The gut microbiota and inflammatory bowel disease
Open accessAbstract
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gut. Although the precise cause of IBD remains unknown, the most accepted hypothesis of IBD pathogenesis to date is that an aberrant immune response against the gut microbiota is triggered by environmental factors in a genetically susceptible host. The advancement of next-generation sequencing technology has enabled identification of various alterations of the gut microbiota composition in IBD. While some results related to dysbiosis in IBD are different between studies owing to variations of sample type, method of investigation, patient profiles, and medication, the most consistent observation in IBD is reduced bacterial diversity, a decrease of Firmicutes, and an increase of Proteobacteria. It has not yet been established how dysbiosis contributes to intestinal inflammation. Many of the known IBD susceptibility genes are associated with recognition and processing of bacteria, which is consistent with a role of the gut microbiota in the pathogenesis of IBD. A number of trials have shown that therapies correcting dysbiosis, including fecal microbiota transplantation and probiotics, are promising in IBD.
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Increasing evidence suggests that the intestinal microbiota may play a role in the development of IBD.
“In addition, increasing evidence suggests that the intestinal microbiota may play a role in the development of IBD [48, 49].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [48]
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Community Structure Follows Simple Assembly Rules in Microbial Microcosms
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RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review
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- Authors
- Matsuoka, K., & Kanai, T.
- Affiliations
- Keio University (JP)
- ORCID
- Matsuoka, Katsuyoshi
- Venue
- Seminars in Immunopathology
- Published
- 2014-11-25
- Volume
- 37
- Issue
- 1
- Pages
- 47-55
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- PMC
- PMC4281375
- OpenAlex
- W2048830729
- Cited by
- 804
- References
- 79
- Citations by year
- 2026: 38 · 2025: 68 · 2024: 104 · 2023: 101 · 2022: 90 · 2021: 93 · 2020: 67 · 2019: 85 · 2018: 68 · 2017: 50 · 2016: 25 · 2015: 9 · 2014: 3 · 2013: 3
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Seminars in Immunopathology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Keio University
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Japan Society for the Promotion of Science (25460961)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, inflammatory bowel disease, dysbiosis, bacterial diversity, Firmicutes, Proteobacteria, IBD pathogenesis, fecal microbiota transplantation, probiotics, intestinal inflammation
- MeSH terms
- Humans, Intestines, Inflammatory Bowel Diseases, Microbiota
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