The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota
Open accessAbstract
Summary: We conducted a placebo-controlled, cross-over trial to examine the effect of Lactobacillus casei Shirota (LcS) on natural killer (NK) cell activity in humans. NK cell activity exhibited a declining trend during the period of placebo ingestion, but NK cell activity increased after intake for 3 weeks of fermented milk containing 4 × 1010 live LcS. When human peripheral blood mononuclear cells were cultured in the presence of heat-killed LcS, NK cell activity was enhanced. The ability of LcS to enhance NK cell activity and induce interleukin (IL)-12 production was correlated, and the addition of anti-IL-12 monoclonal antibody reduced the enhancement of NK cell activity triggered by LcS. In addition, separation of NK cells from LcS-stimulated monocytes with membrane filter reduced NK cell activity to the intermediate level and almost deprived monocytes of the ability to produce IL-12. These results demonstrate that LcS can enhance NK cell activity in vivo and in vitro in humans, and IL-12 may be responsible for enhancement of NK cell activity triggered by LcS.
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Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485
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Metadata
- Authors
- Takeda, K., Suzuki, T., Shimada, S.-I., Shida, K., Nanno, M., & Okumura, K.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-08-16
- Volume
- 146
- Issue
- 1
- Pages
- 109-115
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W2016840712
- Cited by
- 171
- References
- 1
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Takeda, K., Suzuki, T., Shimada, S.-I., Shida, K., Nanno, M., & Okumura, K. (2006). Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota. Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.2006.03165.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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