The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.
Review article: yeast as probiotics – Saccharomyces boulardii
Abstract
Summary: Background: Probiotics are defined as live micro‐organisms which confer a health benefit on the host. Although most probiotics are bacteria, one strain of yeast, Saccharomyces boulardii , has been found to be an effective probiotic in double‐blind clinical studies. Aims: To compare the main properties that differentiates yeast from bacteria and to review the properties of S. boulardii explaining its potential benefits as a probiotic. Methods: The PubMed and Medline databases were searched using the keywords ‘probiotics’, ‘yeast’, ‘antibiotic associated diarrhea’, ‘ Saccharomyces boulardii’, ‘bacterial diarrhea’ and ‘inflammatory bowel disease’ in various combinations. Results: Several clinical studies have been conducted with S. boulardii in the treatment and prevention of various forms of diarrhoea. Promising research perspectives have been opened in terms of maintenance treatment of inflammatory bowel diseases. The mechanism of S. boulardii ’s action has been partially elucidated. Conclusion: Saccharomyces boulardii is a strain of yeast which has been extensively studied for its probiotic effects. The clinical activity of S. boulardii is especially relevant to antibiotic‐associated diarrhoea and recurrent Clostridium difficile intestinal infections. Experimental studies clearly demonstrate that S. boulardii has specific probiotic properties, and recent data has opened the door for new therapeutic uses of this yeast as an ‘immunobiotic’.
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“In contrast, yeast probiotics like Saccharomyces boulardii are inherently antibiotic-resistant and effective against C. difficile and Helicobacter pylori.”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [4]
In the citing paper
“Key strains like Lactobacillus rhamnosus GG, Bifidobacterium, Bacillus spp., and Saccharomyces cerevisiae boulardii are given at 5–20 billion CFUs/d based on age.4,5”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [4]
In the citing paper
“They help treat acute diarrhea by restoring gut flora, strengthening mucosal barriers, and modulating immunity.1,4”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [4]
In the citing paper
“In contrast to bacterial probiotics, S. boulardii–based products lacked detectable ARGs or virulence factors while exhibiting intrinsic, non-transferable antibiotic resistance, supporting a comparatively favorable safety profile in high-risk clinical settings.4,9,36,37”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [4]
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Metadata
- Authors
- CZERUCKA, D., PICHE, T., & RAMPAL, P.
- Affiliations
- Inserm (FR)
- Princess Grace Hospital Centre (MC)
- Corresponding author
- CZERUCKA, D.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-07-19
- Volume
- 26
- Issue
- 6
- Pages
- 767-778
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2128822399
- Cited by
- 587
- References
- 77
- Citations by year
- 2026: 34 · 2025: 43 · 2024: 50 · 2023: 49 · 2022: 52 · 2021: 50 · 2020: 41 · 2019: 38 · 2018: 34 · 2017: 28 · 2016: 22 · 2015: 35 · 2014: 12 · 2013: 27 · 2012: 20
- FWCI
- 19.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Saccharomyces boulardii, probiotic yeast, antibiotic-associated diarrhea, Clostridium difficile infection, inflammatory bowel disease, immunobiotics, probiotic mechanisms of action, recurrent diarrhea
- MeSH terms
- Anti-Inflammatory Agents, Anti-Bacterial Agents, Diarrhea, Double-Blind Method, Humans, Saccharomyces, Treatment Outcome, Probiotics
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