Cited by 112Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

END‐ORGAN RESPONSES TO THYROXINE THERAPY IN SUBCLINICAL HYPOTHYROIDISM

BELL, G. M., TODD, W. T. A., FORFAR, J. C., MARTYN, C., WATHEN, C. G., GOW, S., RIEMERSMA, R., TOFT, A. D.·1985·Clinical Endocrinology

Abstract

SUMMARY: We studied variables known to change with thyroid hormone status in 18 patients with subclinical hypothyroidism before and during treatment with thyroxine in a dose sufficient to restore the plasma TSH response to TRH to normal. There was an associated increase in both plasma total T4 and free T4 within the normal range but plasma total T3 and free T3 were unchanged. As a result of thyroxine treatment there was a small but significant increase (P < 0.05) in left ventricular ejection fraction (LVEF) with maximal exercise but no significant changes in LVEF at rest and moderate exercise, continuously monitored mean sleeping heart rate, day/night ratios of urinary sodium excretion, peripheral nerve conduction velocities, fasting serum triglycerides, total cholesterol (TC), high density lipoproteins (HDL) or TC/HDL ratios. On this evidence we do not consider that thyroxine replacement therapy is indicated in patients with subclinical hypothyroidism.

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Crossref · 10.1111/j.1365-2265.1985.tb01068.x

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Authors
BELL, G. M., TODD, W. T. A., FORFAR, J. C., MARTYN, C., WATHEN, C. G., GOW, S., RIEMERSMA, R., & TOFT, A. D.
Affiliations
Edinburgh Royal Infirmary (GB)
Corresponding author
TOFT, A. D.
ORCID
GOW, S.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1985-01
Volume
22
Issue
1
Pages
83-89
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
OpenAlex
W2077688299
Cited by
112
References
33
Citations by year
2021: 1 · 2019: 2 · 2018: 6 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
3.62
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
subclinical hypothyroidism, thyroxine replacement, levothyroxine, thyroid hormone status, left ventricular ejection fraction, exercise stress, sodium excretion, peripheral nerve conduction velocity, serum triglycerides, cholesterol, HDL cholesterol, total thyroxine, free thyroxine, total T3, free T3, TSH response to TRH
MeSH terms
Adult, Female, Heart, Humans, Hypothyroidism, Male, Middle Aged, Thyrotropin, Thyroxine, Triiodothyronine

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