Mitogen activated protein kinases: a role in inflammatory bowel disease?

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Unravelling the pathogenesis of inflammatory bowel disease

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo

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The genetics and immunopathogenesis of inflammatory bowel disease

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MAP Kinases

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NF‐κB in inflammatory bowel disease

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MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

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Targeting dual-specificity phosphatases: Manipulating MAP kinase signalling and immune responses

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MAPKs and their relevance to arthritis and inflammation

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TNF: A master switch for inflammation to cancer

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MAPK signalling: ERK5 versus ERK1/2

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The p38 MAP kinase pathway as a therapeutic target in inflammatory disease

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p38 Mitogen-Activated Protein Kinase Is Activated and Linked to TNF-α Signaling in Inflammatory Bowel Disease

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Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease

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Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor α expression by inducing Elk-1 phosphorylation and Egr-1 expression

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Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease

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Atypical mitogen-activated protein kinases: Structure, regulation and functions

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Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

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Anti-Inflammatory Effects of a p38 Mitogen-Activated Protein Kinase Inhibitor During Human Endotoxemia

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p38 Pathway Kinases as Anti-inflammatory Drug Targets

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The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

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Inhibition of p38 MAP kinase‐and RICK/NF‐κB‐signaling suppresses inflammatory bowel disease

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Oral p38 Mitogen-Activated Protein Kinase Inhibition With BIRB 796 for Active Crohn’s Disease: A Randomized, Double-Blind, Placebo-Controlled Trial

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Combinations of ERK and p38 MAPK Inhibitors Ablate Tumor Necrosis Factor-α (TNF-α) mRNA Induction

Rutault, K., Hazzalin, C. A., & Mahadevan, L. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005486200 · Cited by 177

Intestinal Epithelial Cell Differentiation Involves Activation of p38 Mitogen-activated Protein Kinase That Regulates the Homeobox Transcription Factor CDX2

Houde, M., Laprise, P., Jean, D., Blais, M., Asselin, C., & Rivard, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100236200 · Cited by 155

AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3

Zhang, R., He, X., Liu, W., Lü, M., Hsieh, J., & Wang, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17790 · Cited by 152

MKP-7, a Novel Mitogen-activated Protein Kinase Phosphatase, Functions as a Shuttle Protein

Masuda, K., Shima, H., Watanabe, M., & Kikuchi, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104600200 · Cited by 151

A Functional Role for Interleukin-21 in Promoting the Synthesis of the T-Cell Chemoattractant, MIP-3α, by Gut Epithelial Cells

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Inhibition of RICK/Nuclear Factor-κB and p38 Signaling Attenuates the Inflammatory Response in a Murine Model of Crohn Disease

Hollenbach, E., Vieth, M. W., Roessner, A., Neumann, M., Malfertheiner, P., & Naumann, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500966200 · Cited by 149

Role of the JNK signal transduction pathway in inflammatory bowel disease

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Genome-wide Association Scanning Highlights Two Autophagy Genes,ATG16L1andIRGM, as Being Significantly Associated with Crohn’s Disease

Massey, D. C. O., & Parkes, M. (2007) · Autophagy · doi:10.4161/auto.5075 · Cited by 141

Role of STAT3 in inflammatory bowel disease

Sugimoto, K. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5110 · Cited by 133

Both Nuclear-Cytoplasmic Shuttling of the Dual Specificity Phosphatase MKP-3 and Its Ability to Anchor MAP Kinase in the Cytoplasm Are Mediated by a Conserved Nuclear Export Signal

Karlsson, M. E., Mathers, J. E., Dickinson, R. J., Mandl, M., & Keyse, S. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406720200 · Cited by 132

Rdp58 Is a Novel and Potentially Effective Oral Therapy for Ulcerative Colitis

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Crohn's disease: beyond antagonists of tumour necrosis factor

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Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis

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The specific JNK inhibitor SP600125 targets tumour necrosis factor‐α production and epithelial cell apoptosis in acute murine colitis

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Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis.

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Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-κB pathways

Garat, C. (2003) · Cytokine · doi:10.1016/s1043-4666(03)00182-0 · Cited by 92

The IRAK-1-BCL10-MALT1-TRAF6-TAK1 Cascade Mediates Signaling to NF-κB from Toll-like Receptor 4

Dong, W., Liu, Y., Jinhong, P., Chen, L., Zou, T., Xiao, H., Liu, Z., Li, W., Bu, Y., & Qi, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513057200 · Cited by 92

Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease.

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ERK5 Activation Inhibits Inflammatory Responses via Peroxisome Proliferator-activated Receptor δ (PPARδ) Stimulation

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Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF promoter in stimulated mast cells

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Altered TAB1:IκB Kinase Interaction Promotes Transforming Growth Factor β–Mediated Nuclear Factor-κB Activation during Breast Cancer Progression

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Altered ENaC Expression Leads to Impaired Sodium Absorption in the Noninflamed Intestine in Crohn's Disease

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MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages

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Epithelial: Lamina Propria Lymphocyte Interactions Promote Epithelial Cell Differentiation

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Scaffold Proteins in Mammalian MAP Kinase Cascades

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Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease

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Regulation of PRAK Subcellular Location by p38 MAP Kinases

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Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells

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Inflammatory bowel disease: Genetic and epidemiologic considerations

Cho, J. H. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.338 · Cited by 65

ERK5/BMK1 Is Indispensable for Optimal Colony-Stimulating Factor 1 (CSF-1)-Induced Proliferation in Macrophages in a Src-Dependent Fashion

Rovida, E., Spinelli, E., Sdelci, S., Barbetti, V., Morandi, A., Giuntoli, S., & Sbarba, P. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.4166 · Cited by 63

Compartmentalised MAPK Pathways

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Dextran sulfate sodium enhances interleukin-1β release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages

Kwon, K. H., Ohigashi, H., & Murakami, A. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.05.022 · Cited by 55

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-α MODULATES THE ANTI-INFLAMMATORY EFFECT OF GLUCOCORTICOIDS IN A MODEL OF INFLAMMATORY BOWEL DISEASE IN MICE

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MAPK phosphatases as novel targets for rheumatoid arthritis

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Specific Inhibition of c-Raf Activity by Semapimod Induces Clinical Remission in Severe Crohn’s Disease

Löwenberg, M., Verhaar, A. P., van den Blink, B., ten Kate, F. J. W., van Deventer, S. J. H., Peppelenbosch, M. P., & Hommes, D. W. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2293 · Cited by 46

Regulation of RELM/FIZZ isoform expression byCdx2in response to innate and adaptive immune stimulation in the intestine

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HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts

Mari, J. F. D., Saada, J. I., Mifflin, R. C., Valentich, J. D., & Powell, D. W. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00117.2007 · Cited by 44

Inhibitors of c-jun-N-Terminal Kinase (JNK)

LoGrasso, P. V., & Kamenecka, T. M. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708784912120 · Cited by 40

Interleukins 2 and 15 Regulate Ets1 Expression via ERK1/2 and MNK1 in Human Natural Killer Cells

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Genetic Deletion of JNK1 and JNK2 Aggravates the DSS-Induced Colitis in Mice

Chromik, A. M., Müller, A. M., Körner, J., Belyaev, O., Holland‐Letz, T., Schmitz, F., Herdegen, T., Uhl, W. H., & Mittelkötter, U. (2007) · Journal of Investigative Surgery · doi:10.1080/08941930601126140 · Cited by 35

Regulation of c-fos, c-jun and c-myc Gene Expression by Angiotensin II in Primary Cultured Rat Astrocytes: Role of ERK1/2 MAP Kinases

Delaney, J., Chiarello, R., Villar, D., Kandalam, U., Castejon, A. M., & Clark, M. A. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9474-y · Cited by 33

Mechanisms of Disease: transcription factors in inflammatory arthritis

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State-of-the-art of irritable bowel syndrome and inflammatory bowel disease research in 2008

McFarland, L. V. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2625 · Cited by 31

Rational Design and Development of RDP58

Iyer, S., Lahana, R., & Buelow, R. (2002) · Current Pharmaceutical Design · doi:10.2174/1381612023393170 · Cited by 29

No Evidence for an Involvement of the P38 and JNK Mitogen-Activated Protein in Inflammatory Bowel Diseases

Malamut, G., Cabane, C., Dubuquoy, L., Body–Malapel, M., Dérijard, B., Gay, J., Tamboli, C., Colombel, J., & Desreumaux, P. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9116-2 · Cited by 24

Differential Regulation of the Antiapoptotic Action of B-Cell Lymphoma 2 (Bcl-2) and B-Cell Lymphoma Extra Long (Bcl-xL) by c-Jun N-Terminal Protein Kinase (JNK) 1-Involved Pathway in Neuroglioma Cells

Jeong, H., Choi, H.-Y., Choi, T.-W., Kim, B., Kim, J., Lee, E.-R., & Cho, S. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1686 · Cited by 23

743 Rdea119, a Potent and Highly Selective MEK Inhibitor Ameliorates Murine Colitis

Miampamba, M. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)60502-8 · Cited by 5

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

Nandipati, K. C., Subramanian, S., & Agrawal, D. K. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2878-8 · Cited by 214

Involvement of MAPK/NF-κB Signaling in the Activation of the Cholinergic Anti-Inflammatory Pathway in Experimental Colitis by Chronic Vagus Nerve Stimulation

Sun, P., Zhou, K., Wang, S., Li, P., Chen, S., Lin, G., Zhao, Y., & Wang, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069424 · Cited by 209

Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence

Chen, L., Teng, H., Jia, Z., Battino, M. A., Miron, A., Yu, Z., Cao, H., & Xiao, J. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1345853 · Cited by 205

γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor

Zhang, H., Kovacs-Nolan, J., Kodera, T., Eto, Y., & Mine, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.023 · Cited by 186

MAP kinases in inflammatory bowel disease

Coskun, M., Olsen, J., Seidelin, J. B., & Nielsen, O. H. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.12.020 · Cited by 176

MAP kinases in inflammatory bowel disease

Coskun, M., Olsen, J., Seidelin, J. B., & Nielsen, O. H. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.12.020 · Cited by 176

Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease

Docena, G. H., Rovedatti, L., Kruidenier, L., Fanning, A., Leakey, N., Knowles, C. H., Lee, K., Shanahan, F., Nally, K., McLean, P. G., et al. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04203.x · Cited by 59

The role of p38 mitogen‐activated protein kinase in the pathogenesis of inflammatory bowel disease

Feng, Y., & Li, Y. Y. (2011) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2011.00525.x · Cited by 104

Molecular signaling blockade as a new approach to inhibit leukocyte-endothelial interactions for Inflammatory bowel disease treatment

Scaldaferri, F., Correale, C., Gasbarrini, A., & Danese, S. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.3.9152 · Cited by 8

Signaling Pathways Associated with Inflammatory Bowel Disease

Wei, J., & Feng, J. (2010) · Recent Patents on Inflammation & Allergy Drug Discovery · doi:10.2174/187221310791163071 · Cited by 171