Cited by 178Inflammatory Bowel DiseaseNF-κB Signaling PathwaysProtein Kinase Regulation and GTPase Signaling

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Mitogen activated protein kinases: a role in inflammatory bowel disease?

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Broom, O J, Widjaya, B, Troelsen, J, Olsen, J, Nielsen, O H·2009·Clinical and Experimental Immunology

DOI 10.1111/j.1365-2249.2009.04033.xPMC PMC2792822

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Abstract

Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.

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Authors: Broom, O. J., Widjaya, B., Troelsen, J., Olsen, J., & Nielsen, O. H.
Affiliations: University of Copenhagen (DK)
Herlev Hospital (DK)
Corresponding author: Broom, O J
Nielsen, O H
ORCID: Troelsen, J
Olsen, J
Nielsen, O H
Venue: Clinical and Experimental Immunology
Publisher: Oxford University Press (OUP)
Published: 2009-09-30
Volume: 158
Issue: 3
Pages: 272-280
ISSN: 0009-9104 (ISSN-L)
1365-2249
DOI: 10.1111/j.1365-2249.2009.04033.x
PMC: PMC2792822
OpenAlex: W2068392219
Cited by: 177
References: 77
Citations by year: 2026: 8 · 2025: 8 · 2024: 16 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 12 · 2019: 17 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 6 · 2013: 8 · 2012: 8
FWCI: 0.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical & Experimental Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Aase og Ejnar Danielsens Fond
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: mitogen-activated protein kinase, inflammatory bowel disease, ulcerative colitis, Crohn's disease, inflammatory signalling, MAPK signaling, disease progression
MeSH terms: Humans, Inflammatory Bowel Diseases, Inflammation Mediators, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Protein Kinase Inhibitors

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Mitogen activated protein kinases: a role in inflammatory bowel disease?

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