The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
Open accessAbstract
Summary: Background: The intestinal microbiota is involved in the pathogenesis of inflammatory bowel disease ( IBD ). Faecal microbiota transplantation ( FMT ) has been used for the management of IBD as well as infectious diarrhoea. Aim: To undertake a systematic review of FMT in patients with IBD . Methods: The systematic review followed Cochrane and PRISMA recommendations. Nine electronic databases were searched in addition to hand searching and contacting experts. Inclusion criteria were reports ( RCT , nonrandomised trials, case series and case reports) of FMT in patients with IBD . Results: Of the 5320 articles identified, 17 fulfilled the inclusion criteria, none of which were controlled trials. There were nine case series/case reports of patients receiving FMT for management of their IBD , and eight where FMT was for the treatment of infectious diarrhoea in IBD . These 17 articles reported on 41 patients with IBD (27 UC , 12 Crohn's, 2 unclassified) with a follow‐up period of between 2 weeks and 13 years. Where reported, FMT was administered via colonoscopy/enema (26/33) or via enteral tube (7/33). In patients treated for their IBD , the majority experienced a reduction of symptoms (19/25), cessation of IBD medications (13/17) and disease remission (15/24). There was resolution of C. difficile infection in all those treated for such (15/15). Conclusions: Whilst the available evidence is limited and weak, it suggests that faecal microbiota transplantation has the potential to be an effective and safe treatment for IBD , at least when standard treatments have failed. Well‐designed randomised controlled trials are required to investigate these findings.
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Cited by
The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
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The gut microbiota and inflammatory bowel disease
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The chicken gastrointestinal microbiome
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Metadata
- Authors
- Anderson, J. L., Edney, R. J., & Whelan, K.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2012-07-25
- Volume
- 36
- Issue
- 6
- Pages
- 503-516
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2143358720
- Cited by
- 313
- References
- 61
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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