transduction, Rats, Wistar, Muscle, Skeletal, Glycogen Synthase Kinase 3, Proto-Oncogene Proteins c-akt, Glucose Transporter Type 4, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin action and signalling in fat and muscle from dexamethasone-treated rats

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks