The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Review article: lactose intolerance in clinical practice – myths and realities
Abstract
Summary: Background Approximately 70% of the world population has hypolactasia, which often remains undiagnosed and has the potential to cause some morbidity. However, not everyone has lactose intolerance, as several nutritional and genetic factors influence tolerance. Aims To review current clinical practice and identify published literature on the management of lactose intolerance. Methods PubMed was searched using the terms lactose, lactase and diet to find original research and reviews. Relevant articles and clinical experience provided the basis for this review. Results Lactose is found only in mammalian milk and is hydrolysed by lactase in the small intestine. The lactase gene has recently been identified. ‘Wild‐type’ is characterized by lactase nonpersistence, often leading to lactose intolerance. Two genetic polymorphisms responsible for persistence have been identified, with their distribution concentrated in north Europeans. Symptoms of lactose intolerance include abdominal pain, bloating, flatulence and diarrhoea. Diagnosis is most commonly by the lactose hydrogen breath test. However, most people with hypolactasia, if given appropriate advice, can tolerate some lactose‐containing foods without symptoms. Conclusion In clinical practice, some people with lactose intolerance can consume milk and dairy foods without developing symptoms, whereas others will need lactose restriction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Pimentel, M., Lin, H. C., Enayati, P., van den Burg, B., Lee, H.-R., Chen, J. H., Park, S., Kong, Y., & Conklin, J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00574.2004 · Cited by 508
Cambridge Handbook of Psychology, Health and Medicine
(2001) · doi:10.1017/cbo9780511543579 · Cited by 393
Cited by
Hammer, H. F., Fox, M. R., Keller, J., Salvatore, S., Basilisco, G., Hammer, J., Lopetuso, L., Benninga, M., Borrelli, O., Dumitrascu, D., et al. (2022) · United European Gastroenterology Journal · doi:10.1002/ueg2.12133 · Cited by 189
Gastrointestinal malabsorption of thyroxine
Virili, C., Antonelli, A., Santaguida, M. G., Benvenga, S., & Centanni, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00168 · Cited by 164
Nutritional and Dietary Aspects of Celiac Disease
García‐Manzanares, Á., & Lucendo, A. J. (2011) · Nutrition in Clinical Practice · doi:10.1177/0884533611399773 · Cited by 142
Almeida, C. C., Lorena, S. L. S., Pavan, C. R., Akasaka, H. M. I., & Mesquita, M. A. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612440289 · Cited by 100
Schiller, L. R., Pardi, D. S., Spiller, R., Semrad, C. E., Surawicz, C. M., Giannella, R. A., Krejs, G. J., Farthing, M. J. G., & Sellin, J. H. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12392 · Cited by 95
Cow's Milk protein allergy as a model of food allergies
Giannetti, A., Toschi Vespasiani, G., Ricci, G., Miniaci, A., di Palmo, E., & Pession, A. (2021) · Nutrients · doi:10.3390/nu13051525 · Cited by 92
Blondin, S. A., Djang, H. C., Metayer, N., Anzman-Frasca, S., & Economos, C. D. (2015) · Public Health Nutrition · doi:10.1017/s1368980014002948 · Cited by 83
Production of coconut milk: A sustainable alternative plant-based milk
Tulashie, S. K., Amenakpor, J., Atisey, S., Odai, R., & Akpari, E. E. A. (2022) · Case Studies in Chemical and Environmental Engineering · doi:10.1016/j.cscee.2022.100206 · Cited by 77
Systematic appraisal of lactose intolerance as cause of increased need for oral thyroxine
Cellini, M., Santaguida, M. G., Gatto, I., Virili, C., Del Duca, S. C., Brusca, N., Capriello, S., Gargano, L., & Centanni, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1217 · Cited by 72
Gastrointestinal synthetic epithelial linings
Li, J., Wang, T., Kirtane, A. R., Shi, Y., Jones, A., Moussa, Z., Lopes, A., Collins, J., Tamang, S. M., Hess, K., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abc0441 · Cited by 70
MONTALTO, M., GALLO, A., SANTORO, L., D’ONOFRIO, F., CURIGLIANO, V., COVINO, M., CAMMAROTA, G., GRIECO, A., GASBARRINI, A., & GASBARRINI, G. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03815.x · Cited by 63
Evidence-based and mechanistic insights into exclusion diets for IBS
Moayyedi, P., Simrén, M., & Bercik, P. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0270-3 · Cited by 64
Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms—a Pilot Study
Gingold-Belfer, R., Levy, S., Layfer, O., Pakanaev, L., Niv, Y., Dickman, R., & Perets, T. T. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9507-7 · Cited by 46
The role of food storage in human niche construction: An example from Neolithic Europe
O'Brien, M. J., & Bentley, R. A. (2015) · Environmental Archaeology · doi:10.1179/1749631414y.0000000053 · Cited by 23
Jojima, T., Shinzawa, T., Ohira, E., Sakurai, S., Tomaru, T., Iijima, T., Kogai, T., Usui, I., & Aso, Y. (2022) · Endocrine Journal · doi:10.1507/endocrj.ej21-0656 · Cited by 6
Metadata
- Authors
- LOMER, M. C. E., PARKES, G. C., & SANDERSON, J. D.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-10-23
- Volume
- 27
- Issue
- 2
- Pages
- 93-103
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1716554424
- Cited by
- 566
- References
- 3
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
