The DOI matches its Crossref record; 75 of the 77 references it cites were found in a registry or an index.
Mitogen activated protein kinases: a role in inflammatory bowel disease?
Open accessAbstract
Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.
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“These TFs have been previously reported to be associated with IBD in the literature.”
From Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data (2025) · cites this paper as [68]
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1 retracted
Regulation of Cyclooxgenase-2 mRNA Stability by Taxanes
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RetractedAssociation of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039
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NF‐κB in inflammatory bowel disease
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Cited by
Sorted by citations
Nandipati, K. C., Subramanian, S., & Agrawal, D. K. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2878-8 · Cited by 214
Sun, P., Zhou, K., Wang, S., Li, P., Chen, S., Lin, G., Zhao, Y., & Wang, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069424 · Cited by 209
Chen, L., Teng, H., Jia, Z., Battino, M. A., Miron, A., Yu, Z., Cao, H., & Xiao, J. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1345853 · Cited by 205
Zhang, H., Kovacs-Nolan, J., Kodera, T., Eto, Y., & Mine, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.023 · Cited by 186
MAP kinases in inflammatory bowel disease
Coskun, M., Olsen, J., Seidelin, J. B., & Nielsen, O. H. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.12.020 · Cited by 176
Self-citation
Metadata
- Authors
- Broom, O. J., Widjaya, B., Troelsen, J., Olsen, J., & Nielsen, O. H.
- Affiliations
- University of Copenhagen (DK)
- Herlev Hospital (DK)
- Corresponding author
- Broom, O J
- Nielsen, O H
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-09-30
- Volume
- 158
- Issue
- 3
- Pages
- 272-280
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- PMC
- PMC2792822
- OpenAlex
- W2068392219
- Cited by
- 177
- References
- 77
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 16 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 12 · 2019: 17 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 6 · 2013: 8 · 2012: 8
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical & Experimental Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Aase og Ejnar Danielsens Fond
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- mitogen-activated protein kinase, inflammatory bowel disease, ulcerative colitis, Crohn's disease, inflammatory signalling, MAPK signaling, disease progression
- MeSH terms
- Humans, Inflammatory Bowel Diseases, Inflammation Mediators, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Protein Kinase Inhibitors
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