Allergen‐loaded biodegradable poly(d,l‐lactic‐co‐glycolic) acid nanoparticles down‐regulate an ongoing Th2 response in the BALB/c mouse model
Open accessAbstract
Summary: Background and objective Biocompatible and biodegradable microparticles have gained interest as antigen delivery systems during the recent years. We investigated whether biodegradable poly(d,l‐lactic‐co‐glycolic) acid (PLGA) nanospheres could be used as allergen vehicles for few‐shot therapy of type I allergy. Methods The major birch pollen allergen Bet v 1 was encapsulated in PLGA nanospheres (PLGA‐Bet v 1). We examined the antigenicity and the immune response to PLGA‐Bet v 1 in a BALB/c mouse model. Results The antigenicity of Bet v 1 was largely unaffected by PLGA entrapment. When BALB/c mice were immunized subcutaneously with PLGA‐Bet v 1, they formed allergen‐specific IgG antibodies, but did not develop hypersensitivity to Bet v 1, as shown by type I skin tests. To evaluate their therapeutic potential, PLGA‐Bet v 1 with or without Al(OH)3 or non‐entrapped Bet v 1 with Al(OH)3 were used for single‐shot treatment of sensitized mice. Both groups treated with PLGA‐Bet v 1 developed high levels of Bet v 1‐specific IgG2a antibodies (P<0.01), whereas IgG1 levels decreased significantly (P<0.01). Moreover, T cells from mice treated with PLGA‐Bet v 1 showed IFN‐γ and IL‐10 production. The synthesis of these cytokines was enhanced in the groups where Al(OH)3 had been added to the vaccine formulation. Conclusion Allergen‐loaded PLGA nanoparticles modulate an ongoing Th2 response in the BALB/c mouse model, as demonstrated by down‐regulation of IgG1 and production of IFN‐γ and IL‐10. Our data strongly suggest that PLGA nanospheres can advantageously be used for formulations of allergen extracts or allergen derivatives for the few‐shot treatment of type I allergy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Subcutaneously applied NPs encapsulating Bet v1 induced comparable IgG1, IgG2a, and IgG2b titers in BALB/c mice as subcutaneous treatment with allergen plus aluminum.
“Subcutaneously applied NPs encapsulating the birch pollen allergen Bet v1 induced comparable IgG1, IgG2a and IgG2b titers in BALB/c mice as subcutaneous treatment with allergen combined with aluminum [55].”
From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [55]
The immune system is shifted towards a Th1 milieu depending on particle size.
“However, the immune system is shifted towards a Th1 milieu depending on particle size [4–6].”
From Characterization of Vibrio cholerae neuraminidase as an immunomodulator for novel formulation of oral allergy immunotherapy (2018) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692 · see citing works
Allergen immunotherapy: Therapeutic vaccines for allergic diseases A WHO position paper
Bousquet, J., Lockey, R. F., & Malling, H. ‐. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70271-4 · Cited by 1,582 · see citing works
PROPHYLACTIC INOCULATION AGAINST HAY FEVER
Noon, L. (1911) · The Lancet · doi:10.1016/s0140-6736(00)78276-6 · Cited by 1,343 · see citing works
Aalberse, R. C., van der Gaag, R., & van Leeuwen, J. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.2.722 · Cited by 740 · see citing works
Adjuvants — a balance between toxicity and adjuvanticity
Rk, G., Relyveld, E. H., Lindblad, E. B., Bizzini, B., Ben‐Efraim, S., & Gupta, C. K. (1993) · Vaccine · doi:10.1016/0264-410x(93)90190-9 · Cited by 546 · see citing works
Brewer, J. M., Conacher, M., Hunter, C. A., Mohrs, M., Brombacher, F., & Alexander, J. K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6448 · Cited by 442 · see citing works
The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells
Levings, M. K., Bacchetta, R., Schulz, U., & Roncarolo, M. G. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000067596 · Cited by 423 · see citing works
Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay
Carson, R. T., & Vignali, D. A. A. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(99)00069-1 · Cited by 404 · see citing works
JAROLIM, E., Rumpold, H., ENDLER, A. T., Ebner, H., Breitenbach, M., Scheiner, O., & Kraft, D. (1989) · Allergy · doi:10.1111/j.1398-9995.1989.tb04169.x · Cited by 218 · see citing works
Self-citationControlled release microparticles for vaccine development
O’Hagan, D. T., Jeffery, H., Roberts, M. J. J., McGee, J. P., & Davis, S. S. (1991) · Vaccine · doi:10.1016/0264-410x(91)90295-h · Cited by 149 · see citing works
Ball, T., Sperr, W. R., Valent, P., Lidholm, J., Spitzauer, S., Ebner, C., Kraft, D., & Valenta, R. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06 · Cited by 141 · see citing works
Raghuvanshi, R. S., Katare, Y. K., Lalwani, K., Ali, M. M., Singh, O., & Panda, A. K. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00342-3 · Cited by 140 · see citing works
Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity
Nixon, D. F., Hioe, C. E., Chen, P., Bian, Z., Kuebler, P., Li, M.-L., Qiu, H., Li, X.-M., Singh, M., Richardson, J. L., et al. (1996) · Vaccine · doi:10.1016/s0264-410x(96)00099-0 · Cited by 133 · see citing works
Igartúa, M., Hernández, R. M., Esquisabel, A., Rodríguez‐Gascón, A., Calvo, M. B., & Pedraz, J. L. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00077-7 · Cited by 105 · see citing works
Jepson, M. A., Simmons, N. L., O’Hagan, D. T., & Hirst, B. H. (2003) · Journal of drug targeting · doi:10.1080/10611860310001636502 · Cited by 101 · see citing works
Lam, X. M., Duenas, E. T., & Cleland, J. L. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.1088 · Cited by 100 · see citing works
Jensen‐Jarolim, E., Tejkl, M., Rohac, M., Schlerka, G., Scheiner, O., Kraft, D., Breitenbach, M., & Rumpold, H. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000235000 · Cited by 96 · see citing works
Self-citationLaschinger, M., Vajkoczy, P., & Engelhardt, B. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200212)32:12 · Cited by 82 · see citing works
Biodegradable PLGA microspheres as a delivery system for malaria synthetic peptide SPf66
Rosas, J. E., Hernández, R. M., Rodríguez‐Gascón, A., Igartúa, M., Guzmán, F., Patarroyo, M. E., & Pedraz, J. L. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00192-x · Cited by 67 · see citing works
Biodegradable microspheres containing influenza A vaccine: immune response in mice
Hilbert, A. K., Fritzsche, U., & Kissel, T. (1999) · Vaccine · doi:10.1016/s0264-410x(98)00323-5 · Cited by 67 · see citing works
Poly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system
Lima, K. M., & Júnior, J. M. R. (1999) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1999000200005 · Cited by 65 · see citing works
Allergen mimotopes in food enhance type I allergic reactions in mice
Jensen‐Jarolim, E., Wiedermann, U., Ganglberger, E., Zürcher, A. W., Stadler, B. M., Boltz‐Nitulescu, G., Scheiner, O., & Breiteneder, H. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1586 · Cited by 64 · see citing works
Self-citationA long-term follow-up study of hyposensitization with immunoblotting
Jensen‐Jarolim, E., Poulsen, L. K., Stadler, B. M., Mosbech, H., ØSterballe, O., Kraft, D., & Weeke, B. (1990) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(90)90043-4 · Cited by 62 · see citing works
Self-citationVenkataprasad, N. (1999) · Vaccine · doi:10.1016/s0264-410x(98)00372-7 · Cited by 55 · see citing works
Mechanisms of adjuvancy: I?metal oxides as adjuvants
Naim, J. O. (1997) · Vaccine · doi:10.1016/s0264-410x(97)00016-9 · Cited by 54 · see citing works
Wiedermann, U., Herz, U., Baier, K., Vrtala, S., Neuhaus‐Steinmetz, U., Bohle, B., Dekan, G., Renz, H. E., Ebner, C., Valenta, R., et al. (2001) · International Archives of Allergy and Immunology · doi:10.1159/000049496 · Cited by 51 · see citing works
Coombes, A. G. A., Scholes, P., Davies, M. C., Illum, L., & Davis, S. S. (1994) · Biomaterials · doi:10.1016/0142-9612(94)90165-1 · Cited by 50 · see citing works
Encapsulation of rotavirus into poly(lactide-co-glycolide) microspheres
Sturesson, C., Artursson, P., Ghaderi, R., Johansen, K., Mirazimi, A., Uhnoo, I., Svensson, L., Albertsson, A., & Carlfors, J. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00014-0 · Cited by 45 · see citing works
Chattaraj, S. C., Rathinavelu, A., & DAS, S. K. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00161-8 · Cited by 40 · see citing works
Preparation of 2,6-Dimethyl-4-arylpyridine- 3,5-dicarbonitrile: A Paired Electrosynthesis
Batanero, B., Barba, F., & Martı́n, A. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo016065h · Cited by 39 · see citing works
Spiers, I. D., Eyles, J. E., Baillie, L. W. J., Williamson, E. D., & Alpar, H. O. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001777324 · Cited by 37 · see citing works
Jones, D. (1995) · Vaccine · doi:10.1016/0264-410x(95)99876-j · Cited by 36 · see citing works
Tetanus toxoid loaded ‘preformed microspheres’ of cross-linked dextran
Diwan, M., Khar, R. K., & Talwar, G. P. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00140-2 · Cited by 28 · see citing works
The Immune Response to Intrinsic and Extrinsic Allergens: Determinants of Allergic Disease
Woodfolk, J. A., & Platts‐Mills, T. A. E. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000067595 · Cited by 24 · see citing works
A new synthetic absorbable suture.
Postlethwait, R. W., & Smith, B. M. (1975) · PubMed · Cited by 20 · see citing works
Tippett, J. (1999) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(05)70058-8 · Cited by 16 · see citing works
Daser, A., Bätjer, N., Kölsch, U., Kötz, K., Schmeling, H., Schou, C., & Harald, R. (1998) · International Archives of Allergy and Immunology · doi:10.1159/000024017 · Cited by 13 · see citing works
Sah, H., & Chien, Y. W. (1996) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1996.tb05872.x · Cited by 12 · see citing works
Igartua, M., Hernández, R. M., Gutierro, I., Gascón, A. R., & Pedraz, J. L. (2001) · Pharmaceutical Development and Technology · doi:10.1081/pdt-120000299 · Cited by 12 · see citing works
Henryk, S., Jośko, J., Jędrzejowska–Szypułka, H., Jarząb, B., & Döhler, K.-D. (1999) · PubMed · Cited by 11 · see citing works
Raghuvanshi, R. S., Singh, O., & Panda, A. K. (2002) · Drug Delivery · doi:10.1080/10426500290095557 · Cited by 11 · see citing works
Quantitative Evaluation of Passive Cutaneous Anaphylaxis (PCA) Using a Hand-Held Spectrophotometer.
Akiyama, H., Teshima, R., Akasaka, R., FUJIMORI, K., Goda, Y., Sawada, J., & TOYODA, M. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.1112 · Cited by 9 · see citing works
New Synthetic Absorbable Suture
Hudson, H. C., & Glenn, J. F. (1979) · The Journal of Urology · doi:10.1016/s0022-5347(17)56451-4 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- O'Hagan DT, 1993, Controlled release microparticles for vaccine development, J Drug Target, 1, 245
- Waldegrave W., 1986, Directive CEE 86/609, J Officiel Communautés, 358, 1
- Vordermeier HM, 1999, Synthetic delivery system for tuberculosis vaccines, immunological evaluation of the M. tuberculosis 38 kDa protein entrapped in biodegradable PLG microparticles, 17, 1814
- Batanero E, 2002, Biodegradable poly (dl‐lactide glycolide) microparticles as a vehicle for allergen‐specific vaccines, a study performed with Ole e 1, the main allergen of olive pollen, 67, 2369
- Sharif S, 1994, Proceedings of the International Symposium on Control Rel Bioact Mater, 292
- Katare YK, 2001, Effect of alum on in vitro release profile and immunogenicity of microencapsulated tetanus toxoid, Proc Int Symp Control Rel Bioact Mater, 28, 1059
Cited by
Sorted by citations
Minireview: Nanoparticles and the Immune System
Zolnik, B. S., González-Fernández, A., Sadrieh, N., & Dobrovolskaia, M. A. (2010) · Endocrinology · doi:10.1210/en.2009-1082 · Cited by 914 · see citing works
Biocompatibility of engineered nanoparticles for drug delivery
Naahidi, S., Jafari, M., Edalat, F., Raymond, K. P., Khademhosseini, A., & Chen, P. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.12.013 · Cited by 814 · see citing works
Synthesis and characterization of PLGA nanoparticles
Astete, C. E., & Sabliov, C. M. (2006) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856206775997322 · Cited by 782 · see citing works
Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells
Palomares, Ó., Akdis, M., Martín‐Fontecha, M., & Akdiş, C. A. (2017) · Immunological Reviews · doi:10.1111/imr.12555 · Cited by 336 · see citing works
Current understanding of interactions between nanoparticles and the immune system
Dobrovolskaia, M. A., Shurin, M. R., & Shvedova, A. A. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.12.022 · Cited by 313 · see citing works
The ABC of clinical and experimental adjuvants—A brief overview
Brunner, R., Jensen‐Jarolim, E., & Pali‐Schöll, I. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.10.005 · Cited by 140 · see citing works
Self-citationCell Delivery of Therapeutic Nanoparticles
McMillan, J., Batrakova, E. V., & Gendelman, H. E. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-416020-0.00014-0 · Cited by 137 · see citing works
Polymeric nanogels as vaccine delivery systems
Ferreira, S. A., Gama, M., & Vilanova, M. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.06.001 · Cited by 131 · see citing works
In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance
Pearson, R. M., Casey, L. M., Hughes, K. R., Miller, S. D., & Shea, L. D. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.005 · Cited by 113 · see citing works
Bennewitz, N. L., & Babensee, J. E. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.08.023 · Cited by 101 · see citing works
Blank, F., Gerber, P., Rothen-Rutishauser, B., Sakulkhu, U., Salaklang, J., De Peyer, K., Gehr, P., Nicod, L. P., Hofmann, H., Geiser, T., et al. (2011) · Nanotoxicology · doi:10.3109/17435390.2010.541293 · Cited by 97 · see citing works
Smarr, C. B., Yap, W. T., Neef, T., Pearson, R. M., Hunter, Z. N., Ifergan, I., Getts, D. R., Bryce, P. J., Shea, L. D., & Miller, S. D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505782113 · Cited by 94 · see citing works
Nanoparticulate Adjuvants and Delivery Systems for Allergen Immunotherapy
Rebouças, J. D. S., Esparza, I., Ferrer, M., Sanz, M. L., Irache, J. M., & Gamazo, C. (2012) · BioMed Research International · doi:10.1155/2012/474605 · Cited by 89 · see citing works
Recent advances in the use of nanoparticles for allergen‐specific immunotherapy
Pohlit, H., Bellinghausen, I., Frey, H., & Saloga, J. (2017) · Allergy · doi:10.1111/all.13199 · Cited by 84 · see citing works
Broos, S., Lundberg, K., Akagi, T., Kadowaki, K., Akashi, M., Greiff, L., Borrebaeck, C. A. K., & Lindstedt, M. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.05.004 · Cited by 72 · see citing works
Pfaar, O., Cazan, D., Klimek, L., Larenas‐Linnemann, D. E., & Calderón, M. A. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32835a11d6 · Cited by 61 · see citing works
Adjuvants for allergy vaccines
Moingeon, P. E. (2012) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.21688 · Cited by 61 · see citing works
Pali‐Schöll, I., Szöllösi, H., Starkl, P. M., Scheicher, B., Stremnitzer, C., Hofmeister, A., Roth‐Walter, F., Lukschal, A., Diesner, S. C., Zimmer, A., et al. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.03.003 · Cited by 60 · see citing works
Self-citationClinical use of adjuvants in allergen-immunotherapy
Klimek, L., Schmidt‐Weber, C. B., Kramer, M. F., Skinner, M. A., & Heath, M. D. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1292133 · Cited by 60 · see citing works
M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy
Roth-Walter, F., Schöll, I., Untersmayr, E., Fuchs, R., Boltz-Nitulescu, G., Weissenböck, A., Scheiner, O., Gabor, F., & Jensen-Jarolim, E. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.08.010 · Cited by 58 · see citing works
Self-citationJoshi, V. B., Adamcakova‐Dodd, A., Jing, X., Wongrakpanich, A., Gibson-Corley, K. N., Thorne, P. S., & Salem, A. K. (2014) · The AAPS Journal · doi:10.1208/s12248-014-9624-5 · Cited by 57 · see citing works
Pali‐Schöll, I., Herzog, R., Wallmann, J., Szalai, K., Brunner, R., Lukschal, A., Karagiannis, P., Diesner, S. C., & Jensen‐Jarolim, E. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03468.x · Cited by 56 · see citing works
Self-citationMucosal targeting of allergen-loaded microspheres by Aleuria aurantia lectin
Roth-Walter, F., Schöll, I., Untersmayr, E., Ellinger, A., Boltz-Nitulescu, G., Scheiner, O., Gabor, F., & Jensen-Jarolim, E. (2005) · Vaccine · doi:10.1016/j.vaccine.2004.11.052 · Cited by 55 · see citing works
Self-citationEffects of Caryota mitis profilin-loaded PLGA nanoparticles in a murine model of allergic asthma
Mei, L., Zeng, X., Liu, Z., Zhang, X., Ma, L., Xiao, X., Liu, X., & Yu, H. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s51633 · Cited by 53 · see citing works
Schöll, I., Boltz-Nitulescu, G., & Jensen-Jarolim, E. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.020 · Cited by 51 · see citing works
Self-citationAre nanomaterials a threat to the immune system?
Dwivedi, P. D., Misra, A., Shanker, R., & Das, M. (2009) · Nanotoxicology · doi:10.1080/17435390802604276 · Cited by 51 · see citing works
Hantusch, B., Pali‐Schöll, I., Harwanegg, C., Krieger, S., Becker, W., Spitzauer, S., Boltz‐Nitulescu, G., & Jensen‐Jarolim, E. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.10.002 · Cited by 48 · see citing works
Self-citationCarbohydrate modified ultrafine ceramic nanoparticles for allergen immunotherapy
Pandey, R. S., Sahu, S., Sudheesh, M. S., Madan, J., Kumar, M., & Dixit, V. K. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.02.004 · Cited by 47 · see citing works
Antigen-Specific Tolerance in Immunotherapy of Th2-Associated Allergic Diseases
Smarr, C. B., Bryce, P. J., & Miller, S. D. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013007046 · Cited by 47 · see citing works
Nanoparticle Based-immunotherapy Against Allergy
Gamazo, C., Gastaminza, G., Ferrer, M., Sanz, M. L., & Irache, J. M. (2014) · Immunotherapy · doi:10.2217/imt.14.63 · Cited by 46 · see citing works
Pohlit, H., Bellinghausen, I., Schömer, M., Heydenreich, B., Saloga, J., & Frey, H. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00458 · Cited by 44 · see citing works
Use of lectin-functionalized particles for oral immunotherapy
Diesner, S. C., Wang, X.-Y., Jensen-Jarolim, E., Untersmayr, E., & Gabor, F. (2012) · Therapeutic Delivery · doi:10.4155/tde.11.146 · Cited by 40 · see citing works
Self-citationBiodegradable PLGA Particles for Improved Systemic and Mucosal Treatment of Type I Allergy
Schöll, I., Kopp, T., Bohle, B., & Jensen-Jarolim, E. (2006) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2006.02.007 · Cited by 40 · see citing works
Self-citationA novel nanoparticulate adjuvant for immunotherapy with Lolium perenne
Gómez, S., Gamazo, C., Román, B. S., Grau, A., Espuelas, S., Ferrer, M., Sanz, M. L., & Irache, J. M. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.005 · Cited by 39 · see citing works
Salari, F., Varasteh, A., Vahedi, F., Hashemi, M., & Sankian, M. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.09.011 · Cited by 37 · see citing works
Marazuela, E. G., Prado, N., Moro, E., Fernández‐García, H., Villalba, M., Rodrı́guez, R., & Batanero, E. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02922.x · Cited by 37 · see citing works
Adjuvants and Vector Systems for Allergy Vaccines
Moingeon, P. E., Lombardi, V., Saint-Lu, N., Tourdot, S., Bodo, V., & Mascarell, L. (2011) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2011.03.001 · Cited by 34 · see citing works
Adjuvants for allergy immunotherapeutics
Gamazo, C., D’Amelio, C., Gastaminza, G., Ferrer, M., & Irache, J. M. (2017) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1348447 · Cited by 34 · see citing works
The Use of Adjuvants for Enhancing Allergen Immunotherapy Efficacy
Chesné, J., Schmidt‐Weber, C. B., & Bieren, J. E. (2015) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2015.08.009 · Cited by 33 · see citing works
Nanoparticle–allergen complexes for allergen immunotherapy
Felice, G. D., & Colombo, P. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s134630 · Cited by 33 · see citing works
Hajavi, J., Hashemi, M., & Sankian, M. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.03.040 · Cited by 30 · see citing works
Application of polymeric nanoparticles in immunotherapy
Craparo, E. F., & Bondı̀, M. L. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3283588c57 · Cited by 30 · see citing works
Peng, X., Liang, Y., Yin, Y., Liao, H., & Li, L. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.07.047 · Cited by 28 · see citing works
Román, B. S., Irache, J. M., Gómez, S., Gamazo, C., & Espuelas, S. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000189193 · Cited by 27 · see citing works
Rebouças, J. D. S., Irache, J. M., Camacho, A. I., Esparza, I., del Pozo, V., Sanz, M. L., Ferrer, M., & Gamazo, C. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.06.014 · Cited by 26 · see citing works
Nouri, H. R., Varasteh, A., Jaafari, M. R., Davies, J. M., & Sankian, M. (2015) · Immunologic Research · doi:10.1007/s12026-015-8659-8 · Cited by 24 · see citing works
Liu, M., Thijssen, S., Hennink, W. E., Garssen, J., van Nostrum, C. F., & Willemsen, L. E. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1053107 · Cited by 24 · see citing works
Recombinant allergens for immunotherapy. Where do we stand?
Niederberger, V., & Valenta, R. (2004) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200412000-00013 · Cited by 23 · see citing works
Debbage, P. L., & Thurner, G. C. (2010) · Pharmaceuticals · doi:10.3390/ph3113371 · Cited by 22 · see citing works
Role of nanostructures in allergy: Diagnostics, treatments and safety
Mayorga, C., Pérez‐Inestrosa, E., Rojo, J., Ferrer, M., & Montañez, M. I. (2021) · Allergy · doi:10.1111/all.14764 · Cited by 21 · see citing works
Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials
Himly, M., Mills-Goodlet, R., Geppert, M., & Duschl, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00471 · Cited by 21 · see citing works
Scheiblhofer, S., Machado, Y. J., Feinle, A., Thalhamer, J., Hüsing, N., & Weiss, R. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1203898 · Cited by 21 · see citing works
Genetic allergen modification in the development of novel approaches to specific immunotherapy
Mutschlechner, S., Deifl, S., & Bohle, B. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03317.x · Cited by 20 · see citing works
Palomares, F., Ramos‐Soriano, J., Gómez, F., Mascaraque, A., Bogas, G., Perkins, J. R., González, M., Torres, M. J., Díaz‐Perales, A., Rojo, J., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900553 · Cited by 20 · see citing works
Román, B. S., Espuelas, S., Gómez, S., Gamazo, C., Sanz, M. L., Ferrer, M., & Irache, J. M. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02654.x · Cited by 19 · see citing works
New and old adjuvants in allergen‐specific immunotherapy: With a focus on nanoparticles
Feng, Z., Yi, X., & Hajavi, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29941 · Cited by 17 · see citing works
Nanoparticles in allergen immunotherapy
Longo, A., Longo, V., & Colombo, P. (2021) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000782 · Cited by 15 · see citing works
Differences and similarities between sublingual immunotherapy of allergy and oral tolerance
Moingeon, P. E., & Mascarell, L. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.07.003 · Cited by 14 · see citing works
Turkish Guidelines for Diagnosis and Treatment of Allergic Rhinitis (ART)
Ecevit, M. C., Özcan, M., Can, İ. H., Tatar, E. Ç., Özer, S., Esen, E., Atan, D., Göde, S., Elsürer, Ç., Eryılmaz, A., et al. (2021) · Turkish Archives of Otorhinolaryngology · doi:10.4274/tao.2021.suppl.1 · Cited by 14 · see citing works
Peng, X., Liang, Y., Li, J., 蔺丽慧, Wang, J., Yin, Y., Liao, H., & Li, L. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.105172 · Cited by 12 · see citing works
Application of Nanoparticles for Immunotherapy of Allergic Rhinitis
Li, K., Jin, J., Yang, Y., Luo, X., Wang, Y., Xu, A., Hao, K., & Wang, Z. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s484327 · Cited by 10 · see citing works
Nanotoxicology: Towards Safety by Design
Andón, F. T., & Fadeel, B. (2014) · Advances in delivery science and technology · doi:10.1007/978-3-319-08084-0_14 · Cited by 10 · see citing works
Pali‐Schöll, I., DeBoer, D. J., Alessandri, C., Seida, A. A., Mueller, R. S., & Jensen‐Jarolim, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01697 · Cited by 10 · see citing works
Self-citationDiesner, S. C., Bergmayr, C., Wang, X.-Y., Heiden, D., Exenberger, S., Roth-Walter, F., Starkl, P., Ret, D., Pali-Schöll, I., Gabor, F., et al. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.03.017 · Cited by 9 · see citing works
Self-citationThe use of poly(D,L-lactic-co-glycolic) acid microspheres in the treatment of allergic disease
Reisacher, W. R., & Liotta, D. R. (2011) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0b013e328345013a · Cited by 8 · see citing works
Castenmiller, C., Nagy, N. A., Kroon, P. Z., Auger, L., Desgagnés, R., Martel, C., Mirande, L., Morel, B., Roberge, J., Stordeur, V., et al. (2023) · World Allergy Organization Journal · doi:10.1016/j.waojou.2023.100839 · Cited by 7 · see citing works
Boraschi, D., & Duschl, A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-386940-1.00010-6 · Cited by 7 · see citing works
Khakzad, M. R., Hajavi, J., Sadeghdoust, M., & Aligolighasemabadi, F. (2019) · International Journal of Polymeric Materials · doi:10.1080/00914037.2018.1561453 · Cited by 7 · see citing works
Boraschi, D., Fadeel, B., & Duschl, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809199-9.00013-6 · Cited by 6 · see citing works
The Significance of Nanoparticles in Medicine and Their Potential Application in Asthma
Tortorella, S. M., & Karagiannis, T. C. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0706-9_10 · Cited by 6 · see citing works
Nanoparticles in Allergen‐Delivery Systems for Allergen‐Specific Immunotherapy
Lee, J. H., Chandrawati, R., & Lee, N. A. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400223 · Cited by 5 · see citing works
Asymmetric IgG Antibodies Induced by Different Immunotherapies in a Murine Model of Allergy
Apicella, C., Roldan, E. R., Chiappetta, D. A., Molinari, C., Bregni, C., Dokmetjian, J. C., & Gentile, T. (2009) · Immunological Investigations · doi:10.1080/08820130903005961 · Cited by 5 · see citing works
Desensitizing mice to ovalbumin through subcutaneous microsphere immunotherapy (SMITH)
Reisacher, W. R., Liotta, D. R., Yazdi, S., & Putnam, D. A. (2011) · International Forum of Allergy & Rhinology · doi:10.1002/alr.20074 · Cited by 4 · see citing works
Haghnavaz, N., Rezaee, M. A., Pordel, S., Shobeiri, S. S., Dashti, M., Ansari, B., Khorrami, M., Moghadam, M., & Sankian, M. (2024) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2024.2410291 · Cited by 3 · see citing works
Vaccines as therapies for food allergies
Landers, J. J., & O’Konek, J. J. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.01.003 · Cited by 3 · see citing works
Sapin‐Minet, A., Clavreul, A., Garcion, E., Benoît, J., & Meneï, P. (2006) · Journal of neurosurgery · doi:10.3171/jns.2006.105.5.745 · Cited by 3 · see citing works
Nuevas formas farmacéuticas para el tratamiento de enfermedades alérgicas
Ferrer, M., Sanz, M. L., Gastaminza, G., del Pozo, V., de Souza, J., & Irache, J. M. (2012) · Anales del Sistema Sanitario de Navarra · doi:10.4321/s1137-66272012000100005 · Cited by 2 · see citing works
An Overview of Nanotechnological Approaches for the Diagnosis and Treatment of Allergic Illness
Sharma, B., & Deshmukh, R. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230828104015 · Cited by 2 · see citing works
Pordel, S., Rezaee, M. A., Moghadam, M., & Sankian, M. (2024) · Immunological Investigations · doi:10.1080/08820139.2023.2298397 · Cited by 2 · see citing works
New advances in allergy immunotherapy
Reisacher, W. R., & Schwanke, T. W. (2016) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0000000000000255 · Cited by 2 · see citing works
Vaccines Against Non-Infectious, Non-Cancer Novel Targets
Garside, D. A., Acevedo, R., Alsaadi, M., Nimmo, N., Gebril, A., Lamprou, D. A., Mullen, A. B., & Ferro, V. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-416603-5.00010-9 · Cited by 1 · see citing works
Nanoparticles as Adjuvant-Vectors for Vaccination
Espuelas, S., Gamazo, C., Blanco‐Prieto, M. J., & Irache, J. M. (2007) · CRC Press eBooks · doi:10.1201/9781420008449.ch20 · Cited by 1 · see citing works
Shape variation in cranium, mandible and teeth in selected mouse strains
Ağaç, D. K., Oktay, E., Onuk, B., Kabak, M., & Gündemir, O. (2024) · Anatomia Histologia Embryologia · doi:10.1111/ahe.13064 · Cited by 1 · see citing works
Solid Lipid and Polymeric Nanoparticles for Drug Delivery
Pedraz, J. L., Orive, G., Igartúa, M., Rodríguez‐Gascón, A., Hernández, R. M., Solinís, M. Á., & Esquisabel, A. (2003) · Wiley eBooks · doi:10.1002/9783527610419.ntls0116 · Cited by 1 · see citing works
Nanotechnology and Food Allergy
Mills, E. N. C., Aleexev, Y., & Mackie, A. R. (2011) · Wiley eBooks · doi:10.1002/9783527634798.ch13 · Cited by 1 · see citing works
Novel allergen preparations for use in allergen-specific immunotherapy
Neimert-Andersson, T. (2008) · Figshare
Bennewitz, N. L. (2004) · UPT. Syiah Kuala University Library (Syiah Kuala University)
Therapeutic Immune Tolerance Approaches for the Treatment of Allergic Disease
Smarr, C. B., Getts, D. R., & Miller, S. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801577-3.00011-3
Roth‐Walter, F., Untersmayr, E., Fuchs, R., Boltz‐Nitulescu, G., Scheiner, O., Gabor, F., & Jensen‐Jarolim, E. (2004)
Self-citationApplications of Nanomaterials for Activation and Suppression of Immune Responses
Shakya, A. K., & Nandakumar, K. S. (2014) · Advances in chemical and materials engineering book series · doi:10.4018/978-1-4666-6363-3.ch011
PLGA microparticles for oral allergen immunotherapy
Ratzinger, G., Roth‐Walter, F., Untersmayr, E., Michael, Jensen‐Jarolim, E., & Gabor, F. (2007)
Self-citationExpanding Allergen-specific Tr-1 CD4+ T cells to treat Allergic Asthma
Chakraborty, M. (2017) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/26039
Applications of Nanomaterials for Activation and Suppression of Immune Responses
Shakya, A. K., & Nandakumar, K. S. (2017) · IGI Global eBooks · doi:10.4018/978-1-5225-1798-6.ch034
Innovative approaches to immunization
O’Konek, J. J., & Baker, J. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-96018-2.00074-2
Biodegradable particles as vaccine delivery systems
Joshi, V. B., Salem, A. K., Donovan, M. D., Flanagan, D. R., Thorne, P. S., & Stevens, L. L. (2014) · doi:10.17077/etd.q3wwcov7
- Authors
- Schöll, I., Weissenböck, A., Förster‐Waldl, E., Untersmayr, E., Walter, F., Willheim, M., Boltz‐Nitulescu, G., Scheiner, O., Gabor, F., & Jensen‐Jarolim, E.
- Affiliations
- University of Vienna (AT)
- Corresponding author
- Jensen‐Jarolim, E.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2004-02
- Volume
- 34
- Issue
- 2
- Pages
- 315-321
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W2050131389
- Semantic Scholar
- 042d1f3daa4036d07518d86fa745bc22fc70e1cd
- Cited by
- 95
- References
- 45
- Citations by year
- 2024: 5 · 2023: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 11 · 2016: 3 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 10
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical & Experimental Allergy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Austrian Science Fund
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- PLGA nanospheres, Bet v 1, birch pollen allergen, type I allergy, allergen-specific IgG1, IgG2a, interferon-gamma, IL-10, adjuvants, aluminum hydroxide, allergen immunotherapy, antigen delivery
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Allergens, Animals, Antibodies, Biodegradation, Environmental, Desensitization, Immunologic, Female, Hypersensitivity, Immunoglobulin G, Mice, Inbred BALB C, Plant Proteins, Polyglycolic Acid, Polymers, Skin Tests, T-Lymphocytes, Th2 Cells, Lactic Acid, Nanotubes, Mice, Antigens, Plant
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review