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Paroxetine and fluoxetine in pregnancy: a prospective, multicentre, controlled, observational study

Open access
Diav‐Citrin, Orna, Shechtman, Svetlana, Weinbaum, Dafna, Wajnberg, Rebecka, Avgil, Meytal, Di Gianantonio, Elena, Clementi, Maurizio, Weber‐Schoendorfer, Corinna, Schaefer, Christof, Ornoy, Asher·2008·British Journal of Clinical Pharmacology
DOI 10.1111/j.1365-2125.2008.03261.x
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Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In recent years there has been concern regarding the possibility that selective serotonin reuptake inhibitors (SSRIs) cause an increased rate of congenital cardiovascular anomalies. • As of today, there is still debate in the literature as to the possible effects of paroxetine and fluoxetine on the embryonic cardiovascular system. WHAT THIS STUDY ADDS • Based on prospective data from three Teratogen Information Services, we have demonstrated an increased rate of congenital cardiovascular anomalies among the offspring of fluoxetine‐ and paroxetine‐treated mothers. AIMS: Recent studies have suggested a possible association between maternal use of selective serotonin reuptake inhibitors (SSRIs) in early pregnancy and cardiovascular anomalies. The aim of the present study was to evaluate the teratogenic risk of paroxetine and fluoxetine. METHODS: This multicentre, prospective, controlled study evaluated the rate of major congenital anomalies after first‐trimester gestational exposure to paroxetine, fluoxetine or nonteratogens. RESULTS: We followed up 410 paroxetine, 314 fluoxetine first‐trimester exposed pregnancies and 1467 controls. After exclusion of genetic and cytogenetic anomalies, there was a higher rate of major anomalies in the SSRI groups compared with the controls [paroxetine 18/348 (5.2%), fluoxetine 12/253 (4.7%) and controls 34/1359 (2.5%)]. The main risk applied to cardiovascular anomalies [paroxetine 7/348 (2.0%), crude odds ratio (OR) 3.47, 95% confidence interval (CI) 1.13, 10.58; fluoxetine 7/253 (2.8%), crude OR, 4.81 95% CI 1.56, 14.71; and controls 8/1359 (0.6%)]. On logistic regression analysis only cigarette smoking of ≥10 cigarettes day−1 and fluoxetine exposure were significant variables for cardiovascular anomalies. The adjusted ORs for paroxetine and fluoxetine were 2.66 (95% CI 0.80, 8.90) and 4.47 (95% CI 1.31, 15.27), respectively. CONCLUSION: This study suggests a possible association between cardiovascular anomalies and first‐trimester exposure to fluoxetine.

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Metadata

Authors
Diav‐Citrin, O., Shechtman, S., Weinbaum, D., Wajnberg, R., Avgil, M., Di Gianantonio, E., Clementi, M., Weber‐Schoendorfer, C., Schaefer, C., & Ornoy, A.
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
2008-10-28
Volume
66
Issue
5
Pages
695-705
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
DOI
10.1111/j.1365-2125.2008.03261.x
OpenAlex
W1990280908
Cited by
207
References
5
FWCI
21.08
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Paroxetine and fluoxetine in pregnancy: a prospective, multicentre, controlled, observational study. https://app.cochat.ai/papers/10.1111/j.1365-2125.2008.03261.x
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Diav‐Citrin, O., Shechtman, S., Weinbaum, D., Wajnberg, R., Avgil, M., Di Gianantonio, E., Clementi, M., Weber‐Schoendorfer, C., Schaefer, C., & Ornoy, A. (2008). Paroxetine and fluoxetine in pregnancy: a prospective, multicentre, controlled, observational study. British Journal of Clinical Pharmacology. https://doi.org/10.1111/j.1365-2125.2008.03261.x

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