Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Routy, B., Le Chatelier, E., Derosa, L., Duong, C. P. M., Alou, M. T., Daillère, R., Fluckiger, A., Messaoudene, M., Rauber, C., Roberti, M. P., et al. (2018) · Science · doi:10.1126/science.aan3706 · Cited by 5,671 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., et al. (2018) · Science · doi:10.1126/science.aan4236 · Cited by 4,812 · see citing works

Proteobacteria: Microbial signature of dysbiosis in gut microbiota

Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954 · see citing works

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Peterson, L. W., & Artis, D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3608 · Cited by 3,191 · see citing works

IL-10: The Master Regulator of Immunity to Infection

Couper, K. N., Blount, D. G., & Riley, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5771 · Cited by 2,220 · see citing works

Immunotherapy in colorectal cancer: Rationale, challenges and potential

Ganesh, K., Stadler, Z. K., Cercek, A., Mendelsohn, R. B., Shia, J., Segal, N. H., & Diaz, L. A. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0126-x · Cited by 1,954 · see citing works

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

Schwechheimer, C., & Kuehn, M. J. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3525 · Cited by 1,932 · see citing works

Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

Davar, D., Dzutsev, A. K., McCulloch, J. A., Rodrigues, R. R., Chauvin, J.-M., Morrison, R. M., Deblasio, R. N., Menna, C., Ding, Q., Pagliano, O., et al. (2021) · Science · doi:10.1126/science.abf3363 · Cited by 1,781 · see citing works

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

Paone, P., & Cani, P. D. (2020) · Gut · doi:10.1136/gutjnl-2020-322260 · Cited by 1,602 · see citing works

Reciprocal interactions of the intestinal microbiota and immune system

Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598 · cited 1× · see citing works

PD-L1 as a biomarker of response to immune-checkpoint inhibitors

Doroshow, D. B., Bhalla, S., Beasley, M. B., Sholl, L. M., Kerr, K. M., Gnjatic, S., Wistuba, I. I., Rimm, D. L., Tsao, M. S., & Hirsch, F. R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00473-5 · Cited by 1,575 · see citing works

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

Zuo, T., Zhang, F., Lui, G. C. Y., Yeoh, Y. K., Li, A. Y. L., Zhan, H., Wan, Y., Chung, A. C. K., Cheung, C. P., Chen, N., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.048 · Cited by 1,537 · see citing works

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

Ma, C., Han, M., Heinrich, B., Fu, Q., Zhang, Q., Sandhu, M., Agdashian, D., Terabe, M., Berzofsky, J. A., Fako, V., et al. (2018) · Science · doi:10.1126/science.aan5931 · Cited by 1,508 · see citing works

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363 · see citing works

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286 · see citing works

Gut Bacteroides species in health and disease

Zafar, H., & Saier, M. H. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1848158 · Cited by 1,258 · see citing works

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136 · cited 1× · see citing works

Environmental triggers in IBD: a review of progress and evidence

Ananthakrishnan, A. N., Bernstein, C. N., Iliopoulos, D., Macpherson, A., Neurath, M. F., Ali, R. A. R., Vavricka, S. R., & Fiocchi, C. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.136 · Cited by 948 · see citing works

Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

Chelakkot, C., Choi, Y., Kim, D., Park, H. T., Ghim, J., Kwon, Y., Jeon, J., Kim, M.-S., Jee, Y., Gho, Y. S., et al. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.282 · Cited by 852 · see citing works

Bacteroides thetaiotaomicron and Faecalibacterium prausnitziiinfluence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

Wrzosek, L., Miquel, S., Noordine, M.-L., Bouet, S., Curt, M. J.-C., Robert, V., Philippe, C., Bridonneau, C., Cherbuy, C., Masselot, C. R., et al. (2013) · BMC Biology · doi:10.1186/1741-7007-11-61 · Cited by 807 · see citing works

Regulation of the intestinal barrier by nutrients: The role of tight junctions

Suzuki, T. (2020) · Animal Science Journal · doi:10.1111/asj.13357 · Cited by 754 · see citing works

Targeting immune cell circuits and trafficking in inflammatory bowel disease

Neurath, M. F. (2019) · Nature Immunology · doi:10.1038/s41590-019-0415-0 · Cited by 703 · see citing works

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

Yang, W., & Cong, Y. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00661-4 · Cited by 701 · see citing works

Gut microbiota utilize immunoglobulin A for mucosal colonization

Donaldson, G. P., Ladinsky, M. S., Yu, K. B., Sanders, J. G., Yoo, B. B., Chou, W., Conner, M. E., Earl, A. M., Knight, R. D., Björkman, P. J., et al. (2018) · Science · doi:10.1126/science.aaq0926 · Cited by 633 · see citing works

Our gut microbiome: The evolving inner self

Kundu, P., Blacher, E., Elinav, E., & Pettersson, S. (2017) · Cell · doi:10.1016/j.cell.2017.11.024 · Cited by 633 · see citing works

A purified membrane protein from <i>Akkermansia muciniphila</i> or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8 ⁺ T cells in mice

Wang, L., Tang, L., Feng, Y., Zhao, S., Han, M., Zhang, C., Yuan, G., Zhu, J., Cao, S., Wu, Q., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320105 · Cited by 630 · see citing works

Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

Ma, L., Ni, Y., Wang, Z., Tu, W., Ni, L., Zhuge, F., Zheng, A., Hu, L., Zhao, Y., Zheng, L., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1832857 · Cited by 596 · see citing works

The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair

Kuo, W., Zuo, L., Odenwald, M. A., Madha, S., Singh, G., Gurniak, C. B., Abraham, C., & Turner, J. R. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.08.047 · Cited by 537 · see citing works

International consensus conference on stool banking for faecal microbiota transplantation in clinical practice

Cammarota, G., Ianiro, G., Kelly, C. R., Mullish, B. H., Allegretti, J. R., Kassam, Z., Putignani, L., Fischer, M., Keller, J. J., Costello, S. P., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-319548 · Cited by 506 · cited 2× · see citing works

Occludin: Structure, function and regulation

FELDMAN, G., Mullin, J. M., & RYAN, M. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.009 · Cited by 485 · see citing works

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Weingarden, A. R., & Vaughn, B. P. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1290757 · Cited by 469 · see citing works

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

Plaza‐Díaz, J., Ruiz‐Ojeda, F. J., Vilchez-Padial, L. M., & Gil, Á. (2017) · Nutrients · doi:10.3390/nu9060555 · Cited by 432 · see citing works

IgA Responses to Microbiota

Bunker, J. J., & Bendelac, A. S. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.011 · Cited by 386 · see citing works

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

Mills, R. H., Dulai, P. S., Vázquez-Baeza, Y., Sauceda, C., Daniel, N., Gerner, R. R., Batachari, L. E., Malfavon, M., Zhu, Q., Weldon, K., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-021-01050-3 · Cited by 385 · see citing works

Tight junction proteins in gastrointestinal and liver disease

Zeisel, M. B., Dhawan, P., & Baumert, T. F. (2018) · Gut · doi:10.1136/gutjnl-2018-316906 · Cited by 373 · see citing works

Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice

Ito, R., Shin‐Ya, M., Kishida, T., Urano, A., Takada, R., Sakagami, J., Imanishi, J., Kita, M., Ueda, Y., Iwakura, Y., et al. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03214.x · Cited by 365 · see citing works

Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment

Cao, Z., Wang, X., Pang, Y., Cheng, S., & Liu, J. (2019) · Nature Communications · doi:10.1038/s41467-019-13727-9 · Cited by 340 · see citing works

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches

Reboldi, A., Arnon, T. I., Rodda, L. B., Atakilit, A., Sheppard, D., & Cyster, J. G. (2016) · Science · doi:10.1126/science.aaf4822 · Cited by 339 · see citing works

Bacteria and host interactions in the gut epithelial barrier

Ashida, H., Ogawa, M., Kim, M., Mimuro, H., & Sasakawa, C. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.741 · Cited by 335 · see citing works

Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria

Yue, Y., Xu, J., Li, Y., Cheng, K., Feng, Q., Ma, X., Ma, N., Zhang, T., Wang, X., Zhao, X., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00886-2 · Cited by 269 · see citing works

Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles

Hickey, C., Kuhn, K. A., Donermeyer, D. L., Porter, N. T., Jin, C., Cameron, E. A., Jung, H., Kaiko, G. E., Wegorzewska, M. M., Malvin, N. P., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.002 · Cited by 247 · see citing works

A microbial perspective of human developmental biology

Charbonneau, M. R., Blanton, L. V., DiGiulio, D. B., Relman, D. A., Lebrilla, C. B., Mills, D. A., & Gordon, J. I. (2016) · Nature · doi:10.1038/nature18845 · Cited by 246 · see citing works

Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment

Lv, J., Jia, Y., Li, J., Kuai, W., Li, Y., Guo, F., Xu, X., Zhao, Z., Lv, J., & Li, Z. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1638-6 · Cited by 242 · see citing works

Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection

Dillon, S. M., Lee, E. J., Kotter, C. V., Austin, G. L., Gianella, S., Siewe, B. T., Smith, D. M., LANDAY, A. L., McManus, M. C., Robertson, C. E., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.33 · Cited by 216 · see citing works

Diversity and dynamism of IgA−microbiota interactions

Huus, K. E., Petersen, C., & Finlay, B. B. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00506-1 · Cited by 198 · see citing works

Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route

Zhou, X. W., Zhang, X., Han, S., Dou, Y., Liu, M., Zhang, L., Guo, J., Shi, Q., Gong, G., Wang, R., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b04523 · Cited by 145 · see citing works

Akkermansia muciniphila : is it the Holy Grail for ameliorating metabolic diseases?

Yan, J., Sheng, L., & Li, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1984104 · Cited by 142 · see citing works

Fecal Myeloperoxidase as a Biomarker for Inflammatory Bowel Disease

Hansberry, D. R., Shah, K. C., Agarwal, P., & Agarwal, N. (2017) · Cureus · doi:10.7759/cureus.1004 · Cited by 141 · see citing works

Bacteroides thetaiotaomicron in the gut: Molecular aspects of their interaction

Zocco, M. A., Ainora, M. E., Gasbarrini, A., & Gasbarrini, A. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.04.003 · Cited by 138 · see citing works

Interaction of Bacterial Membrane Vesicles with Specific Species and Their Potential for Delivery to Target Cells

Tashiro, Y., Hasegawa, Y., Shintani, M., Takaki, K., Ohkuma, M., Kimbara, K., & Futamata, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00571 · Cited by 115 · see citing works

Microbiota-antibody interactions that regulate gut homeostasis

Weis, A. M., & Round, J. L. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.02.009 · Cited by 112 · see citing works

The role of the microbiota in human genetic adaptation

Suzuki, T. A., & Ley, R. E. (2020) · Science · doi:10.1126/science.aaz6827 · Cited by 110 · see citing works

A Soluble Fiber Diet Increases Bacteroides fragilis Group Abundance and Immunoglobulin A Production in the Gut

Nakajima, A., Sasaki, T., Itoh, K., Kitahara, T., Takema, Y., Hiramatsu, K., Ishikawa, D., Shibuya, T., Kobayashi, O., Osada, T., et al. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.00405-20 · Cited by 104 · see citing works

Regulation of epithelial proliferation by tight junction proteins

Farkas, A. E., Capaldo, C., & Nusrat, A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06556.x · Cited by 70 · see citing works

Eurotium cristatum , a Probiotic Fungus from Fuzhuan Brick Tea, and Its Polysaccharides Ameliorated DSS-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota

Lu, X., Jing, Y., Zhang, N., & Cao, Y. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c08301 · Cited by 68 · see citing works

Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

Sui, Q., Liu, D., Wu, J., Tang, J., Kong, L.-H., Han, K., Liao, L., Li, Y., Ou, Q., Xiao, B., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001498 · Cited by 66 · see citing works

Outer Membrane Vesicles (OMVs) of Pseudomonas aeruginosa Provide Passive Resistance but Not Sensitization to LPS-Specific Phages

Augustyniak, D., Olszak, T., & Drulis‐Kawa, Z. (2022) · Viruses · doi:10.3390/v14010121 · Cited by 61 · see citing works

Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis

Hiraishi, K., Zhao, F., Kurahara, L. H., Li, X., Yamashita, T., Hashimoto, T., Matsuda, Y., Sun, Z., Zhang, H., & Hirano, K. (2022) · Nutrients · doi:10.3390/nu14030649 · Cited by 60 · see citing works

<i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids

Wu, W., Kaicen, W., Bian, X., Yang, L., Ding, S., Li, Y., Li, S., Zhuge, A., & Li, L. (2023) · Microbial Biotechnology · doi:10.1111/1751-7915.14293 · Cited by 129 · see citing works

Bacterial therapies at the interface of synthetic biology and nanomedicine

Hahn, J., Ding, S., Im, J., Harimoto, T., Leong, K. W., & Danino, T. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00119-4 · Cited by 125 · see citing works

A Gas Therapy Strategy for Intestinal Flora Regulation and Colitis Treatment by Nanogel‐Based Multistage NO Delivery Microcapsules

Fu, Y., Zhao, X., Wang, L., Li, K., Jiang, N., Zhang, S., Wang, R., Zhao, Y., & Yang, W. M. (2024) · Advanced Materials · doi:10.1002/adma.202309972 · Cited by 103 · see citing works

Extracellular vesicles derived from Lactobacillus johnsonii promote gut barrier homeostasis by enhancing M2 macrophage polarization

Tao, S., Fan, J., Li, J., Wu, Z., Yao, Y., Wang, Z., Wu, Y., Liu, X., Xiao, Y., & Wei, H. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.011 · Cited by 102 · see citing works

Akkermansia muciniphila: A key player in gut microbiota-based disease modulation

Shaheen, N., Khursheed, W., Gurung, B., & Wang, S. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128317 · Cited by 99 · see citing works

Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice

Zheng, T., Hao, H., Liu, Q., Li, J., Yao, Y., Liu, Y., Zhang, T., Zhang, Z., & Yi, H. (2023) · Nutrients · doi:10.3390/nu15224722 · Cited by 91 · see citing works

Engineered bacterial outer membrane vesicles: a versatile bacteria-based weapon against gastrointestinal tumors

Zheng, K., Feng, Y., Li, L., Kong, F., Gao, J., & Kong, X. (2024) · Theranostics · doi:10.7150/thno.85917 · Cited by 88 · see citing works

Novel mechanism by which extracellular vesicles derived from Lactobacillus murinus alleviates deoxynivalenol-induced intestinal barrier disruption

Fan, J., Zhang, Y., Zuo, M., Ding, S., Li, J., Feng, S., Xiao, Y., & Tao, S. (2024) · Environment International · doi:10.1016/j.envint.2024.108525 · Cited by 87 · see citing works

Roseburia intestinalis ‐derived extracellular vesicles ameliorate colitis by modulating intestinal barrier, microbiome, and inflammatory responses

Han, H. S., Hwang, S., Choi, K. Y., Hitayezu, E., Mabwi, H. A., Enkhbayar, A., Song, D., Kim, M., Park, J. S., Park, Y., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12487 · Cited by 71 · see citing works

Bifidobacterium longum NSP001-derived extracellular vesicles ameliorate ulcerative colitis by modulating T cell responses in gut microbiota-(in)dependent manners

Nie, X., Li, Q., Ji, H., Zhang, S., Wang, Y., Xie, J., & Nie, S. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00663-4 · Cited by 68 · see citing works

Extracellular Vesicles from Nanomedicine‐Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis

Zu, M., Liu, G., Xu, H., Zhu, Z., Zhen, J., Li, B., Shi, X., Shahbazi, M., Reis, R. L., Kundu, S. C., et al. (2024) · Advanced Materials · doi:10.1002/adma.202409138 · Cited by 62 · see citing works

Immunomodulatory Effects of Probiotic-Derived Extracellular Vesicles: Opportunities and Challenges

Chen, X., Li, Q., Xie, J., & Nie, S. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c04223 · Cited by 61 · see citing works

Bacterial Outer Membrane Vesicles: Role in Pathogenesis and Host-Cell Interactions

Magaña, G., Harvey, C., Taggart, C. C., & Rodgers, A. M. (2023) · Antibiotics · doi:10.3390/antibiotics13010032 · Cited by 60 · see citing works

Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

Hu, S., Zhao, R., Xu, Y., Gu, Z., Zhu, B., & Hu, J. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb02302h · Cited by 60 · see citing works

Inflammation-targeted delivery of probiotics for alleviation of colitis and associated cognitive disorders through improved vitality and colonization

Chen, Y., Shui, M., Li, H., Guo, M., Yuan, Q., Hao, W., Wang, T., Zhou, H., Chen, Z., & Wang, S. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123163 · Cited by 61 · see citing works

Gastrointestinal Self-Adaptive and Nutrient Self-Sufficient Akkermansia muciniphila–Gelatin Porous Microgels for Synergistic Therapy of Ulcerative Colitis

Zhang, Y., Wang, Y., Zhang, X., Wang, P., Shi, F., Zhang, Z., Wang, R., Wu, D., & She, J. (2024) · ACS Nano · doi:10.1021/acsnano.4c07658 · Cited by 57 · see citing works

Bacterial extracellular vesicles: An emerging postbiotic

Xie, J., Li, Q., & Nie, S. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104275 · Cited by 56 · see citing works

Bacterial extracellular vesicles at the interface of gut microbiota and immunity

Melo-Marques, I., Cardoso, S. M., & Empadinhas, N. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2396494 · Cited by 59 · see citing works

Bacterial Outer Membrane Vesicles and Immune Modulation of the Host

Charpentier, L. A., Dolben, E. F., Hendricks, M. R., Hogan, D. A., Bomberger, J. M., & Stanton, B. A. (2023) · Membranes · doi:10.3390/membranes13090752 · Cited by 56 · see citing works

Microbe-material hybrids for therapeutic applications

Chen, M., Xia, L., Wu, C., Wang, Z., Ding, L. S., Xie, Y., Feng, W., & Chen, Y. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00655g · Cited by 55 · see citing works

Gut commensal bacteria Parabacteroides goldsteinii-derived outer membrane vesicles suppress skin inflammation in psoriasis

Su, D., Li, M., Xie, Y., Xu, Z., Lv, G., Jiu, Y., Lin, J., Chang, C., Chen, H., & Cheng, F. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.11.014 · Cited by 53 · see citing works

Recent progress on engineered micro/nanomaterials mediated modulation of gut microbiota for treating inflammatory bowel disease

Kan, L., Zheng, Z., Fu, W., Ma, Y., Wang, W., Qian, H., & Xu, L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.04.014 · Cited by 51 · see citing works

Akkermansia muciniphila - friend or foe in colorectal cancer?

Gubernatorova, E. O., Gorshkova, E. A., Bondareva, M. A., Podosokorskaya, O. A., Sheynova, A. D., Yakovleva, A. S., Bonch-Osmolovskaya, E. A., Nedospasov, S. A., Kruglov, A., & Drutskaya, M. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1303795 · Cited by 47 · see citing works

The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication

Zhang, X., Wang, Y., Qiyu, E., Naveed, M., Wang, X., Liu, Y., & Li, M. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03435-6 · Cited by 47 · see citing works

Breaking down barriers: is intestinal mucus degradation by Akkermansia muciniphila beneficial or harmful?

Tingler, A. M., & Engevik, M. A. (2025) · Infection and Immunity · doi:10.1128/iai.00503-24 · Cited by 53 · see citing works

Nanocrystalline Cellulose Modulates Dysregulated Intestinal Barriers in Ulcerative Colitis

Wang, M., Cha, R., Hao, W., & Jiang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c04569 · Cited by 46 · see citing works

Hyaluronic Acid‐Nanocoated Bacteria Generate an Anti‐Inflammatory Tissue‐Repair Effect in Impaired Gut and Extraintestinal Organs

Deng, B., Lin, S., Wang, Y., Zhang, M., Shen, Y., Zhou, P., Shen, A., Wang, L., Ding, F. H., & Liu, J. (2024) · Advanced Materials · doi:10.1002/adma.202412783 · Cited by 46 · see citing works

Oral Microto-Nano Genome-Editing System Enabling Targeted Delivery and Conditional Activation of CRISPR-Cas9 for Gene Therapy of Inflammatory Bowel Disease

Lin, S., Han, S., Wang, X., Wang, X., Shi, X., He, Z., Sun, M., & Sun, J. (2024) · ACS Nano · doi:10.1021/acsnano.4c07750 · Cited by 46 · see citing works

Fusobacterium nucleatum ‐Derived Outer Membrane Vesicles Promote Immunotherapy Resistance via Changes in Tryptophan Metabolism in Tumour‐Associated Macrophages

Li, W., Zhang, Z., Wu, R., Mao, M., Ji, Y., Wang, X., Dou, S., Yan, M., & Chen, W. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70070 · Cited by 46 · see citing works

Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host

Nie, X., Li, Q., Chen, X., Onyango, S. O., Xie, J., & Nie, S. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127733 · Cited by 44 · see citing works

Dietary Lactobacillus johnsonii -derived extracellular vesicles ameliorate acute colitis by regulating gut microbiota and maintaining intestinal barrier homeostasis

Li, Z., Li, M., Fang, X., Yu, D., & Hu, X. (2024) · Food & Function · doi:10.1039/d4fo04194a · Cited by 42 · see citing works

From trash to treasure: the role of bacterial extracellular vesicles in gut health and disease

Sun, D., Chen, P., Xi, Y., & Sheng, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1274295 · Cited by 39 · see citing works

Roles of bacterial extracellular vesicles in systemic diseases

Wang, Y., Luo, X., Xiang, X., Hao, C., & Ma, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1258860 · Cited by 38 · see citing works

Surface nanocoating of bacteria as a versatile platform to develop living therapeutics

Cao, Z., & Liu, J.-Y. (2024) · Nature Protocols · doi:10.1038/s41596-024-01019-6 · Cited by 33 · see citing works

The emerging role of bacterial extracellular vesicles in human cancers

Liang, A., Korani, L., Yeung, C. L. S., Tey, S. K., & Yam, J. W. P. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12521 · Cited by 37 · see citing works

Outer membrane vesicles from genetically engineered Salmonella enterica serovar Typhimurium presenting Helicobacter pylori antigens UreB and CagA induce protection against Helicobacter pylori infection in mice

Liu, Q., Shang, Y., Lu, S., Yu, X., Cao, Y., Zeng, L., Zhang, H., Rao, Z., Li, Y., Tao, Z., et al. (2024) · Virulence · doi:10.1080/21505594.2024.2367783 · Cited by 36 · see citing works

Colon health benefits of plant-derived exosome-like nanoparticles via modulating gut microbiota and immunity

Han, Y., Guo, X., Ji, Z., Guo, Y., Ma, W., Du, H., Guo, Y., & Xiao, H. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2479066 · Cited by 36 · see citing works

Review of the Potential of Probiotics in Disease Treatment: Mechanisms, Engineering, and Applications

Liu, M., Chen, J., Dharmasiddhi, I. P. W., Chen, S., Liu, Y., & Liu, H. (2024) · Processes · doi:10.3390/pr12020316 · Cited by 35 · see citing works

Bacterial membrane vesicles in the pathogenesis and treatment of inflammatory bowel disease

Olovo, C. V., Ocansey, D. K. W., Ji, Y., Huang, X., & Xu, M. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2341670 · Cited by 32 · see citing works

Bacterial extracellular vesicles for gut microbiome–host communication and drug development

Qian, D., Xu, P., Wang, X., Du, C., Zhao, X., & Xu, J. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.03.008 · Cited by 36 · see citing works

Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis

Yue, N., Zhao, H., Hu, P., Zhang, Y., Tian, C., Chen, K., Mai, Z., Huang, L., Luo, Q., Wei, D., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03158-8 · Cited by 33 · see citing works

Odoribacter splanchnicus-derived extracellular vesicles alleviate inflammatory bowel disease by modulating gastrointestinal inflammation and intestinal barrier function via the NLRP3 inflammasome suppression

Zhuang, J., Zhuang, Z.-C., Chen, B., Yang, Y., Chen, H.-K., & Guan, G.-X. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01063-2 · Cited by 33 · see citing works

Bacterial extracellular vesicles in the initiation, progression and treatment of atherosclerosis

Lin, Y., Wang, J., Bu, F., Zhang, R., Wang, J., Wang, Y., Huang, M., Huang, Y., Zheng, L., Wang, Q., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2452229 · Cited by 31 · see citing works

Navigating the duality of Akkermansia muciniphila

Grant, E. T., Monzel, E., & Desai, M. S. (2026) · Nature Microbiology · doi:10.1038/s41564-025-02222-1 · Cited by 35 · see citing works

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

Chen, C., Beloqui, A., & Xu, Y. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115117 · Cited by 29 · see citing works

RNA-Based Anti-Inflammatory Effects of Membrane Vesicles Derived from Lactiplantibacillus plantarum

Yamasaki-Yashiki, S., Kawashima, F., Saika, A., Hosomi, R., Kunisawa, J., & Katakura, Y. (2024) · Foods · doi:10.3390/foods13060967 · Cited by 30 · see citing works

Recent development of micro-nano carriers for oral antineoplastic drug delivery

Li, H., Chen, X., Rao, S., Zhou, M., Lu, J., Liang, D., Zhu, B., Li, M., Lin, J., Ding, X., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101445 · Cited by 31 · see citing works

Next-generation probiotics and engineered BEVs for precision therapeutics in osteoporosis

Wei, J., Ding, W., Song, K., Zhang, Y.-K., Luo, Q., & Qi, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1581971 · Cited by 28 · see citing works

Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance

Chai, Q., Li, D., Zhang, M., Gu, Y., Li, A., Wu, X., Liu, X., & Liu, J. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101277 · Cited by 30 · see citing works

Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives

Wu, Q., Kan, J., Fu, C., Liu, X., Cui, Z., Wang, S., Le, Y., Li, Z., Liu, Q., Zhang, Y., et al. (2024) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2024.100301 · Cited by 29 · see citing works

Exosomes of immune cell origin and their therapeutic potential for tumors

Ai, H., Zou, Y., Zheng, X., Li, G., Lei, C., Fu, W., & Hu, S. (2024) · Open Research (University of Surrey) · doi:10.1002/viw.20240029 · Cited by 28 · see citing works

Oral Pathobiont-Derived Outer Membrane Vesicles in the Oral–Gut Axis

Catalán, E. A., Seguel-Fuentes, E., Fuentes, B., Aranguiz-Varela, F., Castillo-Godoy, D. P., Rivera-Asín, E., Bocaz, E., Fuentes, J. A., Bravo, D., Schinnerling, K., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011141 · Cited by 30 · see citing works

Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy

Hamza, M., Wang, S., Wu, H., Sun, J., Du, Y., Zeng, C., Liu, Y., Li, K., Zhu, X., Liu, H., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.03.014 · Cited by 28 · see citing works

Bacterial extracellular vesicles: emerging mediators of gut-liver axis crosstalk in hepatic diseases

Zhou, Y.-T., Sun, Y., Yin, P., Zuo, S., Li, H., & Cao, K. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1620829 · Cited by 31 · see citing works

Probiotic Bacteria as Therapeutics and Biohybrid Drug Carriers: Advances, Design Strategies, and Future Outlook

Sahoo, D., Rodriguez, E., Nguyen, K. T., & Chintapula, U. K. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00959 · Cited by 31 · see citing works

Orchestrating Gut Disorders by Oral Delivery of a Living-Synthetic Hybrid Hydrogel.

Zhang, K., Liang, Y., Chen, Q., Zhang, S., Liu, Y., Wu, W., Zhu, L., Qu, K., Qin, X., Chen, Y.-D., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c08982 · Cited by 28 · see citing works

Bacteria‐Based Living Probes: Preparation and the Applications in Bioimaging and Diagnosis

Jiang, H., Cao, Z., Liu, Y., Liu, R., Zhou, Y., & Liu, J. (2023) · Advanced Science · doi:10.1002/advs.202306480 · Cited by 26 · see citing works

Reprogramming peritoneal macrophages with outer membrane vesicle-coated PLGA nanoparticles for endometriosis prevention

Wu, N., Han, Z., Lv, W., Huang, Y., Zhu, J., Deng, J., & Xue, Q. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123198 · Cited by 26 · see citing works

Gut Microbiota Metabolites and Chronic Diseases: Interactions, Mechanisms, and Therapeutic Strategies

Liu, W., Wang, L., Ou, J., Peng, D., Zhang, Y., Chen, W., & Wang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083752 · Cited by 31 · see citing works

Enhancing phage therapy by coating single bacteriophage-infected bacteria with polymer to preserve phage vitality

Lin, S., Xie, G., He, J., Meng, L., Pang, Y., & Liu, J. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01354-3 · Cited by 25 · see citing works

Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release

Wu, Y., Huang, X., Li, Q., Yang, C., Huang, X., Du, H., Situ, B., Zheng, L., & Ou, Z. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03280-7 · Cited by 25 · see citing works

Micro‐to‐Nano Oncolytic Microbial System Shifts from Tumor Killing to Tumor Draining Lymph Nodes Remolding for Enhanced Immunotherapy

Chen, Z., Liu, Y., Yu, Y., Yang, S., Feng, J. Q., Zhu, Y., Huang, W., Qin, B. Y., Guan, X., He, Z., et al. (2023) · Advanced Materials · doi:10.1002/adma.202306488 · Cited by 25 · see citing works

Layer by layer self-assembled hyaluronic acid nanoarmor for the treatment of ulcerative colitis

Zhao, X., Zhang, Y.-C., Wang, P., Liu, K.-L., Zheng, Y.-H., Wen, J.-P., Wang, K., & Wen, X. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02933-3 · Cited by 19 · see citing works

Microneedle delivery platform integrated with Staphylococcus epidermidis-derived extracellular vesicles-based nanoantibiotics for efficient bacterial infection atopic dermatitis treatment

Zhou, H. W., Zhang, S., Liu, X., Feng, A., Chen, S., & Liu, W. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.02.038 · Cited by 25 · see citing works

Engineered probiotics remodel the intestinal epithelial barrier and enhance bacteriotherapy for inflammatory bowel diseases

Chen, Y., Bi, S., Zhang, X., Chen, J., Xin, J., Liu, Z., Guan, Q., Qiu, P., Wang, P., & Liu, J. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.04.016 · Cited by 24 · see citing works

Genetically engineered Bacillus subtilis-derived extracellular vesicles Alleviates Ulcerative colitis by restoring intestinal barrier and regulating gut microbiota

Chen, J., Wei, C., Pan, C., You, W., Li, B., Liu, T., Wang, X., Wen, Z., Zhao, Y., Zhang, M., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.162727 · Cited by 24 · see citing works

Akkermansia muciniphila: a microbial guardian against oxidative stress–gut microbiota crosstalk and clinical prospects

Ye, W.-Y., & Cai, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07149-z · Cited by 25 · see citing works

Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic Applications

Duan, L., Lin, W., Zhang, Y., Jin, L., Xiao, J., Wang, H., Pang, S., Wang, H., Sun, D., Gong, Y., et al. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-09013-2 · Cited by 23 · see citing works

Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization

Tao, S., Song, M., Fan, J., Zhu, F., Lv, T., & Wei, H. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.06.035 · Cited by 23 · see citing works

Limosilactobacillus johnsoni and Limosilactobacillus mucosae and Their Extracellular Vesicles Alleviate Gut Inflammatory Injury by Mediating Macrophage Polarization in a Lipopolysaccharide-Challenged Piglet Model

Li, J., Feng, S., Pi, Y., Jiang, X., Li, X., Zhou, Z., Liu, X., Wei, H., & Tao, S. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.06.009 · Cited by 23 · see citing works

Bacterial Extracellular Vesicles in Oncology: Molecular Mechanisms and Future Clinical Applications

Bhanu, P., Godwin, A. K., Umar, S., & Mahoney, D. E. (2025) · Cancers · doi:10.3390/cancers17111774 · Cited by 22 · see citing works

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Yang, Y., Yang, L., Yang, Y., Deng, H., Su, S., Xia, Y.-X., Su, J., Liu, Y., Wu, J.-W., Zhang, J., et al. (2025) · Advancement of science · doi:10.1002/advs.202500781 · Cited by 30 · see citing works

Lactobacillus johnsonii-derived extracellular vesicles restore mucosal immunity via taurine-linked Th17/Treg and IgA/IgG regulation in colitis

Zhao, H., Yue, N., Mai, Z., Zhang, Y., Tian, C., Chen, K., Huang, L., Shi, R., Liang, Y., Yao, J., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03702-6 · Cited by 22 · see citing works

The gut microbiota and host immunity synergistically orchestrate colonization resistance

Li, N., & Guo, X. (2026) · Gut Microbes · doi:10.1080/19490976.2025.2611545 · Cited by 23 · see citing works

Advanced Bioinspired Multifunctional Platforms Focusing on Gut Microbiota Regulation

Li, M., Wang, L., Lin, D., Liu, Z., Wang, H., Yang, Y., Sun, C., Ye, J., & Liu, Y. (2024) · ACS Nano · doi:10.1021/acsnano.4c05013 · Cited by 22 · see citing works

The Role of Akkermansia muciniphila in Disease Regulation

Ding, Y., Hou, Y., & Lao, X. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10642-y · Cited by 21 · see citing works

Extracellular vesicles and their indispensable roles in pathogenesis and treatment of inflammatory bowel disease: A comprehensive review

Chen, L., Ou, Q., & Kou, X. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121830 · Cited by 20 · see citing works

Impact of probiotics-derived extracellular vesicles on livestock gut barrier function

Zhang, Y., Song, M., Fan, J., Guo, X., & Tao, S. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01102-8 · Cited by 20 · see citing works

Linking microbial communities to rheumatoid arthritis: focus on gut, oral microbiome and their extracellular vesicles

Lü, J., Wang, Y., Wu, J., Duan, Y., Zhang, H., & Du, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1503474 · Cited by 20 · see citing works

Interaction Between Microbiota and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and New Therapeutic Opportunities

Zeng, J., He, Z., Wang, G., Ma, Y., & Zhang, F. (2025) · MedComm · doi:10.1002/mco2.70265 · Cited by 25 · see citing works

Bioorthogonal Engineering of Bacterial Outer Membrane Vesicles for NIR-II Fluorescence Imaging-Guided Synergistic Enhanced Immunotherapy

Li, N., Wang, M., Liu, F., Wu, P., Wu, F., Xiao, H., Kang, Q., Li, Z., Yang, S., Wu, G., et al. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c04449 · Cited by 20 · see citing works

Potential therapeutic application and mechanism of gut microbiota-derived extracellular vesicles in polycystic ovary syndrome

Yang, L., Liu, T., Liao, Y., Ren, Y., Zheng, Z., Zhang, M., Yu, Y., Liu, C., Wang, C., Chen, T., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117504 · Cited by 20 · see citing works

Harnessing Akkermansia muciniphila Membrane Coating for Probiotic Therapy in Inflammatory Bowel Disease

Su, Z., Li, W., Li, S., Wang, R. L., Sheng, D., Zhao, G., Cao, H., & Zhang, L. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c18134 · Cited by 19 · see citing works

Microfluidic Fabrication of Hyaluronic Acid–Cysteine-Modified Chitosan Microspheres for CD44-Targeted Probiotic Delivery in Colitis Treatment

Qiao, F., Luo, Y., Lei, P., Wang, S., Duan, Z., Cui, H., Liu, T., Yi, H., Souza, C. D., Xuan, G., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c10456 · Cited by 19 · see citing works

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

Al-Jipouri, A., Eritja, À., & Božić, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010485 · Cited by 19 · see citing works

Probiotic Membrane-Modified Nanocomposite Alleviates Inflammation and Microbiota Dysbiosis in Colitis by Scavenging Oxidative Stress and Restoring Immune Homeostasis

Yang, H., Zhang, X., Wu, J., Xiao, Y., Dai, L., Wang, G., Zhang, X., Hu, C., He, S., & Yuan, Z. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c22004 · Cited by 19 · see citing works

Microscopic messengers: microbiota-derived bacterial extracellular vesicles in inflammatory bowel disease

Zubair, M., Abouelnazar, F. A., Dawood, A. S., Pan, J., Zheng, X., Chen, T., Liu, P., Mao, F., Yan, Y., & Chu, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1481496 · Cited by 17 · see citing works

Engineered Therapeutic Bacteria with High-Yield Membrane Vesicle Production Inspired by Eukaryotic Membrane Curvature for Treating Inflammatory Bowel Disease

chen, J., Liu, M., Chen, S., Chou, C.-H. P., Liu, H., Wu, D., & Liu, Y. (2025) · ACS Nano · doi:10.1021/acsnano.4c13069 · Cited by 17 · see citing works

Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b/NF-κB-mediated macrophage polarization

Song, M., Zhou, W., Fan, J., Jia, C., Xiong, W., Wei, H., & Tao, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2541036 · Cited by 17 · see citing works

Akkermansia muciniphila ameliorates chronic stress-induced colorectal tumor growth by releasing outer membrane vesicles

Jin, S., Lu, Y., Zuo, Y., Xu, Q., Hao, Y., Zuo, H., Cui, Z., Zhang, X., Wang, M., Li, H., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2555618 · Cited by 18 · see citing works

Probiotic extracellular vesicles reprogram macrophage immunometabolism: From gut crosstalk to host health

Li, Y., Liu, Y., Wei, X., Wang, C. Z., Khan, M. Z., & Ma, Q. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2614115 · Cited by 17 · see citing works

Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

Li, S., Li, X., Meng, J., Bao, W., Wang, S., Ye, P., Gao, X., & Wei, W. (2023) · Nano Research · doi:10.1007/s12274-023-6225-6 · Cited by 17 · see citing works

Physiochemically and Genetically Engineered Bacteria: Instructive Design Principles and Diverse Applications

Lin, X., Jiao, R., Cui, H., Yan, X., & Zhang, K. (2024) · Advanced Science · doi:10.1002/advs.202403156 · Cited by 16 · see citing works

Yin-Yang: two sides of extracellular vesicles in inflammatory diseases

Zeng, B., Li, Y., Khan, N., Su, A., Yang, Y., Mi, P., Jiang, B., Liang, Y., & Duan, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02779-9 · Cited by 17 · see citing works

Engineered bacterial extracellular vesicles for gastrointestinal diseases

Nie, X., Li, Q., He, Y., Xu, Y., Qiao, S., Wang, X., Meng, F., Xie, J., & Nie, S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113972 · Cited by 16 · see citing works

Oral natural extracellular vesicles for biomedical applications: Advances and clinical perspectives

Guan, X., Zhu, M., Zhu, H., Wang, Q., Chen, J., Chen, Y., Mou, X., & Si, J. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.003 · Cited by 16 · see citing works

The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism

Wang, X., Li, A., Jing, H., Zhang, X., Dong, X., Song, Z., Wu, N., & Zheng, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1653472 · Cited by 16 · see citing works

Akkermansia muciniphila Protects Against Trinitrobenzene Sulfonic Acid Induced Colitis by Inhibiting IL6/STAT3 Pathway

Jiang, M., Jia, Y., Ma, C., Zeng, Z., Wu, Y., Gan, H., & Zhang, H. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf057 · Cited by 15 · see citing works

Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and health care

Zhang, H., Lee, B. J. Y., Wang, T., Xiang, X., Tan, Y., Han, Y., Bi, Y., Zhi, F., Wang, X., He, F., et al. (2025) · hLife · doi:10.1016/j.hlife.2025.04.004 · Cited by 16 · see citing works

Activation of Immune and Defense Responses in the Intestinal Mucosa by Outer Membrane Vesicles of Commensal and Probiotic Escherichia coli Strains

Fábrega, M.-J., Aguilera, L., Gíménez, R., Varela, E., Cañas, M. A., Antolı́n, M., Badı́a, J., & Baldomà, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00705 · Cited by 143 · see citing works

Outer membrane vesicles blebbing contributes to B. vulgatus mpk-mediated immune response silencing

Maerz, J. K., Steimle, A., Lange, A., Bender, A., Fehrenbacher, B., & Frick, J.-S. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1344810 · Cited by 104 · see citing works

Microbial membrane vesicles and the intestinal epithelium: a crosstalk in health and disease

Abubakari, A. W., Salvador‐Oke, K. T., M-Kamal, H. S., & Johnson, A. M. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04562-2 · Cited by 3 · see citing works

ID: 178

Maerz, J. K., Steimle, A., Grohnbach, K., Fehrenbacher, B., Autenrieth, I. B., & Frick, J.-S. (2015) · Cytokine · doi:10.1016/j.cyto.2015.08.188 · Cited by 1 · see citing works

Modulation of intestinal immune response by Outer Membrane Vesicles from probiotic and commensal Escherichia coli strains

Fábrega, M.-J. (2018) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)