The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice
Open accessAbstract
Summary: Cytokines may be crucially involved in the pathogenesis of inflammatory bowel diseases (IBD), but it remains controversial whether interferon (IFN)-γ, a typical proinflammatory cytokine, is an essential mediator to cause the disorders. In the present study, IFN-γ–/– and wild-type (WT) C57BL/6 mice were fed 2·5% dextran sodium sulphate (DSS) in drinking water for 7 days, in order to investigate DSS-induced intestinal inflammation. The DSS-treated WT mice exhibited a robust production of IFN-γ in the gut, a remarkable loss of body weight, as well as high rate of mortality (60%). In striking contrast, IFN-γ deficient mice did not develop DSS-induced colitis, as indicated by the maintenance of body weight and survival rate of 100%. Severe intestinal inflammation was demonstrated exclusively in WT animals in terms of the shortening of the bowel as well as the elevation of the disease activity index, myeloperoxidase (MPO) activity and serum haptoglobin level. Histological study of DSS-treated WT intestine revealed disruption of mucosal epithelium and massive infiltration of inflammatory cells, while the organ from IFN-γ–/– mice remained virtually normal in appearance. Enzyme-linked immunosorbent assay (ELISA) analyses indicated abundant production of three chemokines, i.e. monokine induced by interferon-γ (MIG), interferon-inducible protein 10 (IP-10) and monocyte chemoattractant protein-1 (MCP-1), in the DSS-irritated intestine of WT but not of IFN-γ–/– mice. The present results demonstrate clearly that IFN-γ plays indispensable roles in the initiation of DSS colitis, and some chemokines are produced in an IFN-γ-dependent fashion.
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Cites
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Cited by
Chronic inflammation and cytokines in the tumor microenvironment
Landskron, G., De la Fuente, M., Thuwajit, P., Thuwajit, C., & Hermoso, M. A. (2014) · Journal of Immunology Research · doi:10.1155/2014/149185 · Cited by 1,765
Nava, P., Koch, S., Laukoetter, M. G., Lee, W. Y., Kolegraff, K., Capaldo, C. T., Beeman, N., Addis, C., Gerner-Smidt, K., Neumaier, I., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.001 · Cited by 337
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
Imam, T., Park, S., Kaplan, M. H., & Olson, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01212 · Cited by 267
Takedatsu, H., Michelsen, K. S., Wei, B., Landers, C. J., Thomas, L. S., Dhall, D., Braun, J., & Targan, S. R. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.037 · Cited by 254
Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis
Wang, X., Lin, S., Wang, L., Cao, Z., Zhang, M., Zhang, Y., Liu, R., & Liu, J. (2023) · Science Advances · doi:10.1126/sciadv.ade5079 · Cited by 220
Metadata
- Authors
- Ito, R., Shin-Ya, M., Kishida, T., Urano, A., Takada, R., Sakagami, J., Imanishi, J., Kita, M., Ueda, Y., Iwakura, Y., Kataoka, K., Okanoue, T., & Mazda, O.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-27
- Volume
- 146
- Issue
- 2
- Pages
- 330-338
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W2022245027
- Cited by
- 364
- References
- 64
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Ito, R., Shin-Ya, M., Kishida, T., Urano, A., Takada, R., Sakagami, J., Imanishi, J., Kita, M., Ueda, Y., Iwakura, Y., Kataoka, K., Okanoue, T., & Mazda, O. (2006). Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice. Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.2006.03214.x
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