Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial
Open accessAbstract
Summary: Background : Helicobacter pylori eradication fails in about 10% of patients, particularly because of the occurrence of resistance to antibiotics and side‐effects. During anti‐H. pylori therapy, probiotics have been successfully used to reduce the incidence of side‐effects. Aim : To evaluate the effect of Bacillus clausii, a probiotic, on incidence (primary variable) and severity of antibiotic‐associated side‐effects during anti‐H. pylori therapy. Methods : One hundred and twenty H. pylori‐positive patients were randomly screened to receive: (i) a standard 7 days triple therapy with rabeprazole 20 mg b.d., clarithromycin 500 mg b.d. and amoxicillin 1 g b.d. and B. clausii t.d.s. (each preparation containing 2 × 10 9 spores) for 14 days starting from the first day of treatment. (ii) The same 7 days triple therapy and placebo t.d.s. for 14 days starting from the first day of treatment. Side‐effects were assessed using a validated questionnaire and were recorded for 4 weeks from the start of therapy. Results : The incidences of nausea, diarrhoea and epigastric pain in patients treated with B. clausii were significantly lower than in placebo group, in both PP and ITT analysis. Equally, intensity of nausea and diarrhoea in patients treated with B. clausii was significantly lower than in placebo group. There were no differences in adherence to treatment and H. pylori eradication rates between groups. Conclusion : In symptom‐free, H. pylori‐positive subjects B. clausii bacteriotherapy reduces the incidence of the most common side‐effects related to anti‐H. pylori antibiotic therapy compared with placebo.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The results for two of the probiotic treatments were mixed, with a significant benefit seen after 1 week but not 2 weeks in one study, and significantly fewer days with diarrhoea and shorter mean duration of diarrhoea episodes but no significant difference in frequency of diarrhoea episodes in another study.
“However, the results for two of the probiotic treatments were mixed, with a significant benefit of the specific probiotic treatment seen after 1 week, but not 2 weeks, in one study,49 and significantly fewer days with diarrhoea and shorter mean duration of diarrhoea episodes, but no significant difference in frequency of diarrhoea episodes, in the probiotic group compared with the placebo group in”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [49]
All four studies reported a significant benefit of specific probiotic treatments compared with placebo.
“All four studies reported a significant benefit of specific probiotic treatments compared with placebo.46–49”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Malfertheiner, P., Mégraud, F., O'Morain, C. A., Hungin, A. P. S., Jones, R. H., Axon, A. T. R., Graham, D. Y., Tytgat, G. N. J., & The European Helicobacter Pylori Study Group (EHPSG) (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01169.x · Cited by 1,238 · see citing works
Fuller, R. (1991) · Gut · doi:10.1136/gut.32.4.439 · Cited by 844 · see citing works
Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea
Cremonini, F., Caro, S. D., Nista, E. C., Bartolozzi, F., Capelli, G., Gasbarrini, A., & Gasbarrini, A. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01318.x · Cited by 385 · see citing works
Self-citationCremonini, F., Caro, S., Covino, M., Armuzzi, A., Gabrielli, M., Santarelli, L., Nista, E. C., Cammarota, G., Gasbarrini, G., & Gasbarrini, A. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07063.x · Cited by 341 · see citing works
Self-citationPeters, D. H., & Clissold, S. P. (1992) · Drugs · doi:10.2165/00003495-199244010-00009 · Cited by 298 · see citing works
Armuzzi, A., Cremonini, F., Bartolozzi, F., Canducci, F., Candelli, M., Ojetti, V., Cammarota, G., Anti, M., LORENZO, A. D., Pola, P., et al. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00923.x · Cited by 296 · see citing works
Self-citationIsolauri, E. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1142s · Cited by 291 · see citing works
Laine, L., Hunt, R. H., El-Zimaity, H. M. T., Nguyen, B., Osato, M. S., & Spénard, J. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.t01-1-07288.x · Cited by 242 · see citing works
High eradication rates of Helicobacter pylori with a new sequential treatment
Zullo, A., Vaira, D., Vakil, N. B., Hassan, C., Gatta, L., Ricci, C., Francesco, V. D., Menegatti, M., Tampieri, A., Perna, F., et al. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01461.x · Cited by 221 · see citing works
Bacillus clausii Probiotic Strains
Urdaci, M. C., Bressollier, P., & Pinchuk, I. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128925.06662.69 · Cited by 182 · see citing works
Katelaris, P., Forbes, G. M., Talley, N. J., & Crotty, B. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.37051 · Cited by 160 · see citing works
Triple vs. quadruple therapy for treating Helicobacter pylori infection: an updated meta‐analysis
Gené, E., Calvet, X., Azagra, R., & Gisbert, J. P. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.t01-1-01712.x · Cited by 140 · see citing works
Triple vs. quadruple therapy for treating Helicobacter pylori infection: a meta‐analysis
Gené, E., Calvet, X., Azagra, R., & Gisbert, J. P. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01566.x · Cited by 120 · see citing works
Senesi, S., Celandroni, F., Tavanti, A., & Ghelardi, E. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.2.834-839.2001 · Cited by 111 · see citing works
de Boer, W. A., Thys, J., Borody, T. J., Graham, D. Y., O'Morain, C. A., & Tytgat, G. N. J. (1996) · PubMed · Cited by 85 · see citing works
Levofloxacin based regimens for the eradication of Helicobacter pylori
Caro, S. D., Zocco, M. A., Cremonini, F., Candelli, M., Nista, E. C., Bartolozzi, F., Armuzzi, A., Cammarota, G., Santarelli, L., & Gasbarrini, A. (2002) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200212000-00004 · Cited by 69 · see citing works
Self-citationProbiotics — Role in inflammatory bowel disease
Gionchetti, P., Amadini, C., Rizzello, F., Venturi, A., Palmonari, V., Morselli, C., Romagnoli, R., & Campieri, M. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80166-9 · Cited by 60 · see citing works
Chromosomal aadD2 Encodes an Aminoglycoside Nucleotidyltransferase in Bacillus clausii
Bozdoğan, B., Galopin, S., Gerbaud, G., Courvalin, P. M., & Leclercq, R. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.4.1343-1346.2003 · Cited by 47 · see citing works
Ciffo, F. (1984) · PubMed · Cited by 37 · see citing works
Studies on the antibiotic resistance of Bacillus subtilis strains used in oral bacteriotherapy.
Mazza, P. G., Zani, F., & Martelli, P. R. (1992) · PubMed · Cited by 33 · see citing works
Diagnosis and treatment of Helicobacter: a 2002 updated review
Basset, C., Holton, J., Ricci, C., Gatta, L., Tampieri, A., Perna, F., Miglioli, M., & Vaira, D. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.17.s2.6.x · Cited by 30 · see citing works
Helicobacter pylori Treatment: A Role for Probiotics?
Cremonini, F., Canducci, F., Caro, S. D., Santarelli, L., Armuzzi, A., Gasbarrini, A., & Gasbarrini, A. (2001) · Digestive Diseases · doi:10.1159/000050669 · Cited by 23 · see citing works
Self-citationFranzin, L., Pennazio, M., Cabodi, D., Rossini, F. P., & Gioannini, P. (2000) · Current Microbiology · doi:10.1007/s002849910018 · Cited by 16 · see citing works
Efficacy and tolerability of antibiotics in patients undergoing H. pylori eradication.
Danese, S., Armuzzi, A., Romano, A. G., Cremonini, F., Candelli, M., Franceschi, F., Ojetti, V., Venuti, A., Pola, P., Gasbarrini, G. B., et al. (2001) · PubMed · Cited by 14 · see citing works
Self-citationAntibiotic administration and oral bacterial therapy in infants.
Benoni, G., Marcer, V., Cuzzolin, L., & Raimo, F. (1984) · PubMed · Cited by 11 · see citing works
Adhesiveness of Bacillus subtilis Strains to Epithelial Cells Cultured in vitro
Angioi, A., Zanetti, S., Sanna, A., Delogu, G., & Fadda, G. (1994) · Microbial Ecology in Health and Disease · doi:10.3109/08910609509141385 · Cited by 8 · see citing works
Quadruple treatments for Helicobacter pylori
Mascitelli, L., & Pezzetta, F. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12171-x · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Ciffo F, Da Carro C, Giovannetti M. Gastric resistance of Bacillus subtilis spores used in oral bacteriotherapy: in vitro studies. Farmaci e terapia 1987; 3: 163-169.
Cited by
Sorted by citations
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
Malfertheiner, P., Mégraud, F., O'Morain, C. A., Gisbert, J. P., Kuipers, E. J., Axon, A. T. R., Bazzoli, F., Gasbarrini, A., Atherton, J. C., Graham, D. Y., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312288 · Cited by 2,969 · see citing works
Self-citationMcFarland, L. V. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00465.x · Cited by 872 · see citing works
Cutting, S. M. (2010) · Food Microbiology · doi:10.1016/j.fm.2010.03.007 · Cited by 827 · see citing works
Functional cultures and health benefits
Shah, N. P. (2007) · International Dairy Journal · doi:10.1016/j.idairyj.2007.01.014 · Cited by 793 · see citing works
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Goldenberg, J. Z., Ma, S. S., Saxton, J. D., Martzen, M. R., Vandvik, P. O., Thorlund, K., Guyatt, G. H., & Johnston, B. C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub3 · Cited by 741 · see citing works
Probiotics for the prevention of pediatric antibiotic-associated diarrhea
Goldenberg, J. Z., Lytvyn, L., Steurich, J., Parkin, P. C., Mahant, S., & Johnston, B. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004827.pub4 · Cited by 625 · see citing works
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Goldenberg, J. Z., Yap, C., Lytvyn, L., Lo, C. K.-F., Beardsley, J., Mertz, D., & Johnston, B. C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub4 · Cited by 550 · see citing works
Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier
Lee, N., Kim, W.-S., & Paik, H. (2019) · Food Science and Biotechnology · doi:10.1007/s10068-019-00691-9 · Cited by 393 · see citing works
Treatment of Helicobacter pylori Infection
O’Connor, A., Gisbert, J. P., & O'Morain, C. A. (2009) · Helicobacter · doi:10.1111/j.1523-5378.2009.00704.x · Cited by 282 · see citing works
Probiotics and health: An evidence-based review
Aureli, P., Capurso, L., Castellazzi, A. M., Clerici, M., Giovannini, M., Morelli, L., Poli, A., Pregliasco, F. E., Salvini, F. M., & Zuccotti, G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.02.006 · Cited by 281 · see citing works
Probiotics for the prevention of pediatric antibiotic-associated diarrhea
Guo, Q., Goldenberg, J. Z., Humphrey, C., El Dib, R., & Johnston, B. C. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004827.pub5 · Cited by 275 · see citing works
The Role of Probiotics and Prebiotics in Inducing Gut Immunity
Vieira, A. T., Teixeira, M. M., & Martins, F. S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00445 · Cited by 275 · see citing works
TONG, J. L., Ran, Z. H., Shen, J., Zhang, C.-J., & Xiao, S. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03179.x · Cited by 256 · see citing works
Hungin, A. P. S., Mulligan, C., Pot, B., Whorwell, P., Agréus, L., Fracasso, P., Lionis, C., Mendive, J., Philippart de Foy, J.-M., Rubin, G., et al. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12460 · Cited by 212 · see citing works
Probiotic Lactic Acid Bacteria: A Review
Quinto, E. J., Jiménez, P., Caro, I., Tejero, J., Mateo, J., & Girbés, T. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.518190 · Cited by 210 · see citing works
World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics
Guarner, F., Sanders, M. E., Szajewska, H., Cohen, H., Eliakim, R., Herrera-deGuise, C., Karakan, T., Merenstein, D., Piscoya, A., Ramakrishna, B., et al. (2024) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002002 · Cited by 209 · see citing works
Probiotics in Helicobacter pylori eradication therapy: A systematic review and meta-analysis
Zhang, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i14.4345 · Cited by 176 · see citing works
Hu, Y., Zhu, Y., & Lü, N. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00168 · Cited by 175 · see citing works
Lionetti, E., Miniello, V. L., Castellaneta, S. P., Magistà, A. M., Canio, A. D., Maurogiovanni, G., Ierardi, E., Cavallo, L., & Francavilla, R. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03145.x · Cited by 170 · see citing works
Dang, Y., Reinhardt, J. D., Zhou, X., & Zhang, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111030 · Cited by 168 · see citing works
Probiotics in Gastrointestinal Diseases in Children
Szajewska, H., Setty, M., Mrukowicz, J. Z., & Guandalini, S. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000221913.88511.72 · Cited by 163 · see citing works
Treatment of Helicobacter pylori
Egan, B. J., Katičić, M., O'Connor, H. J., & O'Morain, C. A. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00538.x · Cited by 158 · see citing works
Meta‐analysis: probiotics in antibiotic‐associated diarrhoea
Videlock, E. J., & Cremonini, F. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05104.x · Cited by 157 · see citing works
Self-citationHungin, A. P. S., Mitchell, C. R., Whorwell, P., Mulligan, C., Cole, O., Agréus, L., Fracasso, P., Lionis, C., Mendive, J., Philippart de Foy, J. ‐., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14539 · Cited by 154 · see citing works
Current understanding of antibiotic-associated dysbiosis and approaches for its management
Kesavelu, D., & Jog, P. P. (2023) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361231154443 · Cited by 149 · see citing works
Probiotics and nutraceuticals: non-medicinal treatments of gastrointestinal diseases
PENNER, R., Fedorak, R. N., & Madsen, K. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.06.009 · Cited by 147 · see citing works
Are probiotics useful in Helicobacter pylori eradication?
Homan, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10644 · Cited by 142 · see citing works
Cindoruk, M., Erkan, G., Karakan, T., Dursun, A., & Unal, S. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00516.x · Cited by 135 · see citing works
Alternative therapies for Helicobacter pylori: probiotics and phytomedicine
Vítor, J. M. B., & Vale, F. F. (2011) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2011.00865.x · Cited by 131 · see citing works
International consensus statement on microbiome testing in clinical practice
Porcari, S., Mullish, B. H., Asnicar, F., Ng, S. C., Zhao, L., Hansen, R., O’Toole, P. W., Raes, J., Hold, G. L., Putignani, L., et al. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(24)00311-x · Cited by 119 · see citing works
Self-citationLv, Z., WANG, B., Zhou, X., Wang, F., Xie, Y., Zheng, H., & Lv, N. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2174 · Cited by 111 · see citing works
Ianiro, G., Rizzatti, G., Plomer, M., Lopetuso, L. R., Scaldaferri, F., Franceschi, F., Cammarota, G., & Gasbarrini, A. (2018) · Nutrients · doi:10.3390/nu10081074 · Cited by 110 · see citing works
Self-citationProbiotics for the Prevention of Antibiotic-associated Diarrhea and Clostridium difficile Diarrhea
Katz, J. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00017 · Cited by 108 · see citing works
Khodadad, A., Farahmand, F., Mehri, N., & Shoaran, M. (2013) · Europe PMC (PubMed Central) · Cited by 104 · see citing works
Lü, C., Sang, J., He, H., Wan, X., Lin, Y., Li, L., Li, Y., & Yu, C. (2016) · Scientific Reports · doi:10.1038/srep23522 · Cited by 104 · see citing works
Ripert, G., Racedo, S., Elie, A.-M., Jacquot, C., Bressollier, P., & Urdaci, M. C. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02815-15 · Cited by 103 · see citing works
Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy
Zhu, R., Chen, K., Zheng, Y., Zhang, H., Wang, J., Xia, Y., Dai, W., Wang, F., Shen, M., Cheng, P., et al. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.18013 · Cited by 100 · see citing works
Probiotics in Clinical Practice: An Overview
Zuccotti, G., Meneghin, F., Raimondi, C., Dilillo, D., Agostoni, C. V., Riva, E., & Giovannini, M. (2008) · Journal of International Medical Research · doi:10.1177/14732300080360s101 · Cited by 99 · see citing works
Impact of Probiotics on Risk Factors for Cardiovascular Diseases. A Review
Ebel, B., Lemetais, G., Beney, L., Cachon, R., Sokol, H., Langella, P., & Gervais, P. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.579361 · Cited by 97 · see citing works
Ojetti, V., Bruno, G., Ainora, M. E., Gigante, G. E., Rizzo, G., Roccarina, D., & Gasbarrini, A. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/740381 · Cited by 90 · see citing works
Self-citationLi, S., Huang, X.-L., Sui, J., Chen, S., Xie, Y., Deng, Y., Wang, J., Xie, L., Li, T., He, Y., et al. (2013) · European Journal of Pediatrics · doi:10.1007/s00431-013-2220-3 · Cited by 89 · see citing works
Review article: probiotics in gastrointestinal and liver diseases
Jonkers, D. M. A. E., & Stockbrügger, R. W. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03480.x · Cited by 88 · see citing works
Ghelardi, E., Celandroni, F., Salvetti, S., Gueye, S. A., Lupetti, A., & Senesi, S. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12848 · Cited by 85 · see citing works
Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections
Keikha, M., & Karbalaei, M. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01977-1 · Cited by 85 · see citing works
Lionetti, E., Indrio, F., Pavone, L., Borrelli, G., Cavallo, L., & Francavilla, R. (2010) · Helicobacter · doi:10.1111/j.1523-5378.2009.00743.x · Cited by 81 · see citing works
Soares, M. B., de Almada, C. N., Pereira, E. P. R., Ferreira, B. M., Balthazar, C. F., Khorshidian, N., Rocha, R. S., Xavier-Santos, D., da Cruz, A. G., Ranadheera, C. S., et al. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.06.029 · Cited by 81 · see citing works
Probiotics for Preventive Health
Minocha, A. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533608331177 · Cited by 80 · see citing works
Current Progress and Future Perspectives on the Use of Bacillus clausii
Ghelardi, E., y Abreu, A. T. A., Marzet, C. B., Calatayud, G. Á., Perez, M. I., & Castro, A. P. M. (2022) · Microorganisms · doi:10.3390/microorganisms10061246 · Cited by 79 · see citing works
Choi, G. H., Holzapfel, W. H., & Todorov, S. D. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2090227 · Cited by 78 · see citing works
Fakharian, F., Asgari, B., Nabavi-Rad, A., Sadeghi, A., Soleimani, N., Yadegar, A., & Zali, M. R. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.953718 · Cited by 78 · see citing works
Probiotics as a Treatment Strategy for Gastrointestinal Diseases?
Bergonzelli, G. E., Blum, S., Brüssow, H., & Corthesy-Theulaz, I. E. (2005) · Digestion · doi:10.1159/000087638 · Cited by 78 · see citing works
Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults
Liao, W., Chen, C., Wen, T., & Zhao, Q. (2020) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001464 · Cited by 77 · see citing works
Marianelli, C., Cifani, N., & Pasquali, P. (2010) · Research in Microbiology · doi:10.1016/j.resmic.2010.06.007 · Cited by 74 · see citing works
Lau, C. S. M., Ward, A. A., & Chamberlain, R. S. (2016) · Infection and Drug Resistance · doi:10.2147/idr.s117886 · Cited by 74 · see citing works
Probiotics, prebiotics and the gastrointestinal tract in health and disease
Vitetta, L., Briskey, D. R., Alford, H., Hall, S., & Coulson, S. (2014) · Inflammopharmacology · doi:10.1007/s10787-014-0201-4 · Cited by 72 · see citing works
Zhang, M., Zhang, C., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104403 · Cited by 70 · see citing works
Jafarnejad, S., Shab‐Bidar, S., Speakman, J. R., Parastui, K., Daneshi‐Maskooni, M., & Djafarian, K. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616639399 · Cited by 68 · see citing works
Bacillus clausii and gut homeostasis: state of the art and future perspectives
Lopetuso, L. R., Scaldaferri, F., Franceschi, F., & Gasbarrini, A. (2016) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2016.1200465 · Cited by 66 · see citing works
Self-citationYang, C., Liang, L., Lv, P., Liu, L., Wang, S., Wang, Z., & Chen, Y. (2021) · Helicobacter · doi:10.1111/hel.12856 · Cited by 65 · see citing works
Non-dairy probiotic beverages: the next step into human health
Gawkowski, D., & Chikindas, M. L. (2012) · Beneficial Microbes · doi:10.3920/bm2012.0030 · Cited by 64 · see citing works
Probiotics in the Prevention and Treatment of Gastrointestinal Infections
Huebner, E. S., & Surawicz, C. M. (2006) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2006.03.005 · Cited by 64 · see citing works
Probiotics for antibiotic-associated diarrhea: Do we have a verdict?
Issa, I. A., & Moucari, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17788 · Cited by 63 · see citing works
Treating Bugs with Bugs: The Role of Probiotics as Adjunctive Therapy for Helicobacter pylori
Wilhelm, S. M., Johnson, J. L. H., & Kale-Pradhan, P. B. (2011) · Annals of Pharmacotherapy · doi:10.1345/aph.1q104 · Cited by 59 · see citing works
‘Rescue’ Therapies for the Management of Helicobacter pylori Infection
Mario, F. D., Cavallaro, L. G., & Scarpignato, C. (2006) · Digestive Diseases · doi:10.1159/000090315 · Cited by 58 · see citing works
Horosheva, T. V., Vodyanoy, V., & Sorokulova, I. (2014) · JMM Case Reports · doi:10.1099/jmmcr.0.004036 · Cited by 57 · see citing works
“Previously, the Bacillus clausii probiotic strain was found to be effective in the reduction of diarrhoea incidents related to anti-Helicobacter pylori antibiotic therapy (Nista et al., 2004).”
BackgroundOptimal Management of Peptic Ulcer Disease in the Elderly
Pilotto, A., Franceschi, M., Maggi, S., Addante, F., & Sancarlo, D. (2010) · Drugs & Aging · doi:10.2165/11537380-000000000-00000 · Cited by 57 · see citing works
Plomer, M., Perez, M. I., & Greifenberg, D. M. (2020) · Infectious Diseases and Therapy · doi:10.1007/s40121-020-00333-2 · Cited by 56 · see citing works
Bacillus clausii for Gastrointestinal Disorders: A Narrative Literature Review
Acosta-Rodríguez-Bueno, C. P., y Abreu, A. T. A., Guarner, F., Guno, M. J. V.-R., Pehlıvanoğlu, E., & Perez, M. I. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02285-0 · Cited by 56 · see citing works
Dajani, A. I., Hammour, A. A., Yang, D., Chung, P., Nounou, M., Yuan, K., Zakaria, M. A., & Schi, H. (2013) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.111953 · Cited by 56 · see citing works
Characterization, health benefits and applications of fruits and vegetable probiotics
James, A., & Wang, Y. (2019) · CyTA - Journal of Food · doi:10.1080/19476337.2019.1652693 · Cited by 56 · see citing works
Treatment of Helicobacter pylori
Bytzer, P. M., & O'Morain, C. A. (2005) · Helicobacter · doi:10.1111/j.1523-5378.2005.00333.x · Cited by 55 · see citing works
Sudha, M. R., Bhonagiri, S., & Kumar, M. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0034 · Cited by 53 · see citing works
Treatment of Helicobacter pylori Infection
Egan, B., Marzio, L., O'Connor, H. J., & O'Morain, C. A. (2008) · Helicobacter · doi:10.1111/j.1523-5378.2008.00639.x · Cited by 53 · see citing works
Role of Probiotics in Patients with Helicobacter pylori Infection
Franceschi, F., Cazzato, A., Nista, E. C., Scarpellini, E., Roccarina, D., Gigante, G. E., Gasbarrini, A., & Gasbarrini, A. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00565.x · Cited by 52 · see citing works
Self-citationCenci, G., Trotta, F., & Caldini, G. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.03042.x · Cited by 50 · see citing works
The Human Microbiome and Probiotics: Implications for Pediatrics
Hsieh, M. H., & Versalovic, J. A. (2008) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2008.09.001 · Cited by 48 · see citing works
Probiotics as an adjuvant treatment in Helicobacter pylori eradication therapy
Zhu, X. Y., & Liu, F. (2017) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12466 · Cited by 47 · see citing works
Effects of probiotics on the gastrointestinal tract
Snelling, A. M. (2005) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000182103.32504.e3 · Cited by 46 · see citing works
Wang, Y., Wang, X., Cao, X.-Y., Zhu, H., & Miao, L. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1120789 · Cited by 46 · see citing works
Morelli, S., Holdich, R. G., & Dragosavac, M. M. (2015) · Chemical Engineering Journal · doi:10.1016/j.cej.2015.12.024 · Cited by 45 · see citing works
Efficacy of probiotics in Helicobacter pylori eradication therapy
Yaşar, B., Abut, E., Kayadibi, H., TOROS, B., Sezikli, M., Akkan, Z., Keskin, Ö., & Kurdaş, O. Ö. (2010) · The Turkish Journal of Gastroenterology · doi:10.4318/tjg.2010.0090 · Cited by 44 · see citing works
Picó-Monllor, J. A., & Mingot-Ascencao, J. M. (2019) · Nutrients · doi:10.3390/nu11102322 · Cited by 43 · see citing works
Activities of muscadine grape skin and polyphenolic constituents againstHelicobacter pylori
Brown, J., & Jiang, X. (2013) · Journal of Applied Microbiology · doi:10.1111/jam.12129 · Cited by 43 · see citing works
de Castro, J.-A. A., Guno, M. J. V.-R., & Perez, M. I. (2019) · Tropical Diseases Travel Medicine and Vaccines · doi:10.1186/s40794-019-0089-5 · Cited by 42 · see citing works
Caro, S. D., Tao, H., Grillo, A., Franceschi, F., Elia, C., Zocco, M. A., Gasbarrini, A., Sepulveda, A. R., & Gasbarrini, A. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200509000-00011 · Cited by 41 · see citing works
Self-citationWorld Gastroenterology Organisation practice guideline: Probiotics and prebiotics
(2009) · Arab Journal of Gastroenterology · doi:10.1016/j.ajg.2009.03.001 · Cited by 39 · see citing works
Yoon, H., Kim, N., Kim, J. Y., Park, S. Y., Park, J. H., Jung, H. C., & Song, I. S. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06477.x · Cited by 38 · see citing works
Gong, Y., Li, Y., & Sun, Q. (2015) · PubMed Central · Cited by 38 · see citing works
Meta‐analysis: efficacy of bovine lactoferrin in Helicobacter pylori eradication
Sachdeva, A., & Nagpal, J. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.03934.x · Cited by 37 · see citing works
Mirza, M. A., Aruna, D., & Irukulla, M. M. (2022) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2022.100523 · Cited by 33 · see citing works
Wong‐Chew, R. M., de Castro, J.-A. A., Morelli, L., Perez, M. I., & Özen, M. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2085559 · Cited by 33 · see citing works
Chang, Y. W., Park, Y. M., Oh, C. H., Oh, S. J., Cho, J., Kim, J., & Jang, J. Y. (2019) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2019.139 · Cited by 32 · see citing works
Vázquez-Frías, R., Consuelo‐Sánchez, A., Acosta-Rodríguez-Bueno, C. P., Blanco-Montero, A., Robles, D. C., Cohen, V., Márquez, D., & Perez, M. I. (2022) · Pediatric Drugs · doi:10.1007/s40272-022-00536-9 · Cited by 32 · see citing works
Immunomodulatory and Antioxidant Properties of a Novel Potential Probiotic Bacillus clausii CSI08
Khokhlova, E. V., Colom, J., Simon, A., Mazhar, S., García‐Laínez, G., Llopis, S., González, N., Enrique-López, M., Álvarez, B., Martorell, P., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11020240 · Cited by 32 · see citing works
Scarpellini, E., Cazzato, A., Lauritano, C., Gabrielli, M., Lupascu, A., Gerardino, L., Abenavoli, L., Petruzzellis, C., Gasbarrini, G., & Gasbarrini, A. (2008) · Digestive Diseases · doi:10.1159/000116776 · Cited by 32 · see citing works
Self-citationTanashat, M., Abuelazm, M. T., Abouzid, M., Al‐Ajlouni, Y. A., Ramadan, A., Alsalah, S., Sharaf, A., Ayman, D., Elharti, H., Zhana, S. A., et al. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.11.016 · Cited by 30 · see citing works
Zojaji, H., Ghobakhlou, M., Rajabalinia, H., Ataei, E., Sherafat, S. J., Moghimi-Dehkordi, B., & Bahreiny, R. (2013) · Gastroenterology and hepatology from bed to bench. · Cited by 30 · see citing works
Efficacy of fermented milk and whey proteins in Helicobacter pylori eradication: A review
Sachdeva, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i3.724 · Cited by 30 · see citing works
Maity, C., & Gupta, A. K. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07993 · Cited by 29 · see citing works
Bleich, A., & Mähler, M. (2005) · Pathobiology · doi:10.1159/000091327 · Cited by 28 · see citing works
- Authors
- Nista, E. C., Candelli, M., Cremonini, F., Cazzato, I. A., Zocco, M. A., Franceschi, F., Cammarota, G., Gasbarrini, G., & Gasbarrini, A.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2004-11
- Volume
- 20
- Issue
- 10
- Pages
- 1181-1188
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2120773585
- Cited by
- 212
- References
- 27
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 12 · 2023: 15 · 2022: 29 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 2 · 2017: 9 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 16 · 2012: 11
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Bacillus clausii, probiotics, Helicobacter pylori eradication, antibiotic adverse effects, triple therapy, clarithromycin, amoxicillin, rabeprazole, nausea, diarrhea, epigastric pain, Helicobacter pylori infection
- MeSH terms
- Adolescent, Adult, Aged, Amoxicillin, Anti-Ulcer Agents, Bacillus, Benzimidazoles, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Omeprazole, Prospective Studies, Helicobacter pylori, Helicobacter Infections, Clarithromycin, Probiotics, 2-Pyridinylmethylsulfinylbenzimidazoles, Rabeprazole
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
