Expression of C‐IAP1, C‐IAP2 and SURVIVIN discriminates different types of lymphoid malignancies
Abstract
Summary: (De‐)regulation of apoptosis plays an important role in normal and malignant lymphopoiesis. Apoptosis‐regulating genes of the BCL‐2 family and the recently identified inhibitors of apoptosis (IAP) family have been implicated in different types of non‐Hodgkin lymphoma (NHL). To investigate whether expression of specific apoptosis‐regulating genes correlated with different types of lymphoid malignancies, we measured the expression of five BCL‐2 family genes, four IAP family genes and SMAC by real‐time quantitative polymerase chain reaction in patient samples. In total, 137 samples from B‐ and T‐cell acute lymphoblastic leukaemia (ALL), B‐cell chronic lymphocytic leukaemia (CLL), six different NHL types and three control tissue types were analysed. The data were further analysed using cluster and discriminant analysis. Three specific expression patterns were identified for CLL, ALL and NHL respectively. CLL samples, as well as B‐ALL and follicular lymphoma samples showed high similarity in the expression of these apoptosis‐regulating genes and could be distinguished from each other and other diseases and controls. Discriminant analysis identified three members of the IAP family, C‐IAP1, C‐IAP2 and SURVIVIN, as the most informative genes to discriminate between these lymphoid malignancies.
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BIRC3 is highly expressed in many hematologic malignant cells, such as CLL, MCL, FL, MZL, SMZL, and DLBCL, compared to other IAP family proteins.
“it is highly expressed in many hematologic malignant cells, such as CLL, MCL, follicular lymphoma (FL), marginal zone lymphoma (MZL), splenic marginal zone lymphoma (SMZL), and DLBCL, compared to the other members of the IAP family proteins [228, 229].”
From Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies (2020) · cites this paper as [228]
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Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
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- Authors
- de Graaf, A. O., Han van Krieken, J., Tönnissen, E., Wissink, W., van de Locht, L., Overes, I., Dolstra, H., de Witte, T., van der Reijden, B. A., & Jansen, J. H.
- Corresponding author
- Jansen, Joop H.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2005-08-31
- Volume
- 130
- Issue
- 6
- Pages
- 852-859
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2125201177
- Cited by
- 42
- References
- 30
- Citations by year
- 2020: 1 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 4 · 2012: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Haematology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Keywords
- cIAP1, cIAP2, survivin, inhibitor of apoptosis proteins, Bcl-2 family genes, Smac/DIABLO, apoptosis regulation, lymphoid malignancies, non-Hodgkin lymphoma, B-cell chronic lymphocytic leukaemia, acute lymphoblastic leukemia, follicular lymphoma, gene expression profiling, differential diagnosis
- MeSH terms
- Survivin, Diagnosis, Differential, Humans, Leukemia, Lymphoid, Lymphoma, Non-Hodgkin, Microtubule-Associated Proteins, Neoplasm Proteins, Proteins, Biomarkers, Tumor, Discriminant Analysis, Polymerase Chain Reaction, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Ubiquitin-Protein Ligases, Inhibitor of Apoptosis Proteins
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